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PLOS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0119738
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2009, Volume 329, Issue 3, pp. 995 - 1005
The Smoothened receptor (Smo) mediates hedgehog (Hh) signaling critical for development, cell growth, and migration, as well as stem cell maintenance. Aberrant... 
SYSTEM | SONIC HEDGEHOG | BASAL-CELL CARCINOMA | FRACTURE REPAIR | PHARMACOLOGY & PHARMACY | MUTATIONS | SKIN | TUMORS | EXPRESSION | HEDGEHOG SIGNALING PATHWAY | NIH 3T3 Cells | Receptors, G-Protein-Coupled - metabolism | Humans | Benzamides - metabolism | Piperazines - metabolism | Thiophenes - metabolism | Tomatine - chemistry | Piperazines - chemistry | Receptors, G-Protein-Coupled - agonists | Veratrum Alkaloids - metabolism | Benzimidazoles - chemistry | Anilides | Pyrazoles - chemistry | Transfection | Smoothened Receptor | Cell Membrane - metabolism | Molecular Structure | Radioligand Assay | beta-Lactamases - metabolism | Binding Sites | Benzamides - chemistry | Binding, Competitive | Recombinant Proteins - metabolism | Cell Line | Pyridines | Recombinant Proteins - antagonists & inhibitors | Purines - metabolism | Cyclohexylamines - chemistry | Recombinant Proteins - chemistry | Genes, Reporter - genetics | Morpholines - metabolism | Tomatine - metabolism | Recombinant Proteins - agonists | Tomatine - analogs & derivatives | Pyrazoles - metabolism | Morpholines - chemistry | Veratrum Alkaloids - chemistry | Animals | Purines - chemistry | Benzimidazoles - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice | Kinetics | Thiophenes - chemistry | Cyclohexylamines - metabolism | Receptors, G-Protein-Coupled - chemistry
Journal Article
G3-GENES GENOMES GENETICS, ISSN 2160-1836, 11/2019, Volume 9, Issue 11, pp. 3791 - 3800
A variety of genetic techniques have been devised to determine cell lineage relationships during tissue development. Some of these systems monitor cell... 
SYSTEM | EYE | MARKED CLONES | education | G-TRACE | GENETICS & HEREDITY | NEURONS | CURE | GENERATION | gene expression | STEM | cure | g-trace | stem
Journal Article
by Milne, Roger L and Burwinkel, Barbara and Michailidou, Kyriaki and Arias Perez, Jose-Ignacio and Pilar Zamora, M and Menéndez-Rodríguez, Primitiva and Hardisson, David and Mendiola, Marta and González-Neira, Anna and Pita, Guillermo and Rosario Alonso, M and Dennis, Joe and Wang, Qin and Bolla, Manjeet K and Swerdlow, Anthony and Ashworth, Alan and Orr, Nick and Schoemaker, Minouk and Ko, Yon-Dschun and Brauch, Hiltrud and Hamann, Ute and Andrulis, Irene L and Knight, Julia A and Glendon, Gord and Tchatchou, Sandrine and Matsuo, Keitaro and Ito, Hidemi and Iwata, Hiroji and Tajima, Kazuo and Li, Jingmei and Brand, Judith S and Brenner, Hermann and Dieffenbach, Aida Karina and Arndt, Volker and Stegmaier, Christa and Lambrechts, Diether and Peuteman, Gilian and Christiaens, Marie-Rose and Smeets, Ann and Jakubowska, Anna and Lubinski, Jan and Jaworska-Bieniek, Katarzyna and Durda, Katazyna and Hartman, Mikael and Hui, Miao and Lim, Wei Yen and Chan, Ching Wan and Marme, Federick and Yang, Rongxi and Bugert, Peter and Lindblom, Annika and Margolin, Sara and García-Closas, Montserrat and Chanock, Stephen J and Lissowska, Jolanta and Figueroa, Jonine D and Bojesen, Stig E and Nordestgaard, Børge G and Flyger, Henrik and Hooning, Maartje J and Kriege, Mieke and van den Ouweland, Ans M.W and Koppert, Linetta B and Fletcher, Olivia and Johnson, Nichola and dos-Santos-Silva, Isabel and Peto, Julian and Zheng, Wei and Deming-Halverson, Sandra and Shrubsole, Martha J and Long, Jirong and Chang-Claude, Jenny and Rudolph, Anja and Seibold, Petra and Flesch-Janys, Dieter and Winqvist, Robert and Pylkäs, Katri and Jukkola-Vuorinen, Arja and Grip, Mervi and Cox, Angela and Cross, Simon S and Reed, Malcolm W.R and Schmidt, Marjanka K and Broeks, Annegien and Cornelissen, Sten and Braaf, Linde and Kang, Daehee and Choi, JiYeob and Park, Sue K and Noh, Dong-Young and Simard, Jacques and Dumont, Martine and Goldberg, Mark S and Labrèche, France and Fasching, Peter A and Hein, Alexander and Ekici, Arif B and Beckmann, Matthias W and Radice, Paolo and Peterlongo, Paolo and ... and Australian Ovarian Canc Study Grp and kConFab Investigators and TNBCC and GENICA Network and Australian Ovarian Cancer Study Group and The GENICA Network
Human Molecular Genetics, ISSN 0964-6906, 11/2014, Volume 23, Issue 22, pp. 6096 - 6111
Journal Article
by Guo, Xingyi and Long, Jirong and Zeng, Chenjie and Michailidou, Kyriaki and Ghoussaini, Maya and Bolla, Manjeet and Wang, Qing and Milne, Roger L and Shu, Xiao-Ou and Cai, Qiuyin and Beesley, Jonathan and Kar, Siddhartha and Anulis, Irene and Anton-Culver, Hoda and Arndt, Volker and Beckmann, Matthias and Beeghly-Fadiel, Alicia and Benítez, Javier and Blot, William and Bogdanova, Natalia and Bojesen, Stig and Brauch, Hiltrud and Brenner, Hermann and Brinton, Louise and Broekss, Annegien and Brüning, Thomas and Burwinkel, Barbara and Cai, Hui and Canisius, Sander and Chang-Claude, Jenny and Choi, J and Couch, Fergus and Cox, Angela and Cross, Simon and Czene, Kamila and Darabi, Hatef and Devilee, Peter and it, Arnaud and Dörk, Thilo and Fasching, Peter and Fletcher, Olivia and Flyger, Henrik and Fostira, Florentia and Gaborieau, Valerie and García-Closas, Montserrat and Giles, Graham G and Grip, Mervi and Guénel, Pascal and Haiman, Christopher A and Hamann, Ute and Hartman, Joost and Hollestelle, Antoinette and Hopper, John L and Hsiung, Chia-Ni and Ito, Hidemi and Jakubowska, Anna and Johnson, Nichola and Kabisch, Maria and Kang, Daehee and Khan, Sofia and Knight, Julia and Kosma, Veli-Matti and Lambrechts, Diether and Le Marchand, Loic and Li, Jingmei and Lindblom, Annika and Lophatananon, Artitaya and Lubinski, Jan and Mannermaa, Arto and Manoukian, Siranoush and Margolin, Sara and Marme, Federick and Matsuo, Keitaro and McLean, Catriona Ann and Meindl, Alfons and Muir, Kenneth and Neuhausen, Susan and Nevanlinna, Heli and Nord, Silje and Olson, Janet and Orr, Nick and Peterlongo, Paolo and Putti, Thomas Choudary and Rudolph, Anja and Sangrajrang, Suleeporn and Sawyer, Elinor and Schmidt, Marjanka and Schmutzler, Rita and Shen, Chen-Yang and Shi, Jiajun and Shrubsole, Martha and Southey, Melissa and Swerdlow, Anthony and Teo, Soo Hwang and Thienpont, Bernard and Toland, Amanda and Tollenaar, Rob and Tomlinson, Ian and Truong, Thérèse and Tseng, Chiu-chen and ...
Cancer Epidemiology, Biomarkers & Prevention, ISSN 1055-9965, 01/2015, Volume 24, Issue 11, pp. 1680 - 1691
textabstractBackground: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent... 
Journal Article
Molecular bioSystems, ISSN 1742-206X, 02/2014, Volume 10, Issue 2, pp. 251 - 257
Epigenetic regulation by histone methylation is crucial for proper programming of the genome during development. Homeostasis of histone methylation is balanced... 
Databases, Pharmaceutical | Phenotype | Signal Transduction - drug effects | Epigenesis, Genetic | Humans | Methyltransferases - metabolism | Cell Line, Tumor | Drug Discovery - methods | Histones - metabolism | Methylation | High-Throughput Screening Assays - methods | Peptides - pharmacology
Journal Article
Molecular BioSystems, ISSN 1742-206X, 02/2014, Volume 10, Issue 2, pp. 251 - 257
Epigenetic regulation by histone methylation is crucial for proper programming of the genome during development. Homeostasis of histone methylation is balanced... 
LYSINE 27 | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | LYMPHOMA | TARGETS | H3K27 | HYPERTRIMETHYLATION | INHIBITORS | IDENTIFICATION | EZH2
Journal Article
ISSN 1742-206X, 12/2013, Volume 1, Issue 2, pp. 251 - 257
Epigenetic regulation by histone methylation is crucial for proper programming of the genome during development. Homeostasis of histone methylation is balanced... 
Journal Article
Journal of Biomolecular Screening, ISSN 1087-0571, 8/2012, Volume 17, Issue 7, pp. 900 - 911
In this study, the development of an image-based high-content screening (HCS) binding assay for the seven-transmembrane (7TM) receptor Smoothened (Smo) is... 
seven transmembrane receptor (7TM) | baculovirus gene delivery (BacMam) | BODIPY-cyclopamine | Smoothened (Smo) | high-content screening (HCS) | CELLS | CHEMISTRY, ANALYTICAL | ANTAGONIST | GENE DELIVERY | SMALL-MOLECULE | SONIC HEDGEHOG | BIOCHEMICAL RESEARCH METHODS | TRAFFICKING | PRIMARY CILIUM | INHIBITION | PROTEIN-COUPLED RECEPTOR | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Receptors, G-Protein-Coupled - metabolism | Humans | Benzamides - metabolism | Baculoviridae - genetics | Piperazines - metabolism | Thiophenes - metabolism | Piperazines - chemistry | Benzimidazoles - chemistry | Pyrazoles - chemistry | Cyclohexylamines - pharmacology | Smoothened Receptor | HEK293 Cells | Benzamides - pharmacology | Genes, Reporter | Benzamides - chemistry | High-Throughput Screening Assays - methods | Pyrazoles - pharmacology | Cell Line | Drug Evaluation, Preclinical - methods | Purines - metabolism | Purines - pharmacology | Cyclohexylamines - chemistry | Morpholines - pharmacology | Thiophenes - pharmacology | Morpholines - metabolism | Pyrazoles - metabolism | Piperazines - pharmacology | Morpholines - chemistry | Algorithms | Purines - chemistry | Benzimidazoles - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Protein Binding | Benzimidazoles - pharmacology | Thiophenes - chemistry | Cyclohexylamines - metabolism | Fluorescent Dyes | Fluorescence polarization | Statistical analysis | Gene transfer | Image processing | Data processing | Fluorescent indicators | Statistics
Journal Article
SLAS technology, 02/2019, p. 2472630318820017
Recent advancements in science and engineering are revolutionizing our understanding of an individual's disease, and with this knowledge we are gaining an... 
Journal Article
SLAS Technology, ISSN 2472-6303, 6/2019, Volume 24, Issue 3, pp. 245 - 255
Recent advancements in science and engineering are revolutionizing our understanding of an individual’s disease, and with this knowledge we are gaining an... 
CHEMISTRY, ANALYTICAL | CHIP | array-based cellular assays | assay on a chip | BIOCHEMICAL RESEARCH METHODS | small-molecule microarray | miniaturization | ATTRITION | TECHNOLOGY | DISCOVERY | MICROFLUIDICS
Journal Article
Knight Ridder Tribune News Service, 08/2002, p. 1
One agent pulled [Maggie Anderson]'s sports bra above her chest and ran her hands across Anderson's breasts. The agent pulled down Anderson's pants and put one... 
Newspaper Article
by Hein, Rebecca and Maranian, Melanie and Hopper, John and Kapuscinski, Miroslaw and Southey, Melissa and Park, Daniel and Schmidt, Marjanka and Broeks, Annegien and Hogervorst, Frans and Bueno-de-Mesquit, Bas and Muir, Kenneth and Lophatananon, Artitaya and Rattanamongkongul, Suthee and Puttawibul, Puttisak and Fasching, Peter and Hein, Alexander and Ekici, Arif and Beckmann, Matthias and Fletcher, Olivia and Johnson, Nichola and Santos Silva, Isabel and Peto, Julian and Sawyer, Elinor and Tomlinson, Ian and Kerin, Michael and Miller, Nicola and Marmee, Frederick and Schneeweiss, Aneas and Sohn, Christof and Burwinkel, Barbara and Guénel, Pascal and Cordina-Duverger, Emilie and Menegaux, Florence and Truong, Thérèse and Bojesen, Stig and Nordestgaard, Børge and Flyger, Henrik and Milne, Roger and Perez, Jose Ignacio Arias and Zamora, Pilar and Benítez, Javier and Anton-Culver, Hoda and Ziogas, Argyrios and Bernstein, Leslie and Clarke, Christina and Brenner, Hermann and Müller, Heike and Arndt, Volker and Stegmaier, Christa and Rahman, Nazneen and Seal, Sheila and Turnbull, Clare and Renwick, Anthony and Meindl, Alfons and Schott, Sarah and Bartram, Claus and Schmutzler, Rita and Brauch, Hiltrud and Hamann, Ute and Ko, Yon-Dschun and Wang-Gohrke, Shan and Dörk, Thilo and Schürmann, Peter and Karstens, Johann and Hillemanns, Peter and Nevanlinna, Heli and Heikinen, Tuomas and Aittomäki, Kristiina and Blomqvist, Carl and Bogdanova, Natalia and Zalutsky, Iosif and Antonenkova, Natalia and Bermisheva, Marina and Prokovieva, Darya and Farahtdinova, Albina and Khusnutdinova, Elza and Lindblom, Annika and Margolin, Sara and Mannermaa, Arto and Kataja, Vesa and Kosma, Veli-Matti and Hartikainen, Jaana and Chen, Xiaoqing and Beesley, Jonathan and Lambrechts, Diether and Zhao, Hui and Neven, Patrick and Wildiers, Hans and Nickels, Stefan and Flesch-Janys, Dieter and Radice, Paolo and Peterlongo, Paolo and Manoukian, Siranoush and Barile, Monica and Couch, Fergus and Olson, Janet and Wang, Xianshu and Fredericksen, Zachary and Giles, Graham and Baglietto, Laura and ... and GENICA Network and Kconfab Investigators and AOCS Group
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e42380
textabstractThe 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism... 
Genetic Predisposition to Disease | Genome-Wide Association Study | Receptors, Estrogen - genetics | Europe | Humans | Risk Factors | Linkage Disequilibrium - genetics | Chromosomes, Human, Pair 6 - genetics | Haplotypes - genetics | Breast Neoplasms - genetics | Asia | Polymorphism, Single Nucleotide - genetics | Female
Journal Article
Antiviral Research, ISSN 0166-3542, 11/2015, Volume 123, pp. 39 - 49
Journal Article