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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2018, Volume 82, Issue 4, pp. 625 - 633
Peripheral sensory neuropathy (PSN) and thrombocytopenia are the main dose-limiting toxicities of oxaliplatin for the treatment of advanced gastric cancer... 
Oxaliplatin | Medicine & Public Health | Paclitaxel | Oncology | Cancer Research | Pharmacology/Toxicology | Gastric cancer | Cisplatin | 1ST-LINE TREATMENT | FLUOROURACIL | CHEMOTHERAPY | TRIAL | THERAPY | ONCOLOGY | PLUS S-1 | RANDOMIZED PHASE-III | COLORECTAL-CANCER | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | Peripheral Nervous System Diseases - diagnosis | Severity of Illness Index | Peripheral Nervous System Diseases - chemically induced | Blood Cell Count - methods | Prospective Studies | Risk Assessment | Humans | Japan | Risk Factors | Hypesthesia - chemically induced | Male | Stomach Neoplasms - pathology | Thrombocytopenia - chemically induced | Antineoplastic Agents - administration & dosage | Stomach Neoplasms - drug therapy | Oxaliplatin - adverse effects | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Hypesthesia - diagnosis | Female | Thrombocytopenia - diagnosis | Aged | Oxaliplatin - administration & dosage | Neoplasm Staging | Thrombocytopenia | Antimitotic agents | Medical research | Medicine, Experimental | Antineoplastic agents | Stomach cancer | Risk factors | Cancer | Toxicity | Diabetes mellitus | Health risks | Neuropathy | Males | Multivariate analysis | Risk analysis | Patients | Chemotherapy | Informed consent | Diabetes | Females | Parasympathetic nervous system
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 8/2017, Volume 80, Issue 2, pp. 333 - 342
Standard therapy for advanced small bowel adenocarcinoma (SBA) has not yet been established. The present study assessed the efficacy and safety of chemotherapy... 
Chemotherapy | Medicine & Public Health | Oncology | Cancer Research | Advanced small bowel adenocarcinoma | Pharmacology/Toxicology | Molecular targeting therapy | Bevacizumab | LYNCH-SYNDROME | ADVANCED ADENOCARCINOMA | PROGNOSTIC-FACTORS | OXALIPLATIN | METASTATIC COLORECTAL-CANCER | CAPECITABINE | ONCOLOGY | GASTRIC-CANCER | RANDOMIZED PHASE-III | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | 1ST-LINE THERAPY | Capecitabine - administration & dosage | Leucovorin - administration & dosage | Adenocarcinoma - pathology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Intestine, Small - pathology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Cisplatin - administration & dosage | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Aged, 80 and over | Adult | Female | Retrospective Studies | Bevacizumab - administration & dosage | Japan | Neoplasm Recurrence, Local | Survival Rate | Oxonic Acid - administration & dosage | Adenocarcinoma - drug therapy | Intestinal Neoplasms - pathology | Disease-Free Survival | Tegafur - administration & dosage | Aged | Intestinal Neoplasms - drug therapy | Drug Combinations | Organoplatinum Compounds - adverse effects | Antimitotic agents | Complications and side effects | Care and treatment | Relapse | Analysis | Colorectal cancer | Antineoplastic agents | Cancer | Diseases | Adenocarcinoma | Duodenum | Ampulla of Vater | Patients | Institutions | Ileum | Survival | Cisplatin | Jejunum | Oxaliplatin | Intestine | Safety | Added value
Journal Article
International Journal of Clinical Oncology, ISSN 1341-9625, 5/2019, Volume 24, Issue 5, pp. 508 - 515
Dose modification of chemotherapy for metastatic colorectal cancer (MCRC) is often needed, especially in second-line and later-line treatments due to adverse... 
Irinotecan | Medicine & Public Health | Colorectal cancer | Oncology | Cancer Research | Ramucirumab | Surgical Oncology | Relative dose intensity | LINE CARCINOEMBRYONIC ANTIGEN | LEUCOVORIN | BEVACIZUMAB | OXALIPLATIN | FLUOROURACIL | COMBINATION | CHEMOTHERAPY | ONCOLOGY | 1ST-LINE THERAPY | CARCINOMA | Medicine, Experimental | Medical research | Chemotherapy | Metastasis | Cancer
Journal Article
Cancer Science, ISSN 1347-9032, 09/2016, Volume 107, Issue 9, pp. 1198 - 1205
Podoplanin (aggrus) is highly expressed in several types of cancers, including malignant pleural mesothelioma (MPM). Previously, we developed a rat anti‐human... 
NZ‐12 | mesothelioma | orthotopic xenograft model | antibody‐dependent cellular cytotoxicity | podoplanin | Mesothelioma | Antibody-dependent cellular cytotoxicity | NZ-12 | Orthotopic xenograft model | Podoplanin | antibody-dependent cellular cytotoxicity | CANCER-ASSOCIATED FIBROBLASTS | TUMOR PROGRESSION | DENDRITIC CELLS | DEPENDENT CELLULAR CYTOTOXICITY | AGGREGATION-INDUCING FACTOR | ONCOLOGY | LUNG ADENOCARCINOMA | SUPPRESSES | EXPRESSION | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | Mesothelioma - immunology | Lung Neoplasms - drug therapy | Mesothelioma - pathology | Humans | Lung Neoplasms - metabolism | Antibody-Dependent Cell Cytotoxicity - immunology | Complement System Proteins - immunology | Lung Neoplasms - pathology | Male | Pleural Neoplasms - drug therapy | Pemetrexed - pharmacology | Pleural Neoplasms - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Immunotherapy | Antineoplastic Agents - pharmacology | Drug Therapy, Combination | Pleural Neoplasms - pathology | Disease Models, Animal | Pleural Neoplasms - immunology | Antibodies, Monoclonal - pharmacology | Rats | Mesothelioma - drug therapy | Xenograft Model Antitumor Assays | Lung Neoplasms - immunology | Animals | Mesothelioma - metabolism | Cell Line, Tumor | Mice | Cytotoxicity, Immunologic | Viral antibodies | Antibodies | Analysis | Flow cytometry | Animal models | Immunoglobulins | Severe combined immunodeficiency | Cytokines | Effusion | Research & development--R&D | Brain cancer | Pleural effusion | Cytotoxicity | Cancer therapies | Experiments | Chemotherapy | Medical prognosis | Cell lines | Xenografts | Monoclonal antibodies | Antitumor activity | Natural killer cells | CD56 antigen | Tumors | Original
Journal Article
Cancer Science, ISSN 1347-9032, 09/2017, Volume 108, Issue 9, pp. 1843 - 1849
Spliced variant isoforms of CD44 (CD44v) are a marker of cancer stem cells in solid tumors. They stabilize the xCT subunit of the transporter system xc(–) and... 
Cancer stem cell | salazosulfapyridine | non‐small‐cell lung cancer | CD44v | oxidative stress | non-small-cell lung cancer | METASTASIS | CARCINOMA CELLS | CLEAVAGE | CHEMOTHERAPY | VARIANT EXONS 8-10 | TRIAL | ONCOLOGY | SULFASALAZINE | EXOSOMES | EXPRESSION | CD44 | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - drug therapy | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Lung Neoplasms - pathology | Male | Treatment Outcome | Hyaluronan Receptors - blood | Antineoplastic Combined Chemotherapy Protocols - toxicity | Cisplatin - administration & dosage | Biomarkers, Tumor - blood | Sulfasalazine - administration & dosage | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pemetrexed - administration & dosage | Adult | Carcinoma, Non-Small-Cell Lung - blood | Female | Aged | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Neoplasm Staging | Antimitotic agents | Antioxidants | Medical research | Chemotherapy | Stem cells | Clinical trials | Medicine, Experimental | Sulfasalazine | Lung cancer, Non-small cell | Antineoplastic agents | Cancer | Cell proliferation | Anorexia | Toxicity | Lung cancer | Kinases | Cancer therapies | CD44 antigen | Drug dosages | Genotypes | Glutathione | Neutropenia | Alanine | Research & development--R&D | Patients | Cisplatin | Hypotension | Pneumonitis | Cell death | Medical prognosis | Isoforms | Alanine transaminase | Solid tumors | Apoptosis | Tumors | Index Medicus | Original
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 432 - 432
Journal Article
Gastric Cancer, ISSN 1436-3291, 11/2017, Volume 20, Issue 6, pp. 1004 - 1009
Journal Article
Journal Article
Cancer Science, ISSN 1347-9032, 10/2013, Volume 104, Issue 10, pp. 1323 - 1329
Cancer development is often preceded by the appearance of preneoplastic lesions. In gastric carcinogenesis, chronic inflammation and histopathologic... 
OXYNTIC ATROPHY | WILD-TYPE | ONCOLOGY | GASTRIC-CANCER | ACTIVATED MACROPHAGES | TUMOR-CELLS | PROSTAGLANDIN E-2 PATHWAY | HELICOBACTER-PYLORI | CARCINOMA | CD44 | TRANSGENIC MICE | Adenocarcinoma - pathology | Adenocarcinoma - etiology | Humans | Neoplasm Proteins - physiology | Stomach Neoplasms - metabolism | Amino Acid Transport System y+ - genetics | Gastric Mucosa - pathology | Helicobacter Infections - complications | Precancerous Conditions - metabolism | Stomach Neoplasms - pathology | Sulfasalazine - pharmacology | Gastric Mucosa - metabolism | Hyaluronan Receptors - physiology | Adenocarcinoma - metabolism | Amino Acid Transport System y+ - antagonists & inhibitors | Precancerous Conditions - pathology | Neoplasm Proteins - genetics | Stomach Neoplasms - etiology | Amino Acid Transport System y+ - physiology | Biomarkers, Tumor - analysis | Neoplasm Proteins - biosynthesis | Mice, Inbred C57BL | Mice, Transgenic | Disease Progression | Protein Isoforms - physiology | Cocarcinogenesis | Metaplasia | Amino Acid Transport System y+ - biosynthesis | Adenocarcinoma - prevention & control | Animals | Cell Transformation, Neoplastic | Cystine - metabolism | Stomach Neoplasms - prevention & control | Mice | Peptides - analysis | Development and progression | Cysteine | Ablation (Surgery) | Analysis | Gastrointestinal diseases | Cystine | Index Medicus
Journal Article