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PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e71845
Biofilms of the Gram-negative bacterium Pseudomonas aeruginosa are one of the major causes of complicated urinary tract infections with detrimental outcome. To... 
TRANSCRIPTIONAL REGULATOR | HEME-BINDING PROTEIN | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | FE(III)-PYOCHELIN RECEPTOR | PYOVERDINE BIOSYNTHESIS | QUINOLONE SIGNAL SYNTHESIS | ANAEROBIC SURVIVAL | MASS-SPECTROMETRY | VIRULENCE FACTOR EXPRESSION | QUORUM-SENSING SYSTEMS | Adaptation, Physiological | Amino Acids, Aromatic - metabolism | Quorum Sensing | Virulence Factors - genetics | Stress, Physiological | Glucuronic Acid - metabolism | Metabolome | Proteome | Gene Expression Profiling | Pseudomonas aeruginosa - physiology | Gene Regulatory Networks | Alginates - metabolism | Iron - metabolism | Pseudomonas Infections - microbiology | Biofilms | Energy Metabolism | Metabolic Networks and Pathways | Urinary Tract Infections - microbiology | Virulence Factors - metabolism | Gene Expression Regulation, Bacterial | Hexuronic Acids - metabolism | Lipase | Fatty acids | Lactates | Polysaccharides | Metabolites | Analysis | Physiological aspects | Pseudomonas aeruginosa | Urinary tract infections | Cross infection | Nosocomial infections | Health aspects | Chromosomes | Alginic acid | Virulence | Biochemistry | Urinary tract | Proteins | Enzymatic activity | Virulence factors | Bioinformatics | Carbon sources | Enzymes | Operons | Metabolism | Gene expression | Urinary tract diseases | Urea | Scientific imaging | Mass spectrometry | Phosphates | Enzyme activity | Leukemia | Metabolic networks | Amino acids | Iron | Biosynthesis | Genomes | Infections | Reduction | LipA protein | Urogenital system | Adaptation | Urine | Creatinine | Bacterial infections | Cystic fibrosis | Chemotaxis | Catheters | Chromatography | Citric acid | Acids | Antibiotics | Lungs | Proteomics | Lactic acid | Proteomes | Respiration | Flagella
Journal Article
BMC Genomics, ISSN 1471-2164, 03/2015, Volume 16, Issue 1, pp. 175 - 175
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182974
Phenotypic assays using human primary cells are highly valuable tools for target discovery and validation in drug discovery. Expression knockdown (KD) of such... 
AIRWAY EPITHELIAL-CELLS | RNAI | TGF-BETA | ENDONUCLEASE | MULTIDISCIPLINARY SCIENCES | CRISPR-CAS9 SYSTEM | MICE | CAS9 | EXPRESSION | GENOME | REVEALS | Endonucleases - genetics | Epithelial Cells - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Epithelial Cells - drug effects | Humans | Actins - metabolism | Epithelial-Mesenchymal Transition - drug effects | Smad3 Protein - metabolism | Endonucleases - metabolism | Epithelial-Mesenchymal Transition - genetics | INDEL Mutation | Actins - genetics | Smad3 Protein - genetics | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | Adenoviridae - genetics | Bronchi - metabolism | Epithelial Cells - cytology | Bronchi - cytology | Fibroblasts - metabolism | Transduction, Genetic | Genetic Vectors - chemistry | Gene Expression Regulation | Gene Silencing | Genetic Vectors - metabolism | Smad3 Protein - antagonists & inhibitors | Fibronectins - metabolism | Gene Editing | Protein Transport | Transforming Growth Factor beta - pharmacology | Fibroblasts - drug effects | CRISPR-Cas Systems | Fibroblasts - cytology | Fibronectins - genetics | Adenoviridae - metabolism | Primary Cell Culture | Genome, Human | Fibronectins | Drug discovery | Research | Gene expression | Adenoviruses | Biotechnology | Mesenchyme | Epithelial cells | Insertion | Editing | Smooth muscle | Genomes | Smad3 protein | Inactivation | Assaying | gRNA | Fibronectin | Clonal deletion | Actin | Fibroblasts | Protein transport | Deoxyribonucleic acid--DNA | Expression vectors | Translocation | CRISPR | Deactivation | Nuclear transport | Mutagenesis | Lungs | Plasmids | Cell lines | Fibrosis | Stem cells | Genetic engineering | Mutation | Deoxyribonucleic acid | DNA
Journal Article
European Journal of Surgical Oncology, ISSN 0748-7983, 2016, Volume 42, Issue 9, pp. 1407 - 1413
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e88368
Pseudomonas aeruginosa is a human pathogen that frequently causes urinary tract and catheter-associated urinary tract infections. Here, using C-13-metabolic... 
URINARY-TRACT-INFECTIONS | OXIDATIVE STRESS | VIRULENCE FACTORS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ESCHERICHIA-COLI | ADAPTATION | ISOCITRATE LYASE | CYSTIC-FIBROSIS | BACTERIAL | CORYNEBACTERIUM-GLUTAMICUM | Pseudomonas aeruginosa - isolation & purification | Humans | Male | Glyoxylates - metabolism | Pseudomonas aeruginosa - genetics | Pseudomonas aeruginosa - metabolism | Urinary Tract Infections - etiology | Glucose - metabolism | Female | Urinary Tract Infections - microbiology | Citric Acid Cycle - physiology | NADP - metabolism | Urinary Catheterization - adverse effects | Microbial metabolism | Causes of | Physiological aspects | Urinary tract infections | Development and progression | Pseudomonas aeruginosa | Genetic aspects | Research | Phosphates | Tricarboxylic acid cycle | Oxidative stress | Laboratories | Pathogenesis | Clinical isolates | Pyruvic acid | Amino acids | Infections | Biosynthesis | Glucose | Urinary tract | Overflow | Engineering | Metabolic flux | E coli | Metabolites | Entner-Doudoroff pathway | Pentose | NADP | Urogenital system | Adaptation | Quantitative analysis | Pentose phosphate | Enzymes | Pathogens | Fluctuations | Bacterial infections | Medical instruments | Glycerol | Cystic fibrosis | Fluxes | Metabolism | Catheters | Urinary tract diseases | Pentose phosphate pathway | Glycolysis
Journal Article
Journal of Pain and Symptom Management, ISSN 0885-3924, 2016, Volume 52, Issue 2, pp. 265 - 271
Journal Article
BMC NEPHROLOGY, ISSN 1471-2369, 04/2019, Volume 20, Issue 1, pp. 143 - 16
BackgroundTo support effective self-management after kidney transplantation, a holistic nurse-led self-management support intervention was developed using the... 
CHRONIC ILLNESS CARE | Nurse practitioner | CONSUMER ASSESSMENT | VALIDATION | EDUCATION | Self-care | Pilot study | DUTCH VERSION | End-stage-renal disease | Nursing | EFFECTS QUESTIONNAIRE | DISEASE | UROLOGY & NEPHROLOGY | PEOPLE | Organ transplantation | Intervention evaluation | QUALITY-OF-LIFE | HEALTH | Self-management support | Transplant Recipients - education | Self Efficacy | Holistic Nursing - standards | Holistic Nursing - methods | Humans | Middle Aged | Problem Solving | Social Support | Internet-Based Intervention | Male | Kidney Transplantation - rehabilitation | Self-Management - education | Self-Management - methods | Feasibility Studies | Transplant Recipients - psychology | Netherlands | Pilot Projects | Quality of Life | Adult | Female | Outcome Assessment, Health Care | Quality of Health Care | Medical research | Nurse practitioners | Clinics | Kidneys | Laws, regulations and rules | Goal setting | Organ transplant recipients | Transplantation | Analysis | Medicine, Experimental | Self-care, Health | Medical care | Kidney diseases | Quality management | Intervention | Fidelity | Transplants & implants | Hemodialysis | Psychotherapy | Evidence-based nursing | Management | Patients | Quality of life | Motivation | Nurses | Questionnaires | Problem solving | Interviews | Communication | Kidney transplantation | Chronic illnesses
Journal Article
British Journal of Surgery, ISSN 0007-1323, 2018, Volume 105, Issue 8, pp. 1020 - 1027
Background The incidence, treatment and outcome of patients with newly diagnosed gastrointestinal stromal tumour (GIST) were studied in an era known for... 
LIVER METASTASES | SURVIVAL | SURGERY | GIST | SARCOMA GROUP | 2 DOSE LEVELS | TYROSINE KINASE | RANDOMIZED-TRIAL | PROGRESSION-FREE | ADJUVANT IMATINIB | MUTATIONAL STATUS | Antimitotic agents | Metastasis | Antineoplastic agents | Patient outcomes | Original
Journal Article