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1. Full Text Influenza's signature move
by Tough, David F
Nature Immunology, ISSN 1529-2908, 06/2018, Volume 19, Issue 6, pp. 518 - 520
Care and treatment | Genetic aspects | Research | Gene expression | Influenza | Risk factors
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2. Full Text Influenza’s signature move
by Tough, David F
Nature Immunology, ISSN 1529-2908, 06/2018, Volume 19, Issue 6, pp. 518 - 520
Analysis of whole-blood transcriptional profiles in adults hospitalized with influenza reveals time- and severity-related gene-expression signatures. 
Adults | Transcription | Gene expression | Influenza
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3. Full Text Epigenetic Regulation of T Cell Memory: Recalling Therapeutic Implications
by Tough, David F and Rioja, Inma and Modis, Louise K and Prinjha, Rab K
Trends in Immunology, ISSN 1471-4906, 12/2019
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4. Full Text Systematic analysis of immunodeficiency
by Tough, David F
Nature Immunology, ISSN 1529-2908, 11/2014, Volume 15, Issue 12, pp. 1097 - 1098
Humans deficient in the adaptor MyD88 or the kinase IRAK4 suffer from primary immunodeficiency. Blood cells from these patients show defective induction of... 
IMMUNOLOGY | Interleukin-1 Receptor-Associated Kinases - genetics | Humans | Interleukin-1 Receptor-Associated Kinases - immunology | Myeloid Differentiation Factor 88 - genetics | Immunologic Deficiency Syndromes - genetics | Female | Male | Mutation | Immunologic Deficiency Syndromes - immunology | Medicine, Experimental | Medical research | Research | Properties | Phosphotransferases | Immunodeficiency
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5. Full Text Modulation of T‐cell function by type I interferon
by Tough, David F
Immunology and Cell Biology, ISSN 0818-9641, 05/2012, Volume 90, Issue 5, pp. 492 - 497
Production of type I interferon (IFN‐α/β) is a common cellular response to virus infection. IFN‐α/β has a dual role in combating infection, triggering innate... 
type I interferon | cytotoxic T cell | apoptosis | T cells | Th1 | MEMORY FORMATION | VIRUS-INFECTION | DENDRITIC CELLS | DIRECT STIMULATION | IMMUNOLOGY | VIRAL-INFECTION | CUTTING EDGE | CELL BIOLOGY | HUMAN NK | GAMMA PRODUCTION | CLONAL EXPANSION | IFN-ALPHA | Adaptive Immunity | Receptor Cross-Talk - immunology | Signal Transduction - immunology | Animals | Virus Diseases - immunology | Humans | Cellular Microenvironment | T-Lymphocytes - immunology | Immunity, Innate | Interferon Type I - immunology
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6. Full Text Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription
by Kaikkonen, Minna U and Spann, Nathanael J and Heinz, Sven and Romanoski, Casey E and Allison, Karmel A and Stender, Joshua D and Chun, Hyun B and Tough, David F and Prinjha, Rab K and Benner, Christopher and Glass, Christopher K
Molecular Cell, ISSN 1097-2765, 08/2013, Volume 51, Issue 3, pp. 310 - 325
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers,... 
RNA-POLYMERASE-II | GLUCOCORTICOID-RECEPTOR BINDING | CHROMATIN ACCESSIBILITY | HISTONE H3 | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENOME-WIDE ANALYSIS | GENE-EXPRESSION | BROMODOMAIN PROTEIN BRD4 | P-TEFB | CELL BIOLOGY | Myeloid-Lymphoid Leukemia Protein - metabolism | Macrophage Activation - genetics | Male | NF-kappa B - metabolism | DNA Methylation | Base Sequence | Transcription, Genetic | Macrophages - immunology | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Gene Expression | RNA Polymerase II - antagonists & inhibitors | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Sequence Analysis, DNA | Toll-Like Receptor 4 - metabolism | Macrophages - metabolism | Animals | Histones - genetics | Enhancer Elements, Genetic | Histone-Lysine N-Methyltransferase - metabolism | Transcription Factor RelA - metabolism | Trans-Activators - metabolism | Mice | Histones - metabolism | Genetic transcription | RNA | Methylation | Macrophages | Analysis
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7. Full Text Epigenetic drug discovery: Breaking through the immune barrier
by Tough, David F and Tak, Paul P and Tarakhovsky, Alexander and Prinjha, Rab K
Nature Reviews Drug Discovery, ISSN 1474-1776, 11/2016, Volume 15, Issue 12, pp. 835 - 853
Immune-mediated diseases are clinically heterogeneous but they share genetic and pathogenic mechanisms. These diseases may develop from the interplay of... 
THYMINE DNA GLYCOSYLASE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ARTHRITIS SYNOVIAL FIBROBLASTS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | AIRWAY SMOOTH-MUSCLE | HISTONE DEACETYLASE INHIBITORS | BET BROMODOMAIN INHIBITOR | CYTOKINE GENE-EXPRESSION | NUCLEOSOME CORE PARTICLE | Animals | Inflammation - drug therapy | Drug Discovery | Epigenesis, Genetic | Humans | Autoimmune Diseases - drug therapy
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8. Preview: Turnabout Is Fair Play: T Cell Stimulation by Dendritic Cell-Expressed CD40L
by Tough, David F
Immunity, ISSN 1074-7613, 02/2009, Volume 30, Issue 2, pp. 171 - 173
CD40L expressed on T cells plays an important role in stimulating the function of dendritic cells (DCs). In this issue of Immunity, Johnson et al. (2009)... 
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9. Full Text Turnabout Is Fair Play: T Cell Stimulation by Dendritic Cell-Expressed CD40L
by Tough, David F
Immunity, ISSN 1074-7613, 2009, Volume 30, Issue 2, pp. 171 - 173
CD40L expressed on T cells plays an important role in stimulating the function of dendritic cells (DCs). In this issue of , demonstrate a role for DC-expressed... 
HELP | IMMUNOLOGY | CD8 MEMORY | T-Lymphocytes - immunology | Animals | CD40 Ligand - metabolism | Dendritic Cells - immunology | CD40 Ligand - immunology | Dendritic Cells - metabolism | Studies | Hypotheses | Immunization | Cytokines | Rodents | Licenses | Ligands | T cell receptors | Experiments
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10. Full Text Targeting CCR4 as an emerging strategy for cancer therapy and vaccines
by Bayry, Jagadeesh and Tartour, Eric and Tough, David F
Trends in Pharmacological Sciences, ISSN 0165-6147, 2014, Volume 35, Issue 4, pp. 163 - 165
Advanced Basic Science | SURVIVAL | REGULATORY T-CELLS | LYMPHOMA | ANTIBODY | PHARMACOLOGY & PHARMACY | Cancer Vaccines - immunology | Neoplasms - therapy | Animals | Receptors, CCR4 - immunology | Neoplasms - immunology | Cancer Vaccines - pharmacology | Humans | Molecular Targeted Therapy | Receptors, CCR4 - antagonists & inhibitors
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11. Full Text Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN
by Le Bon, Agnes and Thompson, Clare and Kamphuis, Elisabeth and Durand, Vanessa and Rossmann, Cornelia and Kalinke, Ulrich and Tough, David F
The Journal of Immunology, ISSN 0022-1767, 02/2006, Volume 176, Issue 4, pp. 2074 - 2078
Type I IFN (IFN-alphabeta) is induced rapidly by infection and plays a key role in innate antiviral defense. IFN-alphabeta also exerts stimulatory effects on... 
Antibody Formation - immunology | Membrane Proteins - genetics | Receptors, Interferon - deficiency | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Type I - immunology | Mice, Knockout | Receptors, Interferon - metabolism | Receptor, Interferon alpha-beta | B-Lymphocytes - drug effects | Membrane Proteins - deficiency | Animals | B-Lymphocytes - immunology | Interferon Type I - pharmacology | T-Lymphocytes - drug effects | Antibody Formation - drug effects | T-Lymphocytes - immunology | Membrane Proteins - metabolism | Mice | Receptors, Interferon - genetics
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12. Full Text An IFN-γ-dependent pathway controls stimulation of memory phenotype CD8+ T cell turnover in vivo by IL-12, IL-18, and IFN-γ1
by Tough, David F and Zhang, Xiaohong and Sprent, Jonathan
Journal of Immunology, ISSN 0022-1767, 05/2001, Volume 166, Issue 10, pp. 6007 - 6011
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13. Full Text Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome
by Schulz, Danae and Mugnier, Monica R and Paulsen, Eda-Margaret and Kim, Hee-Sook and Chung, Chun-wa W and Tough, David F and Rioja, Inmaculada and Prinjha, Rab K and Papavasiliou, F. Nina and Debler, Erik W
PLoS Biology, ISSN 1544-9173, 12/2015, Volume 13, Issue 12, p. e1002316
Trypanosoma brucei, the causative agent of African sleeping sickness, is transmitted to its mammalian host by the tsetse. In the fly, the parasite's surface is... 
LIFE-CYCLE | ANTIGENIC VARIATION | MESSENGER-RNA | EXPRESSION SITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | BIOLOGY | BRUCEI | DISTINCT ROLES | RNA-POLYMERASE I | UNTRANSLATED REGION | CCCH PROTEIN | Trypanosomiasis, African - drug therapy | Transcription Factors - chemistry | Protozoan Proteins - antagonists & inhibitors | Virulence | Protozoan Proteins - genetics | Gene Knockdown Techniques | Trypanosoma brucei brucei - physiology | Protein Isoforms - metabolism | Protozoan Proteins - metabolism | Protein Isoforms - chemistry | Trypanosoma brucei brucei - pathogenicity | Protozoan Proteins - chemistry | Trypanocidal Agents - therapeutic use | Binding Sites | Trypanosomiasis, African - physiopathology | Recombinant Proteins - metabolism | Cell Line | Mice, Inbred C57BL | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Gene Knockout Techniques | Trypanosoma brucei brucei - drug effects | Mice, Knockout | Transcription Factors - metabolism | Trypanosomiasis, African - parasitology | Animals | Immune Evasion | Trypanocidal Agents - pharmacology | Mutant Proteins - chemistry | Survival Analysis | Protein Conformation | Mice | Protein Isoforms - antagonists & inhibitors | Amino Acid Substitution | Protein Isoforms - genetics | Trypanosoma brucei brucei - immunology | Proteins | Protozoa | Immunoglobulins | Data collection | Parasites | Mammals | Gene expression | Experiments | Crystal structure
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14. Full Text Selective inhibition of CD4⁺ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
by Hozefa S. Bandukwala and John Gagnon and Susan Togher and Jason A. Greenbaum and Edward D. Lamperti and Nigel J. Parr and Amy M. H. Molesworth and Nicholas Smithers and Kevin Lee and Jason Witherington and David F. Tough and Rab K. Prinjha and Bjoern Peters and Anjana Rao
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 36, pp. 14532 - 14537
Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone... 
T lymphocytes | Proteins | Molecules | Betting | Cytokines | Genes | Central nervous system | Histones | Cultured cells | Inflammation | BRD inhibitors | Transcriptional pausing | 5,6-dichloro-1-β-D- ribofuranosylbenzimidazole | Positive transcription elongation factor b | BRD4 | ENCEPHALOMYELITIS | ACTIVATION | 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole | CHROMATIN | MULTIDISCIPLINARY SCIENCES | transcriptional pausing | RECEPTOR | BROMODOMAINS | T(H)17 CELLS | GM-CSF | DISEASE | LEUKEMIA | positive transcription elongation factor b | EXPRESSION | Phosphorylation | Encephalomyelitis, Autoimmune, Experimental - immunology | Gene Expression Profiling | Adoptive Transfer | Positive Transcriptional Elongation Factor B - metabolism | Flow Cytometry | Microarray Analysis | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | Salivary alpha-Amylases - antagonists & inhibitors | Benzodiazepines - pharmacology | Cytokines - metabolism | Gene Expression Regulation - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Cell Differentiation - immunology | Animals | Cell Differentiation - drug effects | Transcription, Genetic - immunology | Mice | Thiazoles - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Biological Sciences | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole
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15. Full Text Initial T cell frequency dictates memory CD8 + T cell lineage commitment
by Klonowski, Kimberly D and Lefrançois, Leo and Tough, David F and Marzo, Amanda L and Bon, Agnes Le and Borrow, Persephone
Nature Immunology, ISSN 1529-2908, 08/2005, Volume 6, Issue 8, pp. 793 - 799
Memory T cells can be divided into central memory T cell (TCM cell) and effector memory T cell (TEM cell) subsets based on homing characteristics and effector... 
RESPONSES | IN-VIVO | SUBSETS | GENERATION | DIFFERENTIATION | IMMUNOLOGY | NAIVE | VIRAL-INFECTION | CUTTING EDGE | ANTIGEN | LYMPHOCYTES | Cell Proliferation | Cell Separation | Mice, Transgenic | Cell Lineage | Animals | Flow Cytometry | Lymphocytes - immunology | Bromodeoxyuridine - pharmacology | T-Lymphocytes - metabolism | Models, Biological | Immunologic Memory | T-Lymphocytes - immunology | Cell Differentiation | Mice | CD8-Positive T-Lymphocytes - immunology
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16. Full Text Cross-priming of CD8 + T cells stimulated by virus-induced type I interferon
by Ashton, Miranda and Le Bon, Agnes and Etchart, Nathalie and Hou, Sam and Borrow, Persephone and Rossmann, Cornelia and Gewert, Dirk and Tough, David F
Nature Immunology, ISSN 1529-2908, 10/2003, Volume 4, Issue 10, pp. 1009 - 1015
CD8(+) T cell responses can be generated against antigens that are not expressed directly within antigen-presenting cells (APCs), through a process known as... 
DENDRITIC CELLS | EXOGENOUS ANTIGEN | CD8-T-CELL MEMORY | SOLUBLE-ANTIGEN | CD4-T-CELL HELP | ANTIGEN PRESENTATION | TUMOR-CELLS | HUMAN BLOOD | SELF-ANTIGENS | IMMUNOLOGY | DNA-BASED VACCINES | Lymphocytic choriomeningitis virus - immunology | Lymphocytic Choriomeningitis - virology | Specific Pathogen-Free Organisms | Ovalbumin - immunology | Dendritic Cells - immunology | Mice, Inbred C57BL | Antigen Presentation - immunology | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | CD40 Ligand - immunology | Mice, Knockout | Interferon Type I - biosynthesis | Lymphocyte Activation - immunology | Animals | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - metabolism | Female | Mice | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology
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