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1. Full Text Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
by Rivas, Manuel A and Beaudoin, Mélissa and Gardet, Agnes and Stevens, Christine and Sharma, Yashoda and Zhang, Clarence K and Boucher, Gabrielle and Ripke, Stephan and Ellinghaus, David and Burtt, Noel and Fennell, Tim and Kirby, Anew and Latiano, Anna and Goyette, Philippe and Green, Todd and Halfvarson, Jonas and Haritunians, Talin and Korn, Joshua M and Kuruvilla, Finny and Lagacé, Caroline and Neale, Benjamin and Lo, Ken Sin and Schumm, Phil and Törkvist, Leif and Dubinsky, Marla C and Brant, Steven R and Silverberg, Mark S and Duerr, Richard H and Altshuler, David and Gabriel, Stacey and Lettre, Guillaume and Franke, Ane and D'Amato, Mauro and McGovern, Dermot P. B and Cho, Judy H and Rioux, John D and Xavier, Ramnik J and Daly, Mark J and Parkes, Miles and Lee, James and Zhang, Hu and Bredin, Francesca and Ahmad, Tariq and Satsangi, Jack and Nimmo, Elaine and mmond, Hazel and Lees, Charlie and Mansfield, John and Mathew, Christopher G and Prescott, Natalie and Harrison, Kristina and Sanderson, Jeremy and Newman, William and Phillips, Anne and Mowat, Craig and Edwards, Cathryn and Wilson, David C and Barrett, Jeffrey and Anderson, Carl and Gray, Emma and Edkins, Sarah and Russell, Richard K and Henderson, Paul and Anderson, Carl A and Annese, Vito and Baldassano, Robert N and Balschun, Tobias and Barclay, Murray and Barrett, Jeffrey C and Bayless, Theodore M and Bis, Joshua C and Brand, Stephan and Bumpstead, Suzanne and Buning, Carsten and Cohen, Albert and Colombel, Jean-Frederick and Cottone, Mario and D'Inca, Renata and Denson, Ted and Dubinsky, Marla and Florin, Tim and Franchimont, Denis and Gearry, Richard and Georges, Michel and Glas, Jurgen and van Gossum, Ane and Griffiths, Anne M and Guthery, Stephen L and Hakonarson, Hakon and Hugot, Jean-Pierre and de Jong, Dirk J and Jostins, Luke and Kugathasan, Subra and Kullack-Ublick, Gerd and Laukens, Debby and Lawrance, Ian and Lees, Charlie W and Lemann, Marc and Levine, Arie and Libioulle, Cecile and ... and United Kingdom Inflammatory Bowel and Natl Inst Diabet Digestive Kidney and Int Inflammatory Bowel Dis and United Kingdom Inflammatory Bowel Disease Genetics Consortium and National Institute of Diabetes and Digestive Kidney Diseases Inflammatory Bowel Disease Genetics Consortium (NIDDK IBDGC) and International Inflammatory Bowel Disease Genetics Consortium and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2011, Volume 43, Issue 11, pp. 1066 - 1073
More than 1,000 susceptibility loci have been identified through genome-wide association studies (GWAS) of common variants; however, the specific genes and... 
RECRUITMENT | RISK LOCI | CROHNS-DISEASE | GENE | FREQUENCY | GENETICS & HEREDITY | MURAMYL DIPEPTIDE RECOGNITION | SUSCEPTIBILITY LOCI | CARD15 MUTATIONS | NOD2 | GENOME-WIDE ASSOCIATION | Cell Line | Genetic Predisposition to Disease | Genome-Wide Association Study | RNA Splicing | Humans | Inflammatory Bowel Diseases - genetics | Nod2 Signaling Adaptor Protein - genetics | Receptors, Interleukin - genetics | Sequence Analysis, DNA | Case-Control Studies | Inflammatory bowel disease | Studies | Design | Medical research | Genealogy | Genes | Genetics | Data processing | Genomes | Grants | Diabetes | Twins | Index Medicus | Medicin | Medicine | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text Association of TNFSF15 polymorphism with irritable bowel syndrome
by Zucchelli, Marco and Camilleri, Michael and Nixon Andreasson, Anna and Bresso, Francesca and Dlugosz, Aldona and Halfvarson, Jonas and Törkvist, Leif and Schmidt, Peter T and Karling, Pontus and Ohlsson, Bodil and Duerr, Richard H and Simren, Magnus and Lindberg, Greger and Agreus, Lars and Carlson, Paula and Zinsmeister, Alan R and D'Amato, Mauro and Örebro universitet and Institutionen för hälsovetenskap och medicin
Gut, ISSN 0017-5749, 12/2011, Volume 60, Issue 12, pp. 1671 - 1677
BackgroundIrritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting more than 10% of the general population worldwide. Although a... 
POPULATION | CROHNS-DISEASE | NEUROPEPTIDE S RECEPTOR | INFLAMMATION | MAST-CELLS | SUSCEPTIBILITY LOCI | IMMUNE ACTIVATION | CELL-FUNCTION | SYMPTOMS | GASTROENTEROLOGY & HEPATOLOGY | FUNCTIONAL GASTROINTESTINAL DISORDERS | Constipation - genetics | Crohn Disease - genetics | Genetic Predisposition to Disease - genetics | Genetic Association Studies | Humans | Middle Aged | Genotype | Male | Irritable Bowel Syndrome - genetics | Alleles | Polymorphism, Single Nucleotide - genetics | Adult | Female | Tumor Necrosis Factor Ligand Superfamily Member 15 - genetics | Causes of | Genetic aspects | Research | Genetic susceptibility | Irritable bowel syndrome | Motility | Pathogenesis | Medical records | Neuropeptides | Inflammation | Gene expression | Crohns disease | Studies | Inflammatory bowel disease | Genotype & phenotype | Hypotheses | Immunology | Rodents | Bacteria | Constipation | Index Medicus | Abridged Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Gastroenterology and Hepatology | Gastroenterologi
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3. Full Text Genome-wide association identifies multiple ulcerative colitis susceptibility loci
by McGovern, Dermot P. B and Gardet, Agnès and Törkvist, Leif and Goyette, Philippe and Essers, Jonah and Taylor, Kent D and Neale, Benjamin M and Ong, Rick T. H and Lagacé, Caroline and Li, Chun and Green, Todd and Stevens, Christine R and Beauchamp, Claudine and Fleshner, Phillip R and Carlson, Marie and D'Amato, Mauro and Halfvarson, Jonas and Hibberd, Martin L and Lördal, Mikael and Padyukov, Leonid and Aniulli, Angelo and Colombo, Elisabetta and Latiano, Anna and Palmieri, Orazio and Bernard, Edmond-Jean and Deslanes, Colette and Hommes, Daan W and de Jong, Dirk J and Stokkers, Pieter C and Weersma, Rinse K and Sharma, Yashoda and Silverberg, Mark S and Cho, Judy H and Wu, Jing and Roeder, Kathryn and Brant, Steven R and Schumm, L. Phillip and Duerr, Richard H and Dubinsky, Marla C and Glazer, Nicole L and Haritunians, Talin and Ippoliti, Andy and Melmed, Gil Y and Siscovick, David S and Vasiliauskas, Eric A and Targan, Stephan R and Annese, Vito and Wijmenga, Cisca and Pettersson, Sven and Rotter, Jerome I and Xavier, Ramnik J and Daly, Mark J and Rioux, John D and Seielstad, Mark and NIDDK IBD Genetics Consortium and The NIDDK IBD Genetics Consortium and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2010, Volume 42, Issue 4, pp. 332 - 337
Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort... 
POPULATION | IMMUNITY | CONTRIBUTE | INFLAMMATORY-BOWEL-DISEASE | RETICULUM STRESS-RESPONSE | CROHNS-DISEASE | GENETICS & HEREDITY | RISK | GENETIC-VARIANTS | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Receptors, IgG - genetics | Membrane Proteins - genetics | Humans | Colitis, Ulcerative - genetics | Polymorphism, Single Nucleotide | Quantitative trait loci | Development and progression | Disease susceptibility | Genetic aspects | Research | Identification and classification | Ulcerative colitis | Inflammatory bowel disease | Studies | Gene loci | Thermal cycling | Meta-analysis | Index Medicus | Medicine | Medicin | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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4. Full Text Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men
by Schoultz, Ida and Verma, Deepti and Halfvarsson, Jonas and Törkvist, Leif and Fredrikson, Mats and Sjöqvist, Urban and Lördal, Mikael and Tysk, Curt and Lerm, Maria and Söderkvist, Peter and Söderholm, Johan D and Medicinsk mikrobiologi and Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Kirurgi and Östergötlands Läns Landsting and Hälsouniversitetet and Cellbiologi and Yrkes- och miljömedicin and Kirurgi- och onkologicentrum
The American Journal of Gastroenterology, ISSN 0002-9270, 05/2009, Volume 104, Issue 5, pp. 1180 - 1188
OBJECTIVES : Crohn's disease (CD) is characterized by overproduction of proinflammatory cytokines like interleukin (IL)-1 beta. Production of mature IL-1 beta... 
ARTICULAR SYNDROME | NO ASSOCIATION | ACTIVATION | PROTEIN | INTERLEUKIN-1-BETA | MUTATION | TUCAN | BACTERIAL MURAMYL DIPEPTIDE | MUCKLE-WELLS-SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | Crohn Disease - epidemiology | Crohn Disease - genetics | Multivariate Analysis | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Immunity, Innate - genetics | Male | Reference Values | Neoplasm Proteins - metabolism | Case-Control Studies | CARD Signaling Adaptor Proteins - genetics | Incidence | Genetic Variation | CARD Signaling Adaptor Proteins - metabolism | Aged, 80 and over | Adult | Female | Genetic Predisposition to Disease - epidemiology | Neoplasm Proteins - genetics | Child | Genotype | Logistic Models | Sweden - epidemiology | Crohn Disease - immunology | Carrier Proteins - genetics | Carrier Proteins - metabolism | Analysis of Variance | Adolescent | Alleles | Sex Factors | Aged | Polymorphism, Single Nucleotide | Cohort Studies | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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5. Full Text Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
by Beaudoin, M and Goyette, P and Boucher, G and Lo, K.S and Rivas, M.A and Stevens, C and Alikashani, A and Ladouceur, M and Ellinghaus, D and Torkvist, L and Goel, G and Lagace, C and Annese, V and Bitton, A and Begun, J and Brant, S.R and Bresso, F and Cho, J.H and Duerr, R.H and Halfvarson, J and McGovern, D.P and Radford-Smith, G and Schreiber, S and Schumm, P.L and Sharma, Y and Silverberg, M.S and Weersma, R.K and Quebec, I.B.D.G.C and Consortium, N.I.G and D'Amato, M and Vermeire, S and Franke, A and Lettre, G and Xavier, R.J and Daly, M.J and Rioux, J.D and Jong, D.J. de and Quebec IBD Genetics Consortium and NIDDK IBD Genetics Consortium and Int IBD Genetics Consortium and International IBD Genetics Consortium and Region Örebro län and Örebro universitet and Institutionen för hälsovetenskap och medicin
PLOS Genetics, ISSN 1553-7390, 2013, Volume 9, Issue 9, pp. e1003723 - e1003723
Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated... 
INFLAMMATORY-BOWEL-DISEASE | CROHNS-DISEASE | LIVER | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENETIC-VARIANTS | NUCLEAR FACTOR 4-ALPHA | UBIQUITIN LIGASES | EXPRESSION | INTESTINAL EPITHELIAL-CELLS | GENOME-WIDE ASSOCIATION | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Colitis, Ulcerative - genetics | Colitis, Ulcerative - pathology | Receptors, Interleukin - genetics | CARD Signaling Adaptor Proteins - genetics | Canada | Ethnic Groups | Crohn Disease - pathology | High-Throughput Nucleotide Sequencing | Polymorphism, Single Nucleotide | Ubiquitin-Protein Ligases - genetics | Genomics | Genetic aspects | Crohn's disease | Research | Nucleotide sequencing | Ulcerative colitis | DNA sequencing | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | Inflammatory bowel disease | Medical research | Hospitals | Genes
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6. Full Text Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
by Franke, Ane and McGovern, Dermot P. B and Barrett, Jeffrey C and Wang, Kai and Radford-Smith, Graham L and Ahmad, Tariq and Lees, Charlie W and Balschun, Tobias and Lee, James and Roberts, Rebecca and Anderson, Carl A and Bis, Joshua C and Bumpstead, Suzanne and Ellinghaus, David and Festen, Eleonora M and Georges, Michel and Green, Todd and Haritunians, Talin and Jostins, Luke and Latiano, Anna and Mathew, Christopher G and Montgomery, Grant W and Prescott, Natalie J and Raychaudhuri, Soumya and Rotter, Jerome I and Schumm, Philip and Sharma, Yashoda and Simms, Lisa A and Taylor, Kent D and Whiteman, David and Wijmenga, Cisca and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan and Büning, Carsten and Cohen, Albert and Colombel, Jean-Frederick and Cottone, Mario and Stronati, Laura and Denson, Ted and de Vos, Martine and D'Inca, Renata and Dubinsky, Marla and Edwards, Cathryn and Florin, Tim and Franchimont, Denis and Gearry, Richard and Glas, Jürgen and van Gossum, Ane and Guthery, Stephen L and Halfvarson, Jonas and Verspaget, Hein W and Hugot, Jean-Pierre and Karban, Amir and Laukens, Debby and Lawrance, Ian and Lemann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and Mowat, Craig and Newman, William and Panés, Julián and Phillips, Anne and Proctor, Deborah D and Regueiro, Miguel and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Seibold, Frank and Steinhart, A. Hillary and Stokkers, Pieter C. F and Torkvist, Leif and Kullak-Ublick, Gerd and Wilson, David and Walters, Thomas and Targan, Stephan R and Brant, Steven R and Rioux, John D and D'Amato, Mauro and Weersma, Rinse K and Kugathasan, Subra and Griffiths, Anne M and Mansfield, John C and Vermeire, Severine and Duerr, Richard H and Silverberg, Mark S and Satsangi, Jack and Schreiber, Stefan and Cho, Judy H and Annese, Vito and Hakonarson, Hakon and Daly, Mark J and Parkes, Miles and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2010, Volume 42, Issue 12, pp. 1118 - 1125
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls... 
COMMON VARIANTS | ACTIVATION | INFLAMMATORY-BOWEL-DISEASE | PROTEIN | NEDD4 FAMILY | GENE | GENETICS & HEREDITY | SEQUENCE VARIANTS | RECEPTOR | IDENTIFICATION | ASSOCIATION | Genetic Variation | Crohn Disease - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Humans | Computational Biology | Genetic Loci - genetics | Crohn Disease - etiology | Genome, Human - genetics | Genetic Linkage | Care and treatment | Methyltransferases | Physiological aspects | Disease susceptibility | Genetic aspects | Crohn's disease | Research | Risk factors | Inflammatory bowel disease | Genetics | Genomics | Meta-analysis | Index Medicus | Medicine | Medicin | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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7. Full Text Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
by Anderson, Carl A and Boucher, Gabrielle and Lees, Charlie W and Franke, Ane and D'Amato, Mauro and Taylor, Kent D and Lee, James C and Goyette, Philippe and Imielinski, Marcin and Latiano, Anna and Lagacé, Caroline and Scott, Regan and Amininejad, Leila and Bumpstead, Suzannah and Baidoo, Leonard and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan and Büning, Carsten and Colombel, Jean-Frédéric and Denson, Lee A and de Vos, Martine and Dubinsky, Marla and Edwards, Cathryn and Ellinghaus, David and Fehrmann, Rudolf S. N and Floyd, James A. B and Florin, Timothy and Franchimont, Denis and Franke, Lude and Georges, Michel and Glas, Jürgen and Glazer, Nicole L and Guthery, Stephen L and Haritunians, Talin and Hayward, Nicholas K and Hugot, Jean-Pierre and Jobin, Gilles and Laukens, Debby and Lawrance, Ian and Lémann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and McGovern, Dermot P and Milla, Monica and Montgomery, Grant W and Morley, Katherine I and Mowat, Craig and Ng, Aylwin and Newman, William and Ophoff, Roel A and Papi, Laura and Palmieri, Orazio and Peyrin-Biroulet, Laurent and Panés, Julián and Phillips, Anne and Prescott, Natalie J and Proctor, Deborah D and Roberts, Rebecca and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Schumm, Philip and Seibold, Frank and Sharma, Yashoda and Simms, Lisa A and Seielstad, Mark and Steinhart, A. Hillary and Targan, Stephan R and van den Berg, Leonard H and Vatn, Morten and Verspaget, Hein and Walters, Thomas and Wijmenga, Cisca and Wilson, David C and Westra, Harm-Jan and Xavier, Ramnik J and Zhao, Zhen Z and Ponsioen, Cyriel Y and Andersen, Vibeke and Torkvist, Leif and Gazouli, Maria and Anagnou, Nicholas P and Karlsen, Tom H and Kupcinskas, Limas and Sventoraityte, Jurgita and Mansfield, John C and Kugathasan, Subra and Silverberg, Mark S and Halfvarson, Jonas and Rotter, Jerome I and Mathew, Christopher G and Griffiths, Anne M and Gearry, Richard and Ahmad, Tariq and Brant, Steven R and Chamaillard, Mathias and ... and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2011, Volume 43, Issue 3, pp. 246 - 252
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six... 
COMMON VARIANTS | CELLS | INFLAMMATORY-BOWEL-DISEASE | PROTEIN | CROHNS-DISEASE | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENE-EXPRESSION | ENRICHMENT | MULTIPLE | GENOME-WIDE ASSOCIATION | Crohn Disease - genetics | Risk | Genome-Wide Association Study | Humans | Colitis, Ulcerative - genetics | Genetic aspects | Disease susceptibility | Research | Risk factors | Ulcerative colitis | Meta-analysis | Studies | Inflammatory bowel disease | Celiac disease | Genetics | Genomics | Genes | Index Medicus | Medicine | Medicin | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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