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1. Full Text Pushing the boundaries: The development of super-resolution microscopy at Yale and beyond: An interview with Derek Toomre, PHD
by Zwick, Rachel K and Schmidt, Barbara A
Yale Journal of Biology and Medicine, ISSN 0044-0086, 2014, Volume 87, Issue 1, pp. 55 - 62
Super-resolution microscopy | Microscopy | TIRF | microscopy | super-resolution microscopy | Endocytosis | Biological Transport | Microscopy, Fluorescence - methods | Humans | Cell Membrane - metabolism | Exocytosis | Cell Biology - instrumentation | Microscopy, Fluorescence - instrumentation
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2. Full Text Lipid rafts and signal transduction
by Toomre, Derek and Simons, Kai
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 10/2000, Volume 1, Issue 1, pp. 31 - 39
Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear... 
MEMBRANE DOMAINS | FC-EPSILON-RI | TYROSINE PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING | T-CELL ACTIVATION | PLASMA-MEMBRANE | CAVEOLAE MEMBRANE | GPI-ANCHORED PROTEINS | LIVING CELLS | CELL BIOLOGY | Animals | Caveolae - metabolism | Membrane Microdomains - metabolism | Models, Biological | Membrane Microdomains - chemistry | Receptors, Cell Surface - metabolism | Signal Transduction - physiology | Sphingolipids - metabolism | Molecular Structure | Phospholipids - metabolism | Cholesterol - metabolism | Endocytosis - physiology
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3. Full Text A new wave of cellular imaging
by Toomre, Derek and Bewersdorf, Joerg
Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 11/2010, Volume 26, Issue 1, pp. 285 - 314
Fluorescence imaging methods that push or break the diffraction limit of resolution (approximately 200 nm) have grown explosively. These super-resolution... 
single molecule | live cell imaging | total internal reflection fluorescence microscopy (TIRFM) | light microscopy | fluorescence | super-resolution | POINT-SPREAD FUNCTION | PHOTOACTIVATED LOCALIZATION MICROSCOPY | REFLECTION FLUORESCENCE MICROSCOPY | DIFFRACTION RESOLUTION LIMIT | DEVELOPMENTAL BIOLOGY | OPTICAL RECONSTRUCTION MICROSCOPY | STED MICROSCOPY | LIVE CELLS | STRUCTURED-ILLUMINATION MICROSCOPY | CELL BIOLOGY | GROUND-STATE-DEPLETION | STIMULATED-EMISSION | Animals | Organelles - ultrastructure | Image Processing, Computer-Assisted | Microscopy, Fluorescence - methods | Nanotechnology - methods | Microscopy, Fluorescence - instrumentation | Cell research | Fluorescence microscopy | Methods
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4. Full Text Spatial control of EGF receptor activation by reversible dimerization on living cells
by Chung, Inhee and Akita, Robert and Vandlen, Richard and Toomre, Derek and Schlessinger, Joseph and Mellman, Ira
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7289, pp. 783 - 787
Epidermal growth factor receptor (EGFR) is a type I receptor tyrosine kinase, the deregulation of which has been implicated in a variety of human... 
GROWTH-FACTOR RECEPTOR | DOMAIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | TRACKING | SURFACE | MEMBRANES | DYNAMICS | TYROSINE KINASES | LIVE CELLS | BINDING | Cell Polarity | Receptor, Epidermal Growth Factor - agonists | Receptor, Epidermal Growth Factor - genetics | Cricetulus | Humans | Actins - metabolism | Enzyme Stability - drug effects | Thermodynamics | Receptor, Epidermal Growth Factor - metabolism | GRB2 Adaptor Protein - genetics | Diffusion | CHO Cells | Cricetinae | Signal Transduction | Cell Survival | Gene Expression Regulation | Epidermal Growth Factor - metabolism | Enzyme Activation - drug effects | Receptor, Epidermal Growth Factor - chemistry | Protein Transport | Animals | Cell Line, Tumor | Ligands | Epidermal Growth Factor - pharmacology | Kinetics | GRB2 Adaptor Protein - metabolism | Protein Multimerization - drug effects | Physiological aspects | Genetic aspects | Ligand binding (Biochemistry) | Research | Muscle proteins | Proteins | Quantum dots | Methods | Cell adhesion & migration | Binding | Receptors | Activation | Dimers | Kinases | Signalling | Dimerization
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5. Full Text Optogenetic control of phosphoinositide metabolism
by Olof Idevall-Hagren and Eamonn J. Dickson and Bertil Hille and Derek K. Toomre and Pietro De Camilli
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2012, Volume 109, Issue 35, pp. E2316 - E2323
Phosphoinositides (PIs) are lipid components of cell membranes that regulate a wide variety of cellular functions. Here we exploited the blue light-induced... 
Polarity | Endocytosis | Rapamycin | Ruffles | Ion channel | HUMAN-DISEASE | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | MULTIDISCIPLINARY SCIENCES | LIGHT | BINDING-PROTEIN | ruffles | PLASMA-MEMBRANE | 4,5-BISPHOSPHATE | SPATIOTEMPORAL CONTROL | ion channel | 5-PHOSPHATASES | endocytosis | polarity | rapamycin | LIVING CELLS | PHOSPHATASES | Phosphorylation - physiology | Endocytosis - radiation effects | Humans | Actins - metabolism | Cercopithecus aethiops | Cryptochromes - genetics | Membrane Potentials - radiation effects | Phosphatidylinositol 3-Kinases - metabolism | KCNQ3 Potassium Channel - physiology | PC12 Cells | Recombinant Fusion Proteins - metabolism | Arabidopsis Proteins - metabolism | Phosphatidylinositol 4,5-Diphosphate - metabolism | Light | Binding Sites - physiology | Phosphatidylinositols - metabolism | Cell Membrane - metabolism | KCNQ2 Potassium Channel - physiology | Signal Transduction - radiation effects | Cell Membrane - radiation effects | Cryptochromes - metabolism | Arabidopsis Proteins - genetics | Phosphoric Monoester Hydrolases - genetics | Rats | Membrane Potentials - physiology | Endocytosis - physiology | Amino Acid Motifs - physiology | Phosphorylation - radiation effects | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Phosphoric Monoester Hydrolases - metabolism | COS Cells | Biological Sciences | PNAS Plus
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6. Full Text Video-rate nanoscopy using sCMOS camera-specific single-molecule localization algorithms
by Huang, Fang and Hartwich, Tobias M.P and Rivera-Molina, Felix E and Lin, Yu and Duim, Whitney C and Long, Jane J and Uchil, Pradeep D and Myers, Jordan R and Baird, Michelle A and Mothes, Walther and Davidson, Michael W and Toomre, Derek and Bewersdorf, Joerg
Nature Methods, ISSN 1548-7091, 07/2013, Volume 10, Issue 7, pp. 653 - 658
Newly developed scientific complementary metal-oxide semiconductor (sCMOS) cameras have the potential to dramatically accelerate data acquisition, enlarge the... 
FLUOROPHORES | SUPERRESOLUTION MICROSCOPY | ACQUISITION | RESOLUTION | TRACKING | BIOCHEMICAL RESEARCH METHODS | FLUORESCENT PROTEINS | ENDOCYTOSIS | LIVE CELLS | LIVING CELLS | ACCURACY | Microscopy, Video - instrumentation | Signal Processing, Computer-Assisted - instrumentation | Algorithms | Semiconductors | Molecular Imaging - instrumentation | Nanotechnology - instrumentation | Image Enhancement - instrumentation | Equipment Design | Equipment Failure Analysis | Pattern Recognition, Automated - methods | Cameras | Usage | Noise | Analysis | Nanotechnology | Molecules | Video
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7. Full Text Land-locked mammalian Golgi reveals cargo transport between stable cisternae
by Dunlop, Myun Hwa and Ernst, Andreas M and Schroeder, Lena K and Toomre, Derek K and Lavieu, Grégory and Rothman, James E
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 432 - 14
The Golgi is composed of a stack of cis, medial, trans cisternae that are biochemically distinct. The stable compartments model postulates that permanent... 
GRASP65 | ORGANIZATION | STACKING | COMPLEX | PROTEIN | MICROTUBULES | PDZ DOMAIN | MULTIDISCIPLINARY SCIENCES | CELL-FREE SYSTEM | ENDOPLASMIC-RETICULUM | MATURATION | Mammals - metabolism | Fluorescence Recovery After Photobleaching | Membrane Fusion | Coated Vesicles - metabolism | Humans | Mitochondria - metabolism | Golgi Matrix Proteins | Mitochondria - ultrastructure | Animals | Biological Transport | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | HeLa Cells | Golgi Apparatus - ultrastructure | Cargo | Traffic models | Compartments | Light microscopy | Communications traffic | Transport | Anterograde transport | Golgi apparatus
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8. Full Text Both Daughter Cells Traffic and Exocytose Membrane at the Cleavage Furrow during Mammalian Cytokinesis
by John W. Goss and Derek K. Toomre
The Journal of Cell Biology, ISSN 0021-9525, 6/2008, Volume 181, Issue 7, pp. 1047 - 1054
Membrane trafficking during cytokinesis is not well understood. We used advanced live cell imaging techniques to track exocytosis of single vesicles to... 
Microscopy | Report | Imaging | Biological transport | Traffic | HeLa cells | Cell membranes | Cytokinesis | Exocytosis | Daughter cells | Endosomes | ANIMAL CYTOKINESIS | HIGHER-PLANTS | MIDBODY | LATE MITOSIS | SPINDLE | MECHANISMS | COMPLETION | MICROSCOPY | CLATHRIN | REVEALS | CELL BIOLOGY | Fluorescence Recovery After Photobleaching | Humans | Mammals | Recombinant Fusion Proteins - metabolism | Microscopy, Confocal | Animals | Biological Transport | Transport Vesicles - metabolism | Golgi Apparatus - metabolism | Cell Membrane - metabolism | HeLa Cells | Intracellular Membranes - metabolism | Microscopy, Fluorescence | Evaluation | Diagnostic imaging | Properties | Methods | Fluorescence microscopy
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9. Full Text Super‐Resolution Imaging of the Golgi in Live Cells with a Bioorthogonal Ceramide Probe
by Erdmann, Roman S and Takakura, Hideo and Thompson, Alexander D and Rivera‐Molina, Felix and Allgeyer, Edward S and Bewersdorf, Joerg and Toomre, Derek and Schepartz, Alanna
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2014, Volume 53, Issue 38, pp. 10242 - 10246
We report a lipid‐based strategy to visualize Golgi structure and dynamics at super‐resolution in live cells. The method is based on two novel reagents: a... 
fluorophores | membranes | bioorthogonal chemistry | click chemistry | STED | Membranes | Click chemistry | Bioorthogonal chemistry | Fluorophores | LOCALIZATION | MOLECULE | MICROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | PATHWAY | SERINE PALMITOYLTRANSFERASE | SECRETION | PROTEINS | Golgi Apparatus - enzymology | Microscopy, Confocal | Coloring Agents - analysis | Cell Survival | Humans | Golgi Apparatus - metabolism | Ceramides - chemistry | HeLa Cells | Microscopy, Fluorescence | Coloring Agents - chemistry | Enzymes | Cells | Investigations | Dyes | Microscopy | Dynamics | Imaging | Lipids | Strategy | Confocal | Endoplasmic reticulum | Three dimensional
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10. Full Text Repair of Injured Plasma Membrane by Rapid ca²⁺-Dependent Endocytosis
by Vincent Idone and Christina Tam and John W. Goss and Derek Toomre and Marc Pypaert and Norma W. Andrews
The Journal of Cell Biology, ISSN 0021-9525, 3/2008, Volume 180, Issue 5, pp. 905 - 914
Ca²⁺ influx through plasma membrane lesions triggers a rapid repair process that was previously shown to require the exocytosis of lysosomal organelles (Reddy,... 
T lymphocytes | Endocytosis | Dextrans | Neurons | Report | HeLa cells | Neurosecretory cells | Cell membranes | Exocytosis | Cells | Endosomes | NUCLEATED CELLS | RECOVERY | RESISTANT | LYSOSOMES | POLYMORPHONUCLEAR LEUKOCYTES | EXOCYTOSIS | ENLARGEOSOME | COMPLEMENT ATTACK | PROTEINS | FIBROBLASTS | CELL BIOLOGY | Sterols - metabolism | Epithelial Cells - metabolism | Calcium - metabolism | Calcium Signaling - physiology | Epithelial Cells - drug effects | Humans | Bacterial Toxins - toxicity | Streptolysins - toxicity | Cell Membrane Structures - metabolism | Time Factors | Immunity, Innate - physiology | Cell Membrane - metabolism | Membrane Proteins - metabolism | Cell Membrane - drug effects | Cell Line | Cell Membrane Structures - drug effects | Epithelial Cells - ultrastructure | Rats | Cell Membrane - ultrastructure | Reaction Time - physiology | Endocytosis - physiology | Cell Membrane Structures - ultrastructure | Animals | Wound Healing - physiology | HeLa Cells | Index Medicus
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11. Full Text Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
by Garrett, Wendy and Mellman, Ira and Chow, Amy and Toomre, Derek
Nature, ISSN 0028-0836, 08/2002, Volume 418, Issue 6901, pp. 988 - 994
Central to the initiation of immune responses is recognition of peptide antigen by T lymphocytes. The cell biology of dendritic cells makes them ideally suited... 
EVANESCENT-WAVE MICROSCOPY | IMMUNITY | ENDOCYTIC COMPARTMENTS | EXOCYTOSIS | MULTIDISCIPLINARY SCIENCES | INFLAMMATORY STIMULI | MACROPINOCYTOSIS | COMPLEXES | DOWN-REGULATION | SURFACE | DEVELOPMENTAL REGULATION | Membrane Glycoproteins - analysis | Stem Cells - immunology | Dendritic Cells - immunology | Mice, Inbred C57BL | Cells, Cultured | Microscopy, Video | Stem Cells - cytology | Stem Cells - metabolism | Endosomes - metabolism | Protein Transport | Antigens, CD - analysis | Endocytosis | Animals | Lysosomes - metabolism | Antigen Presentation | Histocompatibility Antigens Class II - metabolism | Cell Differentiation | Cell Membrane - metabolism | Dendritic Cells - cytology | Mice | Lysosome-Associated Membrane Glycoproteins | Dendritic Cells - metabolism | Plasma | Cellular biology | Peptides | Life cycles
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12. Full Text Two-colour live-cell nanoscale imaging of intracellular targets
by Bottanelli, Francesca and Kromann, Emil B and Allgeyer, Edward S and Erdmann, Roman S and Baguley, Stephanie Wood and Sirinakis, George and Schepartz, Alanna and Baddeley, David and Toomre, Derek K and Rothman, James E and Bewersdorf, Joerg
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 10778
Stimulated emission depletion (STED) nanoscopy allows observations of subcellular dynamics at the nanoscale. Applications have, however, been severely limited... 
STIMULATED-EMISSION | CYTOSKELETON | SUPERRESOLUTION MICROSCOPY | VESICLES | MULTIDISCIPLINARY SCIENCES | RESOLUTION | GOLGI | STED MICROSCOPY | FUSION PROTEINS | LIVING CELLS | REVEALS | Animals | Microscopy, Fluorescence - methods | Nanotechnology - methods | Humans | Heterocyclic Compounds, 4 or More Rings - chemistry | Cercopithecus aethiops | HeLa Cells | Rhodamines - chemistry | COS Cells | Luminescent Proteins
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