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Archives of Disease in Childhood, ISSN 0003-9888, 06/2019, Volume 104, Issue 6, pp. e19 - e19
BackgroundEuropean Medicines Agency (EMA) outlines criterion for validation of bioanalytical assay applied under Good Clinical Laboratory Practice (GCLP)... 
Clinical trials | Neonates | Labelling | Adolescents | Quality | Quality control
Journal Article
Archives of Disease in Childhood, ISSN 0003-9888, 06/2019, Volume 104, Issue 6, pp. e56 - e56
BackgroundPhysiological and pathophysiological circumstances of the paediatric renin-angiotensin-aldosterone-system (RAAS) are still inadequately understood.... 
Neonates | Pharmacodynamics | Renin | Angiotensin | Aldosterone | Adolescents | Heart diseases | Coronary artery disease | Investigations | Enzyme-linked immunosorbent assay
Journal Article
Journal of Immunoassay and Immunochemistry, ISSN 1532-1819, 11/2017, Volume 38, Issue 6, pp. 579 - 594
Introduction: The pharmacotherapy of pediatric patients suffering from heart failure is extrapolated from adults due to missing data in children.Objectives:... 
Renin | low-volume | validation | immunoassay | pediatric | Immunoassay - standards | Humans | Pediatrics - methods | Adult | Female | Healthy Volunteers | Renin - blood | Child | Missing data | Immunoassay | Pediatrics | Adults | Pharmacology | Children | Coefficient of variation | Heart diseases
Journal Article
The AAPS Journal, ISSN 1550-7416, 11/2019, Volume 21, Issue 6, pp. 1 - 11
Journal Article
Practical Laboratory Medicine, ISSN 2352-5517, 11/2019, Volume 17, p. e00144
Investigations of plasma renin activity (PRA) in children are urgently required. Small-volume, regulatory guideline compliant, bioanalytical assays tailored... 
Validation | Pharmacodynamic | Paediatric | Immunoassay | Low-volume | Plasma renin activity
Journal Article
The AAPS journal, ISSN 1550-7416, 01/2020, Volume 22, Issue 2, p. 37
The LENA collaborator list below was not included in the original article.s. 
Journal Article
Journal Article
Practical Laboratory Medicine, ISSN 2352-5517, 12/2017, Volume 9, pp. 28 - 38
Heart failure is well investigated in adults, but data in children is lacking. To overcome this shortage of reliable data, appropriate bioanalytical assays are... 
Validation | Pharmacodynamic | Immunoassay | Low-volume | Aldosterone | Pediatric
Journal Article
Spinal Cord, ISSN 1362-4393, 03/2015, Volume 53, Issue S1, pp. S6 - S9
Journal Article
Archives of Disease in Childhood, ISSN 0003-9888, 01/2016, Volume 101, Issue 1, pp. e1.28 - e1
BackgroundClinical investigations on pharmacokinetics and pharmacodynamics are highly required to improve paediatric pharmacotherapy. Especially in neonates... 
Drugs | Analysis | Pharmacology | Dosage and administration | Children | Pharmacokinetics | Health aspects
Journal Article
Archives of Disease in Childhood, ISSN 0003-9888, 01/2016, Volume 101, Issue 1, pp. e1.69 - e1
BackgroundHeart failure is a life-threatening disease in neonates up to adolescents. The angiotensin-converting enzyme inhibitor enalapril is a recommended... 
Heart failure | Care and treatment | Enalapril | Analysis | Enalaprilat | Practice guidelines (Medicine) | Dosage and administration
Journal Article
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