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genome-wide association study (12) 12
humans (12) 12
science & technology (12) 12
genetic predisposition to disease (7) 7
genomes (7) 7
life sciences & biomedicine (7) 7
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genetics (4) 4
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analysis (3) 3
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1. Full Text A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure
by Yu, Zhi and Coresh, Josef and Qi, Guanghao and Grams, Morgan and Boerwinkle, Eric and Snieder, Harold and Teumer, Alexander and Pattaro, Cristian and Köttgen, Anna and Chatterjee, Nilanjan and Tin, Adrienne
Kidney international, ISSN 0085-2538, 09/2020, Volume 98, Issue 3, pp. 708 - 716
blood pressure | chronic kidney disease | kidney function | Mendelian randomization | biomarkers | genome-wide association study | MORTALITY | UREA TRANSPORTER | ALBUMINURIA | INFERENCE | RISK-FACTOR | DISEASE | HEALTH | INCIDENT HYPERTENSION | ASSOCIATION | PROGRESSION | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Index Medicus
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2. Full Text Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
by Pattaro, Cristian and Teumer, Alexander and Gorski, Mathias and Chu, Auey Y and Li, Man and Mijatovic, Vladan and Garnaas, Maija and Tin, Aienne and Sorice, Rossella and Li, Yong and Taliun, Daniel and Olden, Matthias and Foster, Meredith and Yang, Qiong and Chen, Ming-Huei and Pers, Tune H and Johnson, Anew D and Ko, Yi-An and Fuchsberger, Christian and Tayo, Bamidele and Nalls, Michael and Feitosa, Mary F and Isaacs, Aaron and Dehghan, Abbas and d'Adamo, Pio and Adeyemo, Adebowale and Dieffenbach, Aida Karina and Zonderman, Alan B and Nolte, Ilja M and van der Most, Peter J and Wright, Alan F and Shuldiner, Alan R and Morrison, Alanna C and Hofman, Albert and Smith, Albert V and isbach, Albert W and Franke, Ane and Uitterlinden, Ane G and Metspalu, Anes and Tonjes, Anke and Lupo, Antonio and Robino, Antonietta and Johansson, Asa and Demirkan, Ayse and Kollerits, Barbara and Freedman, Barry I and Ponte, Belen and Oostra, Ben A and Paulweber, Bernhard and Kraemer, Bernhard K and Mitchell, Braxton D and Buckley, Brendan M and Peralta, Carmen A and Hayward, Caroline and Helmer, Catherine and Rotimi, Charles N and Shaffer, Christian M and Mueller, Christian and Sala, Cinzia and van Duijn, Cornelia M and Saint-Pierre, Aude and Ackermann, Daniel and Shriner, Daniel and Ruggiero, Daniela and Toniolo, Daniela and Lu, Yingchang and Cusi, Daniele and Czamara, Darina and Ellinghaus, David and Siscovick, David S and Ruderfer, Douglas and Gieger, Christian and Grallert, Harald and Rochtchina, Elena and Atkinson, Elizabeth J and Holliday, Elizabeth G and Boerwinkle, Eric and Salvi, Erika and Bottinger, Erwin P and Murgia, Federico and Rivadeneira, Fernando and Ernst, Florian and Kronenberg, Florian and Hu, Frank B and Navis, Gerjan J and Curhan, Gary C and Ehret, George B and Homuth, Georg and Coassin, Stefan and Thun, Gian-Ani and Pistis, Giorgio and Gambaro, Giovanni and Malerba, Giovanni and Montgomery, Grant W and Eiriksdottir, Gudny and Jacobs, Gunnar and Li, Guo and Wichmann, H-Erich and Campbell, Harry and Schmidt, Helena and ... and CARDIOGRAM and ICBP Consortium and AGEN Consortium and CHARGe-Heart Failure Grp and ECHOGen Consortium and CHARGe-Heart Failure Group
Nature communications, ISSN 2041-1723, 01/2016, Volume 7, Issue 1, pp. 10023 - 10023
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genotype | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Gene Expression Regulation | Renal Insufficiency, Chronic - genetics | Index Medicus
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3. Full Text A catalog of genetic loci associated with kidney function from analyses of a million individuals
by Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B and Feitosa, Mary F and Gorski, Mathias and Tin, Aienne and Wang, Lihua and Chu, Auey Y and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer S and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L and Bansal, Nisha and De Borst, Martin H and De Vries, Aiko P. J and Demirkan, Ayse and Gansevoort, Ron T and Hartman, Catharina A and Huang, Wei and Nolte, Ilja M and Oldehinkel, Albertine J and Penninx, Brenda W. J. H and Prins, Bram P and Smith, Albert V and Van der Harst, Pim and Verweij, Niek and Wang, Ya Xing and Xu, Liang and Snieder, Harold and Thio, C. H. L and Lifelines COHort Study and V. A. Million Veteran Program and Lifelines Cohort Study
Nature genetics, ISSN 1061-4036, 06/2019, Volume 51, Issue 6, pp. 957 - +
COMMON VARIANTS | METAANALYSIS | TRANSPORTER | TRANS-EQTLS | INTEGRATION | DISEASE | RENAL-FUNCTION | CLASSIFICATION | HERITABILITY | GENOME-WIDE ASSOCIATION | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease | Genome-Wide Association Study | Glomerular Filtration Rate | Quantitative Trait, Heritable | Humans | Genetic Association Studies - methods | European Continental Ancestry Group | Chromosome Mapping | Renal Insufficiency, Chronic - physiopathology | Kidney Function Tests | Inheritance Patterns | Phenotype | Renal Insufficiency, Chronic - genetics | Uromodulin - urine | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Renal Insufficiency, Chronic - urine | Quantitative trait loci | Genetic markers | Chronic kidney failure | Analysis | Genetic aspects | Diagnosis | Identification and classification | Glomerular filtration rate | Phenotypes | Animal models | Kidneys | Epidermal growth factor receptors | Complications | Genes | Cardiovascular disease | Mapping | Genomes | Metabolism | Gene expression | Loci | Human tissues | Meta-analysis | Studies | Urea | Population | Genetics | Gene loci | Kidney diseases | Gene mapping | Bioinformatics | Public health | Index Medicus | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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4. Full Text Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
by Teumer, Alexander and Tin, Aienne and Sorice, Rossella and Gorski, Mathias and Yeo, Nan Cher and Chu, Auey Y and Li, Man and Li, Yong and Mijatovic, Vladan and Ko, Yi-An and Taliun, Daniel and Luciani, Alessano and Chen, Ming-Huei and Yang, Qiong and Foster, Meredith C and Olden, Matthias and Hiraki, Linda T and Tayo, Bamidele O and Fuchsberger, Christian and Dieffenbach, Aida Karina and Shuldiner, Alan R and Smith, Albert V and Zappa, Allison M and Lupo, Antonio and Kollerits, Barbara and Ponte, Belen and Stengel, Bénédicte and Krämer, Bernhard K and Paulweber, Bernhard and Mitchell, Braxton D and Hayward, Caroline and Helmer, Catherine and Meisinger, Christa and Gieger, Christian and Shaffer, Christian M and Müller, Christian and Langenberg, Claudia and Ackermann, Daniel and Siscovick, David and Boerwinkle, Eric and Kronenberg, Florian and Ehret, Georg B and Homuth, Georg and Waeber, Gerard and Navis, Gerjan and Mateo Leach, I and Hillege, Hans L and Verweij, Niek and van der Harst, Pim and Gansevoort, Ron T and DCCT EDIC and DCCT/EDIC
Diabetes (New York, N.Y.), ISSN 0012-1797, 03/2016, Volume 65, Issue 3, pp. 803 - 817
KIDNEY-DISEASE | MORTALITY | GLOMERULAR-FILTRATION-RATE | MODULATES PROTEINURIA | RAB38 | RISK POPULATION COHORTS | COLLABORATIVE METAANALYSIS | EXPRESSION | HERITABILITY | INSIGHTS | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Diabetic Nephropathies - etiology | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | rab GTP-Binding Proteins - genetics | Kidney - metabolism | Diabetes Mellitus, Experimental | Adult | Female | Kidney Tubules - metabolism | Diabetes Mellitus, Type 2 - complications | Sulfotransferases - genetics | rab GTP-Binding Proteins - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Albuminuria - etiology | Cathepsin C - genetics | Rats | Diabetic Nephropathies - genetics | Gene Knockout Techniques | Albuminuria - genetics | Animals | Aged | Polymorphism, Single Nucleotide | Receptors, Cell Surface - genetics | Urine | Cardiovascular disease | Genomes | Gene loci | Diabetes | Kidney diseases | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Proteomics
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5. Full Text Genome-wide association study of kidney function decline in individuals of European descent
by Gorski, Mathias and Tin, Adrienne and Garnaas, Maija and McMahon, Gearoid M and Chu, Audrey Y and Tayo, Bamidele O and Pattaro, Cristian and Teumer, Alexander and Chasman, Daniel I and Chalmers, John and Hamet, Pavel and Tremblay, Johanne and Woodward, Marc and Aspelund, Thor and Eiriksdottir, Gudny and Gudnason, Vilmundur and Harris, Tamara B and Launer, Lenore J and Smith, Albert V and Mitchell, Braxton D and O'Connell, Jeffrey R and Shuldiner, Alan R and Coresh, Josef and Li, Man and Freudenberger, Paul and Hofer, Edith and Schmidt, Helena and Schmidt, Reinhold and Holliday, Elizabeth G and Mitchell, Paul and Wang, Jie Jin and de Boer, Ian H and Li, Guo and Siscovick, David S and Kutalik, Zoltan and Corre, Tanguy and Vollenweider, Peter and Waeber, Gérard and Gupta, Jayanta and Kanetsky, Peter A and Hwang, Shih-Jen and Olden, Matthias and Yang, Qiong and de Andrade, Mariza and Atkinson, Elizabeth J and Kardia, Sharon L.R and Turner, Stephen T and Stafford, Jeanette M and Ding, Jingzhong and Liu, Yongmei and Barlassina, Cristina and Cusi, Daniele and Salvi, Erika and Staessen, Jan A and Ridker, Paul M and Grallert, Harald and Meisinger, Christa and Müller-Nurasyid, Martina and Krämer, Bernhard K and Kramer, Holly and Rosas, Sylvia E and Nolte, Ilja M and Penninx, Brenda W and Snieder, Harold and Fabiola Del Greco, M and Franke, Andre and Nöthlings, Ute and Lieb, Wolfgang and Bakker, Stephan J.L and Gansevoort, Ron T and van der Harst, Pim and Dehghan, Abbas and Franco, Oscar H and Hofman, Albert and Rivadeneira, Fernando and Sedaghat, Sanaz and Uitterlinden, André G and Coassin, Stefan and Haun, Margot and Kollerits, Barbara and Kronenberg, Florian and Paulweber, Bernhard and Aumann, Nicole and Endlich, Karlhans and Pietzner, Mike and Völker, Uwe and Rettig, Rainer and Chouraki, Vincent and Helmer, Catherine and Lambert, Jean-Charles and Metzger, Marie and Stengel, Benedicte and Lehtimäki, Terho and Lyytikäinen, Leo-Pekka and Raitakari, Olli and Johnson, Andrew and Parsa, Afshin and Bochud, Murielle and Heid, Iris M and Goessling, Wolfram and ...
Kidney international, ISSN 0085-2538, 05/2015, Volume 87, Issue 5, pp. 1017 - 1029
population genetics | chronic kidney disease | kidney development | single nucleotide polymorphism | kidney function decline | genome-wide association study | zebrafish | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Index Medicus
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6. Full Text Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
by Tin, Aienne and Marten, Jonathan and Halperin Kuhns, Victoria L and Li, Yong and Wuttke, Matthias and Kirsten, Holger and Sieber, Karsten B and Qiu, Chengxiang and Gorski, Mathias and Yu, Zhi and Giri, Ayush and Sveinbjornsson, Gardar and Li, Man and Chu, Auey Y and Hoppmann, Anselm and O'Connor, Luke J and Prins, Bram and Nutile, Teresa and Noce, Damia and Akiyama, Masato and Cocca, Massimiliano and Ghasemi, Sahar and van der Most, Peter J and Horn, Katrin and Xu, Yizhe and Fuchsberger, Christian and Sedaghat, Sanaz and Afaq, Saima and Amin, Najaf and Ärnlöv, Johan and Bakker, Stephan J L and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L and Biino, Ginevra and Boerwinkle, Eric and Bottinger, Erwin P and Boutin, Thibaud S and Brumat, Marco and de Borst, Martin H and de Vries, Aiko P J and Gansevoort, Ron T and Huang, Wei and Nolte, Ilja M and Penninx, Brenda W J H and Smith, Albert V and van der Harst, Pim and Verweij, Niek and Snieder, Harold and VA Million Vet Program and German Chronic Kidney Dis Study and Lifelines Cohort Study and V. A. Million Veteran Program and German Chronic Kidney Disease Study
Nature genetics, ISSN 1061-4036, 10/2019, Volume 51, Issue 10, pp. 1459 - 1474
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Liver - pathology | Hepatocyte Nuclear Factor 1-alpha - genetics | Kidney - pathology | Humans | Genetic Loci | Cardiovascular Diseases - genetics | Kidney - metabolism | Gout - epidemiology | Cardiovascular Diseases - blood | Cardiovascular Diseases - epidemiology | Uric Acid - blood | Gout - blood | Neoplasm Proteins - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Signal Transduction | Liver - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics | Metabolic Diseases - epidemiology | Metabolic Diseases - blood | Hepatocyte Nuclear Factor 4 - genetics | Genetic Markers | Organ Specificity | Metabolic Diseases - genetics | Gout - genetics | Polymorphism, Single Nucleotide | Cohort Studies | Medical colleges | Analysis | Liver | Genomics | Genes | Genetic research | Genetic aspects | Genomes | Genetic transcription | Regulators | Transcription factors | Transcription | Gout | African Americans | Mapping | Databases | Genetic analysis | Population | Rheumatism | Hepatocyte nuclear factor 4 | Bioinformatics | Kidneys | Organs | Uric acid | Metabolism | Gene expression | Loci | Meta-analysis | Studies | Pleiotropy | Gene loci | Gene mapping | Transporter | Binding sites | Open access | Index Medicus | Medicin och hälsovetenskap
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