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Journal Article
Journal Article
by Ahmadi, Emad and Namati, Jacqueline and Blair, Parry and Padole, Atul and Chico-Calero, Isabel and Lev, Michael and Lee, Jarone and Hamblin, Michael and Vakoc, Benjamin and Yung, Lok and Romero, Angelica and Santiago, Tiffany and Guber, Kenneth and Kastuar, Shivani and Nguyen, Nhuquynh and Wu, Yu-Kuang and Carmel, Jason and Spungen, Ann and Bauman, William and Ziebell, Jenna and Harrison, Jordan and Law, Matthew and Adelson, David and Lifshitz, Jonathan and Kulich, Danielle and Austin, Scarlett and Kranz, Victoria and Houle, John and Mountney, Andrea and Mendelev, Natalia and Mendelev, Natalia and Ge, Yongchao and Shear, Deborah and Haghighi, Fatemeh and Ichkova, Aleksandra and Bessy, Thomas and Bertrand, Sandrine and Badaut, Jerome and Kurpad, Shekar and Schmit, Brian and Muftuler, L. Tugan and Budde, Matthew and Mullah, Saad and Mullah, Saad and Lashof-Sullivan, Margaret and Mehalick, Melissa and Mehalick, Melissa and Shaughness, Michael and Mccarron, Richard and Ahlers, Stephen and Ahlers, Stephen and Ahlers, Stephen and Benner, Brooke and Muccigrosso, Megan and McKim, Daniel and Fenn, Ashley and Lifshitz, Jonathan and Eiferman, Daniel and Godbout, Jonathan and Holmes, Gregory and Aceves, Miriam and Okoreeh, Andre and Okoreeh, Andre and Terminel, Mabel N and Aceves, Alejandro R and Hook, Michelle A and VanRooyen, Jenna and Patel, Samir and Patel, Samir and Mashburn, Charles and Eldahan, Khalid and Cox, David and Sullivan, Patrick and Rabchevsky, Alexander and Rabchevsky, Alexander and Dixit, Shilpi and Boon, Wah Chin and O'Brien, Terence and O'Brien, Terence and Furones, Concepcion and Gurney, Mark and Dietrich, W. Dalton and Dietrich, W. Dalton and Atkins, Coleen and Adewole, Dayo and Browne, Kevin and Browne, Kevin and Petrov, Dmitriy and Struzyna, Laura and Struzyna, Laura and Cullen, D. Kacy and Cullen, D. Kacy and Cullen, D. Kacy and Cullen, D. Kacy and Cullen, D. Kacy and Oh, Byung-Mo and Wang, Zhensheng and Conley, Yvette and Failla, Michelle and Kumar, Raj and ...
Journal of Neurotrauma, ISSN 0897-7151, 07/2016, Volume 33, Issue 13, pp. A-1 - A-139
Journal Article
by Peden, Carol and Peden, Carol J and Stephens, Tim and Martin, Michael and Martin, Graham and Kahan, Brennan and Kahan, Brennan C and Thomson, Ann and Rivett, Kate and Wells, Duncan and Wells, John and Richardson, Peter and Richardson, Gerry and Kerry, Sally and Bion, Julian and Pearse, Rupert M and Pearse, Rupert and Brett, Stephen and Ackland, Gareth and Grocott, Mike and Holt, Peter and Robert, Glenn and Ukoumunne, Obioha and Waring, Justin and Everingham, Kirsty and Phull, Mandeep and Cromwell, David and Evley, Rachel and Lilford, Richard and Kocman, David and Asaria, Miqdad and Tarrant, Carolyn and Yang, Fan and Abraham, Ajit and Bothma, Pieter and Conway, Daniel and Stapleton, Clare and Edwards, Jennifer and Edwards, Mark and Minto, Gary and Saunders, David and Owen, Tom and Waldmann, Carl and Hayden, Paul and Gillies, Michael and Tighe, Sean and Smith, Hannah and Smith, Neil and Mythen, Monty and Murray, Therese and Murray, Dave and Murray, Diane and Murray, David and Lobo, Dileep and Leuwer, Martin and Kirk-Bayley, Justin and Howell, Simon and Gordon, Anthony and Anderson, Iain and Lourtie, Jose and Walker, Simon and Drake, Sharon and Watson, Geoff and Watson, Nick and Watson, Nicholas and Watson, Mark and Szakmany, Tamas and Sutcliffe, Robert and Mahajan, Ravi and Girling, Alan and Forbes, Gordon and Faiz, Omar and Blunt, Mark and Singh, Jagdeep and Singh, Satish and Singh, Surjait and Steel, Alistair and Wong, Kate and Cabreros, Leilani and Chitre, Vivek and Obideyi, Ayodele and Ali, Dhiraj and Blenk, Karl and Broad, Dan and Brodbeck, Andreas and Dumpala, Rajesh and Engel, Arnth and Ganepola, Ranjit and Garg, Sudha and Gay, Mike and Karlikowsk, Michael and Lams, Edward and Millican, Dean and Misane, Inga and Mull, Ajaya and Naik, Veena and Pushpa, Nathan and Nutt, Chris and Sagadai, Saravanna and Stuart, Hazel and ... and Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group
The Lancet, ISSN 0140-6736, 06/2019, Volume 393, Issue 10187, pp. 2213 - 2221
Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to... 
Intervention | Medical personnel | Abdominal surgery | Systemic diseases | Health | Decision making | Health services | Mortality | Health care policy | Critical care | Clinical trials | Emergency medical care | Survival | Patients | Clinical outcomes | Abdomen | Randomization | Hospitals | Motivation | Surgery | Quality control | Clusters | Emergency medical services | Quality of care
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 1, pp. 25 - 34
Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of... 
HEK293 cells | Mitosis | Auroras | Kinetochores | Cell lines | Centromeres | HeLa cells | Antibodies | Reports | Chromosomes | Cells | MITOTIC CHECKPOINT PROTEINS | MAD2 | ACTIVATION | KINASE | DYNAMICS | CENP-E | CHROMOSOME ALIGNMENT | BUB1 | KINETOCHORE LOCALIZATION | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Phosphorylation - physiology | Humans | Multiprotein Complexes - genetics | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Multiprotein Complexes - metabolism | Protein Multimerization - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mad2 Proteins | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Chromosomal Proteins, Non-Histone - genetics | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Tyrosine Kinases | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Genetic aspects | Chemical properties
Journal Article
FT.com, 06/2013
Trade Publication Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 267 - 280
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase... 
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | KINASE-ACTIVITY | LOCALIZATION | BUDDING YEAST | PHOSPHORYLATION | TENSION | mitosis | MAMMALIAN-CELLS | CELL BIOLOGY | chemical biology | CENTROSOME AMPLIFICATION | HISTONE H3 | aneuploidy | spindle checkpoint | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
Journal Article
Journal of Cell Science, ISSN 0021-9533, 11/2011, Volume 124, Issue 22, pp. 3905 - 3916
Journal Article
by Ager, Casey and Reilley, Matthew and Nicholas, Courtney and Bartkowiak, Todd and Jaiswal, Ashvin and Curran, Michael and Albershardt, Tina C and Bajaj, Anshika and Archer, Jacob F and Reeves, Rebecca S and Ngo, Lisa Y and Berglund, Peter and ter Meulen, Jan and Denis, Caroline and Ghadially, Hormas and Arnoux, Thomas and Chanuc, Fabien and Fuseri, Nicolas and Wilkinson, Robert W and Wagtmann, Nicolai and Morel, Yannis and Andre, Pascale and Atkins, Michael B and Carlino, Matteo S and Ribas, Antoni and Thompson, John A and Choueiri, Toni K and Hodi, F. Stephen and Hwu, Wen-Jen and McDermott, David F and Atkinson, Victoria and Cebon, Jonathan S and Fitzharris, Bernie and Jameson, Michael B and McNeil, Catriona and Hill, Andrew G and Mangin, Eric and Ahamadi, Malidi and van Vugt, Marianne and van Zutphen, Mariëlle and Ibrahim, Nageatte and Long, Georgina V and Gartrell, Robyn and Blake, Zoe and Simoes, Ines and Fu, Yichun and Saito, Takuro and Qian, Yingzhi and Lu, Yan and Saenger, Yvonne M and Budhu, Sadna and De Henau, Olivier and Zappasodi, Roberta and Schlunegger, Kyle and Freimark, Bruce and Hutchins, Jeff and Barker, Christopher A and Wolchok, Jedd D and Merghoub, Taha and Burova, Elena and Allbritton, Omaira and Hong, Peter and Dai, Jie and Pei, Jerry and Liu, Matt and Kantrowitz, Joel and Lai, Venus and Poueymirou, William and MacDonald, Douglas and Ioffe, Ella and Mohrs, Markus and Olson, William and Thurston, Gavin and Capasso, Cristian and Frascaro, Federica and Carpi, Sara and Tähtinen, Siri and Feola, Sara and Fusciello, Manlio and Peltonen, Karita and Martins, Beatriz and Sjöberg, Madeleine and Pesonen, Sari and Ranki, Tuuli and Kyruk, Lukasz and Ylösmäki, Erkko and Cerullo, Vincenzo and Cerignoli, Fabio and Xi, Biao and Guenther, Garret and Yu, Naichen and Muir, Lincoln and Zhao, Leyna and Abassi, Yama and Cervera-Carrascón, Víctor and Siurala, Mikko and Santos, João and Havunen, Riikka and Parviainen, Suvi and Hemminki, Akseli and ...
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 11/2016, Volume 4, Issue S1
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2005, Volume 353, Issue 1, pp. 33 - 45
Journal Article