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1. Full Text Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension: What Is the Clinical Significance?
by Touyz, Rhian M
Hypertension, ISSN 0194-911X, 09/2004, Volume 44, Issue 3, pp. 248 - 252
Metabolism of oxygen by cells generates potentially deleterious reactive oxygen species (ROS). Under normal conditions the rate and magnitude of oxidant... 
Antioxidants | Hypertension, essential | Resistance | Free radicals | Arteries | free radicals | NADPH-OXIDASE | PROTEIN | antioxidants | arteries | RATS | ANGIOTENSIN-II | ENDOTHELIAL FUNCTION | resistance | BLOOD-PRESSURE | hypertension, essential | LIFE-STYLE | NAD(P)H OXIDASES | PERIPHERAL VASCULAR DISEASE | EXPRESSION | SMOOTH-MUSCLE CELLS | Reactive Oxygen Species - metabolism | Oxidative Stress | Blood Vessels - metabolism | Humans | NADPH Oxidases - metabolism | Blood Vessels - physiopathology | Kidney - metabolism | Hypertension - prevention & control | Free Radical Scavengers - therapeutic use | Hypertension - genetics | Kidney - physiopathology | Rats, Inbred SHR | Free Radicals | Oxidation-Reduction | Rats | Antioxidants - pharmacology | Enzyme Inhibitors - therapeutic use | Hypertension - physiopathology | Hypertension - metabolism | Mice, Knockout | Randomized Controlled Trials as Topic | Antioxidants - therapeutic use | Animals | Blood Vessels - drug effects | Antioxidants - adverse effects | Mice | Lipid Peroxidation
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2. Full Text Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways: Implications in Diabetes Mellitus–Associated Obesity and Vascular Dysfunction
by Briones, Ana M and Nguyen Dinh Cat, Aurelie and Callera, Glaucia E and Yogi, Alvaro and Burger, Dylan and He, Ying and Corrêa, Jose W and Gagnon, Anne Marie and Gomez-Sanchez, Celso E and Gomez-Sanchez, Elise P and Sorisky, Alexander and Ooi, Teik Chye and Ruzicka, Marcel and Burns, Kevin D and Touyz, Rhian M
Hypertension, ISSN 0194-911X, 05/2012, Volume 59, Issue 5, pp. 1069 - 1078
We reported aldosterone as a novel adipocyte-derived factor that regulates vascular function. We aimed to investigate molecular mechanisms, signaling pathways,... 
Obesity | Adipocytes | Aldosterone | Calcineurin-NFAT | Vascular function | vascular function | calcineurin-NFAT | PERIPHERAL VASCULAR DISEASE | adipocytes | aldosterone | obesity | Diabetic Angiopathies - metabolism | Tetrazoles - pharmacology | Signal Transduction | Aldosterone - biosynthesis | Obesity - complications | Diabetes Complications - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | Diabetic Angiopathies - etiology | Adipocytes - drug effects | Random Allocation | Obesity - metabolism | Animals | Adipocytes - metabolism | Sensitivity and Specificity | Benzimidazoles - pharmacology | Mice | Calcineurin - drug effects | Calcineurin - metabolism | Disease Models, Animal
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3. Full Text Apocynin, NADPH Oxidase, and Vascular Cells: A Complex Matter
by Touyz, Rhian M
Hypertension, ISSN 0194-911X, 02/2008, Volume 51, Issue 2, pp. 172 - 174
PERIPHERAL VASCULAR DISEASE | NAD(P)H OXIDASE | MYELOPEROXIDASE | ACTIVATION | ANGIOTENSIN-II | INHIBITION | Free Radical Scavengers - pharmacology | Animals | Blood Vessels - metabolism | Humans | NADPH Oxidases - antagonists & inhibitors | Acetophenones - pharmacology | Enzyme Inhibitors - pharmacology | Blood Vessels - cytology
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4. Full Text ISH PRE-2 THE VASCULAR PHENOTYPE IN HYPERTENSION – MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS
by Touyz, Rhian M
Journal of Hypertension, ISSN 0263-6352, 09/2016, Volume 34 Suppl 1 - ISH 2016 Abstract Book, pp. e384 - e384
Pathophysiological mechanisms contributing to hypertension include endothelial dysfunction and vascular ignalling. These changes are initially adaptive but... 
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5. Full Text Hypertension Guidelines: Effect of Blood Pressure Targets
by Touyz, Rhian M
Canadian Journal of Cardiology, ISSN 0828-282X, 05/2019, Volume 35, Issue 5, pp. 564 - 569
There has been an abundance of hypertension guidelines over the years. Their purpose is to convey evidence-based findings from clinical trials to clinicians so... 
MORTALITY | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | AMERICAN-COLLEGE | PREVENTION | ADULTS | ADOPTION | CHRONIC KIDNEY-DISEASE | AWARENESS | ASSOCIATION
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6. Full Text Clinical Practice Guidelines for the Management of Hypertension in the Community: A Statement by the American Society of Hypertension and the International Society of Hypertension Clinical Practice Guidelines for the Management of Hypertension in the Community: A Statement by the American Society of Hypertension and the International Society of Hypertension Weber et al
by Weber, Michael A and Schiffrin, Ernesto L and White, William B and Mann, Samuel and Lindholm, Lars H and Kenerson, John G and Flack, John M and Carter, Barry L and Materson, Barry J and Ram, C. Venkata S and Cohen, Debbie L and Cadet, Jean-Claude and Jean-Charles, Roger R and Taler, Sandra and Kountz, David and Townsend, Raymond R and Chalmers, John and Ramirez, Agustin J and Bakris, George L and Wang, Jiguang and Schutte, Aletta E and Bisognano, John D and Touyz, Rhian M and Sica, Dominic and Harrap, Stephen B
Journal of Clinical Hypertension, ISSN 1524-6175, 01/2014, Volume 16, Issue 1, pp. 14 - 26
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7. Full Text Hypertension Editors Welcome Comments From Regional Hypertension Societies
by Dominiczak, Anna F and Touyz, Rhian M
Hypertension, ISSN 0194-911X, 04/2018, Volume 71, Issue 6, pp. 962 - 962
PERIPHERAL VASCULAR DISEASE | American Heart Association | Hypertension | United States | Humans | Proliferating Cell Nuclear Antigen | Cardiology | Advisory Committees
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8. Full Text Extracellular Vesicles as Biomarkers and Biovectors in Primary Aldosteronism
by Neves, Karla Bianca and Touyz, Rhian M
Hypertension, ISSN 0194-911X, 08/2019, Volume 74, Issue 2, pp. 250 - 252
CIRCULATING ENDOTHELIAL MICROPARTICLES | PERIPHERAL VASCULAR DISEASE
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9. Full Text The Neuroimmune Axis in the Kidney: Role in Hypertension
by Touyz, Rhian M
Circulation Research, ISSN 0009-7330, 08/2015, Volume 117, Issue 6, pp. 487 - 489
immune system | Editorials | inflammation | hypertension | sympathetic nervous system | CARDIAC & CARDIOVASCULAR SYSTEMS | DENDRITIC CELLS | RATS | BLOOD-PRESSURE | IMMUNE-SYSTEM | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | T-CELLS | Animals | Sympathectomy | Immunity, Cellular - physiology | Kidney - immunology | Kidney - innervation | Hypertension - immunology | Angiotensin II - toxicity
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10. Full Text Microglia, the Missing Link in the Brain-Gut-Hypertension Axis
by Touyz, Rhian M and Camargo, Livia L
Circulation Research, ISSN 0009-7330, 03/2019, Volume 124, Issue 5, pp. 671 - 673
blood pressure | CARDIAC & CARDIOVASCULAR SYSTEMS | inflammation | metagenomics | PERIPHERAL VASCULAR DISEASE | Editorials | HEMATOLOGY | antibiotics | BLOOD-PRESSURE | dysbiosis
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11. Full Text POA 02-3 SMALL VESSEL DISEASE AND HYPERTENSION – MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS
by Touyz, Rhian M
Journal of Hypertension, ISSN 0263-6352, 09/2016, Volume 34 Suppl 1 - ISH 2016 Abstract Book, pp. e33 - e33
Pathophysiological mechanisms contributing to hypertension include injury to small arteries, characterised by endothelial dysfunction, vascular remodeling,... 
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12. Full Text Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells
by Rhian M. Touyz and Ernesto L. Schiffrin
Pharmacological Reviews, ISSN 0031-6997, 12/2000, Volume 52, Issue 4, pp. 639 - 672
Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II (Ang II) were considered to be rapid, short-lived, and divided... 
SPONTANEOUSLY HYPERTENSIVE RATS | GROWTH-FACTOR-BETA | ACTIVATED PROTEIN-KINASE | STIMULATES TYROSINE PHOSPHORYLATION | AGONIST-INDUCED PHOSPHORYLATION | CONVERTING-ENZYME-INHIBITOR | MESSENGER-RNA EXPRESSION | INTRACELLULAR FREE MAGNESIUM | SUBCUTANEOUS SMALL ARTERIES | PHARMACOLOGY & PHARMACY | FOCAL ADHESION KINASE | Protein-Tyrosine Kinases - physiology | Angiotensin II - pharmacology | Animals | Mitogen-Activated Protein Kinases - physiology | Signal Transduction | Humans | Receptors, Angiotensin - physiology | Hypertension - etiology | Muscle, Smooth, Vascular - drug effects
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13. Full Text Hypertension Guidelines: Is It Time to Reappraise Blood Pressure Thresholds and Targets?
by Touyz, Rhian M and Dominiczak, Anna F
Hypertension, ISSN 0194-911X, 04/2016, Volume 67, Issue 4, pp. 688 - 689
PREVENTION | PERIPHERAL VASCULAR DISEASE | MANAGEMENT | SOCIETY | Reference Standards | Practice Guidelines as Topic - standards | Humans | Blood Pressure Determination - standards | Female | Male | Hypertension - therapy | Evidence-Based Medicine | Hypertension - diagnosis | Needs Assessment
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14. Full Text NOX5: Molecular biology and pathophysiology
by Touyz, Rhian M and Anagnostopoulou, Aikaterini and Rios, Francisco and Montezano, Augusto C and Camargo, Livia L
Experimental Physiology, ISSN 0958-0670, 05/2019, Volume 104, Issue 5, pp. 605 - 616
New Findings What is the topic of this review? This review provides a comprehensive overview of Nox5 from basic biology to human disease and highlights unique... 
cardiovascular disease | kidney disease | cancer | Nox isoforms | oxidative stress | reactive oxygen species | NADPH OXIDASE 5 | OXYGEN SPECIES PRODUCTION | RESPIRATORY BURST | PHYSIOLOGY | VASCULAR SMOOTH-MUSCLE | INTERACTING PROTEIN-2 | HUMAN-NEUTROPHILS | DINUCLEOTIDE PHOSPHATE OXIDASE | POTENTIAL ROLE | EXPRESSION | Oxidases | Hypertension | Medical research | Genomics | Diabetic nephropathies | Crystals | Physiological aspects | Medicine, Experimental | Structure | Cells | Reactive oxygen species | Kidneys | Calcium | NADPH-diaphorase | Cytokines | Homology | Genomes | Biology | Cell membranes | Inflammation | Contraction | NAD(P)H oxidase | Mammalian cells | Cell activation | Vasoactive agents | Transmembrane domains | Cardiovascular diseases | Growth factors | Endoplasmic reticulum | Crystal structure | Cancer | Lecture
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15. Full Text PARP-1 (Poly[ADP-Ribose] Polymerase-1): A Novel Target in Aortic Aneurysm
by Alves-Lopes, Rhéure and Touyz, Rhian M
Hypertension, ISSN 0194-911X, 11/2018, Volume 72, Issue 5, pp. 1087 - 1089
POLY(ADP-RIBOSE) POLYMERASE | PERIPHERAL VASCULAR DISEASE | INHIBITION | STRESS | E-DEFICIENT MICE
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16. Full Text Protecting the heart in obesity: Role of ACE2 and its partners
by Touyz, Rhian M
Diabetes, ISSN 0012-1797, 01/2016, Volume 65, Issue 1, pp. 19 - 21
Animals | Diet, High-Fat | Humans | Myocardium - metabolism | Heart Failure - genetics | Pericardium - immunology | Adipose Tissue - immunology | Obesity - genetics | Peptidyl-Dipeptidase A - deficiency | Macrophages - immunology | Obesity | Care and treatment | Analysis | Angiotensin II receptor blockers | Insulin resistance | Dosage and administration | Diabetes | Cardiovascular diseases | Health aspects | Risk factors
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17. Full Text Brown Adipose Tissue Regulates Small Artery Function Through NADPH Oxidase 4-Derived Hydrogen Peroxide and Redox-Sensitive Protein Kinase G-1
by Friederich-Persson, Malou and Nguyen Dinh Cat, Aurelie and Persson, Patrik and Montezano, Augusto C and Touyz, Rhian M
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2017, Volume 37, Issue 3, pp. 455 - 465
perivascular adipose tissue | cardiovascular disease | vascular function | myosin light chain | brown adipose tissue | contractility | catalase
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18. Full Text Response to the letter regarding the hypothesis paper “Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema”
by Rossitto, Giacomo and Touyz, Rhian M and Petrie, Mark C and Delles, Christian
Clinical Science, ISSN 0143-5221, 03/2019, Volume 133, Issue 6, pp. 761 - 761
Abstract This short article provides a comment on the recent letter by G. Bhave regarding our hypothesis paper [Clinical Science (2018) 132, 2609–2613]. 
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19. Full Text Hypertension
: Methods and Protocols
2017, Methods in Molecular Biology, ISBN 1493966235, Volume 1527
Molecular Medicine | Biomedicine
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20. Full Text TRPM7, Magnesium, and Signaling
by Zou, ZG and Rios, FJ and Montezano, AC and Touyz, RM
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 04/2019, Volume 20, Issue 8, p. 1877
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed chanzyme that possesses an ion channel permeable to the... 
HUMAN OSTEOBLAST | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATION CHANNEL | OSTEOGENIC DIFFERENTIATION | CHEMISTRY, MULTIDISCIPLINARY | EGFR | receptor tyrosine kinases | INDUCED PROLIFERATION | EPIDERMAL-GROWTH-FACTOR | VEGFR | ION-CHANNEL | TRPM7 | SMOOTH-MUSCLE-CELLS | ADVERSE EVENTS | magnesium transporters | Neoplasms - metabolism | Pregnancy | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Signal Transduction | Humans | Female | Magnesium - metabolism | Pre-Eclampsia - metabolism | TRPM Cation Channels - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Protein-Serine-Threonine Kinases - metabolism
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