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Neurology, ISSN 0028-3878, 04/2014, Volume 82, Issue 15, pp. 1373 - 1373
Primary CNS lymphoma (PCNSL), a type of extranodal non-Hodgkin lymphoma, is a potentially curable brain cancer. Ongoing randomized trials assessing treatments... 
CLINICAL NEUROLOGY | Female | Male | Lymphoma - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Central Nervous System Neoplasms - drug therapy | Humans | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 47, pp. 19059 - 19064
Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms... 
Oxygen | Perfusion | Glioblastoma | Biological markers | Radiotherapy | Blood | Tissue oxygenation | Tumors | Cancer | Blood plasma | VEGFR2 | VASCULAR NORMALIZATION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | brain tumor | RADIATION | personalized treatment | TEMOZOLOMIDE | GROWTH-FACTOR RECEPTOR | ANTIANGIOGENIC THERAPY | AMPLIFICATION | MICROENVIRONMENT | TYROSINE KINASE INHIBITOR | Prospective Studies | Humans | Brain Neoplasms - pathology | Quinazolines | Glioblastoma - radiotherapy | Brain Neoplasms - metabolism | Oxygen - metabolism | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Polymerase Chain Reaction | Statistics, Nonparametric | Glioblastoma - metabolism | Brain Neoplasms - radiotherapy | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Enzyme-Linked Immunosorbent Assay | Angiogenesis Inhibitors - pharmacology | Treatment Outcome | Brain Neoplasms - drug therapy | Receptor Protein-Tyrosine Kinases - metabolism | Biomarkers, Tumor - blood | Magnetic Resonance Imaging | Glioblastoma - pathology | Protein Kinase Inhibitors - pharmacology | Glioblastoma - drug therapy | Cancer patients | Chemotherapy | Patient outcomes | Physiological aspects | Dosage and administration | Drug therapy | Glioblastoma multiforme | Methods | Cediranib | Survival analysis | Cell growth | Biomarkers | Clinical trials | Kinases | Patients | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, pp. e17948 - e17948
Pleomorphic xanthoastrocytoma (PXA) is low-grade glial neoplasm principally affecting children and young adults. Approximately 40% of PXA are reported to recur... 
ACTIVATION | FUSION | ANAPLASTIC FEATURES | GANGLIOGLIOMA | IDH1 | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | DUPLICATION | MAPK PATHWAY | EXPRESSION | GENETIC ALTERATIONS | Immunohistochemistry | Phosphorylation | Astrocytoma - therapy | Glioma - diagnosis | Humans | Middle Aged | Molecular Sequence Data | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Glioma - genetics | Young Adult | Astrocytoma - pathology | DNA Mutational Analysis | Base Sequence | Glioma - pathology | Glioma - therapy | Adult | Female | Astrocytoma - diagnosis | Child | Proto-Oncogene Proteins B-raf - metabolism | Astrocytoma - genetics | Genotype | In Situ Hybridization, Fluorescence | Mutation - genetics | Proto-Oncogene Proteins B-raf - genetics | Adolescent | Polymorphism, Single Nucleotide - genetics | Care and treatment | Gene mutations | Gliomas | Analysis | Brain tumors | Genetic aspects | Diagnosis | Radiotherapy | Health aspects | Brain | Brain cancer | Glioblastoma | Radiation | Oncology | Metastasis | Medical diagnosis | Cancer therapies | Medical schools | Gene sequencing | Cell growth | Children | Medical research | Young adults | Hematology | Astrocytes | Melanoma | Extracellular signal-regulated kinase | Central nervous system diseases | Radiation therapy | Children & youth | Pathology | Chemotherapy | Womens health | Medical prognosis | Adults | Diagnostic systems | Mutation | Cancer | Tumors | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4476 - 4481
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously... 
Anti-angiogenic therapy | Macrophage polarization | Tumor microenvironment | Microglia reprogramming | Anti-tumor immunity | anti-angiogenic therapy | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | macrophage polarization | RANDOMIZED-TRIAL | ANGIOPOIETIN-2 | CANCER | THERAPY | microglia reprogramming | TIE2-EXPRESSING MONOCYTES | BLOOD-VESSELS | TUMOR-ASSOCIATED MACROPHAGES | tumor microenvironment | NORMALIZATION | anti-tumor immunity | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Antibodies, Bispecific - pharmacology | Vesicular Transport Proteins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Macrophages - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Animals | Antibodies, Neoplasm - pharmacology | Ribonuclease, Pancreatic - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Mice | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Models | Macrophages | Vascular endothelial growth factor | Health aspects | Glioblastoma multiforme | Genotype & phenotype | Survival analysis | Protein expression | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4470 - 4475
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2)... 
Anti-angiogenic therapy | Colony-stimulating factor 1 | Tumor immunity | Tumor microenvironment | Macrophage | anti-angiogenic therapy | ANGIOPOIETIN-2 FUNCTIONS | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | macrophage | BEVACIZUMAB PLUS IRINOTECAN | RANDOMIZED-TRIAL | ANTIBODY | tumor immunity | KINASE INHIBITOR | ANTIANGIOGENIC THERAPY | PHASE-II TRIAL | colony-stimulating factor 1 | tumor microenvironment | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Macrophages - metabolism | Animals | Antibodies, Neoplasm - pharmacology | Receptors, Vascular Endothelial Growth Factor - metabolism | Ribonuclease, Pancreatic - metabolism | Neovascularization, Pathologic - drug therapy | Glioblastoma - pathology | Cell Line, Tumor | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Glioblastoma - metabolism | Mice | Neovascularization, Pathologic - metabolism | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Quinazolines - pharmacology | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Survival analysis | Gene expression | Kinases | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2010, Volume 28, Issue 17, pp. 2817 - 2823
Journal Article
Journal Article