Nature Immunology, ISSN 1529-2908, 06/2018, Volume 19, Issue 6, pp. 518 - 520
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2018, Volume 19, Issue 6, pp. 518 - 520
Analysis of whole-blood transcriptional profiles in adults hospitalized with influenza reveals time- and severity-related gene-expression signatures.
Adults | Transcription | Gene expression | Influenza
Adults | Transcription | Gene expression | Influenza
Journal Article
Trends in Immunology, ISSN 1471-4906, 12/2019
Journal Article
Nature Immunology, ISSN 1529-2908, 11/2014, Volume 15, Issue 12, pp. 1097 - 1098
Humans deficient in the adaptor MyD88 or the kinase IRAK4 suffer from primary immunodeficiency. Blood cells from these patients show defective induction of...
IMMUNOLOGY | Interleukin-1 Receptor-Associated Kinases - genetics | Humans | Interleukin-1 Receptor-Associated Kinases - immunology | Myeloid Differentiation Factor 88 - genetics | Immunologic Deficiency Syndromes - genetics | Female | Male | Mutation | Immunologic Deficiency Syndromes - immunology | Medicine, Experimental | Medical research | Research | Properties | Phosphotransferases | Immunodeficiency
IMMUNOLOGY | Interleukin-1 Receptor-Associated Kinases - genetics | Humans | Interleukin-1 Receptor-Associated Kinases - immunology | Myeloid Differentiation Factor 88 - genetics | Immunologic Deficiency Syndromes - genetics | Female | Male | Mutation | Immunologic Deficiency Syndromes - immunology | Medicine, Experimental | Medical research | Research | Properties | Phosphotransferases | Immunodeficiency
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 05/2012, Volume 90, Issue 5, pp. 492 - 497
Production of type I interferon (IFN‐α/β) is a common cellular response to virus infection. IFN‐α/β has a dual role in combating infection, triggering innate...
type I interferon | cytotoxic T cell | apoptosis | T cells | Th1 | MEMORY FORMATION | VIRUS-INFECTION | DENDRITIC CELLS | DIRECT STIMULATION | IMMUNOLOGY | VIRAL-INFECTION | CUTTING EDGE | CELL BIOLOGY | HUMAN NK | GAMMA PRODUCTION | CLONAL EXPANSION | IFN-ALPHA | Adaptive Immunity | Receptor Cross-Talk - immunology | Signal Transduction - immunology | Animals | Virus Diseases - immunology | Humans | Cellular Microenvironment | T-Lymphocytes - immunology | Immunity, Innate | Interferon Type I - immunology
type I interferon | cytotoxic T cell | apoptosis | T cells | Th1 | MEMORY FORMATION | VIRUS-INFECTION | DENDRITIC CELLS | DIRECT STIMULATION | IMMUNOLOGY | VIRAL-INFECTION | CUTTING EDGE | CELL BIOLOGY | HUMAN NK | GAMMA PRODUCTION | CLONAL EXPANSION | IFN-ALPHA | Adaptive Immunity | Receptor Cross-Talk - immunology | Signal Transduction - immunology | Animals | Virus Diseases - immunology | Humans | Cellular Microenvironment | T-Lymphocytes - immunology | Immunity, Innate | Interferon Type I - immunology
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2013, Volume 51, Issue 3, pp. 310 - 325
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers,...
RNA-POLYMERASE-II | GLUCOCORTICOID-RECEPTOR BINDING | CHROMATIN ACCESSIBILITY | HISTONE H3 | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENOME-WIDE ANALYSIS | GENE-EXPRESSION | BROMODOMAIN PROTEIN BRD4 | P-TEFB | CELL BIOLOGY | Myeloid-Lymphoid Leukemia Protein - metabolism | Macrophage Activation - genetics | Male | NF-kappa B - metabolism | DNA Methylation | Base Sequence | Transcription, Genetic | Macrophages - immunology | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Gene Expression | RNA Polymerase II - antagonists & inhibitors | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Sequence Analysis, DNA | Toll-Like Receptor 4 - metabolism | Macrophages - metabolism | Animals | Histones - genetics | Enhancer Elements, Genetic | Histone-Lysine N-Methyltransferase - metabolism | Transcription Factor RelA - metabolism | Trans-Activators - metabolism | Mice | Histones - metabolism | Genetic transcription | RNA | Methylation | Macrophages | Analysis
RNA-POLYMERASE-II | GLUCOCORTICOID-RECEPTOR BINDING | CHROMATIN ACCESSIBILITY | HISTONE H3 | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENOME-WIDE ANALYSIS | GENE-EXPRESSION | BROMODOMAIN PROTEIN BRD4 | P-TEFB | CELL BIOLOGY | Myeloid-Lymphoid Leukemia Protein - metabolism | Macrophage Activation - genetics | Male | NF-kappa B - metabolism | DNA Methylation | Base Sequence | Transcription, Genetic | Macrophages - immunology | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Gene Expression | RNA Polymerase II - antagonists & inhibitors | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Sequence Analysis, DNA | Toll-Like Receptor 4 - metabolism | Macrophages - metabolism | Animals | Histones - genetics | Enhancer Elements, Genetic | Histone-Lysine N-Methyltransferase - metabolism | Transcription Factor RelA - metabolism | Trans-Activators - metabolism | Mice | Histones - metabolism | Genetic transcription | RNA | Methylation | Macrophages | Analysis
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 11/2016, Volume 15, Issue 12, pp. 835 - 853
Immune-mediated diseases are clinically heterogeneous but they share genetic and pathogenic mechanisms. These diseases may develop from the interplay of...
THYMINE DNA GLYCOSYLASE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ARTHRITIS SYNOVIAL FIBROBLASTS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | AIRWAY SMOOTH-MUSCLE | HISTONE DEACETYLASE INHIBITORS | BET BROMODOMAIN INHIBITOR | CYTOKINE GENE-EXPRESSION | NUCLEOSOME CORE PARTICLE | Animals | Inflammation - drug therapy | Drug Discovery | Epigenesis, Genetic | Humans | Autoimmune Diseases - drug therapy
THYMINE DNA GLYCOSYLASE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ARTHRITIS SYNOVIAL FIBROBLASTS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EMBRYONIC STEM-CELLS | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | AIRWAY SMOOTH-MUSCLE | HISTONE DEACETYLASE INHIBITORS | BET BROMODOMAIN INHIBITOR | CYTOKINE GENE-EXPRESSION | NUCLEOSOME CORE PARTICLE | Animals | Inflammation - drug therapy | Drug Discovery | Epigenesis, Genetic | Humans | Autoimmune Diseases - drug therapy
Journal Article
Immunity, ISSN 1074-7613, 02/2009, Volume 30, Issue 2, pp. 171 - 173
CD40L expressed on T cells plays an important role in stimulating the function of dendritic cells (DCs). In this issue of Immunity, Johnson et al. (2009)...
Journal Article
Immunity, ISSN 1074-7613, 2009, Volume 30, Issue 2, pp. 171 - 173
CD40L expressed on T cells plays an important role in stimulating the function of dendritic cells (DCs). In this issue of , demonstrate a role for DC-expressed...
HELP | IMMUNOLOGY | CD8 MEMORY | T-Lymphocytes - immunology | Animals | CD40 Ligand - metabolism | Dendritic Cells - immunology | CD40 Ligand - immunology | Dendritic Cells - metabolism | Studies | Hypotheses | Immunization | Cytokines | Rodents | Licenses | Ligands | T cell receptors | Experiments
HELP | IMMUNOLOGY | CD8 MEMORY | T-Lymphocytes - immunology | Animals | CD40 Ligand - metabolism | Dendritic Cells - immunology | CD40 Ligand - immunology | Dendritic Cells - metabolism | Studies | Hypotheses | Immunization | Cytokines | Rodents | Licenses | Ligands | T cell receptors | Experiments
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2014, Volume 35, Issue 4, pp. 163 - 165
Advanced Basic Science | SURVIVAL | REGULATORY T-CELLS | LYMPHOMA | ANTIBODY | PHARMACOLOGY & PHARMACY | Cancer Vaccines - immunology | Neoplasms - therapy | Animals | Receptors, CCR4 - immunology | Neoplasms - immunology | Cancer Vaccines - pharmacology | Humans | Molecular Targeted Therapy | Receptors, CCR4 - antagonists & inhibitors
Journal Article
The Journal of Immunology, ISSN 0022-1767, 02/2006, Volume 176, Issue 4, pp. 2074 - 2078
Type I IFN (IFN-alphabeta) is induced rapidly by infection and plays a key role in innate antiviral defense. IFN-alphabeta also exerts stimulatory effects on...
Antibody Formation - immunology | Membrane Proteins - genetics | Receptors, Interferon - deficiency | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Type I - immunology | Mice, Knockout | Receptors, Interferon - metabolism | Receptor, Interferon alpha-beta | B-Lymphocytes - drug effects | Membrane Proteins - deficiency | Animals | B-Lymphocytes - immunology | Interferon Type I - pharmacology | T-Lymphocytes - drug effects | Antibody Formation - drug effects | T-Lymphocytes - immunology | Membrane Proteins - metabolism | Mice | Receptors, Interferon - genetics
Antibody Formation - immunology | Membrane Proteins - genetics | Receptors, Interferon - deficiency | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Type I - immunology | Mice, Knockout | Receptors, Interferon - metabolism | Receptor, Interferon alpha-beta | B-Lymphocytes - drug effects | Membrane Proteins - deficiency | Animals | B-Lymphocytes - immunology | Interferon Type I - pharmacology | T-Lymphocytes - drug effects | Antibody Formation - drug effects | T-Lymphocytes - immunology | Membrane Proteins - metabolism | Mice | Receptors, Interferon - genetics
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2001, Volume 166, Issue 10, pp. 6007 - 6011
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2015, Volume 13, Issue 12, p. e1002316
Trypanosoma brucei, the causative agent of African sleeping sickness, is transmitted to its mammalian host by the tsetse. In the fly, the parasite's surface is...
LIFE-CYCLE | ANTIGENIC VARIATION | MESSENGER-RNA | EXPRESSION SITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | BIOLOGY | BRUCEI | DISTINCT ROLES | RNA-POLYMERASE I | UNTRANSLATED REGION | CCCH PROTEIN | Trypanosomiasis, African - drug therapy | Transcription Factors - chemistry | Protozoan Proteins - antagonists & inhibitors | Virulence | Protozoan Proteins - genetics | Gene Knockdown Techniques | Trypanosoma brucei brucei - physiology | Protein Isoforms - metabolism | Protozoan Proteins - metabolism | Protein Isoforms - chemistry | Trypanosoma brucei brucei - pathogenicity | Protozoan Proteins - chemistry | Trypanocidal Agents - therapeutic use | Binding Sites | Trypanosomiasis, African - physiopathology | Recombinant Proteins - metabolism | Cell Line | Mice, Inbred C57BL | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Gene Knockout Techniques | Trypanosoma brucei brucei - drug effects | Mice, Knockout | Transcription Factors - metabolism | Trypanosomiasis, African - parasitology | Animals | Immune Evasion | Trypanocidal Agents - pharmacology | Mutant Proteins - chemistry | Survival Analysis | Protein Conformation | Mice | Protein Isoforms - antagonists & inhibitors | Amino Acid Substitution | Protein Isoforms - genetics | Trypanosoma brucei brucei - immunology | Proteins | Protozoa | Immunoglobulins | Data collection | Parasites | Mammals | Gene expression | Experiments | Crystal structure
LIFE-CYCLE | ANTIGENIC VARIATION | MESSENGER-RNA | EXPRESSION SITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | BIOLOGY | BRUCEI | DISTINCT ROLES | RNA-POLYMERASE I | UNTRANSLATED REGION | CCCH PROTEIN | Trypanosomiasis, African - drug therapy | Transcription Factors - chemistry | Protozoan Proteins - antagonists & inhibitors | Virulence | Protozoan Proteins - genetics | Gene Knockdown Techniques | Trypanosoma brucei brucei - physiology | Protein Isoforms - metabolism | Protozoan Proteins - metabolism | Protein Isoforms - chemistry | Trypanosoma brucei brucei - pathogenicity | Protozoan Proteins - chemistry | Trypanocidal Agents - therapeutic use | Binding Sites | Trypanosomiasis, African - physiopathology | Recombinant Proteins - metabolism | Cell Line | Mice, Inbred C57BL | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Gene Knockout Techniques | Trypanosoma brucei brucei - drug effects | Mice, Knockout | Transcription Factors - metabolism | Trypanosomiasis, African - parasitology | Animals | Immune Evasion | Trypanocidal Agents - pharmacology | Mutant Proteins - chemistry | Survival Analysis | Protein Conformation | Mice | Protein Isoforms - antagonists & inhibitors | Amino Acid Substitution | Protein Isoforms - genetics | Trypanosoma brucei brucei - immunology | Proteins | Protozoa | Immunoglobulins | Data collection | Parasites | Mammals | Gene expression | Experiments | Crystal structure
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 36, pp. 14532 - 14537
Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone...
T lymphocytes | Proteins | Molecules | Betting | Cytokines | Genes | Central nervous system | Histones | Cultured cells | Inflammation | BRD inhibitors | Transcriptional pausing | 5,6-dichloro-1-β-D- ribofuranosylbenzimidazole | Positive transcription elongation factor b | BRD4 | ENCEPHALOMYELITIS | ACTIVATION | 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole | CHROMATIN | MULTIDISCIPLINARY SCIENCES | transcriptional pausing | RECEPTOR | BROMODOMAINS | T(H)17 CELLS | GM-CSF | DISEASE | LEUKEMIA | positive transcription elongation factor b | EXPRESSION | Phosphorylation | Encephalomyelitis, Autoimmune, Experimental - immunology | Gene Expression Profiling | Adoptive Transfer | Positive Transcriptional Elongation Factor B - metabolism | Flow Cytometry | Microarray Analysis | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | Salivary alpha-Amylases - antagonists & inhibitors | Benzodiazepines - pharmacology | Cytokines - metabolism | Gene Expression Regulation - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Cell Differentiation - immunology | Animals | Cell Differentiation - drug effects | Transcription, Genetic - immunology | Mice | Thiazoles - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Biological Sciences | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole
T lymphocytes | Proteins | Molecules | Betting | Cytokines | Genes | Central nervous system | Histones | Cultured cells | Inflammation | BRD inhibitors | Transcriptional pausing | 5,6-dichloro-1-β-D- ribofuranosylbenzimidazole | Positive transcription elongation factor b | BRD4 | ENCEPHALOMYELITIS | ACTIVATION | 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole | CHROMATIN | MULTIDISCIPLINARY SCIENCES | transcriptional pausing | RECEPTOR | BROMODOMAINS | T(H)17 CELLS | GM-CSF | DISEASE | LEUKEMIA | positive transcription elongation factor b | EXPRESSION | Phosphorylation | Encephalomyelitis, Autoimmune, Experimental - immunology | Gene Expression Profiling | Adoptive Transfer | Positive Transcriptional Elongation Factor B - metabolism | Flow Cytometry | Microarray Analysis | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | Salivary alpha-Amylases - antagonists & inhibitors | Benzodiazepines - pharmacology | Cytokines - metabolism | Gene Expression Regulation - immunology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Cell Differentiation - immunology | Animals | Cell Differentiation - drug effects | Transcription, Genetic - immunology | Mice | Thiazoles - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Biological Sciences | 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2005, Volume 6, Issue 8, pp. 793 - 799
Memory T cells can be divided into central memory T cell (TCM cell) and effector memory T cell (TEM cell) subsets based on homing characteristics and effector...
RESPONSES | IN-VIVO | SUBSETS | GENERATION | DIFFERENTIATION | IMMUNOLOGY | NAIVE | VIRAL-INFECTION | CUTTING EDGE | ANTIGEN | LYMPHOCYTES | Cell Proliferation | Cell Separation | Mice, Transgenic | Cell Lineage | Animals | Flow Cytometry | Lymphocytes - immunology | Bromodeoxyuridine - pharmacology | T-Lymphocytes - metabolism | Models, Biological | Immunologic Memory | T-Lymphocytes - immunology | Cell Differentiation | Mice | CD8-Positive T-Lymphocytes - immunology
RESPONSES | IN-VIVO | SUBSETS | GENERATION | DIFFERENTIATION | IMMUNOLOGY | NAIVE | VIRAL-INFECTION | CUTTING EDGE | ANTIGEN | LYMPHOCYTES | Cell Proliferation | Cell Separation | Mice, Transgenic | Cell Lineage | Animals | Flow Cytometry | Lymphocytes - immunology | Bromodeoxyuridine - pharmacology | T-Lymphocytes - metabolism | Models, Biological | Immunologic Memory | T-Lymphocytes - immunology | Cell Differentiation | Mice | CD8-Positive T-Lymphocytes - immunology
Journal Article
Nature Immunology, ISSN 1529-2908, 10/2003, Volume 4, Issue 10, pp. 1009 - 1015
CD8(+) T cell responses can be generated against antigens that are not expressed directly within antigen-presenting cells (APCs), through a process known as...
DENDRITIC CELLS | EXOGENOUS ANTIGEN | CD8-T-CELL MEMORY | SOLUBLE-ANTIGEN | CD4-T-CELL HELP | ANTIGEN PRESENTATION | TUMOR-CELLS | HUMAN BLOOD | SELF-ANTIGENS | IMMUNOLOGY | DNA-BASED VACCINES | Lymphocytic choriomeningitis virus - immunology | Lymphocytic Choriomeningitis - virology | Specific Pathogen-Free Organisms | Ovalbumin - immunology | Dendritic Cells - immunology | Mice, Inbred C57BL | Antigen Presentation - immunology | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | CD40 Ligand - immunology | Mice, Knockout | Interferon Type I - biosynthesis | Lymphocyte Activation - immunology | Animals | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - metabolism | Female | Mice | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology
DENDRITIC CELLS | EXOGENOUS ANTIGEN | CD8-T-CELL MEMORY | SOLUBLE-ANTIGEN | CD4-T-CELL HELP | ANTIGEN PRESENTATION | TUMOR-CELLS | HUMAN BLOOD | SELF-ANTIGENS | IMMUNOLOGY | DNA-BASED VACCINES | Lymphocytic choriomeningitis virus - immunology | Lymphocytic Choriomeningitis - virology | Specific Pathogen-Free Organisms | Ovalbumin - immunology | Dendritic Cells - immunology | Mice, Inbred C57BL | Antigen Presentation - immunology | Interferon Type I - immunology | Lymphocytic Choriomeningitis - immunology | CD40 Ligand - immunology | Mice, Knockout | Interferon Type I - biosynthesis | Lymphocyte Activation - immunology | Animals | CD8-Positive T-Lymphocytes - virology | CD8-Positive T-Lymphocytes - metabolism | Female | Mice | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology
Journal Article