Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (13) 13
article (10) 10
animals (9) 9
gene expression (9) 9
humans (8) 8
mice (8) 8
genomics (7) 7
multidisciplinary sciences (7) 7
research (7) 7
rna, messenger - genetics (6) 6
gene expression profiling (5) 5
genetic aspects (5) 5
ribonucleic acid--rna (5) 5
rna-seq (5) 5
heterogeneity (4) 4
male (4) 4
rna sequencing (4) 4
sequence analysis, rna - methods (4) 4
single-cell analysis (4) 4
biochemistry & molecular biology (3) 3
cell biology (3) 3
cytokines (3) 3
gene-expression (3) 3
genetic research (3) 3
mice, inbred c57bl (3) 3
physiological aspects (3) 3
rna (3) 3
sequence analysis, rna (3) 3
single-cell analysis - methods (3) 3
transcriptome (3) 3
tumors (3) 3
base sequence (2) 2
biochemistry, genetics and molecular biology (2) 2
brain neoplasms - classification (2) 2
brain neoplasms - drug therapy (2) 2
brain neoplasms - genetics (2) 2
cell communication (2) 2
cell cycle (2) 2
cell differentiation (2) 2
cell growth (2) 2
cellular biology (2) 2
dendritic cells - immunology (2) 2
evolution (2) 2
exome - genetics (2) 2
expression (2) 2
female (2) 2
flexible materials not otherwise provided for (2) 2
gene (2) 2
gene expression regulation - immunology (2) 2
gene sequencing (2) 2
genetic transcription (2) 2
genetic variation (2) 2
genomes (2) 2
glioblastoma - classification (2) 2
glioblastoma - drug therapy (2) 2
glioblastoma - genetics (2) 2
immune response (2) 2
job satisfaction (2) 2
laundering (2) 2
laundering, drying, ironing, pressing or folding textilearticles (2) 2
metastasis (2) 2
methods (2) 2
microfluidic analytical techniques (2) 2
mutation - genetics (2) 2
neoplastic cells, circulating (2) 2
noise (2) 2
observations (2) 2
paper (2) 2
prognosis (2) 2
prostatic neoplasms - genetics (2) 2
proteins (2) 2
reproducibility of results (2) 2
rna, messenger - chemistry (2) 2
signal transduction (2) 2
single-cell rna-seq (2) 2
textiles (2) 2
transcription, genetic (2) 2
treatment of textiles or the like (2) 2
2-component regulatory system (1) 1
activation (1) 1
acuity (1) 1
adults (1) 1
aged (1) 1
aged, 80 and over (1) 1
airway inflammation (1) 1
allergens (1) 1
allergic reaction (1) 1
allergies (1) 1
allergy (1) 1
amacrine cells (1) 1
analysis (1) 1
antigens, viral - pharmacology (1) 1
anxieties (1) 1
articular-cartilage repair (1) 1
asthma (1) 1
atopic-dermatitis (1) 1
axl kinase (1) 1
bacteria (1) 1
beta-tricalcium phosphate (1) 1
biochemistry, general (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
by Macosko, Evan Z and Basu, Anindita and Satija, Rahul and Nemesh, James and Shekhar, Karthik and Goldman, Melissa and Tirosh, Itay and Bialas, Allison R and Kamitaki, Nolan and Martersteck, Emily M and Trombetta, John J and Weitz, David A and Sanes, Joshua R and Shalek, Alex K and Regev, Aviv and McCarroll, Steven A
Cell, ISSN 0092-8674, 05/2015, Volume 161, Issue 5, pp. 1202 - 1214
Cells, the basic units of biological structure and function, vary broadly in type and state. Single-cell genomics can characterize cell identity and function,... 
AMACRINE CELLS | GENE | RNA-SEQ | BIOCHEMISTRY & MOLECULAR BIOLOGY | RETINA | LENS | CELL BIOLOGY | Microfluidic Analytical Techniques | Genome-Wide Association Study | Animals | Sequence Analysis, RNA | Retina - cytology | Gene Expression Profiling - methods | High-Throughput Nucleotide Sequencing | Mice | Single-Cell Analysis | Genetic transcription | RNA | Analysis | Genomics | Genomes | Gene expression | Population genetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons
by Habib, Naomi and Li, Yinqing and Heidenreich, Matthias and Swiech, Lukasz and Avraham-Davidi, Inbal and Trombetta, John J and Hession, Cynthia and Zhang, Feng and Regev, Aviv
Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, pp. 925 - 928
Single-cell RNA sequencing (RNA-Seq) provides rich information about cell types and states. However, it is difficult to capture rare dynamic processes, such as... 
NEURAL STEM-CELLS | SPINAL-CORD | TRANSCRIPTOME | MULTIDISCIPLINARY SCIENCES | Cell Division - genetics | Spinal Cord - metabolism | Transcriptome | Neurons - cytology | Hippocampus - cytology | Deoxyuridine - analysis | Neurogenesis - genetics | Sequence Analysis, RNA - methods | Hippocampus - metabolism | Animals | Cell Nucleus - metabolism | Deoxyuridine - analogs & derivatives | Single-Cell Analysis - methods | Spinal Cord - pathology | Isotope Labeling | Transcription, Genetic | Mice | Neurons - metabolism | RNA sequencing | Observations | Neurons | Neurogenesis | Methods | Cell growth | Gene expression | Ribonucleic acid--RNA | Cytoplasm | Ribonucleic acids | Dynamics | Adults | Marking | Nuclei | Gene sequencing
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
by Patel, Anoop P and Tirosh, Itay and Trombetta, John J and Shalek, Alex K and Gillespie, Shawn M and Wakimoto, Hiroaki and Cahill, Daniel P and Nahed, Brian V and Curry, William T and Martuza, Robert L and Louis, David N and Rozenblatt-Rosen, Orit and Suvà, Mario L and Regev, Aviv and Bernstein, Bradley E
Science, ISSN 0036-8075, 2014, Volume 344, Issue 6190, pp. 1396 - 1401
Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect... 
STEM-LIKE CELLS | EVOLUTION | GENOTYPE | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | GROWTH | RECEPTOR | EXPRESSION | CANCER | TUMOR HETEROGENEITY | REVEALS | RNA sequencing | Epigenetic inheritance | Oncology, Experimental | Genetic research | Genetic aspects | Research | Glioblastoma multiforme | Cancer | Ribonucleic acid--RNA | Gene expression | Genomics | Brain cancer | Tumors | Brain | Heterogeneity | Genes | Genetics | Genomes | Sequencing
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
by Shalek, Alex K and Satija, Rahul and Adiconis, Xian and Gertner, Rona S and Gaublomme, Jellert T and Raychowdhury, Raktima and Schwartz, Schraga and Yosef, Nir and Malboeuf, Christine and Lu, Diana and Trombetta, John J and Gennert, Dave and Gnirke, Andreas and Goren, Alon and Hacohen, Nir and Levin, Joshua Z and Park, Hongkun and Regev, Aviv
Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7453, pp. 236 - 240
Recent molecular studies have shown that, even when derived from a seemingly homogenous population, individual cells can exhibit substantial differences in... 
LEVEL | MESSENGER-RNA-SEQ | PATHWAY | MULTIDISCIPLINARY SCIENCES | STAT2 Transcription Factor | Reproducibility of Results | Bone Marrow Cells - cytology | Gene Expression Regulation - immunology | Dendritic Cells - immunology | RNA, Messenger - genetics | RNA, Messenger - analysis | In Situ Hybridization, Fluorescence | Viruses - immunology | Gene Expression Profiling | Transcriptome - genetics | Interferons - immunology | Lipopolysaccharides - immunology | Mice, Knockout | Animals | Sequence Analysis, RNA | Interferon Regulatory Factor-7 | Bone Marrow Cells - immunology | RNA Splicing - immunology | Dendritic Cells - cytology | Mice | Single-Cell Analysis | Dendritic Cells - metabolism | Protein Isoforms - genetics | RNA sequencing | Phenotype | Cellular control mechanisms | Research | Gene expression | Observations | Testing | Proteins | Noise | Cell cycle
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
by Tirosh, Itay and Izar, Benjamin and Prakadan, Sanjay M and Wadsworth, Marc H and Treacy, Daniel and Trombetta, John J and Rotem, Asaf and Rodman, Christopher and Lian, Christine and Murphy, George and Fallahi-Sichani, Mohammad and Dutton-Regester, Ken and Lin, Jia-Ren and Cohen, Ofir and Shah, Parin and Lu, Diana and Genshaft, Alex S and Hughes, Travis K and Ziegler, Carly G.K and Kazer, Samuel W and Gaillard, Aleth and Kolb, Kellie E and Villani, Alexandra-Chloé and Johannessen, Cory M and Andreev, Aleksandr Y and Van Allen, Eliezer M and Bertagnolli, Monica and Sorger, Peter K and Sullivan, Ryan J and Flaherty, Keith T and Frederick, Dennie T and Jané-Valbuena, Judit and Yoon, Charles H and Rozenblatt-Rosen, Orit and Shalek, Alex K and Regev, Aviv and Garraway, Levi A
Science, ISSN 0036-8075, 04/2016, Volume 352, Issue 6282, pp. 189 - 196
To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from... 
HETEROGENEITY | CTLA-4 BLOCKADE | SAFETY | MULTIDISCIPLINARY SCIENCES | RESISTANCE | SENSITIVITY | NIVOLUMAB | EXPRESSION | T-CELLS | EXHAUSTION | AXL KINASE | Skin Neoplasms - pathology | Microphthalmia-Associated Transcription Factor - metabolism | Lymphocyte Activation | Stromal Cells - pathology | Genomics | Humans | Transcriptome | Cell Communication | Tumor Microenvironment | Melanoma - secondary | RNA - genetics | Drug Resistance, Neoplasm - genetics | Neoplasm Metastasis | Sequence Analysis, RNA | Cell Cycle | Melanoma - genetics | Base Sequence | Immunotherapy | T-Lymphocytes - immunology | T-Lymphocytes - pathology | Endothelial Cells - pathology | Melanoma - therapy | Single-Cell Analysis | RNA sequencing | Genetic aspects | Metastasis | Methods | Melanoma | Cellular biology | Ribonucleic acid--RNA | Drug resistance | Tumors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
by Shalek, Alex K and Satija, Rahul and Shuga, Joe and Trombetta, John J and Gennert, Dave and Lu, Diana and Chen, Peilin and Gertner, Rona S and Gaublomme, Jellert T and Yosef, Nir and Schwartz, Schraga and Fowler, Brian and Weaver, Suzanne and Wang, Jing and Wang, Xiaohui and Ding, Ruihua and Raychowdhury, Raktima and Friedman, Nir and Hacohen, Nir and Park, Hongkun and May, Andrew P and Regev, Aviv
Nature, ISSN 0028-0836, 2014, Volume 510, Issue 7505, pp. 363 - 369
High-throughput single-cell transcriptomics offers an unbiased approach for understanding the extent, basis and function of gene expression variation between... 
IMMUNE | VARIABILITY | DETERMINES | ACTIVATION | TRANSCRIPTOME | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | STOCHASTICITY | PRINCIPLES | I INTERFERON | Microfluidic Analytical Techniques | Antigens, Viral - pharmacology | Paracrine Communication | Gene Expression Regulation - immunology | Dendritic Cells - immunology | RNA, Messenger - genetics | Cell Communication | Gene Expression Profiling | Animals | Base Sequence | Interferon-beta - genetics | Dendritic Cells - drug effects | RNA, Messenger - chemistry | Mice | Single-Cell Analysis | Immunity - genetics | Principal Component Analysis | Physiological aspects | Unicellular organisms | Cell research | Research | RNA | Dendritic cells | Principal components analysis | Cytokines | Gene expression | Ribonucleic acid--RNA | Genomics | Immune system
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Dynamic regulatory network controlling T H 17 cell differentiation
by Yosef, Nir and Shalek, Alex K and Gaublomme, Jellert T and Jin, Hulin and Lee, Youjin and Awasthi, Amit and Wu, Chuan and Karwacz, Katarzyna and Xiao, Sheng and Jorgolli, Marsela and Gennert, David and Satija, Rahul and Shakya, Arvind and Lu, Diana Y and Trombetta, John J and Pillai, Meenu R and Ratcliffe, Peter J and Coleman, Mathew L and Bix, Mark and Tantin, Dean and Park, Hongkun and Kuchroo, Vijay K and Regev, Aviv
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7446, pp. 461 - 468
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
by Avraham, Roi and Haseley, Nathan and Brown, Douglas and Penaranda, Cristina and Jijon, Humberto B and Trombetta, John J and Satija, Rahul and Shalek, Alex K and Xavier, Ramnik J and Regev, Aviv and Hung, Deborah T
Cell, ISSN 0092-8674, 09/2015, Volume 162, Issue 6, pp. 1309 - 1321
Encounters between immune cells and invading bacteria ultimately determine the course of infection. These interactions are usually measured in populations of... 
2-COMPONENT REGULATORY SYSTEM | RECOGNITION | RNA-SEQ | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | SALMONELLA | TYPHIMURIUM | INFECTION | III SECRETION | VIRULENCE | CELL BIOLOGY | Host-Pathogen Interactions | Salmonella typhimurium - physiology | Animals | Specific Pathogen-Free Organisms | Mice, Inbred C57BL | Salmonella Infections - immunology | Lipopolysaccharides - metabolism | Salmonella Infections - microbiology | Mice | Interferon Type I - immunology | Macrophages - immunology | Bacteria | Immune response | RNA | Gene expression | Gastrointestinal diseases | host-pathogen interaction | macrophage | Single-cell RNA-seq | Salmonella typhimurium | Type I interferon response
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
by Lohr, Jens G and Adalsteinsson, Viktor A and Cibulskis, Kristian and Choudhury, Atish D and Rosenberg, Mara and Cruz-Gordillo, Peter and Francis, Joshua M and Zhang, Cheng-Zhong and Shalek, Alex K and Satija, Rahul and Trombetta, John J and Lu, Diana and Tallapragada, Naren and Tahirova, Narmin and Kim, Sora and Blumenstiel, Brendan and Sougnez, Carrie and Lowe, Alarice and Wong, Bang and Auclair, Daniel and Van Allen, Eliezer M and Nakabayashi, Mari and Lis, Rosina T and Lee, Gwo-Shu M and Li, Tiantian and Chabot, Matthew S and Ly, Amy and Taplin, Mary-Ellen and Clancy, Thomas E and Loda, Massimo and Regev, Aviv and Meyerson, Matthew and Hahn, William C and Kantoff, Philip W and Golub, Todd R and Getz, Gad and Boehm, Jesse S and Love, J Christopher
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 5, pp. 479 - 484
Comprehensive analyses of cancer genomes promise to inform prognoses and precise cancer treatments. A major barrier, however, is inaccessibility of metastatic... 
BREAST-CANCER | HETEROGENEITY | EVOLUTION | COPY-NUMBER | RNA-SEQ | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | MUTATIONAL LANDSCAPE | FRAMEWORK | GENOME | PROGRESSION | Genomics | Genetic research | Genetic aspects | Diagnosis | Metastasis | Research | Prostate cancer | Cellular biology | Tumors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Deconstructing transcriptional heterogeneity in pluripotent stem cells
by Kumar, Roshan M and Cahan, Patrick and Shalek, Alex K and Satija, Rahul and Keyser, Ajay Daley and Li, Hu and Zhang, Jin and Pardee, Keith and Gennert, David and Trombetta, John J and Ferrante, Thomas C and Regev, Aviv and Daley, George Q and Collins, James J
Nature, ISSN 0028-0836, 12/2014, Volume 516, Issue 729, pp. 56 - 61
Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct substates; however, the regulatory circuits specifying these states and... 
GROUND-STATE | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | BIOLOGY | GENE-EXPRESSION | SELF-RENEWAL | NOISE | GENERATION | NANOG | DIFFERENTIATION | MICRORNA | Animals | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Signal Transduction | Gene Expression Regulation, Developmental | Cell Division | Pluripotent Stem Cells - physiology | Cell Death | MicroRNAs - metabolism | Gene Expression Profiling | Mice | Embryonic Stem Cells - physiology | Genetic research | Genetic aspects | Genetic transcription | Research | Stem cells | Cell division | Cell growth | Transcription factors | Metabolism | Gene expression
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights