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1. Full Text Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
by Kempers, Marlies JE, MD and Kuiper, Roland P, PhD and Ockeloen, Charlotte W, MD and Chappuis, Pierre O, MD and Hutter, Pierre, PhD and Rahner, Nils, MD and Schackert, Hans K, Prof and Steinke, Verena, MD and Holinski-Feder, Elke, Prof and Morak, Monika, PhD and Kloor, Matthias, MD and Büttner, Reinhard, MD and Verwiel, Eugene TP, BSc and van Krieken, J Han, Prof and Nagtegaal, Iris D, MD and Goossens, Monique, BSc and van der Post, Rachel S, MD and Niessen, Renée C, PhD and Sijmons, Rolf H, MD and Kluijt, Irma, MD and Hogervorst, Frans BL, PhD and Leter, Edward M, MD and Gille, Johan JP, PhD and Aalfs, Cora M, MD and Redeker, Egbert JW, PhD and Hes, Frederik J, MD and Tops, Carli MJ, PhD and van Nesselrooij, Bernadette PM, MD and van Gijn, Marielle E, PhD and García, Encarna B Gómez, MD and Eccles, Diana M, Prof and Bunyan, David J, PhD and Syngal, Sapna, MD and Stoffel, Elena M, MD and Culver, Julie O, MSc and Palomares, Melanie R, MD and Graham, Tracy, MSc and Velsher, Lea, MD and Papp, Janos, PhD and Oláh, Edith, Prof and Chan, Tsun L, PhD and Leung, Suet Y, Prof and van Kessel, Ad Geurts, Prof and Kiemeney, Lambertus ALM, Prof and Hoogerbrugge, Nicoline, Prof and Ligtenberg, Marjolijn JL, Dr
Lancet Oncology, The, ISSN 1470-2045, 2011, Volume 12, Issue 1, pp. 49 - 55
Summary Background Lynch syndrome is caused by germline mutations in MSH2, MLH1, MSH6 , and PMS2 mismatch-repair genes and leads to a high risk of colorectal... 
Hematology, Oncology and Palliative Medicine | STEM-CELLS | METHYLATION | HYPERMETHYLATION | MANAGEMENT | MSH2 | ONCOLOGY | REPAIR GENE HMSH2 | MUTATION CARRIERS | FAMILIES | SURVEILLANCE | TACSTD1 | Antigens, Neoplasm - genetics | Promoter Regions, Genetic | Sequence Deletion | Cell Adhesion Molecules - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Endometrial Neoplasms - etiology | Male | Risk | MutS Homolog 2 Protein - genetics | Epithelial Cell Adhesion Molecule | Colorectal Neoplasms - etiology | Endometrial Neoplasms - genetics | Gene Deletion | Adolescent | Adult | Female | Aged | Cohort Studies | Prevention | Molecular genetics | Endometrial cancer | Gene mutations | Oncology, Experimental | Research | Universities and colleges | Biometry | Cancer
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2. Full Text MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma
by Burnichon, Nelly and Cascoń, Alberto and Schiavi, Francesca and Morales, NicolePaes and Comino-Méndez, Iñaki and Abermil, Nasséra and Inglada-Pérez, Lucía and Cubas, Aguirre and Amar, Laurence and Barontini, Marta and Quiroś, Sana Bernaldo and Bertherat, Jerome and Bignon, Yves-Jean and Blok, Marinus and Bobisse, Sara and Borrego, Salud and Castellano, Maurizio and Chanson, Philippe and Chiara, A and Corssmit, Eleonora and Giacchè, Mara and Krijger, Ronald and Ercolino, Tonino and Girerd, Xavier and Gómez García, Encarna and Gómez-Graña, Álvaro and Guilhem, Isabelle and Hes, Frederik and Honrado, Emiliano and Korpershoek, Esther and Lenders, Jacques and Letón, Rocío and Mensenkamp, Arjen and Merlo, Anna and Mori, Luigi and Murat, Arnaud and Pierre, Peggy and Plouin, Pierre-Franco̧is and Prodanov, Tamara and Quesada-Charneco, Miguel and Qin, Nan and Rapizzi, Elena and Raymond, Eric and Reisch, Nicole and Roncador, Giovanna and Ruiz-Ferrer, Macarena and Schillo, Frank and Stegmann, Sander and Suarez, Carlos and Taschin, Elisa and Timmers, H.J.L.M and Tops, Carli and Urioste, Miguel and Beuschlein, Felix and Pacak, Karel and Mannelli, Massimo and Dahia, Patricia and Opocher, Giuseppe and Eisenhofer, Graeme and Gimenez-Roqueplo, A.P and Robledo, Mercedes
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 10, pp. 2828 - 2837
textabstractPurpose: Pheochromocytomas (PCC) and paragangliomas (PGL) are genetically heterogeneous neural crest-derived neoplasms. Recently we identified... 
GENE-MUTATIONS | SUCCINATE-DEHYDROGENASE | GERM-LINE MUTATIONS | ONCOLOGY | DNA | LINDAU DISEASE | SUSCEPTIBILITY | SDHB | FAMILIAL PHEOCHROMOCYTOMA | Genetic Predisposition to Disease | Paraganglioma - genetics | Humans | Middle Aged | Child, Preschool | Male | Young Adult | Adolescent | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Aged, 80 and over | Germ-Line Mutation | Adult | Female | Pheochromocytoma - genetics | Aged | Adrenal Gland Neoplasms - genetics | Child | Pheochromocytoma | Paraganglioma | Life Sciences | Human health and pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Adrenal Gland Neoplasms
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3. Full Text Comprehensive Mutation Analysis of PMS2 in a Large Cohort of Probands Suspected of Lynch Syndrome or Constitutional Mismatch Repair Deficiency Syndrome
by van der Klift, Heleen M and Mensenkamp, Arjen R and st, Mark and Bik, Elsa C and Vos, Yvonne J and Gille, Hans J. J. P and Redeker, Bert E. J. W and Tiersma, Yvonne and Zonneveld, José B. M and García, Encarna Gómez and Letteboer, Tom G. W and Olderode-Berends, Maran J. W and van Hest, Liselotte P and van Os, Theo A and Verhoef, Senno and Wagner, Anja and van Asperen, Christi J and ten Broeke, Sanne W and Hes, Frederik J and de Wind, Niels and Nielsen, Maartje and Devilee, Peter and Ligtenberg, Marjolijn J. L and Wijnen, Juul T and Tops, Carli M. J
Human mutation, ISSN 1059-7794, 2016, Volume 37, Issue 11, pp. 1162 - 1179
Monoallelic PMS2 germline mutations cause 5%-15% of Lynch syndrome, a midlife cancer predisposition, whereas biallelic PMS2 mutations cause approximately 60%... 
CMMRD | PMS2 | pseudogenes | mismatch repair | immunohistochemistry | MLH1 | missense variants | Lynch syndrome | PROMOTER HYPERMETHYLATION | CFR PARTICIPANTS | EUROPEAN CONSORTIUM CARE | PSEUDOGENE INTERFERENCE | NONPOLYPOSIS COLON-CANCER | GENE | COLORECTAL-CANCER | GENETICS & HEREDITY | 3' DELETIONS | SYNDROME FAMILIES | Genetic Predisposition to Disease | Microsatellite Instability | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Brain Neoplasms - genetics | Neoplastic Syndromes, Hereditary - metabolism | DNA Mutational Analysis - methods | Brain Neoplasms - metabolism | Genetic Variation | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | Netherlands | Mismatch Repair Endonuclease PMS2 - metabolism | Germ-Line Mutation | Neoplastic Syndromes, Hereditary - genetics | Mismatch Repair Endonuclease PMS2 - genetics | Colorectal Neoplasms - metabolism | Cohort Studies | Immunohistochemistry | Genetic research | Genetic aspects | RNA | Gene mutations | Analysis | Yeast | Genetic disorders | Mutation | Genetic recombination | Cancer
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4. Full Text Cancer Risks for PMS2-Associated Lynch Syndrome
by Broeke, S.W. ten and Klift, H.M. van der and Tops, Carli M.J and Aretz, Stefan and Bernstein, I and Buchanan, Daniel D and Hoogerbrugge, N and Mensenkamp, A.R and Spruijt, L and Nielsen, M and Win, Aung Ko
Journal of Clinical Oncology, ISSN 0732-183X, 2018, Volume 36, Issue 29, pp. 2961 - 2968
PurposeLynch syndrome due to pathogenic variants in the DNA mismatch repair genes MLH1, MSH2, and MSH6 is predominantly associated with colorectal and... 
VARIANTS | ONCOLOGY | NONPOLYPOSIS COLORECTAL-CANCER | GENES | HEREDITARY BREAST | MUTATIONS | PREVALENCE | FAMILY-HISTORY | MLH1 | CARRIERS | ENDOMETRIAL CANCER | ORIGINAL REPORTS
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5. Full Text Recurrence and variability of germline EPCAM deletions in Lynch syndrome
by Kuiper, Roland P and Vissers, Lisenka E. L. M and Venkatachalam, Ramprasath and Bodmer, Danielle and Hoenselaar, Eveline and Goossens, Monique and Haufe, Aline and Kamping, Eveline and Niessen, Renée C and Hogervorst, Frans B. L and Gille, Johan J. P and Redeker, Bert and Tops, Carli M. J and van Gijn, Marielle E and van den Ouweland, Ans M. W and Rahner, Nils and Steinke, Verena and Kahl, Philip and Holinski-Feder, Elke and Morak, Monika and Kloor, Matthias and Stemmler, Susanne and Betz, Beate and Hutter, Pierre and Bunyan, David J and Syngal, Sapna and Culver, Julie O and Graham, Tracy and Chan, Tsun L and Nagtegaal, Iris D and van Krieken, J. Han J. M and Schackert, Hans K and Hoogerbrugge, Nicoline and van Kessel, Ad Geurts and Ligtenberg, Marjolijn J. L
Human mutation, ISSN 1059-7794, 2011, Volume 32, Issue 4, pp. 407 - 414
Recently, we identified 3' end deletions in the EPCAM gene as a novel cause of Lynch syndrome. These truncating EPCAM deletions cause allele-specific... 
TACSTD1 | NAHR | Alu‐mediated recombination | EPCAM | Lynch syndrome | Alu-mediated recombination | MOLECULAR CHARACTERIZATION | METHYLATION | HYPERMETHYLATION | NONPOLYPOSIS COLORECTAL-CANCER | GENOMIC DELETIONS | MLH1 | MSH2 | FREQUENT CAUSE | GENETICS & HEREDITY | MISMATCH-REPAIR GENES | EPIMUTATION | Antigens, Neoplasm - genetics | Promoter Regions, Genetic | Recurrence | Cell Adhesion Molecules - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Molecular Sequence Data | MutS Homolog 2 Protein - genetics | Germ-Line Mutation - genetics | MutS Homolog 2 Protein - metabolism | Cell Adhesion Molecules - metabolism | Epithelial Cell Adhesion Molecule | Genetic Variation | DNA Methylation | Netherlands | Base Sequence | Antigens, Neoplasm - metabolism | Models, Genetic | Sequence Deletion - genetics
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6. Full Text Cancer Risks for PMS2-associated lynch syndrom
by Broeke, Sanne W. Ten and Klift, Heleen M. Vander and Tops, Carli M. J and Aretz, Stefan and Bernstein, Inge and Buchanan, Daniel D and Chapelle, Albert Dela and Capella, Gabriel and Clendenning, Mark and Engel, Christoph and Gallinger, Steven and Garcia, Encarna Gomez and Figueiredo, Jane C and Haile, Robert and Hampel, Heather L and Hopper, John L and Hoogerbrugge, Nicoline and Doeberitz, Magnus Von Knebel and Marchand, Loic Le and Letteboer, Tom G. W and Jenkins, Mark A and Lindblom, Annika and Lindor, Noralane M and Mensenkamp, Arjen R and Møller, Pal and Newcomb, Polly A and van Os, Theo A. M and Pearlman, Rachel and Pineda, Marta and Rahner, Nils and Redeker, Egbert J. W and Olderode-Berends, Maran J. W and Rosty, Christophe and Schackert, Hans K and Scott, Rodney and Senter, Leigha and Spruijt, Liesbeth and Steinke-Lange, Verena and Suerink, Manon and Thibodeau, Stephen and Vos, Yvonne J and Wagner, Anja and Winship, Ingrid and Hes, J. Frederik and Vasen, Hans F. A and Wijnen, Juul T and Nielsen, Maartje and Win, Aung Ko
Journal of clinical oncology, ISSN 0732-183X, 2018, Volume 36, Issue 29, pp. 2961 - 2968
Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes MLH1, MSH2, and MSH6 is predominantly associated with colorectal and endometrial... 
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7. Full Text CDC73-Related Disorders: Clinical Manifestations and Case Detection in Primary Hyperparathyroidism
by van der Tuin, Karin and Tops, Carli M. J and Adank, Muriel A and Cobben, Jan-Maarten and Hamdy, Neveen A. T and Jongmans, Marjolijn C and Menko, Fred H and van Nesselrooij, Bernadette P. M and Netea-Maier, Romana T and Oosterwijk, Jan C and Valk, Gerlof D and Wolffenbuttel, Bruce H. R and Hes, Frederik J and Morreau, Hans
Journal of clinical endocrinology and metabolism, ISSN 0021-972X, 2017, Volume 102, Issue 12, pp. 4534 - 4540
Context: Heterozygous pathogenic germline variants in CDC73 predispose to the development of primary hyperparathyroidism (pHPT) and, less frequently, ossifying... 
PARATHYROID CARCINOMA | HRPT2 GENE | GERMLINE | MANAGEMENT | FAMILIAL ISOLATED HYPERPARATHYROIDISM | JAW TUMOR SYNDROME | ENDOCRINOLOGY & METABOLISM | PARAFIBROMIN | MUTATIONS | GENETIC ANALYSES | CANCER | Parathyroid Neoplasms - pathology | Humans | Middle Aged | Male | Hyperparathyroidism, Primary - genetics | Jaw Neoplasms - pathology | Young Adult | Hyperparathyroidism, Primary - physiopathology | Netherlands | Tumor Suppressor Proteins - genetics | Hyperparathyroidism, Primary - pathology | Aged, 80 and over | Germ-Line Mutation | Adult | Female | Retrospective Studies | Child | Penetrance | Mutation - genetics | Parathyroid Neoplasms - genetics | Adolescent | Heterozygote | Aged | Jaw Neoplasms - genetics | Cohort Studies | Jaw | Disorders | Histology | Adenoma | Patients | Genetic screening | Carriers | Confidence intervals | Genetic counseling | Uterus | Genetics | Mutation | Parathyroid | Hyperparathyroidism | Tumors
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8. Full Text Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma: A Nationwide Study
by Tuin, Karin van der and Mensenkamp, A.R and Tops, Carli M.J and Corssmit, Eleonora P.M and Dinjens, Winand N and Horst-Schrivers, Anouk N. van de and Kunst, H.P.M and Kusters, B and Spruijt, L and Hes, Frederik J and Timmers, H.J.L.M
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 2018, Volume 103, Issue 2, pp. 438 - 445
Context: Paraganglioma (PGL) has the highest degree of heritability among human neoplasms. Current clinical understanding of germline SDHA mutation carriers is... 
HEAD | MUTATIONS | SOCIETY | GENES | ENDOCRINOLOGY & METABOLISM | Humans | Middle Aged | Netherlands - epidemiology | Male | Young Adult | Adrenal Gland Neoplasms - epidemiology | DNA Mutational Analysis | Aged, 80 and over | Germ-Line Mutation | Pheochromocytoma - pathology | Adult | Female | Paraganglioma - epidemiology | Retrospective Studies | Child | Adrenal Gland Neoplasms - pathology | Pheochromocytoma - epidemiology | Genetic Predisposition to Disease | Paraganglioma - pathology | Electron Transport Complex II - genetics | Paraganglioma - genetics | Penetrance | Adolescent | Pheochromocytoma - genetics | Aged | Adrenal Gland Neoplasms - genetics | Head | Pheochromocytoma | Genes | Paraganglioma | Patients | Genetic screening | Neoplasms | Confidence intervals | Clinical aspects | Genetic counseling | Head and neck | Hormone replacement therapy | Heritability | Mutation | Age
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9. Full Text Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians
by Hendriks, Yvonne M.C and de Jong, Andrea E and Morreau, Hans and Tops, Carli M.J and Vasen, Hans F and Wijnen, Juul Th and Breuning, Martijn H and Brocker-Vriends, Annette H.J.T
CA: A Cancer Journal for Clinicians, ISSN 0007-9235, 07/2006, Volume 56, Issue 4, pp. 213 - 225
The patient with a family history for colorectal carcinoma constitutes a complicated diagnostic challenge involving many clinicians. The diagnostic workup of... 
COLON-CANCER | SOMATIC G-C->T-A MUTATIONS | ONCOLOGY | MICROSATELLITE INSTABILITY | MISMATCH REPAIR GENES | MSH6 GERMLINE MUTATIONS | REPLICATION ERRORS | JUVENILE POLYPOSIS SYNDROME | FAMILY-HISTORY | ADENOMATOUS POLYPOSIS | MOLECULAR ANALYSIS | Medical History Taking | Genetic Predisposition to Disease - genetics | Phenotype | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Pedigree | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Humans | Mutation | Genes, Recessive | Genetic Counseling | Care and treatment | Diagnosis | Gene mutations | Analysis | Colorectal cancer | Heredity | Disease management | Medical diagnosis
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10. The phenotype of SDHB germline mutation carriers: A nationwide study
by Niemeijer, Nicolasine D and Rijken, Johannes A and Eijkelenkamp, Karin and Van Der Horst-Schrivers, Anouk N A and Kerstens, Michiel N and Tops, Carli M J and Van Berkel, Anouk and Timmers, Henri J.L.M and Kunst, Henricus P M and Leemans, C René and Bisschop, Peter H and Dreijerink, Koen M.A and Van Dooren, Marieke F and Bayley, Jean-Pierre and Pereira, Alberto M and Jansen, Jeroen C and Hes, Frederik J and Hensen, Erik F and Corssmit, Eleonora P.M
European Journal of Endocrinology, ISSN 0804-4643, 08/2017, Volume 177, Issue 2, pp. 115 - 125
Objective: Succinate dehydrogenase B subunit (SDHB) gene germline mutations predispose to pheochromocytomas, sympathetic paragangliomas, head and neck... 
PARAGANGLIOMA | CLINICAL-MANIFESTATIONS | PHEOCHROMOCYTOMA | NETHERLANDS | GENETICS | ENDOCRINOLOGY & METABOLISM | Follow-Up Studies | Humans | Middle Aged | Netherlands - epidemiology | Male | Paraganglioma - diagnosis | Germ-Line Mutation - genetics | Adrenal Gland Neoplasms - diagnosis | Young Adult | Adrenal Gland Neoplasms - epidemiology | Head and Neck Neoplasms - epidemiology | Adult | Female | Paraganglioma - epidemiology | Retrospective Studies | Child | Pheochromocytoma - epidemiology | Paraganglioma - genetics | Pheochromocytoma - diagnosis | Phenotype | Succinate Dehydrogenase - genetics | Adolescent | Head and Neck Neoplasms - diagnosis | Head and Neck Neoplasms - genetics | Heterozygote | Pheochromocytoma - genetics | Aged | Adrenal Gland Neoplasms - genetics | Cohort Studies
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11. Full Text Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients
by Jansen, A.M.L and Geilenkirchen, M.A and Wezel, Tom and Jagmohan-Changur, Shantie and Ruano, Dina and Klift, Heleen and Van Den Akker, B.E.W.M and Laros, Jeroen F and Van Galen, Michiel and Wagner, Anja and Letteboer, Tom and Gómez García, Encarna and Tops, Carli and Vasen, Hans and Devilee, Peter and Hes, Frederik and Morreau, Hans and Wijnen, Juul
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157381
textabstractBackground and Aims Lynch Syndrome (LS) is caused by pathogenic germline variants in one of the mismatch repair (MMR) genes. However, up to 60% of... 
MISMATCH-REPAIR DEFICIENCY | SOMATIC METHYLATION | GERMLINE MUTATION | NONPOLYPOSIS COLORECTAL-CANCER | MLH1 PROMOTER METHYLATION | MICROSATELLITE INSTABILITY | MUTATION CARRIERS | FREQUENT CAUSE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | REVISED BETHESDA GUIDELINES | Leukocytes - pathology | Colon - pathology | Rectum - pathology | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Rectum - metabolism | Gene Expression Regulation, Neoplastic | Colon - metabolism | DNA Methylation | DNA Mismatch Repair | MutL Protein Homolog 1 - genetics | Germ-Line Mutation | Colorectal Neoplasms - pathology | Leukocytes - metabolism | Cohort Studies | Nucleotide sequence | MLH1 protein | Physicians | Genes | Genomics | Colorectal carcinoma | Colorectal cancer | Regulatory sequences | Family medical history | Gene expression | Patients | Gene sequencing | White blood cells | Pathology | Fertility | Mismatch repair | Gastroenterology | Genetics | Mutation | Deoxyribonucleic acid--DNA | Tumors | Deoxyribonucleic acid | DNA
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12. Full Text Deep sequencing to reveal new variants in pooled DNA samples
by Out, Astrid A and van Minderhout, Ivonne J.H.M and Goeman, Jelle J and Ariyurek, Yavuz and Ossowski, Stephan and Schneeberger, Korbinian and Weigel, Detlef and van Galen, Michiel and Taschner, Peter E.M and Tops, Carli M.J and Breuning, Martijn H and van Ommen, Gert‐Jan B and den Dunnen, Johan T and Devilee, Peter and Hes, Frederik J
Human Mutation, ISSN 1059-7794, 12/2009, Volume 30, Issue 12, pp. 1703 - 1712
We evaluated massive parallel sequencing and long‐range PCR (LRP) for rare variant detection and allele frequency estimation in pooled DNA samples. Exons 2 to... 
pooling | Illumina sequencing | PCR | association study | MUTYH | Association study | Pooling | 8Q24 | COVERAGE | SUSCEPTIBILITY | CANCER | HAPLOTYPE RECONSTRUCTION | HUMAN GENOME | ALIGNMENT | GENETICS & HEREDITY | COHORT | MUTATION NOMENCLATURE | MUTYH-ASSOCIATED POLYPOSIS | DNA - genetics | Gene Frequency - genetics | Humans | Alleles | Polymerase Chain Reaction | Genetic Variation - genetics | Nucleic Acid Denaturation - genetics | Sequence Analysis, DNA - methods | Genome, Human - genetics
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13. Full Text Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
by van Roon, Eddy H. J and van Puijenbroek, Marjo and Middeldorp, Anneke and van Eijk, Ronald and de Meijer, Emile J and Erasmus, Dianha and Wouters, Kim A. D and van Engeland, Manon and Oosting, Jan and Hes, Frederik J and Tops, Carli M. J and van Wezel, Tom and Boer, Judith M and Morreau, Hans
BMC Cancer, ISSN 1471-2407, 05/2010, Volume 10, Issue 1, pp. 180 - 180
Background: To investigate the etiology of MLH1 promoter methylation in mismatch repair (MMR) mutation-negative early onset MSI-H colon cancer. As this type of... 
LYNCH-SYNDROME | HYPERMETHYLATION | DNA METHYLATION | ONCOLOGY | NONPOLYPOSIS COLORECTAL-CANCER | SERRATED POLYPS | MICROSATELLITE INSTABILITY | CARCINOMAS | GERMLINE EPIMUTATIONS | MUTATIONS | CELL-LINES | MutL Protein Homolog 1 | ras Proteins - genetics | Colonic Neoplasms - genetics | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) | Age Factors | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Loss of Heterozygosity | Case-Control Studies | DNA Methylation | DNA Mutational Analysis | DNA Mismatch Repair | Aged, 80 and over | Cell Cycle Proteins - genetics | Adult | Nuclear Proteins - genetics | Promoter Regions, Genetic | Genetic Predisposition to Disease | Risk Factors | Proto-Oncogene Proteins - genetics | Chi-Square Distribution | Polymorphism, Genetic | Proto-Oncogene Proteins B-raf - genetics | Adaptor Proteins, Signal Transducing - genetics | CpG Islands | Aged | Polymorphism, Single Nucleotide | Mutation | Gene mutations | Colorectal cancer | Development and progression | Genetic aspects | Research | Methylation | Observations | Identification and classification | Causes and theories of causation | Genetic polymorphisms | Cancer | Diseases
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