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index medicus (14) 14
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inhibitor of apoptosis proteins - genetics (2) 2
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interferon-gamma - immunology (2) 2
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Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2015, Volume 45, Issue 9, pp. 2672 - 2682
Cellular inhibitor of apoptosis proteins (c‐IAP) 1 and 2 are widely expressed ubiquitin protein ligases that regulate a variety of cellular functions,... 
CD8+ memory T cell | Signal transduction | Ubiquitination | lymphocytic choriomeningitis virus | T‐cell memory | 4‐1BB | CD8 + memory T cell | 4-1BB | Lymphocytic choriomeningitis virus | T-cell memory | APOPTOSIS | CD8(+) memory T cell | KAPPA-B ACTIVATION | FAMILY-MEMBERS | TNFR FAMILY | IMMUNOLOGY | EFFECTOR | RESPONSES | IMMUNE-SYSTEM | COSTIMULATION | INHIBITORS | EXPRESSION | Lymphocytic choriomeningitis virus - immunology | CD8-Positive T-Lymphocytes - pathology | CD8-Positive T-Lymphocytes - transplantation | Inhibitor of Apoptosis Proteins - genetics | NF-kappa B - immunology | Cell Survival - genetics | Apoptosis - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Adoptive Transfer | Lymphocytic Choriomeningitis - immunology | Ubiquitin-Protein Ligases - immunology | Female | Inhibitor of Apoptosis Proteins - metabolism | Immunologic Memory - genetics | Lymphocytic Choriomeningitis - genetics | Lymphocytic Choriomeningitis - virology | Signal Transduction | Lymphocytic Choriomeningitis - pathology | Antibodies, Monoclonal - pharmacology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Cells, Cultured | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Mice, Transgenic | Cell Survival - immunology | Animals | Apoptosis - immunology | NF-kappa B - genetics | CD8-Positive T-Lymphocytes - virology | Lymphocyte Activation - drug effects | Tumor Necrosis Factor Receptor Superfamily, Member 9 - antagonists & inhibitors | Lymphocyte Count | Inhibitor of Apoptosis Proteins - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Cellular signal transduction | Memory (Computers) | T cells | Ligases | Lymphocytes | Rodents | T cell receptors | LCMV | signal transduction | ubiquitination
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 6, p. e11052
Background: HIV-1 Protease Inhibitors, namely PIs, originally designed to inhibit HIV-1 aspartic protease, can modulate the immune response by mechanisms... 
NK CELLS | MACROPHAGES | BIOLOGY | ATHEROSCLEROTIC LESION FORMATION | HIV-1 PROTEASE | ANTIRETROVIRAL THERAPY | INFECTION | DIFFERENTIATION | DYSLIPIDEMIA | ANTIFUNGAL | T-CELLS | HIV Protease Inhibitors - pharmacology | Cell Proliferation | Flow Cytometry | HIV Protease - drug effects | Enzyme-Linked Immunosorbent Assay | Dendritic Cells - immunology | Humans | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | Immunophenotyping | Killer Cells, Natural - drug effects | Autoimmunity | Killer cells | Protease inhibitors | Dendritic cells | Proteases | Analysis | Inflammation | Ritonavir | Cytotoxicity | Saquinavir | Acquired immune deficiency syndrome--AIDS | Protease | Human immunodeficiency virus--HIV | Nelfinavir | Natural killer cells | Immunomodulators | Antigens | Lymphatic system | Cytokines | Immunomodulation | Interleukin 12 | T cell receptors | Proteinase inhibitors | Interleukin 15 | Pathology | Hypoxia | Rehabilitation | Aberration | Drugs | CD86 antigen | Laboratories | Toxicity | Inflammatory response | Viruses | Infections | Metabolic syndrome | Immunosuppressive agents | Immunology | Lymphocytes | Aspartic endopeptidase | Atherosclerosis | Bacteria | Tumor necrosis factor-TNF | Drug therapy | Indinavir | Immune system | Killing | Immune response | CD36 antigen | Monocytes | Molecular biology | Amprenavir | Cancer | Acquired immune deficiency syndrome | AIDS | Human immunodeficiency virus | HIV
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 9, pp. 2174 - 2179
ZAP-70 is a tyrosine kinase that is essential for initiation of T cell antigen receptor (TCR) signaling. We have found that T cell p38 MAP kinase (MAPK), which... 
Signal transduction | MAP kinase | Immune synapse | T cell antigen receptor | Biological Sciences | signal transduction | immune synapse
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 12, pp. 3280 - 3289
Stimulation via the T-cell receptor (TCR) activates p38 alpha and p38 beta by phosphorylation of p38 Tyr-323 (p38(Y323)). Here we characterize knockin mice in... 
GAMMA | ENCEPHALOMYELITIS | PHOSPHORYLATION | PROTEIN-KINASE | ALPHA | GENE-TARGETED MICE | MAPK INHIBITOR | P38-ALPHA | ARTHRITIS | TH1 | HEMATOLOGY | Autoimmunity | Inflammation - pathology | Arthritis, Experimental - genetics | Phosphorylation | Cell Proliferation | Encephalomyelitis, Autoimmune, Experimental - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Enzyme Activation - immunology | Arthritis, Experimental - metabolism | Arthritis, Experimental - pathology | Signal Transduction - immunology | Cell Cycle Proteins - immunology | Inflammation - metabolism | T-Lymphocytes - metabolism | Nuclear Proteins - deficiency | Cell Cycle Proteins - genetics | Female | Phenylalanine - immunology | Receptors, Antigen, T-Cell - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Nuclear Proteins - genetics | Encephalomyelitis, Autoimmune, Experimental - pathology | Phenylalanine - metabolism | Enzyme-Linked Immunosorbent Assay | Receptors, Antigen, T-Cell - metabolism | Lymphocyte Activation | p38 Mitogen-Activated Protein Kinases - genetics | Cell Cycle Proteins - deficiency | Mice, Transgenic | Arthritis, Experimental - immunology | Inflammation - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Nuclear Proteins - immunology | Tyrosine - immunology | Blotting, Western | Gene Knock-In Techniques | Tyrosine - metabolism | Animals | Inflammation - genetics | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Immunobiology
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0188916
Flow cytometry is the primary immunological technique used to analyze multiple parameters on complex cell populations. We present a staining method that... 
ACTIVATION | DIFFERENTIAL EXPRESSION | MULTIDISCIPLINARY SCIENCES | CD8(+) T-CELLS | HELPER-CELLS | Physiological aspects | Flow cytometry | Usage | Research | Biological markers | Lymphocytes
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 10, pp. 2121 - 2130
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2018, Volume 115, Issue 40, p. 9821
Torchia and Ashwell express commentary on the study by Li et al identify a molecular mechanism for the regulation of c-MYC expression and function and describe... 
Transcription factors | Reagents | c-Myc protein | Genomes | Myc protein | Gene expression | Molecular biology | Deoxyribonucleic acid--DNA
Journal Article
Journal of visualized experiments : JoVE, ISSN 1940-087X, 03/2019, Issue 145
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 9, p. 2174
ZAP-70 is a tyrosine kinase that is essential for initiation of T cell antigen receptor (TCR) signaling. We have found that T cell p38 MAP kinase (MAPK), which... 
Tyrosine | Phosphorylation | Alanine | MAP kinase | T cell receptors | Lymphocytes T | Feedback loops | ZAP-70 protein | Kinases | T-cell receptor | Signaling | Negative feedback | Lymphocytes | Protein-tyrosine kinase | Destabilization
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 12/2013, Volume 191, Issue 12
Optineurin is a widely-expressed polyubiquitin (polyUb)-binding protein that has been implicated in regulating cell signaling via its NEMO-homologous... 
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2015, Volume 45, Issue 9, pp. 2672 - 2682
Cellular inhibitor of apoptosis proteins (c-IAP) 1 and 2 are widely expressed ubiquitin protein ligases that regulate a variety of cellular functions,... 
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2015, Volume 45, Issue 9, pp. 2672 - 2682
Journal Article