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1. Techniques in glycobiology
by Hotchkiss, Arland T and Townsend, R. Reid, 1951
1997, ISBN 0824798228, xx, 637
Glycoconjugates | Laboratory manuals | Analysis
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2. Full Text The Haemophilus influenzae HMW1 Adhesin Is a Glycoprotein with an Unusual N-Linked Carbohydrate Modification
by Julia Gross and Susan Grass and Alan E. Davis and Petra Gilmore-Erdmann and R. Reid Townsend and Joseph W. St. Geme III
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 38, pp. 26010 - 26015
The Haemophilus influenzae HMW1 adhesin mediates adherence to respiratory epithelial cells, a critical early step in the pathogenesis of H. influenzae disease.... 
ATTACHMENT | SURFACE-LAYER | METASTABLE DECAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | GLYCOSYLATION | SECRETION | POST-SOURCE-DECAY | PROTEIN-PHOSPHORYLATION | IDENTIFICATION | PATHOGENS | Protein Structure, Tertiary | Amino Acid Sequence | Haemophilus influenzae - metabolism | Models, Chemical | Molecular Sequence Data | Glycosylation | Spectroscopy, Fourier Transform Infrared | Bacterial Adhesion | Adhesins, Bacterial - metabolism | Carbohydrates - chemistry | Mass Spectrometry | Polysaccharides - chemistry | Epithelial Cells - cytology | Glycoproteins - chemistry | Trypsin - chemistry | Index Medicus
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3. Full Text Proteogenomic characterization of human colon and rectal cancer
by Zhang, Bing and Zhang, Bing and Wang, Jing and Wang, Jing and Wang, Xiaojing and Wang, Xiaojing and Zhu, Jing and Zhu, Jing and Liu, Q and Liu, Qi and Shi, Zhiao and Shi, Zhiao and Chambers, Matthew C and Chambers, Matthew C and Zimmerman, Lisa J and Zimmerman, Lisa J and Shaddox, Kent F and Shaddox, Kent F and Kim, Sangtae and Kim, Sangtae and Davies, Sherri R and Davies, Sherri R and Wang, Sean and Wang, Sean and Wang, Pei and Wang, Pei and Kinsinger, Christopher R and Kinsinger, Christopher R and Rivers, Robert C and Rivers, Robert C and Rodriguez, Henry and Rodriguez, Henry and Townsend, R. Reid and Townsend, R Reid and Ellis, Matthew J. C and Ellis, Matthew J C and Carr, Steven A and Carr, Steven A and Tabb, David L and Tabb, David L and Coffey, Robert J and Coffey, Robert J and Slebos, Robbert J C and Slebos, Robbert J. C and Liebler, Daniel C and Liebler, Daniel C and NCI CPTAC, CPTAC and Gillette, Michael A and Klauser, Karl R and Kuhn, Eric and Mani, D.R and Mertins, Philipp and Ketchum, Karen A and Paulovich, Amanda G and Whiteaker, Jeffrey R and Edwards, Nathan J and McGarvey, Peter B and Madhavan, Subha and Chan, Daniel and Pandey, Akhilesh and Shih, Ie-Ming and Zhang, Hui and Zhang, Zhen and Zhu, Heng and Whiteley, Gordon A and Skates, Steven J and White, Forest M and Levine, Douglas A and Boja, Emily S and Hiltke, Tara and Mesri, Mehdi and Shaw, Kenna M and Stein, Stephen E and Fenyo, David and Liu, Tao and McDermott, Jason E and Payne, Samuel H and Rodland, Karin D and Smith, Richard D and Rudnick, Paul and Snyder, Michael and Zhao, Yingming and Chen, Xian and Ransohoff, David F and Hoofnagle, Andrew N and Sanders, Melinda E and Wang, Yue and Ding, Li and NCI CPTAC and the NCI CPTAC
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 382 - 387
Extensive genomic characterization of human cancers presents the problem of inference from genomic abnormalities to cancer phenotypes. To address this problem,... 
ANALYSIS REVEALS | GENE | PEPTIDE IDENTIFICATION | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | PROTEOMIC ANALYSIS | HNF4-ALPHA | RNA-SEQ DATA | MASS-SPECTROMETRY | ABUNDANCE | Colonic Neoplasms - genetics | Proteome - genetics | Genomics | Humans | RNA, Messenger - analysis | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Colonic Neoplasms - metabolism | Mutation, Missense - genetics | Mitochondrial Membrane Transport Proteins - genetics | Point Mutation - genetics | DNA Methylation | RNA, Neoplasm - analysis | Rectal Neoplasms - genetics | Neoplasm Proteins - genetics | RNA, Messenger - genetics | DNA Copy Number Variations - genetics | Hepatocyte Nuclear Factor 4 - genetics | Transcriptome - genetics | Proteome - analysis | Microsatellite Repeats - genetics | Proto-Oncogene Proteins pp60(c-src) - genetics | Proteomics | CpG Islands - genetics | RNA, Neoplasm - genetics | Neoplasm Proteins - analysis | Rectal Neoplasms - metabolism | Proteome - metabolism | Chromosomes, Human, Pair 20 - genetics | Care and treatment | Colon cancer | RNA | Analysis | Colorectal cancer | Genetic aspects | Methylation | Proteins | Peptides | Genes | Colon | Mass spectrometry | Tumors | Cancer | Index Medicus
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4. Full Text Proteogenomics connects somatic mutations to signalling in breast cancer
by Mertins, Philipp and Mani, D.R and Ruggles, Kelly V and Gillette, Michael A and Clauser, Karl R and Wang, Pei and Wang, Xianlong and Qiao, Jana W and Cao, Song and Petralia, Francesca and Kawaler, Emily and Mundt, Filip and Krug, Karsten and Tu, Zhidong and Lei, Jonathan T and Gatza, Michael L and Wilkerson, Matthew and Perou, Charles M and Yellapantula, Venkata and Huang, Kuan-Lin and Lin, Chenwei and McLellan, Michael D and Yan, Ping and Davies, Sherri R and Townsend, R. Reid and Skates, Steven J and Wang, Jing and Zhang, Bing and Kinsinger, Christopher R and Mesri, Mehdi and Rodriguez, Henry and Ding, Li and Paulovich, Amanda G and Fenyö, David and Ellis, Matthew J and Carr, Steven A and NCI CPTAC
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 55 - 62
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly... 
PATHWAYS | HETEROGENEITY | PIK3CA MUTATIONS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENES | BIOLOGY | RECEPTOR | EXPRESSION | SIGNATURE | REVEALS | Protein Kinases - metabolism | Focal Adhesion Kinase 1 - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Receptor, ErbB-2 - genetics | Receptors, G-Protein-Coupled - metabolism | Genomics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Phosphoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Phosphoproteins - analysis | Mass Spectrometry | src-Family Kinases - metabolism | Female | Cyclin-Dependent Kinases - genetics | Focal Adhesion Kinase 1 - metabolism | Chromosomes, Human, Pair 5 - genetics | Breast Neoplasms - classification | Chromosome Deletion | p21-Activated Kinases - genetics | Signal Transduction | Molecular Sequence Annotation | Calcium-Binding Proteins - deficiency | Phosphoproteins - genetics | Mutation - genetics | S-Phase Kinase-Associated Proteins - metabolism | p21-Activated Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Proteomics | S-Phase Kinase-Associated Proteins - genetics | Receptors, G-Protein-Coupled - genetics | src-Family Kinases - genetics | Calcium-Binding Proteins - genetics | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Cancer | Physiological aspects | Methods | Mutation (Biology) | Proteins | Gene amplification | Peptides | Protein expression | Genomes | Mutation | Kinases | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
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5. Full Text The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers
by Russler-Germain, David A and Spencer, David H and Young, Margaret A and Lamprecht, Tamara L and Miller, Christopher A and Fulton, Robert and Meyer, Matthew R and Erdmann-Gilmore, Petra and Townsend, R. Reid and Wilson, Richard K and Ley, Timothy J
Cancer Cell, ISSN 1535-6108, 04/2014, Volume 25, Issue 4, pp. 442 - 454
Somatic mutations in , which encodes a de novo DNA methyltransferase, are found in ∼30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations... 
DNA METHYLTRANSFERASE 3A | PROGNOSTIC IMPACT | METHYLATION | EVOLUTION | MECHANISM | ONCOLOGY | PATTERNS | ACUTE MYELOID-LEUKEMIA | OLIGOMERIZATION | EXPRESSION | SOMATIC MUTATIONS | CELL BIOLOGY | Amino Acid Sequence | Prognosis | Humans | Models, Molecular | Molecular Sequence Data | DNA (Cytosine-5-)-Methyltransferases - chemistry | DNA (Cytosine-5-)-Methyltransferases - genetics | DNA Methylation | Leukemia, Myeloid, Acute - enzymology | Alleles | Protein Conformation | Mutation | Leukemia, Myeloid, Acute - genetics | Physiological aspects | Genetic aspects | Methyltransferases | Genomics | Leukemia | Stem cells | Chromosomes | Index Medicus
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6. Full Text Wavelet-Based Peak Detection and a New Charge Inference Procedure for MS/MS Implemented in ProteoWizard's msConvert
by French, WR and Zimmerman, LJ and Schilling, B and Gibson, BW and Miller, CA and Townsend, RR and Sherrod, SD and Goodwin, CR and McLean, JA and Tabb, DL
JOURNAL OF PROTEOME RESEARCH, ISSN 1535-3893, 02/2015, Volume 14, Issue 2, pp. 1299 - 1307
We report the implementation of high-quality signal processing algorithms into ProteoWizard, an efficient, open-source software package designed for analyzing... 
MASS-SPECTROMETRY DATA | PEPTIDE IDENTIFICATION | ALGORITHM | BIOCHEMICAL RESEARCH METHODS | PROTEIN IDENTIFICATION | deconvolution | LC-MS | REDUCTION | precursor charger determination | SPECTRA | peak-packing signal | Continuous wavelet transformation | deisotoping open-source software mass spectrometry | PROTEOMICS | Algorithms | Peptides - chemistry | Tandem Mass Spectrometry - methods | Databases, Protein | Index Medicus
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7. Full Text Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry
by Chen, Zi-Wei and Fuchs, Karoline and Sieghart, Werner and Townsend, R. Reid and Evers, Alex S
Molecular and Cellular Proteomics, ISSN 1535-9476, 2012, Volume 11, Issue 1, pp. M111.011445 - M111.011445
Mass spectrometric sequencing of low abundance, integral membrane proteins, particularly the transmembrane domains, presents challenges that span the multiple... 
Amino Acid Sequence | Sequence Analysis, Protein - methods | Peptides - chemistry | Electrophoresis, Polyacrylamide Gel | Molecular Sequence Data | Rats | Receptors, GABA-A - chemistry | Animals | Protein Isoforms | Solid Phase Extraction | Chromatography, Liquid | Protein Subunits - chemistry | Neocortex | Mass Spectrometry - methods | Index Medicus
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8. Full Text Targeted peptide measurements in biology and medicine: Best practices for mass spectrometry-based assay development using a fit-for-purpose approach
by Carr, Steven A and Abbatiello, Susan E and Ackermann, Bradley L and Borchers, Christoph and Domon, Bruno and Deutsch, Eric W and Grant, Russell P and Hoofnagle, Andrew N and Hüttenhain, Ruth and Koomen, John M and Liebler, Daniel C and Liu, Tao and MacLean, Brendan and Mani, D.R and Mansfield, Elizabeth and Neubert, Hendrik and Paulovich, Amanda G and Reiter, Lukas and Vitek, Olga and Aebersold, Ruedi and Anderson, Leigh and Bethem, Robert and Blonder, Josip and Boja, Emily and Botelho, Julianne and Boyne, Michael and Bradshaw, Ralph A and Burlingame, Alma L and Chan, Daniel and Keshishian, Hasmik and Kuhn, Eric and Kinsinger, Christopher and Lee, Jerry S.H and Lee, Sang-Won and Moritz, Robert and Oses-Prieto, Juan and Rifai, Nader and Ritchie, James and Rodriguez, Henry and Srinivas, Pothur R and Townsend, R. Reid and Van Eyk, Jennifer and Whiteley, Gordon and Wiita, Arun and Weintraub, Susan
Molecular and Cellular Proteomics, ISSN 1535-9476, 2014, Volume 13, Issue 3, pp. 907 - 917
Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction monitoring (MRM) to study biological and biomedical questions is well underway... 
EUROPEAN BIOANALYSIS FORUM | QUANTITATIVE PROTEOMICS | BIOMARKER DISCOVERY | BIOCHEMICAL RESEARCH METHODS | DATA-INDEPENDENT ACQUISITION | CARDIOVASCULAR-DISEASE | ABSOLUTE QUANTIFICATION | LC-MS/MS ASSAY | ISOTOPE-DILUTION | PROTEIN IDENTIFICATION DATA | INBORN-ERRORS | Medicine | Guidelines as Topic | Reference Standards | Animals | Peptides - metabolism | Proteomics - standards | Humans | Isotope Labeling | Biological Assay - methods | Biology | Software | Mass Spectrometry - methods | Index Medicus | Technological Innovation and Resources
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9. Full Text In vivo substrates of the lens molecular chaperones [alpha]A-crystallin and [alpha]B-crystallin
by Andley, Usha P and Malone, James P and Townsend, Reid R
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4
Hemoglobin | Histones | Calpain | Comparative analysis
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10. Full Text DNMT3A Mutations in Acute Myeloid Leukemia
by Ley, Timothy J and Ding, Li and Walter, Matthew J and McLellan, Michael D and Lamprecht, Tamara and Larson, David E and Kandoth, Cyriac and Payton, Jacqueline E and Baty, Jack and Welch, John and Harris, Christopher C and Lichti, Cheryl F and Townsend, R. Reid and Fulton, Lucinda A and Fulton, Robert S and Dooling, David J and Koboldt, Daniel C and Schmidt, Heather and Zhang, Qunyuan and Osborne, John R and Lin, Ling and O'Laughlin, Michelle and McMichael, Joshua F and Delehaunty, Kim D and McGrath, Sean D and Magrini, Vincent J and Vickery, Tammi L and Hundal, Jasreet and Cook, Lisa L and Conyers, Joshua J and Swift, Gary W and Reed, Jerry P and Alldredge, Patricia A and Wylie, Todd and Walker, Jason and Kalicki, Joelle and Watson, Mark A and Heath, Sharon and Shannon, William D and Varghese, Nobish and Nagarajan, Rakesh and Westervelt, Peter and Tomasson, Michael H and Link, Daniel C and Graubert, Timothy A and DiPersio, John F and Mardis, Elaine R and Wilson, Richard K
The New England Journal of Medicine, ISSN 0028-4793, 12/2010, Volume 363, Issue 25, pp. 2424 - 2433
Whole-genome sequence analysis of cells from a patient with acute myeloid leukemia (AML) revealed a mutation in DNMT3A, which encodes an enzyme that methylates... 
ADULT PATIENTS | RECRUITMENT | DECITABINE | MEDICINE, GENERAL & INTERNAL | PROGNOSTIC IMPACT | DNA METHYLATION | METHYLTRANSFERASES | TRANSCRIPTION | GROUP-B | CLINICAL-RESPONSE | CANCER | Gene Expression | Frameshift Mutation | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Male | DNA Mutational Analysis - methods | Nucleic Acid Amplification Techniques | Leukemia, Myeloid, Acute - mortality | DNA (Cytosine-5-)-Methyltransferases - genetics | DNA Methylation | Karyotyping | Survival Analysis | Adult | Female | Mutation | Leukemia, Myeloid, Acute - genetics | Amino acids | Usage | Chemical properties | Nucleotide sequencing | Health aspects | DNA methylation | Genes | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Abridged Index Medicus
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11. Full Text Recommendations for the generation, quantification, storage, and handling of peptides used for mass spectrometry-based assays
by Hoofnagle, Andrew N and Whiteaker, Jeffrey R and Carr, Steven A and Kuhn, Eric and Liu, Tao and Massoni, Sam A and Thomas, Stefani N and Reid Townsend, R and Zimmerman, Lisa J and Boja, Emily and Chen, Jing and Crimmins, Daniel L and Davies, Sherri R and Gao, Yuqian and Hiltke, Tara R and Ketchum, Karen A and Kinsinger, Christopher R and Mesri, Mehdi and Meyer, Matthew R and Qian, Wei-Jun and Schoenherr, Regine M and Scott, Mitchell G and Shi, Tujin and Whiteley, Gordon R and Wrobel, John A and Wu, Chaochao and Ackermann, Brad L and Aebersold, Ruedi and Barnidge, David R and Bunk, David M and Clarke, Nigel and Fishman, Jordan B and Grant, Russ P and Kusebauch, Ulrike and Kushnir, Mark M and Lowenthal, Mark S and Moritz, Robert L and Neubert, Hendrik and Patterson, Scott D and Rockwood, Alan L and Rogers, John and Singh, Ravinder J and Van Eyk, Jennifer E and Wong, Steven H and Zhang, Shucha and Chan, Daniel W and Chen, Xian and Ellis, Matthew J and Liebler, Daniel C and Rodland, Karin D and Rodriguez, Henry and Smith, Richard D and Zhang, Zhen and Zhang, Hui and Paulovich, Amanda G and Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Clinical Chemistry, ISSN 0009-9147, 01/2016, Volume 62, Issue 1, pp. 48 - 69
BACKGROUND: For many years, basic and clinical researchers have taken advantage of the analytical sensitivity and specificity afforded by mass spectrometry in... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | INTERNAL STANDARD | LC-MS/MS | PROTEIN QUANTIFICATION | PROTEOTYPIC PEPTIDES | MEDICAL LABORATORY TECHNOLOGY | AMINO-ACID-ANALYSIS | QUANTITATIVE BIOANALYSIS | ISOTOPE-DILUTION | PROTEOMICS | PREDICTION | Specimen Handling | Guidelines as Topic | Peptides - isolation & purification | Research Personnel | Clinical Laboratory Techniques | Humans | Mass Spectrometry | Proteomics | Peptides - analysis | Proteins | Medical laboratories | Proteolysis | Mass spectrometry | Chemical properties | Analysis | Medical research | Reference materials | Peptides | Laboratories | Funding | Calibration | 21st century | Quality standards | Researchers | Scientific imaging | Methods | Cancer | Index Medicus | Environmental Molecular Sciences Laboratory | peptide | lc-ms | calibrators | ms | mass spectrometry | reference material | internal standards
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12. Full Text Mechanism of small heat shock protein function in vivo: A knock-in mouse model demonstrates that the R49C mutation in αA-crystallin enhances protein insolubility and cell death
by Xi, Jing-Hua and Bai, Fang and Gross, Julia and Townsend, R. Reid and Menko, A. Sue and Andley, Usha P
Journal of Biological Chemistry, ISSN 0021-9258, 02/2008, Volume 283, Issue 9, pp. 5801 - 5814
alpha A-crystallin (Cryaa/HSPB4) is a small heat shock protein and molecular chaperone that prevents nonspecific aggregation of denaturing proteins. Several... 
HEREDITARY CATARACT | SIGNALING PATHWAYS | AUTOSOMAL-DOMINANT CATARACT | LENS EPITHELIAL-CELLS | INDUCED APOPTOSIS | B-CRYSTALLIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR CHAPERONE | MISSENSE MUTATION | RESONANCE ENERGY-TRANSFER | CHAPERONE-LIKE ACTIVITY | Crystallins - metabolism | Embryonic Stem Cells - metabolism | Phosphorylation | Humans | Cataract - pathology | Apoptosis - genetics | Mutation, Missense | Cell Death - genetics | Recombination, Genetic - genetics | bcl-Associated Death Protein - metabolism | Disease Models, Animal | bcl-Associated Death Protein - genetics | Heat-Shock Proteins, Small - metabolism | Solubility | European Continental Ancestry Group | Exons - genetics | Genetic Diseases, Inborn | Mice, Transgenic | Crystallins - genetics | Cataract - metabolism | Heat-Shock Proteins, Small - genetics | Homozygote | Animals | Embryonic Stem Cells - pathology | Cataract - genetics | Heterozygote | Mice | Amino Acid Substitution | Index Medicus
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13. Full Text Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease
by Perrin, Richard J and Craig-Schapiro, Rebecca and Malone, James P and Shah, Aarti R and Gilmore, Petra and Davis, Alan E and Roe, Catherine M and Peskind, Elaine R and Li, Ge and Galasko, Douglas R and Clark, Christopher M and Quinn, Joseph F and Kaye, Jeffrey A and Morris, John C and Holtzman, David M and Townsend, Reid and Fagan, Anne M
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 1, pp. e16032 - e16032
Background: Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied during the 'preclinical' stage (pathology present with cognition... 
CARBONIC-ANHYDRASE-IV | EPITHELIUM-DERIVED FACTOR | CELL-ADHESION MOLECULE | SECRETORY GRANULE MEMBRANE | MULTIDISCIPLINARY SCIENCES | CEREBRAL-ARTERY OCCLUSION | IMMUNODEFICIENCY-VIRUS ENCEPHALITIS | AMYLOID-BETA-PROTEIN | MILD COGNITIVE IMPAIRMENT | FRONTOTEMPORAL LOBAR DEGENERATION | GENOME-WIDE ASSOCIATION | Severity of Illness Index | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Dementia - diagnosis | Electrophoresis, Gel, Two-Dimensional | Male | Alzheimer Disease - cerebrospinal fluid | Case-Control Studies | Disease Progression | Alzheimer Disease - diagnosis | Tandem Mass Spectrometry | Aged, 80 and over | Female | ROC Curve | Aged | Biomarkers - cerebrospinal fluid | Cerebrospinal Fluid Proteins - analysis | Early Diagnosis | Enzymes | Advertising executives | Medical research | Care and treatment | Medicine, Experimental | Biological markers | Alzheimer's disease | Enzyme-linked immunosorbent assay |