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science & technology (21) 21
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phosphodiesterase inhibitors - pharmacokinetics (2) 2
physiological aspects (2) 2
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1. Full Text Fluorescent Imaging Analysis for Distribution of Fluorescent Dye Labeled- or Encapsulated-Liposome in Monocrotaline-Induced Pulmonary Hypertension Model Rat
by Muraki, Yo and Yamasaki, Midori and Takeuchi, Hirohisa and Tohyama, Kimio and Sano, Noriyasu and Matsuo, Takanori and bTakeda Pharmaceutical Company Limited and aTakeda Pharmaceutical Company Limited
Chemical & pharmaceutical bulletin, ISSN 0009-2363, 2018, Volume 66, Issue 3, pp. 270 - 276
nanoparticle | pulmonary hypertension | liposome | Liposome | Nanoparticle | Pulmonary hypertension | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Encapsulation | Drugs | Reactive oxygen species | Drug delivery systems | Dyes | Monocrotaline | Fluorescent dyes | Fluorescence | Inflammatory response | Drug delivery | Fluorescent indicators | Drug development | Macrophages | Tissues | Accumulation | Polyethylene glycol | Hypertension | Fluoroscopic imaging | Polyethylene | Lung diseases | Exposure | Inflammation | Permeability | Gene expression | Lungs | Liposomes | Index Medicus
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2. Full Text Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities
by Sato, Sho and Tohyama, Kimio and Kosugi, Yohei
European journal of pharmaceutical sciences, ISSN 0928-0987, 01/2020, Volume 142, pp. 105119 - 105119
BCRP | MDR1 | MDCK-MDR1 | Kp,uu,brain | Kp,brain ratio | MDCK-BCRP | LLC-PK1-MDR1 | Brain disposition | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Index Medicus
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3. Full Text Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier
by Atsushi Ose and Hiroyuki Kusuhara and Chihiro Endo and Kimio Tohyama and Mari Miyajima and Satoshi Kitamura and Yuichi Sugiyama
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
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4. Full Text Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C Motif Receptor 9 Antagonist, to Serum Albumins
by Narita, Naohiro and Morohashi, Akio and Tohyama, Kimio and Takeuchi, Toshiyuki and Tagawa, Yoshihiko and Kondo, Takahiro and Asahi, Satoru
Drug metabolism and disposition, ISSN 0090-9556, 03/2018, Volume 46, Issue 3, pp. 204 - 213
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Amino acids | Chemical reduction | Albumins | Imines | Rodents | Pronase | Half-life | Carbon 14 | Adducts | Radioactivity | Carbonyls | Binding | Oral administration | Rats | Albumin | Radioactive half-life | Mass spectroscopy | Liquid chromatography | Pharmacology | Serum albumin | Carbonyl groups | Covalence | Trypsin | Lysine | Mass spectrometry | Chemokines | Index Medicus
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5. Full Text Protective effect of a novel phosphodiesterase 4 selective inhibitor, compound A, in diabetic nephropathy model mice
by Ookawara, Mitsugi and Nio, Yasunori and Yamasaki, Midori and Kuniyeda, Kanako and Hanauer, Guido and Tohyama, Kimio and Hazama, Masatoshi and Matsuo, Takanori
European journal of pharmacology, ISSN 0014-2999, 03/2021, Volume 894, pp. 173852 - 173852
Compound a | Db/db mouse | Uninephrectomy | Diabetic nephropathy | Phosphodiesterase 4 inhibitor | UACR | Glycosylated hemoglobin | Cyclic adenylic acid | Analysis | Leptin | Diabetic nephropathies | Index Medicus
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6. Full Text Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys
by Iwasaki, Shinji and Yamamoto, Syunsuke and Sano, Noriyasu and Tohyama, Kimio and Kosugi, Yohei and Furuta, Atsutoshi and Hamada, Teruki and Igari, Tomoko and Fujioka, Yasushi and Hirabayashi, Hideki and Amano, Nobuyuki
Pharmaceutical research, ISSN 0724-8741, 5/2019, Volume 36, Issue 5, pp. 1 - 14
Biochemistry, general | Biomedicine | intranasal administration | Pharmacy | membrane permeability | Medical Law | drug delivery | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | central nervous system | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Macaca fascicularis | Membranes, Artificial | Rats | Male | Olfactory Bulb - metabolism | Permeability | Administration, Intranasal | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Brain - metabolism | Animals | Pharmaceutical Preparations - administration & dosage | Pharmacokinetics | Drug Delivery Systems - methods | Drugs | Ropinirole | Drug delivery systems | Liability (Law) | Central nervous system | Primates | Methotrexate | Furosemide | Vehicles | Efflux | Intravenous administration | Cimetidine | Intranasal administration | Monkeys | Drug delivery | Atenolol | Monkeys & apes | Sulpiride | Substrates | Liability | Blood-brain barrier | Rodents | Nose | Ranitidine | Metformin | Midazolam | Didanosine | Index Medicus
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7. Full Text Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension
by Muraki, Yo and Naito, Takako and Tohyama, Kimio and Shibata, Sachio and Kuniyeda, Kanako and Nio, Yasunori and Hazama, Masatoshi and Matsuo, Takanori
Bioscience, biotechnology, and biochemistry, ISSN 0916-8451, 06/2019, Volume 83, Issue 6, pp. 1000 - 1010
cAMP | cGMP | rat model of monocrotaline-induced pulmonary hypertension | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Food Science & Technology | Biotechnology & Applied Microbiology | Science & Technology | Index Medicus
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8. Full Text Pre‐clinical Characterization of Absorption, Distribution, Metabolism and Excretion Properties of TAK‐063
by Tohyama, Kimio and Sudo, Miyako and Morohashi, Akio and Kato, Suguru and Takahashi, Junzo and Tagawa, Yoshihiko
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 06/2018, Volume 122, Issue 6, pp. 577 - 587
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Caco-2 Cells | Phosphodiesterase Inhibitors - pharmacokinetics | Humans | Rats, Long-Evans | Half-Life | Phosphoric Diester Hydrolases - drug effects | Rats | Male | Antipsychotic Agents - pharmacokinetics | Pyrazoles - metabolism | Rats, Sprague-Dawley | Intestinal Absorption | Tissue Distribution | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Phosphodiesterase Inhibitors - metabolism | Biotransformation | Dogs | Protein Binding | Antipsychotic Agents - metabolism | Pyridazines - metabolism | Pyridazines - pharmacokinetics | Pyrazoles - pharmacokinetics | Physiological aspects | Schizophrenia | Medicine, Experimental | Medical research | Metabolites | Cytochrome P-450 | Brain | Mental disorders | Liver | Central nervous system | Pyrazole | Absorption | Intestine | Rodents | Excretion | Hydroxylation | Incubation | Oral administration | Feasibility studies | Breast cancer | Pharmacology | Glycoproteins | Bioavailability | Metabolism | Microsomes | Substrates | Liability | Blood circulation | Index Medicus
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9. Full Text Utility of Göttingen minipigs for Prediction of Human Pharmacokinetic Profiles After Dermal Drug Application
by Yamamoto, Syunsuke and Karashima, Masatoshi and Sano, Noriyasu and Fukushi, Chiharu and Tohyama, Kimio and Arai, Yuta and Hirabayashi, Hideki and Amano, Nobuyuki
Pharmaceutical research, ISSN 0724-8741, 11/2017, Volume 34, Issue 11, pp. 2415 - 2424
Biochemistry, general | Biomedical Engineering | Biomedicine | absorption | in vitro/in vivo correlations (IVIVC) | transdermal | Pharmacy | Göttingen minipig | pharmacokinetics | skin | Medical Law | Pharmacology/Toxicology | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Transdermal Patch | Skin Cream - pharmacokinetics | Area Under Curve | Skin - metabolism | Humans | Biological Availability | Administration, Cutaneous | Permeability | Pharmaceutical Preparations - metabolism | Animals | Models, Biological | Swine | Skin Cream - administration & dosage | Swine, Miniature | Skin Absorption - drug effects | Models, Animal | Pharmaceutical Preparations - administration & dosage | Skin Cream - metabolism | Dermatologic agents | Usage | Skin | Dermatology | Formulae, receipts, prescriptions | Drugs | Correlation | Absorption | Data processing | Pharmacology | Bioavailability | Plasmas (physics) | Cosmetics industry | Blood plasma | Index Medicus
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10. Full Text Relationship of MATE1 Inhibition and Cytotoxicity in Nephrotoxicity: Application for Safety Evaluation in Early Drug Discovery
by Tohyama, Kimio and Chisaki, Ikumi and Takai, Yuichi and Handa, Yasuhiro and Miyamoto, Makoto and Amano, Nobuyuki
Toxicological sciences, ISSN 1096-6080, 07/2019, Volume 170, Issue 1, pp. 223 - 233
Life Sciences & Biomedicine | Toxicology | Science & Technology | Cell Survival - drug effects | Kidney - drug effects | Kidney - pathology | Humans | Rats | Drug Discovery - methods | Drug-Related Side Effects and Adverse Reactions - metabolism | Mitochondria - drug effects | Drug-Related Side Effects and Adverse Reactions - pathology | Haplorhini | Hep G2 Cells | Toxicokinetics | Kidney - metabolism | Animals | Organic Cation Transport Proteins - antagonists & inhibitors | Transfection | Computer Simulation | Dogs | Madin Darby Canine Kidney Cells | Drug Evaluation, Preclinical | Organic Cation Transport Proteins - genetics | Pharmaceutical Preparations - administration & dosage | Index Medicus
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11. Full Text Mechanism for covalent binding of MLN3126, an oral chemokine C-C motif receptor 9 antagonist, to serum albuminss
by Narita, Naohiro and Morohashi, Akio and Tohyama, Kimio and Takeuchi, Toshiyuki and Tagawa, Yoshihiko and Kondo, Takahiro and Asahi, Satoru
Drug metabolism and disposition, ISSN 0090-9556, 03/2018, Volume 46, Issue 3, pp. 204 - 213
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12. Full Text Prediction of Human Pharmacokinetic Profile After Transdermal Drug Application Using Excised Human Skin
by Yamamoto, Syunsuke and Karashima, Masatoshi and Arai, Yuta and Tohyama, Kimio and Amano, Nobuyuki
Journal of pharmaceutical sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2787 - 2794
mathematical model | pharmacokinetics | skin | in vitro/in vivo correlations | absorption | transdermal | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Models, Biological | Skin - metabolism | Computer Simulation | Humans | Female | Skin Absorption | Administration, Cutaneous | Index Medicus
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13. Full Text Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation
by Fukuda, Yasunori and Kaishima, Misato and Ohnishi, Toshiyuki and Tohyama, Kimio and Chisaki, Ikumi and Nakayama, Yusuke and Ogasawara-Shimizu, Mari and Kawamata, Yuji
Biochemical and biophysical research communications, ISSN 0006-291X, 03/2017, Volume 484, Issue 2, pp. 358 - 364
MATE2-K | HO-1 | Fluid shear stress | Nrf2 | PTEC | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Kidney Tubules, Proximal - cytology | Humans | NF-E2-Related Factor 2 - metabolism | Cells, Cultured | Kidney Tubules, Proximal - metabolism | Stress, Mechanical | Gene Expression Profiling | Organic Cation Transport Proteins - genetics | Genetic research | Gene expression | Pharmaceutical industry | Genes | Index Medicus
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