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by Swerdlow, Daniel I, Dr and Preiss, David, Dr and Kuchenbaecker, Karoline B, MSc and Holmes, Michael V, PhD and Engmann, Jorgen E L, MSc and Shah, Tina, PhD and Sofat, Reecha, MD and Stender, Stefan, MD and Johnson, Paul C D, PhD and Scott, Robert A, PhD and Leusink, Maarten, MSc and Verweij, Niek, MD and Sharp, Stephen J, MSc and Guo, Yiran, PhD and Giambartolomei, Claudia, MSc and Chung, Christina, MSc and Peasey, Anne, PhD and Amuzu, Antoinette, MSc and Li, KaWah, MSc and Palmen, Jutta, MSc and Howard, Philip, MSc and Cooper, Jackie A, MSc and Drenos, Fotios, PhD and Li, Yun R, BSc and Lowe, Gordon, Prof and Gallacher, John, PhD and Stewart, Marlene C W, PhD and Tzoulaki, Ioanna, PhD and Buxbaum, Sarah G, PhD and van der A, Daphne L, PhD and Forouhi, Nita G, MRCP and Onland-Moret, N Charlotte, PhD and van der Schouw, Yvonne T, Prof and Schnabel, Renate B, MD and Hubacek, Jaroslav A, PhD and Kubinova, Ruzena, MD and Baceviciene, Migle, MD and Tamosiunas, Abdonas, Prof and Pajak, Andrzej, Prof and Topor-Madry, Romanvan, MD and Stepaniak, Urszula, PhD and Malyutina, Sofia, Prof and Baldassarre, Damiano, PhD and Sennblad, Bengt, PhD and Tremoli, Elena, Prof and de Faire, Ulf, Prof and Veglia, Fabrizio, PhD and Ford, Ian, Prof and Jukema, J Wouter, Prof and Westendorp, Rudi G J, Prof and de Borst, Gert Jan, MD and de Jong, Pim A, MD and Algra, Ale, Prof and Spiering, Wilko, MD and der Zee, Anke H Maitland-van, PhD and Klungel, Olaf H, PharmD and de Boer, Anthonius, Prof and Doevendans, Pieter A, Prof and Eaton, Charles B, Prof and Robinson, Jennifer G, Prof and Duggan, David, PhD and Kjekshus, John, Prof and Downs, John R, MD and Gotto, Antonio M, MD and Keech, Anthony C, MD and Marchioli, Roberto, MD and Tognoni, Gianni, MD and Sever, Peter S, Prof and Poulter, Neil R, Prof and Waters, David D, MD and Pedersen, Terje R, MD and Amarenco, Pierre, MD and Nakamura, Haruo, MD and McMurray, John J V, Prof and Lewsey, James D, PhD and Chasman, Daniel I, PhD and Ridker, Paul M, MD and Maggioni, Aldo P, Prof and Tavazzi, Luigi, Prof and Ray, Kausik K, Prof and Seshasai, Sreenivasa Rao Kondapally, MD and Manson, JoAnn E, Prof and Price, Jackie F, MD and Whincup, Peter H, Prof and Morris, Richard W, Prof and Lawlor, Debbie A, Prof and Smith, George Davey, Prof and Ben-Shlomo, Yoav, Prof and Schreiner, Pamela J, Prof and Fornage, Myriam, Prof and Siscovick, David S, Prof and Cushman, Mary, MD and Kumari, Meena, PhD and Wareham, Nick J, Prof and Verschuren, W M Monique, PhD and Redline, Susan, Prof and Patel, Sanjay R, MD and Whittaker, John C, Prof and Hamsten, Anders, Prof and Delaney, Joseph A, PhD and ... and MAGIC Consortium and InterAct Consortium and DIAGRAM Consortium
The Lancet, ISSN 0140-6736, 01/2015, Volume 385, Issue 9965, pp. 351 - 361
Summary Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of... 
Internal Medicine | LDL CHOLESTEROL | MEDICINE, GENERAL & INTERNAL | HIGH-DOSE ATORVASTATIN | METAANALYSIS | STATIN THERAPY | ASSOCIATION ANALYSES | DISEASE | PREVENTION | BODY-MASS INDEX | RISK | MENDELIAN RANDOMIZATION | Type 2 diabetes | Genetic research | Enzymes | Thiols | Diabetes | Low density lipoprotein | Statins | Cholesterol | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e39484 - e39484
Background: Neutrophils are involved in thrombus formation. We investigated whether specific features of neutrophil activation characterize patients with acute... 
PENTRAXIN 3 | LEUKOCYTE INTERACTIONS | STERILE INFLAMMATION | THROMBUS FORMATION | IN-VIVO | ADHERENT PLATELETS | BIOLOGY | P-SELECTIN | ACUTE CORONARY SYNDROMES | PLATELET ACTIVATION | GIANT-CELL ARTERITIS | Angina, Unstable - metabolism | Neutrophil Activation - immunology | P-Selectin - metabolism | Humans | Middle Aged | Autoimmune Diseases - immunology | Neutrophils - immunology | Male | Myocardial Infarction - metabolism | Myocardial Infarction - immunology | Animals | Angina, Unstable - immunology | Adult | Female | Aged | Mice | Autoimmune Diseases - metabolism | Neutrophils - metabolism | Disease Models, Animal | Peroxidase - metabolism | Infection | Medical research | Rheumatoid factor | Cardiac patients | Medicine, Experimental | Arthritis | Angina pectoris | Thrombosis | Heart attack | Blood clot | Integrins | Myocardial infarction | Flow cytometry | Heart attacks | Cardiomyopathy | Disorders | Cardiovascular disease | Activation | Angina | Kinases | Inflammatory diseases | Arteritis | Cell activation | Vasculitis | Blood platelets | Ischemia | Peroxidase | Thromboembolism | Systemic vasculitis | Heart failure | Neutrophils | Glycoproteins | Leukocytes (neutrophilic) | Pattern recognition | Patients | White blood cells | Cytometry | Monocytes | Infectious diseases | Depletion | Fractures | Rheumatoid arthritis | Myocardium | Sepsis | Ligands | Infarction | Bone | Diabetes | Acute coronary syndromes | Autoimmune diseases | Platelets | P-selectin | Index Medicus
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2014, Volume 18, Issue 9, pp. 1785 - 1796
Journal Article
by Willer, Cristen J and Schmidt, Ellen M and Sengupta, Sebanti and Peloso, Gina M and Gustafsson, Stefan and Kanoni, Stavroula and Ganna, Anea and Chen, Jin and Buchkovich, Martin L and Mora, Samia and Beckmann, Jacques S and Bragg-Gresham, Jennifer L and Chang, Hsing-Yi and Demirkan, Ayşe and den Hertog, Heleen M and Do, Ron and Donnelly, Louise A and Ehret, Georg B and Esko, Tõnu and Feitosa, Mary F and Ferreira, Teresa and Fischer, Krista and Fontanillas, Pierre and Fraser, Ross M and Freitag, Daniel F and Gurdasani, Deepti and Heikkilä, Kauko and Hyppönen, Elina and Isaacs, Aaron and Jackson, Anne U and Johansson, Asa and Johnson, Toby and Kaakinen, Marika and Kettunen, Johannes and Kleber, Marcus E and Li, Xiaohui and Luan, Jian'an and Lyytikäinen, Leo-Pekka and Magnusson, Patrik K. E and Mangino, Massimo and Mihailov, Evelin and Montasser, May E and Müller-Nurasyid, Martina and Nolte, Ilja M and O'Connell, Jeffrey R and Palmer, Cameron D and Perola, Markus and Petersen, Ann-Kristin and Sanna, Serena and Saxena, Richa and Service, Susan K and Shah, Sonia and Shungin, Dmitry and Sidore, Carlo and Song, Ci and Strawbridge, Rona J and Surakka, Ida and Tanaka, Toshiko and Teslovich, Tanya M and Thorleifsson, Gudmar and van den Herik, Evita G and Voight, Benjamin F and Volcik, Kelly A and Waite, Lindsay L and Wong, Anew and Wu, Ying and Zhang, Weihua and Absher, Devin and Asiki, Gershim and Barroso, Inês and Been, Latonya F and Bolton, Jennifer L and Bonnycastle, Lori L and Brambilla, Paolo and Burnett, Mary S and Cesana, Giancarlo and Dimitriou, Maria and Doney, Alex S. F and Döring, Angela and Elliott, Paul and Epstein, Stephen E and Eyjolfsson, Gudmundur Ingi and Gigante, Bruna and Goodarzi, Mark O and Grallert, Harald and Gravito, Martha L and Groves, Christopher J and Hallmans, Göran and Hartikainen, Anna-Liisa and Hayward, Caroline and Hernandez, Dena and Hicks, Anew A and Holm, Hilma and Hung, Yi-Jen and Illig, Thomas and Jones, Michelle R and Kaleebu, Pontiano and Kastelein, John J. P and Khaw, Kay-Tee and Kim, Eric and ... and Global Lipids Genetics Consortium and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Institutionen för odontologi and Näringsforskning and Umeå universitet and Medicin
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 11, pp. 1274 - 1283
Journal Article
by Wood, Anew R and Esko, Tonu and Yang, Jian and Vedantam, Sailaja and Pers, Tune H and Gustafsson, Stefan and Chu, Auey Y and Estrada, Karol and Luan, Jian'an and Kutalik, Zoltán and Amin, Najaf and Buchkovich, Martin L and Croteau-Chonka, Damien C and Day, Felix R and Duan, Yanan and Fall, Tove and Fehrmann, Rudolf and Ferreira, Teresa and Jackson, Anne U and Karjalainen, Juha and Lo, Ken Sin and Locke, Adam E and Mägi, Reedik and Mihailov, Evelin and Porcu, Eleonora and Randall, Joshua C and Scherag, Ané and Vinkhuyzen, Anna A. E and Westra, Harm-Jan and Winkler, Thomas W and Workalemahu, Tsegaselassie and Zhao, Jing Hua and Absher, Devin and Albrecht, Eva and Anderson, Denise and Baron, Jeffrey and Beekman, Marian and Demirkan, Ayse and Ehret, Georg B and Feenstra, Bjarke and Feitosa, Mary F and Fischer, Krista and Fraser, Ross M and Goel, Anuj and Gong, Jian and Justice, Anne E and Kanoni, Stavroula and Kleber, Marcus E and Kristiansson, Kati and Lim, Unhee and Lotay, Vaneet and Lui, Julian C and Mangino, Massimo and Mateo Leach, Irene and Medina-Gomez, Carolina and Nalls, Michael A and Nyholt, Dale R and Palmer, Cameron D and Pasko, Dorota and Pechlivanis, Sonali and Prokopenko, Inga and Ried, Janina S and Ripke, Stephan and Shungin, Dmitry and Stancáková, Alena and Strawbridge, Rona J and Sung, Yun Ju and Tanaka, Toshiko and Teumer, Alexander and Trompet, Stella and van der Laan, Sander W and van Setten, Jessica and van Vliet-Ostaptchouk, Jana V and Wang, Zhaoming and Yengo, Loïc and Zhang, Weihua and Afzal, Uzma and Arnlöv, Johan and Arscott, Gillian M and Bandinelli, Stefania and Barrett, Amy and Bellis, Claire and Bennett, Amanda J and Berne, Christian and Blüher, Matthias and Bolton, Jennifer L and Böttcher, Yvonne and Boyd, Heather A and Bruinenberg, Marcel and Buckley, Brendan M and Buyske, Steven and Caspersen, Ida H and Chines, Peter S and Clarke, Robert and Claudi-Boehm, Simone and Cooper, Matthew and Daw, E. Warwick and de Jong, Pim A and Deelen, Joris and Delgado, Graciela and ... and PAGE Consortium and MIGen Consortium and LifeLines Cohort Study and Elect Med Records & Genom eMERGE C and Electronic Medical Records and Genomics (eMEMERGEGE) Consortium and PAGEGE Consortium and The MIGen Consortium and The PAGE Consortium and The Electronic Medical Records and Genomics (eMERGE) Consortium and The LifeLines Cohort Study and Högskolan Dalarna and Akademin Utbildning, hälsa och samhälle and Medicinsk vetenskap
Nature genetics, ISSN 1061-4036, 2014, Volume 46, Issue 11, pp. 1173 - 1186
Journal Article
by Helgadottir, Anna, MD, PhD and Gretarsdottir, Solveig, PhD and Thorleifsson, Gudmar, PhD and Holm, Hilma, MD and Patel, Riyaz S., MD and Gudnason, Thorarinn, MD, PhD and Jones, Gregory T., PhD and van Rij, Andre M., MD and Eapen, Danny J., MD and Baas, Annette F., PhD and Tregouet, David-Alexandre, PhD and Morange, Pierre-Emmanuel, MD and Emmerich, Joseph, MD, PhD and Lindblad, Bengt, MD, PhD and Gottsäter, Anders, MD, PhD and Kiemeny, Lambertus A., PhD and Lindholt, Jes S., MD, PhD and Sakalihasan, Natzi, MD, PhD and Ferrell, Robert E., PhD and Carey, David J., PhD and Elmore, James R., MD and Tsao, Philip S., PhD and Grarup, Niels, MD, PhD and Jørgensen, Torben, MD, DMSci and Witte, Daniel R., MD, PhD and Hansen, Torben, MD, PhD and Pedersen, Oluf, MD, DMSci and Pola, Roberto, MD, PhD and Gaetani, Eleonora, MD and Magnadottir, Hulda B., MD and Wijmenga, Cisca, PhD and Tromp, Gerard, PhD and Ronkainen, Antti, MD, PhD and Ruigrok, Ynte M., MD and Blankensteijn, Jan D and Mueller, Thomas, MD and Wells, Philip S., MD and Corral, Javier, PhD and Soria, Jose Manuel, PhD and Souto, Juan Carlos, MD, PhD and Peden, John F., PhD and Jalilzadeh, Shapour, MD, PhD and Mayosi, Bongani M., DPhil and Keavney, Bernard, MD and Strawbridge, Rona J., PhD and Sabater-Lleal, Maria, PhD and Gertow, Karl, PhD and Baldassarre, Damiano, PhD and Nyyssönen, Kristiina, PhD and Rauramaa, Rainer, MD, PhD and Smit, Andries J., MD, PhD and Mannarino, Elmo, MD and Giral, Philippe, MD and Tremoli, Elena, PhD and de Faire, Ulf, MD, PhD and Humphries, Steve E., PhD and Hamsten, Anders, MD, PhD and Haraldsdottir, Vilhelmina, MD and Olafsson, Isleifur, MD, PhD and Magnusson, Magnus K., MD and Samani, Nilesh J., MD and Levey, Allan I., MD, PhD and Markus, Hugh S., MD and Kostulas, Konstantinos, MD, PhD and Dichgans, Martin, MD and Berger, Klaus, MD and Kuhlenbäumer, Gregor, MD and Ringelstein, E. Bernd, MD and Stoll, Monika, PhD and Seedorf, Udo, PhD and Rothwell, Peter M., MD, PhD and Powell, Janet T., MD and Kuivaniemi, Helena, MD, PhD and Onundarson, Pall T., MD and Valdimarsson, Einar, MD and Matthiasson, Stefan E., MD, PhD and Gudbjartsson, Daniel F., PhD and Thorgeirsson, Guðmundur, MD, PhD and Quyyumi, Arshed A., MD and Watkins, Hugh, MD, PhD and Farrall, Martin, MD and Thorsteinsdottir, Unnur, PhD and Stefansson, Kari, MD, PhD and Lund University and Vascular Diseases - Clinical Research and Vaskulära sjukdomar - kliniska studier and Lunds universitet
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2012, Volume 60, Issue 8, pp. 722 - 729
Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene ( LPA ) on vascular diseases with different... 
Cardiovascular | Internal Medicine | atherosclerosis | genetic | association | thrombosis | lipoprotein(a) | INTIMA-MEDIA THICKNESS | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | METAANALYSIS | MYOCARDIAL-INFARCTION | VASCULAR-DISEASE | WOMEN | PERIPHERAL ARTERIAL-DISEASE | ISCHEMIC-STROKE | SEVERITY | Severity of Illness Index | Myocardial Infarction - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Apolipoproteins A - genetics | Angiography | Carotid Intima-Media Thickness | Intracranial Aneurysm - genetics | Atherosclerosis - genetics | Humans | Risk Factors | Brain Ischemia - genetics | African Americans - genetics | Linear Models | Logistic Models | Aortic Aneurysm, Abdominal - genetics | Stroke - genetics | Venous Thromboembolism - genetics | Peripheral Arterial Disease - genetics | Age of Onset | Coronary Artery Disease - genetics | Polymorphism, Single Nucleotide | Odds Ratio | Medical colleges | Neurosciences | Stock options | Genes | Aneurysms | Coronary heart disease | Biometry | Lipoprotein A | Anopheles | Atherosclerosis | Medical genetics | Genetic research | Genetic aspects | Diabetes | Thromboembolism | Cardiology | Public health | Dementia | Stroke | Medical imaging | Values | Cardiovascular disease | Apolipoproteins | Thrombosis | Studies | Confidence intervals | Coronary vessels | Blood pressure | Drug therapy | Age | Methods | Index Medicus | Abridged Index Medicus | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e41786 - e41786
Background: Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular... 
THERAPEUTICS | INFARCTION | INHIBITION | MULTIDISCIPLINARY SCIENCES | 5-LIPOXYGENASE/LEUKOTRIENE PATHWAY | CARDIOVASCULAR-DISEASE | SLEEP-APNEA | ISCHEMIA | DEFICIENT MICE | EXPRESSION | CORONARY-ARTERIES | Myocardial Ischemia - metabolism | Up-Regulation | Apolipoproteins E - deficiency | Signal Transduction | Humans | Stress, Physiological | Atherosclerosis - complications | Male | Myocardium - pathology | Receptors, Leukotriene - genetics | Myocardial Ischemia - pathology | Cell Hypoxia | Leukotrienes - metabolism | Animals | Glutathione Transferase - genetics | Myocardial Ischemia - complications | Myocardium - metabolism | Myocardial Ischemia - physiopathology | Female | Aged | Cysteine - metabolism | Mice | Disease Models, Animal | Heart | Enzymes | Medical research | Hypercholesterolemia | RNA | Medicine, Experimental | Sleep apnea syndromes | Inflammation | Research | Coronary heart disease | Heart attacks | Enzyme activity | Montelukast | Myocardial ischemia | Cardiovascular disease | Antagonists | Sleep apnea | Biochemistry | Inflammatory diseases | Interleukin 6 | Leukotriene-C4 synthase | Sleep disorders | Receptors | Apnea | Ischemia | Enzymatic activity | Apolipoprotein E | Rodents | Atherosclerosis | Heart diseases | Coronary artery | Pharmacology | Permeability | Gene expression | Coronary artery disease | Asthma | Medicine | Signaling | Ethnicity | Sleep | Leukotrienes | Arteriosclerosis | Collagen | Fibrosis | Myocardium | Hypoxia | Apoptosis | Index Medicus
Journal Article