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Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2012, Volume 131, Issue 3, pp. 548 - 557
Multikinase inhibitor sorafenib inhibits proliferation and angiogenesis of tumors by suppressing the Raf/MEK/ERK signaling pathway and VEGF receptor tyrosine... 
mTOR | HCC | apoptosis | liver | tumor | CANCER-CELLS | ACTIVATION | PROTEIN | MECHANISM | INDUCED APOPTOSIS | HEPATOMA-CELLS | INDUCTION | CELL-DEATH | FAMILY | THERAPY | ONCOLOGY | Niacinamide - analogs & derivatives | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Multiprotein Complexes | Ubiquitin-Activating Enzymes - biosynthesis | Drug Resistance, Neoplasm | Phenylurea Compounds | Autophagy - drug effects | Mechanistic Target of Rapamycin Complex 1 | Chloroquine - pharmacology | Benzenesulfonates - pharmacology | Carcinoma, Hepatocellular - drug therapy | Lysosomes - metabolism | RNA Interference | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Autophagy-Related Protein 7 | Animals | Proteins - metabolism | Mice, Nude | Sorafenib | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | RNA, Small Interfering | TOR Serine-Threonine Kinases | Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - metabolism | Liver cancer | Chemotherapy | Kinases | Autophagy | Tumors
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2012, Volume 70, Issue 8, pp. 1352 - 1355
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 08/2012, Volume 70, Issue 8, p. 1391
Natural toxin poisoning often occurs when amateur who has no expert knowledge of food collects and cooks the wrong material. In many cases, the symptoms of... 
Mushroom Poisoning - therapy | Animals | Charcoal - administration & dosage | Hemofiltration | Humans | Gastric Lavage | Tetraodontiformes | Tetrodotoxin - poisoning | Toxins, Biological - poisoning
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 08/2012, Volume 70, Issue 8, p. 1352
Journal Article
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2012, Volume 70, Issue 8, pp. 1391 - 1394
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2785 - 2801
Journal Article
by Ogihara, Toshio and Saruta, Takao and Rakugi, Hiromi and Saito, Ikuo and Shimamoto, Kazuaki and Matsuoka, Hiroaki and Shimada, Kazuyuki and Ito, Sadayoshi and Horiuchi, Masatsugu and Imaizumi, Tsutomu and Takishita, Shuichi and Higaki, Jitsuo and Katayama, Shigehiro and Kimura, Genjiroh and Umemura, Satoshi and Ura, Nobuyuki and Hayashi, Koichi and Odawara, Masato and Tanahashi, Norio and Ishimitsu, Toshihiko and Kashihara, Naoki and Morita, Satoshi and Teramukai, Satoshi and Anno, T and Aoyama, S and Arima, N and Bando, Y and Dohi, Y and Fujioka, H and Fukuda, M and Fukuda, S and Fukuta, M and Futamura, Y and Hirakawa, Y and Imaeda, K and Imai, H and Imamura, A and Ito, M and Ito, O and Ito, T and Iwa, T and Izumi, J and Kaga, Y and Kanematsu, K and Kato, Y and Kawata, Y and Kitamura, T and Kobayashi, K and Koyasu, M and Kuwabara, S and Kuzuya, M and Maekawa, M and Mihara, H and Mitsuguchi, F and Murohara, T and Narita, T and Negi, K and Numaguchi, Y and Ohya, T and Okayama, N and Okuma, K and Ozaki, N and Ozeki, N and Sato, K and Sawada, T and Seino, Y and Suezawa, M and Suzuki, T and Suzuki, Y and Takahashi, N and Takahashi, R and Tanaka, N and Wakida, Y and Watanuki, H and Watarai, M and Yamada, K and Yamashita, S and Yoshikane, M and Goto, M and Ishida, Y and Kimura, H and Takahashi, K and Yashima, N and Abe, Y and Fujiwara, S and Higashino, H and Kaizuka, M and Minami, O and Ogiu, Y and Osanai, T and Sasaki, T and Sato, A and Sugimoto, K and Takahashi, H and Tanabe, K and Azuma, D and Ibuki, C and Inoya, H and Iyo, T and Kusaka, M and ...
Journal of Hypertension, ISSN 0263-6352, 10/2014, Volume 32, Issue 10, pp. 2054 - 2063
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 11/2007, Volume 293, Issue 5, pp. 1498 - 1508
Dopamine signaling plays a major role in regulation of neuronal apoptosis. During the postnatal period, dopamine signaling is known to be dramatically changed... 
Neuronal culture | Striatum | Adenosine 3′,5′- cyclic monophosphate | Phospholipase C | phospholipase C | BINDING PROTEIN-PHOSPHORYLATION | PHYSIOLOGY | RAT STRIATUM | TYROSINE-HYDROXYLASE | RECEPTOR | SUBSTANTIA-NIGRA | adenosine 3',5'-cyclic monophosphate | CELL-DEATH | CELL BIOLOGY | striatum | ADENYLYL-CYCLASE | POSTNATAL-DEVELOPMENT | neuronal culture | STRIATAL NEURONS | PARKINSONS-DISEASE | Neurons - pathology | Phosphorylation | Age Factors | Apoptosis - drug effects | Basal Ganglia - metabolism | Type C Phospholipases - metabolism | Type C Phospholipases - antagonists & inhibitors | Basal Ganglia - cytology | Feasibility Studies | Receptors, Dopamine D1 - metabolism | Time Factors | Isoenzymes - metabolism | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Egtazic Acid - analogs & derivatives | Neurons - metabolism | Cell Culture Techniques | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Dopamine - metabolism | Adenylyl Cyclases - deficiency | Isoenzymes - genetics | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Adrenergic beta-Agonists - pharmacology | Basal Ganglia - pathology | Adenylyl Cyclases - metabolism | Chelating Agents - pharmacology | Isoenzymes - deficiency | Aging - pathology | Mice, Knockout | Animals | Egtazic Acid - pharmacology | Calcium Signaling - drug effects | Isoproterenol - pharmacology | Neurons - enzymology | Mice | Basal Ganglia - growth & development | Adenylyl Cyclases - genetics | Aging - metabolism | Basal Ganglia - drug effects
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0136539
Journal Article
Journal Article
by Hitomi, Yuki and Hitomi, Yuki and Ueno, Kazuko and Ueno, Kazuko and Kawai, Yosuke and Kawai, Yosuke and Nishida, Nao and Nishida, Nao and Kojima, Kaname and Kawashima, Minae and Aiba, Yoshihiro and Nakamura, Hitomi and Kouno, Hiroshi and Kouno, Hirotaka and Kouno, Hirotaka and Ohta, Hajime and Ohta, Hajime and Sugi, Kazuhiro and Sugi, Kazuhiro and Nikami, Toshiki and Yamashita, Tsutomu and Katsushima, Shinji and Komeda, Toshiki and Ario, Keisuke and Naganuma, Atsushi and Naganuma, Atsushi and Shimada, Masaaki and Hirashima, Noboru and Hirashima, Noboru and Yoshizawa, Kaname and Yoshizawa, Kaname and Makita, Fujio and Furuta, Kiyoshi and Kikuchi, Masahiro and Kikuchi, Masahiro and Naeshiro, Noriaki and Naeshiro, Noriaki and Takahashi, Hironao and Mano, Yutaka and Yamashita, Haruhiro and Yamashita, Haruhiro and Matsushita, Kouki and Tsunematsu, Seiji and Yabuuchi, Iwao and Nishimura, Hideo and Shimada, Yusuke and Yamauchi, Kazuhiko and Yamauchi, Kazuhiko and Komatsu, Tatsuji and Komatsu, Tatsuji and Sugimoto, Rie and Sakai, Hironori and Mita, Eiji and Koda, Masaharu and Nakamura, Yoko and Kamitsukasa, Hiroshi and Sato, Takeaki and Nakamuta, Makoto and Masaki, Naohiko and Masaki, Naohiko and Takikawa, Hajime and Takikawa, Hajime and Tanaka, Atsushi and Ohira, Hiromasa and Ohira, Hiromasa and Zeniya, Mikio and Abe, Masanori and Abe, Masanori and Kaneko, Shuichi and Kaneko, Shuichi and Honda, Masao and Honda, Masao and Arai, Kuniaki and Arai, Kuniaki and Arinaga-Hino, Teruko and Hashimoto, Etsuko and Hashimoto, Etsuko and Taniai, Makiko and Taniai, Makiko and Umemura, Takeji and Umemura, Takeji and Joshita, Satoru and Nakao, Kazuhiko and Nakao, Kazuhiko and Ichikawa, Tatsuki and Ichikawa, Tatsuki and Shibata, Hidetaka and Shibata, Hidetaka and Takaki, Akinobu and Takaki, Akinobu and Yamagiwa, Satoshi and Seike, Masataka and Sakisaka, Shotaro and Takeyama, Yasuaki and Takeyama, Yasuaki and Harada, Masaru and Harada, Masaru and Senju, Michio and Senju, Michio and Yokosuka, Osamu and ...
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 102 - 11
Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our... 
RISK LOCI | IDENTIFY | ALAGILLE-SYNDROME | VARIANTS | TNFSF15 | CIRRHOSIS | MULTIDISCIPLINARY SCIENCES | MUTATIONS | EXPRESSION | HUMAN JAGGED1 | GENOME-WIDE ASSOCIATION | Quantitative trait loci | Liver diseases | Susceptibility | Cholangitis | CD80 antigen | Genomes | Single-nucleotide polymorphism | Chromosome 3 | Bile duct | Glucosyltransferase
Journal Article
by Mukai, Tomoya and Hosomi, Naohisa and Tsunematsu, Miwako and Sueda, Yoshimasa and Shimoe, Yutaka and Ohshita, Tomohiko and Torii, Tsuyoshi and Aoki, Shiro and Nezu, Tomohisa and Maruyama, Hirofumi and Kakehashi, Masayuki and Matsumoto, Masayasu and Haji, Shotaro and Hayashi, Yuki and Kono, Michihiro and Yamashita, Hiroshi and Agari, Dai and Kohriyama, Tatsuo and Muguruma, Kazuki and Nomura, Eiichi and Toji, Hiromasa and Yamawaki, Takemori and Dohi, Eisuke and Fujii, Hiroki and Ishihara, Aiko and Ishihara-Kawase, Kayoko and Kinoshita, Naoto and Kitamura, Juri and Kono, Tomoyuki and Kotozaki, Teppei and Kubo, Satoshi and Kurashige, Takeshi and Matsushima, Hayato and Miyachi, Takafumi and Nagano, Yoshito and Nakamura, Takeshi and Nishikawa, Tomokazu and Ochi, Kazuhide and Ohtsuki, Toshiho and Ota, Yoko and Segawa, Akiko and Shimomura, Ryo and Shinozaki, Yukari and Shishido, Takeo and Sugiura, Tomohito and Takahashi, Tetsuya and Takeda, Ikuko and Tanaka, Hitomi and Tanaka, Hitomi and Ueno, Hiroki and Yamazaki, Yu and Imamura, Eiji and Kataoka, Satoshi and Kushitani, Satomi and Naito, Kasane and Ikawa, Fumio and Wakabayashi, Shinichi and Kitamura, Takeshi and Sugimoto, Takamichi and Dodo, Yoriko and Kuga, Junichiro and Tomimura, Hikaru and Himeno, Takahiro and Kono, Ryuhei and Kuriyama, Masaru and Neshige, Shuichiro and Ota, Taisei and Takamatsu, Kazuhiro and Takeshima, Shinichi and Yoshimoto, Takeshi and Hiroshima Emergency Weather and Hiroshima ‘Emergency and Weather’ Study-stroke collaborators and on behalf of the Hiroshima ‘Emergency and Weather’ Study-stroke collaborators
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0178223
Journal Article