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Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
Critical Reviews in Immunology, ISSN 1040-8401, 01/2014, Volume 34, Issue 1, pp. 41 - 80
Inflammasomes, multiprotein platforms of caspase-1 activation, are assembled in response to a number of exogenous and endogenous danger signals, leading to the... 
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 2006, Volume 25, Issue 5, pp. 745 - 755
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2091 - 19
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells... 
CYTOCHROME-C | PATHWAYS | GSDMD | IL-1-BETA-CONVERTING ENZYME | INFLAMMASOME ACTIVATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DEFICIENT | PYROPTOSIS | CLEAVAGE | CELL-DEATH | Deprivation | Mortality | Cortex | Three axis | Caspase | Macrophages | Caspase-3 | Ablation | Caspase-1 | Necrosis | Nigericin | Organic chemistry | Cell activation | Cell death | Caspase-9 | Mast cells | Dimerization | Apoptosis
Journal Article
Journal Article
Journal Article
MUCOSAL IMMUNOLOGY, ISSN 1933-0219, 09/2019, Volume 12, Issue 5, pp. 1092 - 1103
It is widely accepted that inflammasomes protect the host from microbial pathogens by inducing inflammatory responses through caspase-1 activation. Here, we... 
ACTIVATION | STREPTOCOCCUS-PNEUMONIAE | INCREASED SUSCEPTIBILITY | HOST-DEFENSE | LECTIN REGIII-GAMMA | SPLUNC1 | INFECTION | IMMUNOLOGY | EXPRESSION | PNEUMOLYSIN | SPDEF
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2012, Volume 189, Issue 11, pp. 5113 - 5117
Although the NLRP3 inflammasome plays a pivotal role in host defense, its uncontrolled activation is associated with inflammatory disorders, suggesting that... 
ACTIVATION | PATTERN-RECOGNITION | MACROPHAGES | THIOREDOXIN | IMMUNOLOGY | RECEPTORS | EXPRESSION | Interferon-beta - immunology | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Calcium-Binding Proteins - antagonists & inhibitors | Mitochondria - immunology | Adenosine Triphosphate - pharmacology | Signal Transduction - immunology | Inflammasomes - drug effects | Calcium-Binding Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Female | Nuclear Proteins - genetics | Macrophages, Peritoneal - drug effects | Carrier Proteins - immunology | DNA-Binding Proteins | Apoptosis Regulatory Proteins - immunology | S-Nitroso-N-Acetylpenicillamine - metabolism | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Macrophages, Peritoneal - immunology | Mitochondria - metabolism | Mitochondria - drug effects | Nuclear Proteins - immunology | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Animals | Interferon-beta - pharmacology | Signal Transduction - drug effects | Inflammasomes - immunology | Nuclear Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Macrophages, Peritoneal - metabolism | Nitric Oxide - metabolism | S-Nitroso-N-Acetylpenicillamine - pharmacology | Calcium-Binding Proteins - genetics
Journal Article
Microbiology and Immunology, ISSN 0385-5600, 11/2019
Journal Article
Journal Article
International Immunology, ISSN 0953-8178, 12/2010, Volume 22, Issue 12, pp. 915 - 925
Journal Article
Infection and Immunity, ISSN 0019-9567, 06/2010, Volume 78, Issue 6, pp. 2857 - 2867
Journal Article
Journal Article
Infection and Immunity, ISSN 0019-9567, 04/2008, Volume 76, Issue 4, pp. 1547 - 1557
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
SIGNAL-TRANSDUCTION | IMPAIRED HOST-DEFENSE | INFECTIOUS DISEASES | TOLL-LIKE RECEPTOR-4 | PROTEIN TOXIN | GAMMA-INTERFERON | PNEUMOCOCCAL MENINGITIS | NECROSIS-FACTOR-ALPHA | DEFICIENT MICE | TNF-ALPHA | IMMUNOLOGY | POLYSACCHARIDE VACCINE | Host Response and Inflammation
Journal Article