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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2017, Volume 60, Issue 4, pp. 1247 - 1261
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2013, Volume 4, Issue 12, pp. 1238 - 1243
Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines, and furo[2,3-d]pyrimidines, all of the type II... 
RIP1 | type II kinase inhibitors | necroptosis | AGENT | ISCHEMIA/REPERFUSION INJURY | CHEMISTRY, MEDICINAL | NECROSIS | LETHAL | INFLAMMATORY RESPONSE | NECROSTATINS | CONTRIBUTES | CELL-DEATH
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 09/2019, Volume 9, Issue 1, pp. 13078 - 11
Significant resource is spent by drug discovery project teams to generate numerous, yet unique target constructs for the multiple platforms used to drive drug... 
INTEINS | AMINO | MULTIDISCIPLINARY SCIENCES | PURIFICATION | Proteins | High-throughput screening | C-Terminus | Drug discovery | Lysine | Structure-function relationships
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2016, Volume 59, Issue 5, pp. 2163 - 2178
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 06/2019, Volume 10, Issue 6, pp. 857 - 862
RIP1 regulates cell death and inflammation and is believed to play an important role in contributing to a variety of human pathologies, including... 
type III kinase inhibitors | pancreatic cancer | RIP1 | TARGET | CHEMISTRY, MEDICINAL
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4867 - 4880
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Biochemistry, ISSN 0006-2960, 08/2011, Volume 50, Issue 31, pp. 6642 - 6654
Journal Article
Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, 2014, Volume 112, Issue 2, pp. 163 - 169.e1
Journal Article