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Nature Reviews Microbiology, ISSN 1740-1526, 03/2017, Volume 15, Issue 4, pp. 217 - 231
The WHO recognizes human African trypanosomiasis, Chagas disease and the leishmaniases as neglected tropical diseases. These diseases are caused by parasitic... 
RESISTANCE MECHANISMS | IN-VITRO | TRYPANOTHIONE REDUCTASE | CLINICAL DEVELOPMENT | N-MYRISTOYLTRANSFERASE INHIBITORS | CHAGAS-DISEASE | SELECTIVE INHIBITORS | MICROBIOLOGY | GENETIC VALIDATION | PROTEOMIC ANALYSIS | EXPERIMENTAL-MODELS | Forecasts and trends | Public health | Drug discovery
Journal Article
PloS one, 2019, Volume 14, Issue 5, p. e0217828
The discovery of 20 unconventional kinetochore proteins in Trypanosoma brucei has opened a new and interesting area of evolutionary research to study a... 
Journal Article
The FEBS Journal, ISSN 1742-464X, 11/2019, Volume 286, Issue 22, pp. 4509 - 4524
Burkholderia pseudomallei is a serious, difficult to treat Gram‐negative pathogen and an increase in the occurrence of drug‐resistant strains has been... 
peptidoglycan | enzyme assay | antibacterial | enzyme inhibition | target validation | Enzymes | Alanine | AMP | Peptidoglycans | Biosynthesis | Crystallography | Optimization | Organic chemistry | Antibiotics | Reagents | Computer applications | Ligands | Burkholderia | Recombinant
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2019, Volume 14, Issue 5, p. e0217828
The discovery of 20 unconventional kinetochore proteins in Trypanosoma brucei has opened a new and interesting area of evolutionary research to study a... 
Cdc2 protein | Protozoa | Phosphorylation | Research & development--R&D | Staurosporine | Biological evolution | Cell division | Homology | Pharmacology | Genomes | Parasites | Kinases | Biological activity | Substrates | Tropical diseases | Proteins | Eukaryotes | Cell growth | Parasitic diseases | Life sciences | Recombinant | Research & development | R&D
Journal Article
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7289, pp. 728 - 732
African sleeping sickness or human African trypanosomiasis, caused by Trypanosoma brucei spp., is responsible for similar to 30,000 deaths each year. Available... 
VARIANT SURFACE GLYCOPROTEIN | AFRICAN TRYPANOSOMES | TRYPANOSOMA-BRUCEI | SUBSTRATE PROTEINS | MYRISTOYL-COA | MULTIDISCIPLINARY SCIENCES | COMPLEXES | TRAFFICKING | DRUG TARGET | ENDOCYTOSIS | LEISHMANIA | Acyltransferases - antagonists & inhibitors | Trypanosomiasis, African - drug therapy | Pyrazoles - therapeutic use | Humans | Antiparasitic Agents - metabolism | Aminopyridines - metabolism | Acyltransferases - metabolism | Trypanosoma brucei brucei - enzymology | Aminopyridines - chemistry | Pyrazoles - chemistry | Aminopyridines - therapeutic use | Time Factors | Enzyme Inhibitors - chemistry | Female | Molecular Structure | Trypanosoma brucei brucei - growth & development | Pyrazoles - pharmacology | Enzyme Inhibitors - metabolism | Sulfonamides - chemistry | Enzyme Inhibitors - pharmacology | Rats | Enzyme Assays | Pyrazoles - metabolism | Sulfonamides - pharmacology | Enzyme Inhibitors - therapeutic use | Trypanosoma brucei brucei - drug effects | Antiparasitic Agents - therapeutic use | Trypanosomiasis, African - parasitology | Animals | Sulfonamides - therapeutic use | Aminopyridines - pharmacology | Antiparasitic Agents - pharmacology | Sulfonamides - metabolism | Mice | Antiparasitic Agents - chemistry | Post-translational modification | Usage | Control | Care and treatment | Enzyme inhibitors | Transferases | Physiological aspects | Genetic aspects | Research | Health aspects | Trypanosomiasis | Proteins | Data collection | Enzymes | Human | Inhibitors | Peptides | Central nervous system | Sicknesses | Trypanosome | PARASITES | TRYPANOSOMIASIS | BASIC BIOLOGICAL SCIENCES | SAFETY | SUBSTRATES | VALIDATION | CENTRAL NERVOUS SYSTEM | IN VIVO | 60 APPLIED LIFE SCIENCES | DISEASES | PEPTIDES | TRYPANOSOMA | ENZYMES | IN VITRO | DRUGS | TARGETS | MICE | PROTEINS | TRYPANOSOMES | LEAD COMPOUNDS
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2014, Volume 459, Issue 2, pp. 323 - 332
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 09/2019, Volume 63, Issue 9
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is a potentially life-threatening condition that has become a global issue. Current... 
proteasome | drug discovery | drug screening | PROTEIN-DEGRADATION | pharmacology | CHAGAS-DISEASE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | Chagas' disease | assay development | Trypanosoma cruzi | BENZNIDAZOLE
Journal Article
Nature reviews. Microbiology, ISSN 1740-1526, 11/2018, Volume 16, Issue 11, pp. 714 - 714
The structures of nifurtimox in Table 1 were incorrect and have been updated in the pdf and online. The authors apologize for any confusion caused. 
Drug discovery | Nifurtimox
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 10/2019, Volume 63, Issue 10
Chagas' disease, which is caused by the Trypanosoma cruzi parasite, has become a global health problem that is currently treated with poorly tolerated drugs... 
LEISHMANIA-MEXICANA PHOSPHOMANNOMUTASE | mannose | screening | BRUCEI | MICROBIOLOGY | VIRULENCE | GLYCOSYLPHOSPHATIDYLINOSITOL | drug discovery | ROLES | BIOSYNTHESIS | ligandability | PHARMACOLOGY & PHARMACY | Chagas' disease | target based
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 07/2017, Volume 15, Issue 7, pp. 447 - 447
Journal Article
Nature reviews. Microbiology, ISSN 1740-1526, 4/2017, Volume 15, Issue 4, pp. 217 - 231
The World Health Organization recognizes human African trypanosomiasis, Chagas’ disease and the leishmaniases as neglected tropical diseases. These diseases... 
Journal Article
NATURE REVIEWS MICROBIOLOGY, ISSN 1740-1526, 07/2017, Volume 15, Issue 7, pp. 447 - 447
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8374 - 8389
Crystallography has guided the hybridization of two series of Trypanosoma brucei N-myristoyltransferase (NMT) inhibitors, leading to a novel highly selective... 
MEDICINAL CHEMISTRY | REFINEMENT | CHEMISTRY, MEDICINAL | CANDIDA-ALBICANS | LIGAND EFFICIENCY | DIPEPTIDE AMIDES | PEPTIDOMIMETIC INHIBITORS | BENZOFURANS | IDENTIFICATION | DISCOVERY | LIPOPHILICITY
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e35792
CDP-ME kinase (IspE) contributes to the non-mevalonate or deoxy-xylulose phosphate (DOXP) pathway for isoprenoid precursor biosynthesis found in many species... 
MYCOBACTERIUM-TUBERCULOSIS | ISOPRENOID BIOSYNTHESIS | BACILLUS-SUBTILIS | SMALL-MOLECULE INHIBITORS | CRYSTAL-STRUCTURE | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE | DRUG DISCOVERY | ESCHERICHIA-COLI | BIOLOGY | NON-MEVALONATE PATHWAY | PROTEIN FLEXIBILITY | Protein Structure, Tertiary | Cyclin-Dependent Kinase 2 - metabolism | Humans | Substrate Specificity | Crystallography, X-Ray | Escherichia coli Proteins - metabolism | Organophosphorus Compounds - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Structure-Activity Relationship | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | High-Throughput Screening Assays | Computer Simulation | Escherichia coli - metabolism | Ligands | Escherichia coli Proteins - antagonists & inhibitors | Binding Sites | Hemiterpenes - chemistry | Phosphates | Analysis | Physiological aspects | Amino acids | Chemical properties | Drug discovery | Sugars | Monosaccharides | Control methods | Identification methods | Values | High-throughput screening | Biosynthesis | Parasites | Structure-activity relationships | Drug development | Kinases | Flexibility | Proteins | Accuracy | Mevalonic acid | Xylulose | Bacteria | Life sciences | Enzymes | Medical screening | Screening | Chemistry | Inhibitors | Tuberculosis | Physicochemical properties | Binding sites
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2012, Volume 55, Issue 1, pp. 140 - 152
Journal Article