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1. Full Text The use of Toll-like receptor 7/8 agonists as vaccine adjuvants
by Vasilakos, John P and Tomai, Mark A
Expert review of vaccines, ISSN 1476-0584, 07/2013, Volume 12, Issue 7, pp. 809 - 819
dendritic cells | imiquimod | imidazoquinolines | TLR8 | TLR7 | Aldara | resiquimod (R-848) | Life Sciences & Biomedicine | Immunology | Science & Technology | Antiviral agents | Biological and medical sciences | Medical sciences | Immunomodulators | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Toll-Like Receptor 7 - agonists | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Humans | Aminoquinolines - administration & dosage | Drug Discovery - trends | Imidazoles - administration & dosage | Vaccines - immunology | Clinical Trials as Topic | Imidazoles - pharmacology | Toll-Like Receptor 8 - immunology | Toll-Like Receptor 7 - immunology | Aminoquinolines - pharmacology | Toll-Like Receptor 8 - agonists | Toll-like receptors | Physiological aspects | Adjuvants, Pharmaceutic | Vaccines | Research | Health aspects | Index Medicus
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2. Full Text New horizons in adjuvants for vaccine development
by Reed, Steven G and Tomai, Mark and Gale, Michael J
Current opinion in immunology, ISSN 0952-7915, 08/2020, Volume 65, pp. 97 - 101
Index Medicus
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3. Full Text Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways
by Philbin, Victoria J., DPhil and Dowling, David J., PhD and Gallington, Leighanne C., BSc and Cortés, Guadalupe, PhD and Tan, Zhen, MD and Suter, Eugénie E., MA and Chi, Kevin W., BA and Shuckett, Ariel, MPH and Stoler-Barak, Liat, MSc and Tomai, Mark, PhD and Miller, Richard L., PhD and Mansfield, Keith, DVM and Levy, Ofer, MD, PhD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 130, Issue 1, pp. 195 - 204.e9
Allergy and Immunology | adenosine | innate immunity | adjuvant | inflammasome | neonate | Toll-like receptor 8 | newborn | IL-1β | caspase-1 | alum | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Biological and medical sciences | Medical sciences | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Cytokines - metabolism | Adjuvants, Immunologic | Dendritic Cells - immunology | Humans | Caspase 1 - metabolism | Imidazoles - pharmacology | Macaca mulatta | Monocytes - immunology | Quinolines - pharmacology | Alum Compounds | Animals | Adenosine - metabolism | Adult | Infant, Newborn | Cytokines - immunology | Toll-Like Receptor 8 - agonists | Drugs | Infants (Newborn) | Medical colleges | Drug delivery systems | RNA | Dendritic cells | Cross infection | Children | Nosocomial infections | Adenylic acid | Vehicles | Diseases | Hepatitis | Adenosine | Cytokines | Newborn babies | Aluminum | Immune system | Index Medicus | Abridged Index Medicus
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4. Full Text A Formulated TLR7/8 agonist is a flexible, highly potent and effective adjuvant for pandemic influenza vaccines
by Van Hoeven, Neal and Fox, Christopher B and Granger, Brian and Evers, Tara and Joshi, Sharvari W and Nana, Ghislain I and Evans, Sarah C and Lin, Susan and Liang, Hong and Liang, Li and Nakajima, Rie and Felgner, Philip L and Bowen, Richard A and Marlenee, Nicole and Hartwig, Airn and Baldwin, Susan L and Coler, Rhea N and Tomai, Mark and Elvecrog, James and Reed, Steven G and Carter, Darrick
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 46426 - 46426
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antigens | Animal models | Pandemics | TLR7 protein | Clinical trials | Outbreaks | Vaccines | Avian flu | Disease transmission | Molecular modelling | Toll-like receptors | Hemagglutinins | Public health
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5. Full Text Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
by Gorski, Kevin S and Waller, Emily L and Bjornton-Severson, Jacqueline and Hanten, John A and Riter, Christie L and Kieper, William C and Gorden, Keith B and Miller, Jeffrey S and Vasilakos, John P and Tomai, Mark A and Alkan, Sefik S
International immunology, ISSN 0953-8178, 07/2006, Volume 18, Issue 7, pp. 1115 - 1126
Toll-like receptors | Cytotoxicity | NK cells | Cytokines | Life Sciences & Biomedicine | Immunology | Science & Technology | Toll-Like Receptor 7 - agonists | Antigens, CD - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Humans | Lectins, C-Type | Imidazoles - pharmacology | Quinolines - pharmacology | Toll-Like Receptor 8 - immunology | Lymphocyte Activation - immunology | Animals | Receptors, Interferon - immunology | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Mice, Mutant Strains | Toll-Like Receptor 7 - immunology | K562 Cells | Killer Cells, Natural - immunology | Ligands | Mice | Cytokines - immunology | Interferon Inducers - pharmacology | Toll-Like Receptor 8 - agonists | Index Medicus
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6. Full Text Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
by Saunders, Kevin O and Wiehe, Kevin and Tian, Ming and Acharya, Priyamvada and Bradley, Todd and Alam, S. Munir and Go, Eden P and Scearce, Richard and Sutherland, Laura and Henderson, Rory and Hsu, Allen L and Borgnia, Mario J and Chen, Haiyan and Lu, Xiaozhi and Wu, Nelson R and Watts, Brian and Jiang, Chuancang and Easterhoff, David and Cheng, Hwei-Ling and McGovern, Kelly and Waddicor, Peyton and Chapdelaine-Williams, Aimee and Eaton, Amanda and Zhang, Jinsong and Rountree, Wes and Verkoczy, Laurent and Tomai, Mark and Lewis, Mark G and Desaire, Heather R and Edwards, Robert J and Cain, Derek W and Bonsignori, Mattia and Montefiori, David and Alt, Frederick W and Haynes, Barton F
Science (American Association for the Advancement of Science), ISSN 0036-8075, 12/2019, Volume 366, Issue 6470, p. 1215
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | AIDS Vaccines - immunology | Selection, Genetic | Antibody Affinity - genetics | Epitopes - genetics | Gene Knock-In Techniques | HIV-1 - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | Animals | B-Lymphocytes - immunology | HIV Antibodies - immunology | Mice, Mutant Strains | AIDS Vaccines - genetics | Macaca | Mice | Mutation | Animal models | Variable region | Vaccination | Activation-induced cytidine deaminase | Nucleotides | Vaccines | Antibody response | Design | Engineering | Precursors | Human immunodeficiency virus--HIV | Immunization | Immunoglobulins | Maturation | Glycan | CD4 antigen | Lymphocytes B | Neutralizing | Monoclonal antibodies | Strategy | Affinity | Binding sites | Cytidine deaminase | Neutralization | Index Medicus
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7. Full Text Coated microneedles for transdermal delivery of a potent pharmaceutical peptide
by Kapoor, Yash and Milewski, Mikolaj and Dick, Lisa and Zhang, Jingtao and Bothe, Jameson R and Gehrt, Michele and Manser, Kim and Nissley, Becky and Petrescu, Ioan and Johnson, Peter and Burton, Scott and Moseman, Joan and Hua, Vinh and Grunewald, Tonya and Tomai, Mark and Smith, Ronald
Biomedical microdevices, ISSN 1387-2176, 12/2019, Volume 22, Issue 1, pp. 7 - 7
Engineering | Science & Technology - Other Topics | Nanoscience & Nanotechnology | Technology | Engineering, Biomedical | Science & Technology | Tissue Distribution | Animals | Drug Delivery Systems - instrumentation | Swine | Peptides - pharmacokinetics | Female | Needles | Skin | Peptides - administration & dosage | Peptides - therapeutic use | Peptides | Transdermal medication | Storage | Drug delivery | Bioavailability | Vaccines | Index Medicus
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8. Full Text TLR-7 and -8 agonists as vaccine adjuvants
by Tomai, Mark A and Vasilakos, John P
Expert review of vaccines, ISSN 1476-0584, 04/2011, Volume 10, Issue 4, pp. 405 - 407
vaccine | adjuvant | TLR-8 | imiquimod | TLR-7 | resiquimod | imidazoquinoline | Life Sciences & Biomedicine | Immunology | Science & Technology | Toll-Like Receptor 7 - agonists | Neoplasms - therapy | Adjuvants, Immunologic - pharmacology | Animals | Humans | Vaccines - immunology | Neoplasms - prevention & control | Communicable Disease Control | Toll-Like Receptor 8 - agonists | Cancer vaccines | Genetic aspects | Vaccines | Biosafety | Cancer | Index Medicus
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9. Full Text Nanoformulation of synergistic TLR ligands to enhance vaccination against Entamoeba histolytica
by Abhyankar, Mayuresh M and Noor, Zannatun and Tomai, Mark A and Elvecrog, James and Fox, Christopher B and Petri, William A
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 6, pp. 916 - 922
Allergy and Immunology | Liposome | Vaccine | Amebiasis | Immune response | Entamoeba | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Entamoeba histolytica - immunology | Oligodeoxyribonucleotides - administration & dosage | Adjuvants, Immunologic - administration & dosage | Antigens, Protozoan - immunology | Liposomes - administration & dosage | Lipopolysaccharides - administration & dosage | Interleukin-17 - immunology | Protozoan Vaccines - chemistry | Entamoebiasis - immunology | Immunity, Mucosal - drug effects | Toll-Like Receptor 8 - immunology | Entamoebiasis - parasitology | Adjuvants, Immunologic - chemistry | Toll-Like Receptor 7 - immunology | Mice, Inbred CBA | Polysorbates - administration & dosage | Toll-Like Receptor 3 - genetics | Lectins - chemistry | Membrane Glycoproteins - immunology | Entamoeba histolytica - growth & development | Liposomes - immunology | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Immunization | Tretinoin - administration & dosage | Vaccines, Subunit | Antigens, Protozoan - chemistry | Lectins - immunology | Protozoan Vaccines - immunology | Membrane Glycoproteins - agonists | Squalene - administration & dosage | Toll-Like Receptor 3 - immunology | Toll-Like Receptor 3 - agonists | Interleukin-17 - biosynthesis | Protozoan Vaccines - administration & dosage | Entamoeba histolytica - drug effects | Antibodies, Protozoan - biosynthesis | Membrane Glycoproteins - genetics | Liposomes - chemistry | Animals | Interferon-gamma - immunology | Entamoebiasis - prevention & control | Toll-Like Receptor 8 - genetics | Mice | RNA - administration & dosage | Alum Compounds - administration & dosage | Interferon-gamma - biosynthesis | Vaccination | Drugs | Evaluation | Antigens | Drug delivery systems | Communicable diseases | Mortality | Lectins | Drug therapy, Combination | Cells | Vehicles | Tretinoin | Studies | Aqueous solutions | Cytokines | Ligands | Vaccines | Experiments | Tropical diseases | Index Medicus
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