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2006, Statistics for biology and health, ISBN 9780387290744
Web Resource
2006, Statistics for biology and health, ISBN 9780387290744
Web Resource
2006, Statistics for biology and health, ISBN 9780387290744
Web Resource
Web Resource
02/2010, Statistics for Biology and Health Ser., ISBN 144192115X
Annotation If you have ever wondered when visiting the pharmacy how the dosage of your prescription is determined this book will answer your questions. Dosing... 
Drugs | Pharmacology | Medical
Web Resource
02/2010, Statistics for Biology and Health Ser., ISBN 144192115X
Annotation If you have ever wondered when visiting the pharmacy how the dosage of your prescription is determined this book will answer your questions. Dosing... 
Drugs | Pharmacology | Medical
Web Resource
2006, Statistics for biology and health, ISBN 9780387290744, xiv, 248
When you go to the pharmacy and fill a prescription, have you ever wondered if the dose of the medication is right for you? Can the dose be too low so that the... 
Drugs | Mathematics | Drug development | Dose-response relationshio | Industrial chemistry & manufacturing technologies | Dose-response relationship | Pharmacology/Toxicology | Statistics for Life Sciences, Medicine, Health Sciences | Statistics
Book
2017, ICSA Book Series in Statistics, ISBN 9811041946
This book focuses on how to appropriately plan and develop a Phase II program, and how to design Phase II clinical trials and analyze their data. It provides a... 
Pharmaceutical technology | Management | Statistics
Web Resource
Therapeutic Innovation & Regulatory Science, ISSN 2168-4790, 1/2018, Volume 52, Issue 1, pp. 14 - 21
Journal Article
2015, ICSA Book Series in Statistics, ISBN 9783319126944
This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The six... 
Medicine | Mathematical statistics | Statistics
Web Resource
2015, ICSA Book Series in Statistics, ISBN 9783319126944
This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The six... 
Medicine | Mathematical statistics | Statistics
Web Resource
Statistics in Biopharmaceutical Research, ISSN 1946-6315, 06/2019, pp. 1 - 11
Journal Article
Statistics in Medicine, ISSN 0277-6715, 09/2018, Volume 37, Issue 22, pp. 3244 - 3253
In Phase II clinical development of a new drug, the two most important deliverables are proof of concept (PoC) and dose ranging. Traditionally, a PoC study is... 
clinical trial | two‐stage design | “Go/NoGo” decision | dose ranging | proof‐of‐concept | two-stage design | proof-of-concept | MEDICINE, RESEARCH & EXPERIMENTAL | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MEDICAL INFORMATICS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | STATISTICS & PROBABILITY | "Go | NoGo" decision | DESIGNS
Journal Article
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S445 - S445
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 3/2010, Volume 201, Issue 6, pp. 803 - 813
Background. The MERIT (M̄araviroc versus Ēfavir̄enz īn T̄reatment-Naive Patients) study compared maraviroc and efavirenz, both with zidovudine-lamivudine, in... 
HIV/AIDS | Tropisms | RNA | HIV | Stock options | Response rates | Viruses | Infections | Post hoc | HIV 1 | Virology | INFECTIOUS DISEASES | EFFICACY | SAFETY | MICROBIOLOGY | HIV-1-INFECTED PATIENTS | IMMUNOLOGY | LOPINAVIR-RITONAVIR | THERAPY | VIROLOGICAL FAILURE | RESISTANT HIV-1 | INHIBITOR | CORECEPTOR TROPISM | PLUS | Anti-HIV Agents - pharmacology | Lamivudine - administration & dosage | Cyclohexanes - pharmacology | Humans | Middle Aged | Drug Resistance, Viral | Male | Anti-HIV Agents - standards | Viral Load | Zidovudine - administration & dosage | Young Adult | Cyclohexanes - therapeutic use | Receptors, CCR5 - metabolism | HIV-1 - physiology | Adult | Female | Triazoles - standards | Viral Tropism | Drug Therapy, Combination | CCR5 Receptor Antagonists | Triazoles - therapeutic use | Antiviral Agents - pharmacology | Double-Blind Method | HIV-1 - drug effects | Treatment Outcome | Anti-Retroviral Agents | Benzoxazines - standards | Benzoxazines - therapeutic use | Triazoles - pharmacology | Adolescent | Benzoxazines - pharmacology | Cyclohexanes - standards | HIV Infections - drug therapy | Aged | Drug Combinations | Maraviroc | Patient outcomes | Physiological aspects | Dosage and administration | Genetic aspects | Research | Drug therapy, Combination | Drug therapy | HIV infection | Efavirenz | Chemokines
Journal Article
Statistics in Biosciences, ISSN 1867-1764, 2018, Volume 11, Issue 1, pp. 127 - 140
The objective of a Proof-of-Concept (PoC) clinical trial is to formulate a "Go/NoGo" decision based on study results. If such a decision cannot be made from... 
Dose–ranging | Clinical trial | Inconclusiveness | MSSD | PoC | Go/NoGo | Medicine, Experimental | Medical research | Usage
Journal Article
Drug Information Journal, ISSN 0092-8615, 2011, Volume 45, Issue 4, pp. 431 - 442
Phase 2 is the most critical stage in the entire clinical development process of a new drug because results from this phase are used to make go or no-go... 
Dose ranging | Risk of ambiguity | Phase of clinical development | Chronic disease | TRIAL | DOSE-RESPONSE | HEALTH CARE SCIENCES & SERVICES | PHARMACOLOGY & PHARMACY | DESIGNS | Studies | Design | Regulatory agencies | Candidates | Human body | Investments | Clinical trials | Objectives | Pharmaceutical industry | Chronic illnesses
Journal Article
Journal of Biopharmaceutical Statistics, ISSN 1054-3406, 11/2018, Volume 28, Issue 6, pp. 1119 - 1142
When Phase III treatment effect is diluted from what was observed from Phase II results, we propose to determine the Bayesian sample size for a Phase III... 
Bayesian Predictive Power (BPP) | Bayesian Historical Predictive Power (BHPP) | diluted treatment effect | hook phenomenon | Bayesian Sample Size Determination (SSD) | DESIGN | PRACTICAL GUIDE | EFFICACY | SAFETY | STATISTICS & PROBABILITY | PROBABILITY | DECISIONS | END-POINTS | PHARMACOLOGY & PHARMACY
Journal Article
04/2017, 1st ed. 2017, ICSA Book Series in Statistics, ISBN 981104192X, 252
This book focuses on how to appropriately plan and develop a Phase II program, and how to design Phase II clinical trials and analyze their data. It provides a... 
Management
eBook
Communications in Statistics - Simulation and Computation, ISSN 0361-0918, 07/2017, Volume 46, Issue 6, pp. 4535 - 4546
It has became more popular in the recent statistical literature to see Bayesian approaches for clinical trials, such as assurance calculations for study... 
Bayesian posterior distribution | Hypergeometric function | Frequentist p-values | Beta-binomial | Age-related macular degeneration | Monte-Carlo simulation | STATISTICS & PROBABILITY | Medical research | Assurance | Clinical trials | Binary data | Binary systems (materials) | Bayesian analysis | Two phase
Journal Article
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