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1. Full Text Genome-wide association studies provide new insights into type 2 diabetes aetiology
by Frayling, Timothy M
Nature reviews. Genetics, ISSN 1471-0056, 09/2007, Volume 8, Issue 9, pp. 657 - 662
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Diabetes. Impaired glucose tolerance | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Body Mass Index | Genetic Predisposition to Disease | Oligonucleotide Array Sequence Analysis | Diabetes Mellitus, Type 2 - genetics | Gene Frequency | Humans | Chromosome Mapping | Gene Expression Profiling | Obesity - genetics | Animals | Diabetes Mellitus, Type 2 - etiology | Genome, Human | Genetic Linkage | Type 2 diabetes | Genetic research | Genetic aspects | Research | Analysis | Index Medicus
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2. Full Text Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk
by Hana Lango and Colin N.A. Palmer and Andrew D. Morris and Eleftheria Zeggini and Andrew T. Hattersley and Mark I. McCarthy and Timothy M. Frayling and Michael N. Weedon and UK Type Diab Genetics Consortium and UK Type 2 Diabetes Genetics Consortium and the U.K. Type 2 Diabetes Genetics Consortium
Diabetes (New York, N.Y.), ISSN 0012-1797, 11/2008, Volume 57, Issue 11, pp. 3129 - 3135
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Body Mass Index | Genetic Predisposition to Disease - genetics | Age Factors | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Diabetes Mellitus, Type 2 - prevention & control | Genotype | Male | Female | ROC Curve | Aged | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | Type 2 diabetes | Genetic aspects | Research | Risk factors | Index Medicus | Abridged Index Medicus | Genetics
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3. Full Text Statins and type 2 diabetes: genetic studies on target
by Frayling, Timothy M
The Lancet (British edition), ISSN 0140-6736, 2015, Volume 385, Issue 9965, pp. 310 - 312
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Diabetes Mellitus, Type 2 - genetics | Humans | Polymorphism, Single Nucleotide - genetics | Female | Male | Body Weight - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Type 2 diabetes | Genetic research | Genetic aspects | Statins | Studies | Coronary vessels | Cardiovascular disease | Genetics | Diabetes | Low density lipoprotein | Cholesterol | Index Medicus | Abridged Index Medicus
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4. Full Text Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach
by Menni, Cristina and Fauman, Eric and Erte, Idil and Perry, John R.B and Kastenmüller, Gabi and Shin, So-Youn and Petersen, Ann-Kristin and Hyde, Craig and Psatha, Maria and Ward, Kirsten J and Yuan, Wei and Milburn, Mike and Palmer, Colin N.A and Frayling, Timothy M and Trimmer, Jeff and Bell, Jordana T and Gieger, Christian and Mohney, Rob P and Brosnan, Mary Julia and Suhre, Karsten and Soranzo, Nicole and Spector, Tim D
Diabetes (New York, N.Y.), ISSN 0012-1797, 12/2013, Volume 62, Issue 12, pp. 4270 - 4276
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Metabolomics | Genome-Wide Association Study | Glucose Tolerance Test | Prediabetic State - blood | Diseases in Twins - genetics | Fasting | Prediabetic State - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Biomarkers - blood | Hyperglycemia - genetics | Diabetes Mellitus, Type 2 - blood | Hyperglycemia - blood | Blood Glucose - genetics | Diseases in Twins - blood | Female | Aged | Blood Glucose - metabolism | Type 2 diabetes | Complications and side effects | Glucose metabolism | Hyperglycemia | Research | Risk factors | Metabolites | Biomarkers | Amino acids | Lipids | Insulin resistance | Diabetes | Glucose | Index Medicus | Abridged Index Medicus | Original Research
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5. Full Text Genomic inflation factors under polygenic inheritance
by Yang, Jian and Weedon, Michael N and Purcell, Shaun and Lettre, Guillaume and Estrada, Karol and Willer, Cristen J and Smith, Albert V and Ingelsson, Erik and O'Connell, Jeffrey R and Mangino, Massimo and Mägi, Reedik and Madden, Pamela A and Heath, Andrew C and Nyholt, Dale R and Martin, Nicholas G and Montgomery, Grant W and Frayling, Timothy M and Hirschhorn, Joel N and McCarthy, Mark I and Goddard, Michael E and Visscher, Peter M and GIANT Consortium and the GIANT Consortium
European journal of human genetics : EJHG, ISSN 1018-4813, 07/2011, Volume 19, Issue 7, pp. 807 - 812
polygenic inheritance | genomic inflation factor | genome-wide association study | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | General aspects. Genetic counseling | Medical genetics | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Young Adult | Multifactorial Inheritance - genetics | Genome-Wide Association Study | Computer Simulation | Humans | Adolescent | Genome - genetics | Adult | Models, Genetic | Polymorphism, Single Nucleotide | Quantitative Trait Loci - genetics | Medical research | Statistical analysis | Disease | Linkage disequilibrium | Population structure | Data processing | Genomes | Heredity | Genetic diversity | Epidemiology | Statistics | Meta-analysis | Medicine | Studies | Hypotheses | Hospitals | Artefacts | Population | Genetics | Heritability | Inheritances | Polygenic inheritance | Endocrinology | Index Medicus | Medicin och hälsovetenskap
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6. Full Text Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach
by John R.B. Perry and Mark I. McCarthy and Andrew T. Hattersley and Eleftheria Zeggini and the Wellcome Trust Case Control Consortium and Michael N. Weedon and Timothy M. Frayling and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium and the Wellcome Trust Case Control Consortium
Diabetes (New York, N.Y.), ISSN 0012-1797, 06/2009, Volume 58, Issue 6, pp. 1463 - 1467
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Genetic Variation | Genome-Wide Association Study | Algorithms | Diabetes Mellitus, Type 2 - genetics | Humans | Biology - methods | Reference Values | Chromosome Mapping | Models, Genetic | Polymorphism, Single Nucleotide | Odds Ratio | Case-Control Studies | Type 2 diabetes | Genetic research | Genetic aspects | Research | Diabetes | Genetic variation | Index Medicus | Abridged Index Medicus | Genetics
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7. Full Text Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
by Rachel M. Freathy and Nicholas J. Timpson and Debbie A. Lawlor and Anneli Pouta and Yoav Ben-Shlomo and Aimo Ruokonen and Shah Ebrahim and Beverley Shields and Eleftheria Zeggini and Michael N. Weedon and Cecilia M. Lindgren and Hana Lango and David Melzer and Luigi Ferrucci and Giuseppe Paolisso and Matthew J. Neville and Fredrik Karpe and Colin N.A. Palmer and Andrew D. Morris and Paul Elliott and Marjo-Riitta Jarvelin and George Davey Smith and Mark I. McCarthy and Andrew T. Hattersley and Timothy M. Frayling
Diabetes (New York, N.Y.), ISSN 0012-1797, 05/2008, Volume 57, Issue 5, pp. 1419 - 1426
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Body Mass Index | European Continental Ancestry Group - genetics | Meta-Analysis as Topic | Blood Glucose - analysis | Diabetes Mellitus, Type 2 - genetics | Europe | Humans | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Genotype | Reference Values | Insulin - blood | Obesity - genetics | Genetic Variation | Proteins - genetics | Adult | Type 2 diabetes | Quantitative trait loci | Obesity | Body mass index | Genetic aspects | Diabetes | Gene expression | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
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8. Full Text beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors
by T M Frayling and J C Evans and M P Bulman and E Pearson and L Allen and K Owen and C Bingham and M Hannemann and M Shepherd and S Ellard and A T Hattersley
Diabetes (New York, N.Y.), ISSN 0012-1797, 02/2001, Volume 50, Issue suppl 1, pp. S94 - S100
Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Exons | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Child, Preschool | Genes - genetics | Family Health | Male | Islets of Langerhans - metabolism | Trans-Activators - genetics | Adult | Female | Hepatocyte Nuclear Factor 1-beta | Child | Basic Helix-Loop-Helix Transcription Factors | Hepatocyte Nuclear Factor 1-alpha | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins | Homeodomain Proteins | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Adolescent | Survival Analysis | Diabetes Mellitus, Type 2 - pathology | Hepatocyte Nuclear Factor 4 | Mutation | Hepatocyte Nuclear Factor 1 | Cohort Studies | Index Medicus | Abridged Index Medicus
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9. Full Text Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk
by Christopher J. Groves and Eleftheria Zeggini and Jayne Minton and Timothy M. Frayling and Michael N. Weedon and Nigel W. Rayner and Graham A. Hitman and Mark Walker and Steven Wiltshire and Andrew T. Hattersley and Mark I. McCarthy
Diabetes (New York, N.Y.), ISSN 0012-1797, 09/2006, Volume 55, Issue 9, pp. 2640 - 2644
SNP, single nucleotide polymorphism | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Genetics, Population | Genetic Predisposition to Disease | Diabetes Mellitus, Type 2 - genetics | Gene Frequency | Humans | Middle Aged | Risk Factors | Genotype | Male | United Kingdom | Transcription Factor 7-Like 2 Protein | Linkage Disequilibrium | Adult | Female | Aged | Polymorphism, Single Nucleotide | TCF Transcription Factors - genetics | Type 2 diabetes | Genetic aspects | Genetic susceptibility | Analysis | Risk factors | Index Medicus | Abridged Index Medicus
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10. Height, body mass index, and socioeconomic status: Mendelian randomisation study in UK Biobank
by Tyrrell, Jessica and Jones, Samuel E and Beaumont, Robin and Astley, Christina M and Lovell, Rebecca and Yaghootkar, Hanieh and Tuke, Marcus and Ruth, Katherine S and Freathy, Rachel M and Hirschhorn, Joel N and Wood, Andrew R and Murray, Anna and Weedon, Michael N and Frayling, Timothy M
BMJ (Online), ISSN 0959-8146, 03/2016, Volume 352, p. i582
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Body Mass Index | Income - statistics & numerical data | Humans | Middle Aged | Occupations | Male | Educational Status | Social Class | Biological Specimen Banks | Mendelian Randomization Analysis | Adult | Body Height | Female | Aged | United Kingdom - epidemiology
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11. Full Text Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
by Yang, Jian and Ferreira, Teresa and Morris, Anew P and Medland, Sarah E and Madden, Pamela A. F and Heath, Anew C and Martin, Nicholas G and Montgomery, Grant W and Weedon, Michael N and Loos, Ruth J and Frayling, Timothy M and McCarthy, Mark I and Hirschhorn, Joel N and Goddard, Michael E and Visscher, Peter M and DIAbet Genetics Replication Meta-A and Genetic Invest ANthropometric Trai and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and Genetic Investigation of ANthropometric Traits (GIANT) Consortium
Nature genetics, ISSN 1061-4036, 04/2012, Volume 44, Issue 4, pp. 369 - U170
GENETIC-VARIATION | HUMAN HEIGHT | COMMON SNPS | DISEASE | SUSCEPTIBILITY LOCI | BODY-MASS INDEX | RISK | MAP | HERITABILITY | GENOME-WIDE ASSOCIATION | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Body Mass Index | Data Interpretation, Statistical | Genome-Wide Association Study | Meta-Analysis as Topic | Diabetes Mellitus, Type 2 - genetics | Humans | Genetic Loci - genetics | Genotype | Case-Control Studies | Linkage Disequilibrium | Genetic Variation | Phenotype | Algorithms | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Body Height | Polymorphism, Single Nucleotide | Genome, Human | Type 2 diabetes | Genomes | Genetic aspects | Research | Single nucleotide polymorphisms | Studies | Genomics | Atherosclerosis | Genetics | Statistics | Methods | Meta-analysis | Index Medicus
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