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Medicinal chemistry (Shariqah (United Arab Emirates)), ISSN 1573-4064, 2019, Volume 15, Issue 1, pp. 102 - 118
Background: Thalidomide, the first synthesized phthalimide, has demonstrated sedative-hypnotic and antiepileptic effects on the central nervous system.... 
chirality | thalidomide | anticonvulsant | Phthalimide moiety | mice | sedative | glutamate | CHEMISTRY, MEDICINAL | ANXIETY | BEHAVIOR | DOCKING | NECROSIS-FACTOR-ALPHA | ELEVATED PLUS-MAZE | NMDA RECEPTOR ANTAGONISTS | SEIZURES | DERIVATIVES | Hypnotics and Sedatives - chemistry | Hypnotics and Sedatives - chemical synthesis | Anticonvulsants - chemical synthesis | Stereoisomerism | Humans | Seizures - drug therapy | Anti-Anxiety Agents - pharmacology | Male | Phthalimides - chemistry | Anticonvulsants - pharmacology | Phthalimides - pharmacology | Animals | Phthalimides - chemical synthesis | Anti-Anxiety Agents - chemical synthesis | Receptors, N-Methyl-D-Aspartate - chemistry | Anticonvulsants - chemistry | Anti-Anxiety Agents - chemistry | Ligands | Hypnotics and Sedatives - pharmacology | Mice | Molecular Docking Simulation | Receptors, Metabotropic Glutamate - chemistry | Locomotion - drug effects | Biological properties | Animal models | Model testing | Phthalimide | Central nervous system | N-Methyl-D-aspartic acid receptors | Homology | Glutamic acid receptors | Molecular docking | Substitutes | Stereoselectivity | Organic chemistry | Receptors | Anticonvulsants | Synthesis | Phthalimides | Field tests | In vivo methods and tests | Convulsions | Thalidomide | Glutamic acid receptors (metabotropic) | Locomotor activity | Open-field behavior
Journal Article
Molecules, ISSN 1420-3049, 2019, Volume 24, Issue 11, p. 2061
Two 2,3-disubstituted benzofurans (1 and 2), analogs of gamma-aminobutyric acid (GABA), were synthesized to obtain their 2,3-dihydro derivatives from the... 
selectivity | local reactivity | catalytic reduction | electrophilic | olefinic carbons | global reactivity | OXIDATION | ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | CHEMISTRY | NUCLEOPHILICITY | DENSITY-FUNCTIONAL THEORY
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 01/2018, Volume 22, Issue 3, pp. 298 - 306
Background: In the last few decades, research into boron-containing compounds (BCCs) has notably increased in medicinal chemistry. Multiple maladies are now... 
Computational chemistry | Boron | Molecular dynamics | Organo-metallic | Docking | Drug design | Bioinformatics | GSK2251052 | CARBORANE CLUSTERS | DIAGNOSIS | DESIGN | drug design | CHEMISTRY, ORGANIC | computational chemistry | molecular dynamics | organo-metallic | DISCOVERY | docking | POTENT | bioinformatics | INHIBITORS | BINDING | INSIGHTS
Journal Article
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 8/2017, Volume 182, Issue 4, pp. 1478 - 1490
The enzyme 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGR) is a glycoprotein of the endoplasmic reticulum that participates in the mevalonate pathway, the... 
Biochemistry, general | EC .34 | Biotechnology | HMGR inhibitors | Chemistry | Antifungal | C andida glabrata | Recombinant HMGR | Heterologous expression | Candida glabrata | EC 1.1.1.34 | HMGRinhibitors | COENZYME-A REDUCTASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC PORTION | INHIBITION | GENE | CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RESISTANCE | SIMVASTATIN | Temperature | Humans | Substrate Specificity | Molecular Targeted Therapy | Simvastatin - pharmacology | Hydroxymethylglutaryl CoA Reductases - metabolism | Protein Domains | Drug Evaluation, Preclinical | Hydroxymethylglutaryl CoA Reductases - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Biocatalysis | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemical synthesis | Enzyme Stability | Solubility | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Maltose-Binding Proteins - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Escherichia coli - genetics | Kinetics | Candida glabrata - genetics | Candida glabrata - enzymology | Hydroxymethylglutaryl CoA Reductases - genetics | Hydrogen-Ion Concentration | Enzymes | Hypercholesterolemia | Analysis | Escherichia coli | Phytosterols | Mycoses | Plant lipids | Health aspects | Statins | Sugars | Protein binding | Drugs | Ergosterol | Yeast | Mycosis | Simvastatin | Glycoprotein | Maltose-binding protein | Maltose | Drug development | Gene expression | Cholesterol | Fungi | Mevalonic acid | E coli | Temperature effects | Drug therapy | Endoplasmic reticulum | Recombinant | Reductase
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 11/2013, Volume 56, Issue 21, pp. 8207 - 8223
Because they represent attractive drug targets, adrenoceptors have been widely studied. Recent progress in structural data of beta-adrenoceptors allows us to... 
BETA-2-ADRENERGIC RECEPTOR | BETA ADRENERGIC-RECEPTOR | CHEMISTRY, MEDICINAL | 2ND EXTRACELLULAR LOOP | CRYSTAL-STRUCTURE | PROTEIN-COUPLED-RECEPTORS | HIGH-AFFINITY BINDING | ALLOSTERIC MODULATION | MOLECULAR-DYNAMICS SIMULATIONS | BETA-ADRENERGIC RECEPTOR
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 5, p. 1128
Journal Article
Journal Article
Neurotoxicology, ISSN 0161-813X, 09/2017, Volume 62, pp. 92 - 99
[Display omitted] •We analyzed the toxicity of boronic acids with five-membered cycles as substituent.•We found different profiles for each tested... 
Cerebellum | Boron | Basal ganglia | Thiophen | Dopamine | Movement disorders | OXIDATIVE STRESS | MOUSE |