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The New England Journal of Medicine, ISSN 0028-4793, 01/2016, Volume 374, Issue 1, pp. 54 - 61
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2013, Volume 368, Issue 25, pp. 2395 - 2401
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2015, Volume 112, Issue 11, pp. 3493 - 3498
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2011, Volume 54, Issue 18, pp. 6342 - 6363
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2015, Volume 28, Issue 1, pp. 70 - 81
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138616 - e0138616
Cell cycle checkpoint intervention is an effective therapeutic strategy for cancer when applied to patients predisposed to respond and the treatment is... 
BREAST-CANCER | ANEUPLOIDY | KINETOCHORES | EVOLUTION | MICROTUBULES | MULTIDISCIPLINARY SCIENCES | CDK4/6 INHIBITION | MECHANISMS | DISCOVERY | SPINDLE-ASSEMBLY CHECKPOINT | CHROMOSOMAL INSTABILITY | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Phosphorylation | Intestine, Small - pathology | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Transplantation, Heterologous | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Bone Marrow Cells - drug effects | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Bone Marrow Cells - cytology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Rats | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Mice, SCID | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Animals | Mitosis - drug effects | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Protein Kinase Inhibitors - toxicity | Breast Neoplasms - diagnosis | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Histones - metabolism | G1 Phase Cell Cycle Checkpoints - drug effects | Bone Marrow Cells - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | RNA, Small Interfering - metabolism | Physiological aspects | Genetic aspects | Research | Mitosis | Protein kinases | Toxicity | Body weight | Cytotoxicity | Oncology | Body weight loss | Catalytic activity | Kinases | Cancer therapies | Cyclin-dependent kinase 4 | Genomic instability | Proteins | Cyclin-dependent kinase | Metaphase | Cell cycle | Bone marrow | Physiology | Bioindicators | Inhibition | Pretreatment | Catalysis | Drug therapy | Product safety | Chromosomes | Pharmaceutical sciences | Neutropenia | Stability | Research & development--R&D | Tumor cells | Cell division | Breast cancer | Pharmacology | Hypotheses | Inhibitors | Biomarkers | Safety research | Viability | Anaphase | Apoptosis | Tumors | Cancer | Index Medicus | Research & development | R&D
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2014, Volume 57, Issue 11, pp. 4720 - 4744
Journal Article
Protein Science, ISSN 0961-8368, 10/2014, Volume 23, Issue 10, pp. 1332 - 1340
Journal Article
Protein Science, ISSN 0961-8368, 10/2014, Volume 23, Issue 10, p. 1332
  PI3K[alpha] remains an attractive target for the development of anticancer targeted therapy. A number of p110[alpha] crystal structures in complex with the... 
Protein binding
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2018, Volume 8, Issue 6, pp. 714 - 729
Journal Article
Journal Article