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Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 58 - 62
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 8, pp. 812 - 814
Journal Article
Stem Cell Reports, ISSN 2213-6711, 09/2015, Volume 5, Issue 3, pp. 448 - 459
CRISPR/Cas9 protein fused to transactivation domains can be used to control gene expression in human cells. In this study, we demonstrate that a dCas9 fusion... 
SYSTEM | CRISPR | TALE | PROTEIN | REPRESSION | TRANSCRIPTION | CAS9 | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cellular Reprogramming Techniques | Humans | Adolescent | CRISPR-Cas Systems | Gene Expression Regulation | HEK293 Cells | Female | Male | Aged | Cell Differentiation | Cellular Reprogramming | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 112
Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta cells. Genome wide association and fine mapping studies to identify causal... 
Tyk2 protein | Intracellular signalling | Diabetes mellitus (insulin dependent) | mRNA | Genomes | Kinases | Janus kinase | Pancreas | Stat1 protein | Protein-tyrosine kinase | Endoderm | Tyrosine | Stat2 protein | CRISPR | Nkx6.1 protein | Cytokines | Diabetes mellitus | Stat3 protein | Inflammation | Nkx2.2 protein | Beta cells | Diabetes | Gene mapping | Pluripotency | Apoptosis
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2012, Volume 366, Issue 5, pp. 433 - 442
Journal Article
Journal Article
by Amps, Katherine and Andrews, Peter W and Anyfantis, George and Armstrong, Lyle and Avery, Stuart and Baharvand, Hossein and Baker, Julie and Baker, Duncan and Munoz, Maria B and Beil, Stephen and Benvenisty, Nissim and Ben-Yosef, Dalit and Biancotti, Juan-Carlos and Bosman, Alexis and Brena, Romulo Martin and Brison, Daniel and Caisander, Gunilla and Camarasa, Marãa V and Chen, Jieming and Chiao, Eric and Choi, Young Min and Choo, Andre B. H and Collins, Daniel and Colman, Alan and Crook, Jeremy M and Daley, George Q and Dalton, Anne and De Sousa, Paul A and Denning, Chris and Downie, Janet and Dvorak, Petr and Montgomery, Karen D and Feki, Anis and Ford, Angela and Fox, Victoria and Fraga, Ana M and Frumkin, Tzvia and Ge, Lin and Gokhale, Paul J and Golan-Lev, Tamar and Gourabi, Hamid and Gropp, Michal and Guangxiu, Lu and Hampl, Ales and Harron, Katie and Healy, Lyn and Herath, Wishva and Holm, Frida and Hovatta, Outi and Hyllner, Johan and Inamdar, Maneesha S and Irwanto, Astrid Kresentia and Ishii, Tetsuya and Jaconi, Marisa and Jin, Ying and Kimber, Susan and Kiselev, Sergey and Knowles, Barbara B and Kopper, Oded and Kukharenko, Valeri and Kuliev, Anver and Lagarkova, Maria A and Laird, Peter W and Lako, Majlinda and Laslett, Andrew L and Lavon, Neta and Lee, Dong Ryul and Lee, Jeoung Eun and Li, Chunliang and Lim, Linda S and Ludwig, Tenneille E and Ma, Yu and Maltby, Edna and Mateizel, Ileana and Mayshar, Yoav and Mileikovsky, Maria and Minger, Stephen L and Miyazaki, Takamichi and Moon, Shin Yong and Moore, Harry and Mummery, Christine and Nagy, Andras and Nakatsuji, Norio and Narwani, Kavita and Oh, Steve K. W and Oh, Sun Kyung and Olson, Cia and Otonkoski, Timo and Pan, Fei and Park, In-Hyun and Pells, Steve and Pera, Martin F and Pereira, Lygia V and Qi, Ouyang and Raj, Grace Selva and Reubinoff, Benjamin and Robins, Alan and Robson, Paul and Rossant, Janet and Salekdeh, Ghasem H and ... and Int Stem Cell Initiative and International Stem Cell Initiative and The International Stem Cell Initiative
Nature Biotechnology, ISSN 1087-0156, 12/2011, Volume 29, Issue 12, pp. 1132 - 1144
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 01/2019, Volume 37, Issue 1, pp. 33 - 41
Journal Article
eLife, ISSN 2050-084X, 11/2018, Volume 7
Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to proinsulin misfolding and its retention in endoplasmic reticulum (ER). This... 
Insulin gene mutations | stem cells | beta-cell development | CRISPR-Cas9 | regenerative medicine | induced pluripotent stem cells | human | mTORC1 | endoplasmic reticulum stress | IN-VITRO | UNFOLDED PROTEIN RESPONSE | ER STRESS | BIOLOGY | GENE-EXPRESSION | MUTANT PROINSULIN | GENERATION | ENDOPLASMIC-RETICULUM STRESS | DYSFUNCTION | PANCREATIC PROGENITORS | REVEALS | Diabetes Mellitus - pathology | Proinsulin - chemistry | Diabetes Mellitus - genetics | Induced Pluripotent Stem Cells - chemistry | Humans | Apoptosis - genetics | Male | Endoplasmic Reticulum Stress - genetics | Insulin-Secreting Cells - chemistry | Cell Differentiation - genetics | Insulin-Secreting Cells - metabolism | Female | Single-Cell Analysis | Infant, Newborn | Induced Pluripotent Stem Cells - metabolism | Cell Proliferation - genetics | Endoplasmic Reticulum - genetics | Signal Transduction | Proinsulin - genetics | CRISPR-Cas Systems - genetics | Protein Folding | Animals | Sequence Analysis, RNA | Mice | Mutation | Pancreatic beta cells | Genetic aspects | Gene mutations | Health aspects | Stem cells | Diabetes in children | Cell proliferation | Neonates | Flow cytometry | Stem cell transplantation | Biosynthesis | Glucose | Experiments | Cell growth | CRISPR | Medical research | Secretion | Diabetes mellitus | Ribonucleic acid--RNA | Insulin | Beta cells | Hospitals | Software | Diabetes | Cell size | Electron transport | Endoplasmic reticulum | Pluripotency | Apoptosis | Inhibitory postsynaptic potentials | Index Medicus
Journal Article