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ISSN 1073-449X, 2018
The last 30 years of pulmonary hypertension research is a qualified translational success story. Patients with portopulmonary hypertension (PoPH) have... 
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 04/2019, Volume 199, Issue 7, pp. 819 - 821
BMP9 (bone morphogenetic protein 9), a ligand of the TGF-ß (transforming growth factor-ß) superfamily that has a selective binding affinity to the BMPR2 (bone... 
PULMONARY | RESPIRATORY SYSTEM | BONE MORPHOGENETIC PROTEIN-9 | ALK1 | CRITICAL CARE MEDICINE | Proteins | Liver diseases | Homeostasis | Ligands | Mutation | Growth factors | Pulmonary hypertension | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 3, pp. e91334 - e91334
The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming... 
PROGENITOR CELLS | MORPHOGENESIS | IN-VITRO | COMMITMENT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | EXTRACELLULAR-MATRIX | DIVERSITY | DIFFERENTIATION | CANCER | HOMEOBOX GENES | Embryonic Stem Cells - metabolism | Oligonucleotide Array Sequence Analysis | Homeodomain Proteins - metabolism | Humans | Fetus - metabolism | Gene Expression Profiling | Lung - cytology | RNA, Messenger - metabolism | Cell Differentiation - genetics | Endothelial Cells - ultrastructure | Organ Specificity - genetics | Adult | Real-Time Polymerase Chain Reaction | Gene Ontology | Genes, Homeobox | Cell Line | Reproducibility of Results | Endothelial Cells - metabolism | Neovascularization, Physiologic - genetics | RNA, Messenger - genetics | Rats | Homeodomain Proteins - genetics | Pulmonary Artery - cytology | Phenotype | Animals | Endothelial Cells - cytology | Fetus - embryology | Lung - embryology | Mice | Cluster Analysis | Genetic aspects | Gene expression | Analysis | Genes | Cells | Endothelium | Cluster analysis | Biotechnology | Immunoglobulins | Transcription | Multiple myeloma | Clustering | Chromosome 2 | Pulmonary artery | Endothelial cells | Morphogenesis | Medicine | Ethics | Genotype & phenotype | Angiogenesis | Specialization | DNA microarrays | Microscopy | Cell lines | Stem cells | HOX gene | Microvasculature | Index Medicus
Journal Article
by Farmery, James H. R and Smith, Mike L and Huissoon, Aarnoud and Furnell, Abigail and Mead, Adam and Levine, Adam P and Manzur, Adnan and Thrasher, Adrian and Greenhalgh, Alan and Parker, Alasdair and Sanchis-Juan, Alba and Richter, Alex and Gardham, Alice and Lawrie, Allan and Sohal, Aman and Creaser-Myers, Amanda and Frary, Amy and Greinacher, Andreas and Themistocleous, Andreas and Peacock, Andrew J and Marshall, Andrew and Mumford, Andrew and Rice, Andrew and Webster, Andrew and Brady, Angie and Koziell, Ania and Manson, Ania and Chandra, Anita and Hensiek, Anke and Veld, Anna Huis In'T and Maw, Anna and Kelly, Anne M and Moore, Anthony and Vonk Noordegraaf, Anton and Attwood, Antony and Herwadkar, Archana and Ghofrani, Ardi and Houweling, Arjan C and Girerd, Barbara and Furie, Bruce and Treacy, Carmen M and Millar, Carolyn M and Sewell, Carrock and Roughley, Catherine and Titterton, Catherine and Williamson, Catherine and Hadinnapola, Charaka and Deshpande, Charu and Toh, Cheng-Hock and Bacchelli, Chiara and Patch, Chris and Geet, Chris Van and Babbs, Christian and Bryson, Christine and Penkett, Christopher J and Rhodes, Christopher J and Watt, Christopher and Bethune, Claire and Booth, Claire and Lentaigne, Claire and McJannet, Coleen and Church, Colin and French, Courtney and Samarghitean, Crina and Halmagyi, Csaba and Gale, Daniel and Greene, Daniel and Hart, Daniel and Allsup, David and Bennett, David and Edgar, David and Kiely, David G and Gosal, David and Perry, David J and Keeling, David and Montani, David and Shipley, Debbie and Whitehorn, Deborah and Fletcher, Debra and Krishnakumar, Deepa and Grozeva, Detelina and Kumararatne, Dinakantha and Thompson, Dorothy and Josifova, Dragana and Maher, Eamonn and Wong, Edwin K. S and Murphy, Elaine and Dewhurst, Eleanor and Louka, Eleni and Rosser, Elisabeth and Chalmers, Elizabeth and Colby, Elizabeth and Drewe, Elizabeth and McDermott, Elizabeth and Thomas, Ellen and Staples, Emily and Clement, Emma and Matthews, Emma and Wakeling, Emma and Oksenhendler, Eric and ... and NIHR BioResource-Rare Dis and NIHR BioResource - Rare Diseases
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1300 - 17
Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The... 
MULTIDISCIPLINARY SCIENCES | DISEASE | Telomeres | Ploidy | Computer applications | Data processing | Genomes | Chromosomes | Telomerase | Genotypes | Cancer | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1416 - 16
Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious variation within components of the transforming growth factor-beta... 
SOX17 | GENE | ANGIOGENESIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BMP9 | ASSOCIATION | EXPRESSION | NONSENSE MUTATION | BETA-RECEPTOR | CAVEOLIN-1 | Prognosis | Humans | Male | Familial Primary Pulmonary Hypertension - diagnosis | SOXF Transcription Factors - metabolism | Aquaporin 1 - metabolism | Case-Control Studies | Familial Primary Pulmonary Hypertension - metabolism | Membrane Transport Proteins - genetics | Base Sequence | HEK293 Cells | Adult | Female | Growth Differentiation Factors - genetics | Membrane Transport Proteins - metabolism | Familial Primary Pulmonary Hypertension - pathology | Genetic Predisposition to Disease | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Gene Expression Regulation | Adenosine Triphosphatases - metabolism | Models, Molecular | Familial Primary Pulmonary Hypertension - genetics | Bone Morphogenetic Protein Receptors, Type II - metabolism | Membrane Transport Proteins - chemistry | Whole Genome Sequencing | Aquaporin 1 - chemistry | Aquaporin 1 - genetics | Growth Differentiation Factors - metabolism | Transforming Growth Factor beta - genetics | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Mutation | SOXF Transcription Factors - genetics | Transforming Growth Factor beta - metabolism | SOXF Transcription Factors - chemistry | Growth Differentiation Factors - chemistry | Hypertension | Bone morphogenetic protein receptor type II | Secretion | Lung | Transforming growth factor | Genes | Genomes | Heritability | Aquaporin 1 | Gene sequencing | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 31, pp. 8801 - 8806
Journal Article
Lancet, The, ISSN 0140-6736, 2013, Volume 381, pp. S108 - S108
Abstract Endothelial cells have a remarkable ability for subspecialisation, adapting to the needs of a variety of vascular beds. It is not known how much of... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2013, Volume 305, Issue 2, pp. H259 - H264
This study analyzed the relationship between pulmonary vascular resistance (PVR) and pulmonary arterial compliance (C-a) in patients with idiopathic pulmonary... 
Hypertension | Chronic thromboembolic pulmonary hypertension | Pulmonary endarterectomy | Pulmonary arterial hypertension | Pulmonary circulation | Pulmonary | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | pulmonary circulation | pulmonary | ENDARTERECTOMY | chronic thromboembolic pulmonary hypertension | WAVE | REFLECTION | pulmonary endarterectomy | ARTERY PRESSURE | DISEASE | PERIPHERAL VASCULAR DISEASE | VASCULAR-RESISTANCE | hypertension | pulmonary arterial hypertension | Compliance | Humans | Middle Aged | Hypertension, Pulmonary - physiopathology | Male | Pulmonary Artery - surgery | Endarterectomy, Carotid | Cardiac Catheterization | Arterial Pressure | Time Factors | Adult | Female | Ventricular Dysfunction, Right - physiopathology | Retrospective Studies | Severity of Illness Index | Pulmonary Embolism - complications | Vascular Resistance | Hypertension, Pulmonary - surgery | Familial Primary Pulmonary Hypertension | Linear Models | Treatment Outcome | Pulmonary Artery - physiopathology | Pulmonary Circulation | Analysis of Variance | Ventricular Dysfunction, Right - etiology | Aged | Hemodynamics | Pulmonary Embolism - surgery | Chronic Disease | Hypertension, Pulmonary - etiology | Ventricular Function, Right | Pulmonary Embolism - physiopathology | Physiological aspects | Biophysics | Research | Blood circulation | Health aspects | Pulmonary hypertension | Heart failure | Measurement | Pulmonary arteries | Index Medicus | Integrative Cardiovascular Physiology and Pathophysiology
Journal Article
Journal Article
Journal Article
ISSN 1044-1549, 2018
Pulmonary arterial hypertension (PAH) is characterized by abnormal remodeling and occlusion of pre-capillary arterioles in the lung with a subsequent increase... 
Journal Article
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