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Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144017
G-protein-coupled receptor (GPCR) agonists are known to induce both cellular adaptations resulting in tolerance to therapeutic effects and withdrawal symptoms... 
METABOTROPIC GLUTAMATE-RECEPTOR | SUPRACHIASMATIC NUCLEUS | MOOD DISORDERS | PHARMACOLOGICAL CHARACTERIZATION | MULTIDISCIPLINARY SCIENCES | ACETYLCHOLINE-RELEASE | CENTRAL-NERVOUS-SYSTEM | GROUP-II | PREFRONTAL CORTEX | REM-SLEEP | AMYGDALA | Cricetulus | Sleep, REM - physiology | Allosteric Regulation | Humans | Male | Receptors, Metabotropic Glutamate - metabolism | Bridged Bicyclo Compounds - adverse effects | Receptors, Metabotropic Glutamate - genetics | Cell Membrane - metabolism | Cell Membrane - drug effects | CHO Cells | Binding, Competitive | Recombinant Proteins - metabolism | Sleep, REM - drug effects | Gene Expression | Triazines - pharmacology | Drug Administration Schedule | Allosteric Site - drug effects | Drug Tolerance | Rats | Recombinant Proteins - genetics | Rats, Sprague-Dawley | Animals | Protein Binding | Wakefulness - physiology | Excitatory Amino Acid Agonists - adverse effects | Ligands | Molecular Docking Simulation | Pyridines - pharmacology | Structural Homology, Protein | Receptors, Metabotropic Glutamate - agonists | Physiological aspects | Cell receptors | Genetic aspects | Sleep | Research | Adaptations | Drugs | Neurosciences | Substance abuse treatment | G protein-coupled receptors | Mental disorders | Sleep (REM) | Glutamic acid receptors | Selectivity | Rapid eye movement state | Eye movements | Recovery | Proteins | Receptors | Allosteric properties | Antidepressants | Rodents | Modulation | Docking | Drug dosages | Sleep and wakefulness | Pharmaceutical sciences | Translation | Effectiveness | Withdrawal | Research & development--R&D | Latency | Studies | Brain research | In vivo methods and tests | Psychiatry | Glutamic acid receptors (metabotropic) | Neurotransmission | Binding sites | Chronic effects | Research & development | R&D
Journal Article
Journal Article
Drug Discovery Today, ISSN 1359-6446, 10/2017, Volume 22, Issue 10, pp. 1478 - 1488
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9089 - 9106
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4883 - 10
A congeneric series of 21 phosphodiesterase 2 (PDE2) inhibitors are reported. Crystal structures show how the molecules can occupy a 'top-pocket' of the active... 
TARGET | DESIGN | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LEAD OPTIMIZATION | PERTURBATION | DYNAMICS | FORCE-FIELD | SIMULATION | AFFINITIES | ACCURACY | Proteins | Leucine | Protein structure | Free energy | Crystal structure | Phosphodiesterase
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 7, pp. 2231 - 2241
Statistical analysis reveals the important molecular properties affecting fast and slow dissociating D receptor antagonists. Dopamine D receptor antagonism is... 
Fast dissociation | Residence time | QSAR | koff | Off-rate | Antipsychotic | Atypical | Kinetics | Multivariate analysis | Dopamine D 2 receptor | D 2 antagonist | PRIDOPIDINE | CHEMISTRY, MEDICINAL | Dopamine D-2 receptor | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | CHEMISTRY, ORGANIC | k(off) | OCCUPANCY | ANTIPSYCHOTICS | BINDING-AFFINITY | D-2 antagonist | DOPAMINE | APPLICABILITY | (-)-OSU6162
Journal Article