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Organic Letters, ISSN 1523-7060, 04/2010, Volume 12, Issue 7, pp. 1532 - 1535
We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis.... 
PALLADIUM | GOLDBERG REACTIONS | ACID | CROSS-COUPLING REACTION | C-N | ARYL HALIDES | ARYLATION | AMIDATION | CHEMISTRY, ORGANIC | BOND FORMATION | ULLMANN | Sulfonamides - chemical synthesis | Iodides - chemistry | Molecular Structure | Copper - chemistry | Sulfonamides - chemistry | Stereoisomerism
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2010, Volume 75, Issue 15, pp. 4911 - 4920
Imidazoles are an important group of the azole family of heterocycles frequently found in pharmaceuticals, drug candidates, ligands for transition metal... 
ORGANIC-SYNTHESIS | CROSS-COUPLING REACTIONS | ACTIVATION | ANALOGS | CHEMISTRY, ORGANIC | SITE-SELECTIVE SP | HETEROCYCLIC CARBENES | HETEROAROMATIC-COMPOUNDS | ARYLBORONIC ACIDS | (HETERO)ARENES | CATALYZED DIRECT ARYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 05/2006, Volume 8, Issue 10, pp. 1979 - 1982
The synthesis and catalytic evaluation of palladium complexes containing imidazolyl carbene ligand of varying steric and electronic properties is reported.... 
PYRROLE | CHEMISTRY, ORGANIC | INDOLES
Journal Article
ISSN 1359-7345, 6/2012, Volume 48, Issue 53, pp. 6735 - 6737
The first TiCl 4 -mediated condensation of secondary amides with aldehydes and ketones has been achieved. The reaction proceeds at room temperature and is... 
Journal Article
Chemical Reviews, ISSN 0009-2665, 09/2009, Volume 109, Issue 9, p. 4439
  Multicomponent reaction strategies were developed for the synthesis of complex natural products. The use of multicomponent reaction strategies for the... 
Natural products | Chemical reactions | Chemical synthesis
Journal Article
The Journal of organic chemistry, ISSN 0022-3263, 08/2010, Volume 75, Issue 15, p. 4911
Imidazoles are an important group of the azole family of heterocycles frequently found in pharmaceuticals, drug candidates, ligands for transition metal... 
Alkylation | Imidazoles - chemistry | Arylation | Usage | Dichloropropane | Analysis | Imidazole | Chemical properties | Scanning electron microscopes | Structure
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4711 - 4723
Journal Article
Journal Article
Angewandte Chemie, ISSN 0044-8249, 11/2016, Volume 128, Issue 46, p. 14430
  Können klassische und moderne C-H-Oxidationsreaktionen Biotransformationen bei der Synthese von Wirkstoffmetaboliten ergänzen? Wir haben versucht, bei einer... 
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2015, Volume 56, Issue 23, pp. 3066 - 3069
We aim the power of C–H bond functionalization at a problem of major practical consequence—namely, scalable access to drug metabolites and their analogs. In... 
Drug metabolism | In vivo metabolites | CYP450 | C–H oxidation | Aerobic oxidation | Copper-catalysis | C-H oxidation | LEAD DIVERSIFICATION | AMINES | CHEMISTRY, ORGANIC | GENERATION | Metabolites | Copper | Cytokinins | Drugs | Cytochrome P-450 | Oxidation-reduction reaction | Catalysis
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2004, Volume 43, Issue 15, pp. 2001 - 2004
Step‐economy and stereocontrol are highlighted in a novel three‐component sequential reaction to access substituted piperidines (see scheme). Through combining... 
piperidines | multicomponent reactions | asymmetric synthesis | cycloaddition | allylation | nitrogen heterocycles | Cycloaddition | Multicomponent reactions | Asymmetric synthesis | Nitrogen heterocycles | Piperidines | Allylation
Journal Article
Chemical Communications, ISSN 1359-7345, 07/2012, Volume 48, Issue 53, pp. 6735 - 6737
The first TiCl4-mediated condensation of secondary amides with aldehydes and ketones has been achieved. The reaction proceeds at room temperature and is... 
HALIDES | RHODIUM | PALLADIUM-CATALYZED AMIDATION | 2-PYRIDONES | STEREOSELECTIVE-SYNTHESIS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | Amides - chemistry | Molecular Structure | Ketones - chemistry | Titanium - chemistry | Aldehydes - chemistry | Lewis acid | Synthesis | Amines | Ketones | Titanium | Condensing | Amides | Aldehydes
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2017, Volume 60, Issue 5, pp. 2155 - 2161
While adding the structural features that are more favored by on-target activity is the more common strategy in selectivity optimization, the opposite strategy... 
60 APPLIED LIFE SCIENCES | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
Structure, ISSN 0969-2126, 03/2017, Volume 25, Issue 3, pp. 506 - 513
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2013, Volume 4, Issue 2, pp. 186 - 190
Overexpression of the antiapoptotic members of the Bcl-2 family of proteins is commonly associated with cancer cell survival and resistance to... 
apoptosis | cancer | protein-protein interaction | B cell lymphoma | Bcl-2 family | CHEMISTRY, MEDICINAL | PRODRUGS | DEATH | ANTAGONISTS | DISCOVERY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/1999, Volume 96, Issue 4, pp. 1321 - 1326
Journal Article
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