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Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 8, pp. 1074 - 1087
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics... 
JOUBERT-SYNDROME | RPGRIP1 | TRANSPORT | CENTRIOLE BIOGENESIS | PROTEIN | C-ELEGANS | MUTATIONS | PHOTORECEPTOR CELLS | MASTER REGULATOR | PRIMARY CILIA | CELL BIOLOGY | Humans | Pregnancy Proteins - genetics | Databases, Genetic | Suppressor Factors, Immunologic - genetics | Photoreceptor Cells - ultrastructure | Pregnancy Proteins - metabolism | Ellis-Van Creveld Syndrome - genetics | Cerebellum - abnormalities | Genetic Testing - methods | Suppressor Factors, Immunologic - metabolism | Membrane Proteins - deficiency | Transfection | RNA Interference | HEK293 Cells | Kidney Diseases, Cystic - genetics | Genomics - methods | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Caenorhabditis elegans - metabolism | Cilia - pathology | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Abnormalities, Multiple | Genetic Markers | Eye Abnormalities - genetics | Cilia - metabolism | Zebrafish - genetics | Cilia - genetics | Mice, Knockout | Proteins - genetics | Caenorhabditis elegans - ultrastructure | Phenotype | Animals | Cerebellar Diseases - genetics | Ciliary Motility Disorders - pathology | Proteins - metabolism | Photoreceptor Cells - metabolism | Zebrafish - metabolism | Retina - abnormalities | High-Throughput Nucleotide Sequencing | Ciliary Motility Disorders - metabolism | Mutation | Ciliary Motility Disorders - genetics | RNA | Cilia and ciliary motion | Genetic research | Biosynthesis | Genetic aspects | Research | Gene expression | Properties | reverse genetics | cilia | ciliopathies | Joubert syndrome | whole-genome siRNA screen | Jeune syndrome
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2008, Volume 118, Issue 5, pp. 1739 - 1749
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2019, Volume 14, Issue 5, p. e0216705
Journal Article
Oncogene, ISSN 0950-9232, 07/2012, Volume 31, Issue 27, pp. 3235 - 3243
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 11491
Journal Article
Plos Genetics, ISSN 1553-7404, 2015, Volume 11, Issue 10, p. e1005574
Journal Article
Journal Article
ONCOGENE, ISSN 0950-9232, 07/2012, Volume 31, Issue 29, pp. 3409 - 3418
Deletions of chromosomal arms 1p and 19q are frequent in oligodendroglial tumours and linked to radio- and chemotherapy response as well as longer survival.... 
temozolomide | CANCER-CELLS | OXIDATIVE STRESS | oligodendroglioma | BIOCHEMISTRY & MOLECULAR BIOLOGY | radiosensitivity | peroxiredoxin 1 | CELL BIOLOGY | PEROXIREDOXIN-II | promoter methylation | ONCOLOGY | PROTEOME ANALYSIS | MGMT GENE | GENETICS & HEREDITY | GENE-EXPRESSION | GRADE | CENTRAL-NERVOUS-SYSTEM | chemosensitivity | Oligodendroglia - metabolism | Promoter Regions, Genetic - radiation effects | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Middle Aged | Peroxiredoxins - deficiency | Apoptosis - genetics | Male | Promoter Regions, Genetic - drug effects | Glioma - radiotherapy | Promoter Regions, Genetic - genetics | Gene Knockdown Techniques | Glioma - genetics | Young Adult | Oligodendroglia - drug effects | Peroxiredoxins - genetics | DNA Methylation - radiation effects | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | Adult | Female | Oligodendroglia - radiation effects | Chromosomes, Human, Pair 1 - genetics | Chromosome Deletion | Gene Silencing | Radiation Tolerance - genetics | Isocitrate Dehydrogenase - genetics | Down-Regulation - genetics | Oligodendroglia - pathology | Cell Line, Tumor | CpG Islands - genetics | Aged | Mutation | DNA Methylation - drug effects | Glioma - drug therapy | peroxiredoxin1 | Care and treatment | Chemotherapy | Usage | Physiological aspects | Diagnosis | Research | Gene expression | Health aspects | Oligodendroglioma | Cancer | Proteins | Brain cancer | DNA methylation | Radiation therapy | Apoptosis | Peroxiredoxin | Bisulfite | Brain tumors | Glioblastoma | Chromosome deletion | Chromosome 1 | Promoters | Western blotting | epigenetics | Polymerase chain reaction | Molecular modelling | Glioma | Sodium | Glioma cells | Islands | Tumors
Journal Article
Molecular BioSystems, ISSN 1742-206X, 01/2012, Volume 8, Issue 1, pp. 268 - 281
Traditionally, protein-protein interactions were thought to be mediated by large, structured domains. However, it has become clear that the interactome... 
TRANSCRIPTION FACTORS | ANAPHASE-PROMOTING COMPLEX | LOCALIZATION SIGNAL | STRUCTURAL BASIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRINSICALLY UNSTRUCTURED PROTEINS | DISORDERED PROTEINS | INTERACTION NETWORKS | CELL-CYCLE | P53 TUMOR-SUPPRESSOR
Journal Article