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1. Full Text Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia
by Kastelein, John J.P and Akdim, Fatima and Stroes, Erik S.G and Zwinderman, Aeilko H and Bots, Michiel L and Stalenhoef, Anton F.H and Visseren, Frank L.J and Sijbrands, Eric J.G and Trip, Mieke D and Stein, Evan A and Gaudet, Daniel and Duivenvoorden, Raphael and Veltri, Enrico P and Marais, A. David and de Groot, Eric and ENHANCE Investigators
The New England journal of medicine, ISSN 0028-4793, 04/2008, Volume 358, Issue 14, pp. 1431 - 1443
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Metabolic diseases | General aspects | Medical sciences | Disorders of blood lipids. Hyperlipoproteinemia | Femoral Artery - pathology | Simvastatin - therapeutic use | Tunica Media - pathology | Simvastatin - adverse effects | Cholesterol - blood | Humans | Middle Aged | Ezetimibe | Male | Hyperlipoproteinemia Type II - pathology | Ultrasonography | Adult | Cholesterol, LDL - blood | Female | Tunica Intima - diagnostic imaging | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Double-Blind Method | Azetidines - adverse effects | Treatment Outcome | Anticholesteremic Agents - adverse effects | Tunica Media - diagnostic imaging | Anticholesteremic Agents - therapeutic use | Carotid Arteries - diagnostic imaging | Femoral Artery - diagnostic imaging | Tunica Intima - pathology | Azetidines - therapeutic use | Triglycerides - blood | Carotid Arteries - pathology | Proteolipids | Care and treatment | Lipoproteins | Hypercholesterolemia | Atherosclerosis | Research | Blood lipoproteins | Health aspects | Diet | Cardiovascular disease | Cholesterol | Statins | Veins & arteries | Ambulatory care | Index Medicus | Abridged Index Medicus
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2. Full Text Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy
by Akdim, Fatima and Stroes, Erik S.G and Sijbrands, Eric J.G and Tribble, Diane L and Trip, Mieke D and Jukema, J. Wouter and Flaim, JoAnn D and Su, John and Yu, Rosie and Baker, Brenda F and Wedel, Mark K and Kastelein, John J.P
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2010, Volume 55, Issue 15, pp. 1611 - 1618
inhibition | randomized control trial | apolipoprotein B | low-density lipoprotein cholesterol | statins | mipomersen | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Apolipoproteins B - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Hypercholesterolemia - blood | Prevalence | Double-Blind Method | Drug Administration Schedule | Follow-Up Studies | Oligonucleotides - therapeutic use | Humans | Middle Aged | Cholesterol, LDL - drug effects | Male | Treatment Outcome | Apolipoproteins B - biosynthesis | Apolipoproteins B - blood | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Injections, Subcutaneous | Cholesterol, LDL - blood | Female | Retrospective Studies | Oligonucleotides - administration & dosage | Drug Therapy, Combination | Enzymes | Lipids | Triglycerides | Apolipoproteins | Low density lipoprotein | Drug dosages | Cholesterol | Statins
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3. Full Text Efficacy and Safety of Coadministration of Ezetimibe and Simvastatin in Adolescents With Heterozygous Familial Hypercholesterolemia
by van der Graaf, Anouk and Cuffie-Jackson, Cynthia and Vissers, Maud N and Trip, Mieke D and Gagné, Claude and Shi, Genming and Veltri, Enrico and Avis, Hans J and Kastelein, John J.P
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2008, Volume 52, Issue 17, pp. 1421 - 1429
simvastatin | heterozygous familial hypercholesterolemia | ezetimibe | safety | efficacy | pediatric | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Double-Blind Method | Simvastatin - administration & dosage | Humans | Ezetimibe | Male | Treatment Outcome | Azetidines - administration & dosage | Time Factors | Anticholesteremic Agents - administration & dosage | Adolescent | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Teenagers | Drug therapy | Metabolic disorders | Cholesterol
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4. Full Text Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study
by Sivapalaratnam, Suthesh and Boekholdt, S Matthijs and Trip, Mieke D and Sandhu, Manjinder S and Luben, Robert and Kastelein, John J P and Wareham, Nicholas J and Khaw, Kay-Tee
Heart (British Cardiac Society), ISSN 1355-6037, 12/2010, Volume 96, Issue 24, pp. 1985 - 1989
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Gynecology. Andrology. Obstetrics | Diseases of mother, fetus and pregnancy | Biological and medical sciences | Pregnancy. Fetus. Placenta | Medical sciences | Coronary heart disease | Prospective Studies | Risk Assessment | Humans | Middle Aged | Risk Factors | Coronary Disease - epidemiology | Male | Coronary Disease - genetics | Pedigree | England - epidemiology | Age of Onset | Adult | Female | Aged | Genetic aspects | Diagnosis | Research | Risk factors | Studies | Cardiovascular disease | Heart attacks | Health risk assessment | Index Medicus | Abridged Index Medicus
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5. ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia the CAPTIVATE randomized trial
by Meuwese, Marijn C and De Groot, Eric and Duivenvoorden, Raphaël and Trip, Mieke D and Ose, Leiv and Maritz, Frans J and Basart, Dick C. G and Kastelein, John J. P and Habib, Rafik and Davidson, Michael H and Zwinderman, Aeilko H and Schwocho, Lee R and Stein, Evan A and CAPTIVATE Investigators
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 03/2009, Volume 301, Issue 11, pp. 1131 - 1139
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Carotid Artery Diseases - prevention & control | Prospective Studies | Double-Blind Method | Hyperlipoproteinemia Type II - blood | Humans | Middle Aged | Male | Biomarkers - blood | Enzyme Inhibitors - therapeutic use | Indoleacetic Acids - therapeutic use | Disease Progression | Carotid Artery Diseases - diagnostic imaging | Carotid Artery Diseases - blood | Ultrasonography | Female | Hypolipidemic Agents - therapeutic use | Hyperlipoproteinemia Type II - drug therapy | Sterol O-Acyltransferase - antagonists & inhibitors | Clinical trials | Cardiovascular disease | Inhibitor drugs | Medical disorders | Medical treatment | Cholesterol
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6. Full Text Diagnosing familial hypercholesterolaemia: the relevance of genetic testing
by van Aalst-Cohen, Emily S and Jansen, Angelique C. M and Tanck, Michael W. T and Defesche, Joep C and Trip, Mieke D and Lansberg, Peter J and Stalenhoef, Anton F. H and Kastelein, John J. P
European heart journal, ISSN 0195-668X, 2006, Volume 27, Issue 18, pp. 2240 - 2246
Familial hypercholesterolaemia | Diagnostic methods | Genetic testing | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Receptors, LDL - genetics | Humans | Middle Aged | Risk Factors | Hyperlipoproteinemia Type II - diagnosis | Male | Mutation - genetics | Genetic Counseling | Phenotype | Adult | Female | Retrospective Studies | Cohort Studies | Hyperlipoproteinemia Type II - genetics | Index Medicus
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7. Full Text Arterial stiffness is increased in families with premature coronary artery disease
by Mulders, Ties A and van den Bogaard, Bas and Bakker, Annemieke and Trip, Mieke D and Stroes, Erik S and van den Born, Bert-Jan H and Pinto-Sietsma, Sara-Joan
Heart (British Cardiac Society), ISSN 1355-6037, 03/2012, Volume 98, Issue 6, pp. 490 - 494
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Vascular Stiffness - genetics | Prospective Studies | Coronary Artery Disease - physiopathology | Coronary Artery Disease - complications | Humans | Middle Aged | Coronary Artery Disease - genetics | Pulse | Female | Male | Case-Control Studies | Measurement | Causes of | Blood pressure | Diagnosis | Cardiovascular diseases | Coronary heart disease | Risk factors | Hypertension | Heart attacks | Mortality | Cardiovascular disease | Family medical history | Cholesterol | Studies | Algorithms | Womens health | Coronary vessels | Health risk assessment | Age | Index Medicus | Abridged Index Medicus
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8. Full Text A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis
by Maiwald, Stephanie and Motazacker, Mahdi M and van Capelleveen, Julian C and Sivapalaratnam, Suthesh and van der Wal, Allard C and van der Loos, Chris and Kastelein, John J. P and Ouwehand, Willem H and Hovingh, G. Kees and Trip, Mieke D and van Buul, Jaap D and Dallinga-Thie, Geesje M
European journal of human genetics : EJHG, ISSN 1018-4813, 2016, Volume 24, Issue 1, pp. 86 - 91
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Plaque, Atherosclerotic - genetics | Atherosclerosis - genetics | Humans | Middle Aged | Molecular Sequence Data | Male | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Transfection | Base Sequence | Plasmids - genetics | Adult | Female | Rho Guanine Nucleotide Exchange Factors - metabolism | Plaque, Atherosclerotic - pathology | Genetic Linkage | Atherosclerosis - pathology | Plaque, Atherosclerotic - metabolism | Signal Transduction | Gene Expression Regulation | Rho Guanine Nucleotide Exchange Factors - genetics | Atherosclerosis - metabolism | Pedigree | Age of Onset | Plasmids - chemistry | Protein Binding | HeLa Cells | Mutation | rac1 GTP-Binding Protein - metabolism | Cohort Studies | rac1 GTP-Binding Protein - genetics | Amino acid sequence | RhoA protein | Cardiovascular disease | Rac1 protein | Genomes | Guanine | Proteins | Lipoproteins | Arteriosclerosis | Atherosclerosis | Low density lipoprotein receptors | Genetics | Cardiovascular diseases | Linkage analysis | Index Medicus
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9. Full Text Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study
by Sivapalaratnam, Suthesh and Farrugia, Rosienne and Nieuwdorp, Max and Langford, Cordelia F and van Beem, Rachel T and Maiwald, Stephanie and Zwaginga, Jaap Jan and Gusnanto, Arief and Watkins, Nicholas A and Trip, Mieke D and Ouwehand, Willem H
BMC medical genomics, ISSN 1755-8794, 2011, Volume 4, Issue 1, pp. 64 - 64
Human | In Vivo | Monocytes | LPS infusion | Transcriptome | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Young Adult | Injections, Intravenous | Oligonucleotide Array Sequence Analysis | Atherosclerosis - genetics | Humans | Lipopolysaccharides - administration & dosage | Gene Expression Regulation | Inflammation - genetics | Male | Monocytes - metabolism | Monocytes - immunology | Atherosclerosis - metabolism | Polymerase chain reaction | Usage | Atherosclerosis | Physiological aspects | Genetic aspects | Research | Gene expression | Lipopolysaccharides | Medical research | Heart attacks | Health services | Colleges & universities | Family medical history | Experiments | Manuscripts | Index Medicus
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10. Full Text Common genetic variants do not associate with CAD in familial hypercholesterolemia
by van Iperen, Erik P. A and Sivapalaratnam, Suthesh and Boekholdt, S. Matthijs and Hovingh, G. Kees and Maiwald, Stephanie and Tanck, Michael W and Soranzo, Nicole and Stephens, Jonathan C and Sambrook, Jennifer G and Levi, Marcel and Ouwehand, Willem H and Kastelein, John Jp and Trip, Mieke D and Zwinderman, Aeilko H
European journal of human genetics : EJHG, ISSN 1018-4813, 2014, Volume 22, Issue 6, pp. 809 - 813
association | GWAS | CAD | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Genetic Predisposition to Disease - genetics | Gene Frequency | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Genotype | Male | Transcription Factors - genetics | Risk Assessment - statistics & numerical data | Disease-Free Survival | Coronary Artery Disease - genetics | Female | Aged | Polymorphism, Single Nucleotide | Nuclear Proteins - genetics | DNA Helicases - genetics | Hyperlipoproteinemia Type II - genetics | Lipoproteins (low density) | Risk groups | Coronary artery | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Survival | Low density lipoprotein | Studies | Genetic variance | Hypercholesterolemia | Lipoprotein (low density) receptors | Cardiovascular diseases | Health risk assessment | Heart diseases | Index Medicus | FH
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11. Full Text Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia
by van Wissen, Sanne and Smilde, Tineke J and Trip, Mieke D and Stalenhoef, Anton F.H and Kastelein, John J.P
The American journal of cardiology, ISSN 0002-9149, 2005, Volume 95, Issue 2, pp. 264 - 266
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Drug Administration Schedule | Hyperlipoproteinemia Type II - blood | Cholesterol - blood | Humans | Middle Aged | Male | Treatment Outcome | Coronary Artery Disease - drug therapy | Coronary Artery Disease - blood | Randomized Controlled Trials as Topic | Atorvastatin Calcium | Pyrroles - administration & dosage | Coronary Artery Disease - pathology | Hyperlipoproteinemia Type II - pathology | Triglycerides - blood | Cholesterol, HDL - blood | Heptanoic Acids - administration & dosage | Adult | Cholesterol, LDL - blood | Female | Aged | Hyperlipoproteinemia Type II - drug therapy | Longitudinal Studies | Care and treatment | Hypercholesterolemia | Simvastatin | Low density lipoproteins | Atherosclerosis | Development and progression | Genetic aspects | Studies | Blood vessels | Safety | Drug therapy | Cholesterol | Index Medicus | Abridged Index Medicus
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12. Full Text Atherosclerosis in Patients With Cyanotic Congenital Heart Disease
by Duffels, Mariëlle GJ and Mulder, Karlijn M and Trip, Mieke D and de Groot, Erik and Gort, Johan and van Dijk, Arie PJ and Hoendermis, Elke S and Daliento, Luciano and Zwinderman, Aeiko H and Berger, Rolf MF and Mulder, Barbara JM
Circulation journal : official journal of the Japanese Circulation Society, ISSN 1346-9843, 2010, Volume 74, Issue 7, pp. 1436 - 1441
Carotid intima - media thickness | Eisenmenger syndrome | Cyanotic congenital heart disease | Atherosclerosis | Carotid intima-media thickness | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Blood Pressure | Cholesterol - blood | Humans | Middle Aged | Risk Factors | Blood Platelets | Male | Heart Diseases - congenital | Case-Control Studies | Bilirubin - blood | Adolescent | Cyanosis | Adult | Female | Heart Diseases - pathology | Index Medicus
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