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British Journal of Cancer, ISSN 0007-0920, 08/2016, Volume 115, Issue 4, pp. 442 - 453
Journal Article
Journal Article
Xenobiotica, ISSN 0049-8254, 10/2019, Volume 49, Issue 10, pp. 1229 - 1236
1. The present study investigated inhibitory effects of enasidenib and its metabolite AGI-16903 on (a) recombinant human nucleoside transporters (hNTs) in... 
isocitrate dehydrogenase-2 inhibitor | nucleoside transporter | enasidenib | Acute myeloid leukemia | azacitidine
Journal Article
Clinical pharmacology : advances and applications, ISSN 1179-1438, 2019, Volume 11, pp. 39 - 50
Enasidenib (IDHIFA , AG-221) is a first-in-class, targeted inhibitor of mutant IDH2 proteins for treatment of relapsed or refractory acute myeloid leukemia.... 
Cytochrome | Enzymes | Dehydrogenases | Metabolites | Leukemia | Mutation | Metabolism | Drug dosages | Cholesterol | modeling and simulation | 4β-hydroxycholesterol | CYP3A induction | Enasidenib
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2019, Volume 34, Issue 1, pp. S42 - S42
Journal Article
Pharmacology Research & Perspectives, ISSN 2052-1707, 12/2018, Volume 6, Issue 6, pp. e00436 - n/a
The aim of this study was to assess and compare the pharmacokinetics ( PK ) and safety of Enasidenib in healthy adult male Japanese subjects to healthy adult... 
Caucasian | pharmacokinetics | race | Japanese | IDHIFA | Enasidenib | Patient safety | Drug dosages | Pharmacology | Index Medicus
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 07/2015, Volume 62, Issue 7, pp. 1214 - 1221
Journal Article
Xenobiotica, ISSN 0049-8254, 01/2019, Volume 49, Issue 1, pp. 43 - 53
1. The absorption, distribution, metabolism, and excretion of CC-223 were studied following a single oral dose of [ 14 C]CC-223 to rats (3 mg/kg; 90 μCi/kg),... 
Accelerator mass spectrometry | mTOR kinase inhibitor | ADME | species comparison | DRUG | SAFETY | ACCELERATOR MASS-SPECTROMETRY | BALANCE | THROUGHPUT | PATHWAY | PHARMACOLOGY & PHARMACY | EXPERIENCE | TOXICOLOGY | Index Medicus
Journal Article
Xenobiotica, ISSN 0049-8254, 02/2019, Volume 49, Issue 2, pp. 200 - 210
1.The absorption, distribution, metabolism and excretion of enasidenib were studied following a single oral dose of [C-14]enasidenib to rats (10 mg/kg; 100 mu... 
Absorption | isocitrate dehydrogenase inhibitor | metabolism and excretion | distribution | species comparison | accelerator mass spectrometry | DRUG | CELLS | SAFETY | IDH2 | ACCELERATOR MASS-SPECTROMETRY | BALANCE | PHARMACOLOGY & PHARMACY | EXPERIENCE | TOXICOLOGY | MUTATIONS | LEUKEMIA | Index Medicus
Journal Article
Xenobiotica, ISSN 0049-8254, 01/2019, Volume 49, Issue 1, pp. 54 - 70
1. CC-223 was studied in vitro for metabolism and drug-drug interactions (DDI), and in clinic for interaction with ketoconazole. 2. In vitro, human metabolites... 
PBPK | drug-drug interactions | mTOR kinase inhibitor | transporters | in vitro metabolism | Cytochrome P-450 | drug–drug interactions | QUANTITATIVE-EVALUATION | IN-VITRO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCTION | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 1050 - 1050
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2017, Volume 32, Issue 1, pp. S79 - S79
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 5666 - 5666
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2015, Volume 14, Issue 6, pp. 1295 - 1305
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 07/2015, Volume 62, Issue 7, p. 1214
Nanoparticle albumin-bound paclitaxel (nab-paclitaxel, Abraxane.sub.[R]) is FDA approved for the treatment of several adult cancers. Antimitotic agents are... 
Antimitotic agents | Pediatrics | Sarcoma | Albumin | Antineoplastic agents | Tubulins | Drug approval | Food additives industry
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2014, Volume 32, Issue 15, pp. 2609 - 2609
Conference Proceeding
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