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Genome Biology, ISSN 1474-7596, 12/2018, Volume 19, Issue 1, pp. 226 - 7
Genome editing holds remarkable promise to transform human medicine as new therapies that can directly address the genetic causes of disease. However, concerns... 
CRISPR CAS9 | THERAPY | SPECIFICITY | LANDSCAPE | VERSATILE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | OFF-TARGET CLEAVAGE | GENETICS & HEREDITY | MUTATIONS | ENHANCERS | SEQ | NUCLEASES | CRISPR | Enzymes | Mutagenesis | Lymphocytes | Human immunodeficiency virus--HIV | DNA damage | Stem cells | Hemoglobin | Genomes | Mutation | Sickle cell disease | Deoxyribonucleic acid--DNA
Journal Article
Nature Reviews Genetics, ISSN 1471-0056, 05/2016, Volume 17, Issue 5, pp. 300 - 312
Journal Article
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 6, pp. 569 - 576
  Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we... 
Genetic research | Nucleases | Genetic aspects | Genetic engineering | Zinc finger proteins | Research | Biotechnology | Enzymes | Mutation | Genomics
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 02/2018, Volume 13, Issue 2, pp. 305 - 308
Originally discovered as part of an adaptive bacterial defense system against the invasion of foreign phages, programmable CRISPR-Cas nucleases have emerged as... 
SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | Endonucleases - genetics | CRISPR-Associated Proteins - genetics | Humans | Genome - genetics | Endonucleases - metabolism | CRISPR-Cas Systems - genetics | Gene Editing | DNA - genetics | DNA - chemistry | Animals | CRISPR-Associated Proteins - metabolism | Mutation | Sequence Analysis, DNA - methods
Journal Article
Nature Biotechnology, ISSN 1087-0156, 12/2015, Volume 33, Issue 12, pp. 1293 - 1298
CRISPR-Cas9 nucleases target specific DNA sequences using a guide RNA but also require recognition of a protospacer adjacent motif (PAM) by the Cas9 protein.... 
ENDONUCLEASE | EVOLUTION | DUAL-RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRYSTAL-STRUCTURE | DNA | GUIDE RNA | CAS9 | NUCLEASES | Genetic aspects | Nucleotide sequencing | Gene expression | Observations | Methods | Staphylococcus aureus | DNA sequencing | Microbiology | Molecular biology | Bacteria
Journal Article