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2011, 1. Aufl., ISBN 0470484071, xx, 498
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their... 
Medical | Pharmacology | Drugs
Book
RSC Drug Discovery Series, ISSN 2041-3203, 2015, Volume 2015-, Issue 41, pp. 110 - 131
Journal Article
BMC Neurology, ISSN 1471-2377, 06/2009, Volume 9, Issue 1, pp. S1 - S1
The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates... 
IN-VITRO | TRANSPORT | PERMEABILITY | ENDOTHELIAL-CELLS | TOXICITY | HEPATOTOXICITY | MODEL | BLOOD-BRAIN-BARRIER | CULTURE | CLINICAL NEUROLOGY | P-GLYCOPROTEIN | Central Nervous System Agents - pharmacokinetics | Mitochondria | Biological Transport | Humans | Drug Evaluation, Preclinical | Drug Discovery | Blood-Brain Barrier | Index Medicus
Journal Article
Archives of Toxicology, ISSN 0340-5761, 2017, Volume 91, Issue 7, pp. 2551 - 2575
Journal Article
Journal of the Royal Society of Medicine, ISSN 0141-0768, 12/2018, Volume 111, Issue 12, pp. 433 - 438
Journal Article
Journal of the Royal Society of Medicine, 11/2018, p. 141076818812783
Journal Article
CPT: Pharmacometrics & Systems Pharmacology, ISSN 2163-8306, 01/2020, Volume 9, Issue 1, pp. 5 - 20
The substantial progress made in the basic sciences of the brain has yet to be adequately translated to successful clinical therapeutics to treat central... 
Index Medicus
Journal Article
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, ISSN 1868-596X, 2019, Volume 36, Issue 3, pp. 508 - 517
Systematic reviews (SRs) hold promise for implementing the 3Rs in animal sciences: they can retrieve available alternative models, help refine experiments, and... 
STROKE | MEDICINE, RESEARCH & EXPERIMENTAL | ANIMAL-MODELS | EFFICACY | Animals | Publications | Animal Testing Alternatives | Humans | Systematic Reviews as Topic | Biomedical Research | Software - standards | Medicine, Experimental | Medical research | Software | International economic relations | Computer software industry | Word processing software | Index Medicus
Journal Article
Altex-Alternatives to Animal Experimentation, ISSN 1868-596X, 2019, Volume 36, Issue 1, pp. 3 - 17
Journal Article
Lancet, The, ISSN 0140-6736, 2011, Volume 378, Issue 9802, pp. e2 - e2
  Animal research is far more expensive and labour-intensive than in-vitro research. Since pharmaceutical safety testing is regulated by the UK Government, the... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | Animal Experimentation | Animals | Drug Evaluation, Preclinical | Humans | Drug-Related Side Effects and Adverse Reactions - epidemiology | Laboratory animals | Medical research
Journal Article
Expert Opinion on Drug Metabolism & Toxicology, ISSN 1742-5255, 06/2009, Volume 5, Issue 6, pp. 647 - 660
Journal Article
04/2016, ISBN 9781119053330, 11
The purpose of preclinical ADME, also referred to as early drug metabolism and pharmacokinetics (DMPK), is to reduce the risks and avoid spending valuable... 
in vitro experiments | toxicity | drug discovery | pharmacokinetic properties | ADME optimization strategy | human transporters
Book Chapter
02/2011, ISBN 0470915110, 574
This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their... 
Drugs
eBook
ISBN 0470484071, 524
Early ADMET explained: an integrated approach to successful drug development This practical guide provides medicinal chemists insights into the field of early... 
Drugs | Testing.;Drugs | Design
eBook
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