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1. Full Text Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
by Yamashita, Kohei and Yoshioka, Yasuo and Higashisaka, Kazuma and Mimura, Kazuya and Morishita, Yuki and Nozaki, Masatoshi and Yoshida, Tokuyuki and Ogura, Toshinobu and Nabeshi, Hiromi and Nagano, Kazuya and Abe, Yasuhiro and Kamada, Haruhiko and Monobe, Youko and Imazawa, Takayoshi and Aoshima, Hisae and Shishido, Kiyoshi and Kawai, Yuichi and Mayumi, Tadanori and Tsunoda, Shin-Ichi and Itoh, Norio and Yoshikawa, Tomoaki and Yanagihara, Itaru and Saito, Shigeru and Tsutsumi, Yasuo
Nature nanotechnology, ISSN 1748-3387, 2011, Volume 6, Issue 5, pp. 321 - 328
Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Nanoparticles - chemistry | Maternal-Fetal Exchange | Humans | Fetus - pathology | Nanoparticles - toxicity | Fetus - drug effects | Particle Size | Placenta - drug effects | Pregnancy | Reproduction - drug effects | Animals | Silicon Dioxide | Placenta - pathology | Titanium | Female | Pregnancy Complications - chemically induced | Mice | Mice, Inbred BALB C | Apoptosis | Index Medicus
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2. Full Text Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes
by Nabeshi, Hiromi and Yoshikawa, Tomoaki and Matsuyama, Keigo and Nakazato, Yasutaro and Tochigi, Saeko and Kondoh, Sayuri and Hirai, Toshiro and Akase, Takanori and Nagano, Kazuya and Abe, Yasuhiro and Yoshioka, Yasuo and Kamada, Haruhiko and Itoh, Norio and Tsunoda, Shin-ichi and Tsutsumi, Yasuo
Particle and fibre toxicology, ISSN 1743-8977, 01/2011, Volume 8, Issue 1, pp. 1 - 1
Life Sciences & Biomedicine | Toxicology | Science & Technology | Cell Line | Nucleic Acid Synthesis Inhibitors - pharmacology | Reactive Oxygen Species - metabolism | Endocytosis - drug effects | Humans | Comet Assay | Nanoparticles - toxicity | Endocytosis - physiology | Particle Size | Silicon Dioxide - toxicity | Keratinocytes - drug effects | DNA Damage | Drug Therapy, Combination | DNA - drug effects | Reactive oxygen species | Amorphous substances | DNA damage | Keratinocytes | Physiological aspects | Genetic aspects | Research | Studies | Nanoparticles | Medical research | Health sciences | Quantum dots | Atoms & subatomic particles | Cosmetics | Nanomaterials | Skin | Silica | Deoxyribonucleic acid--DNA | Index Medicus
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3. Full Text Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients
by Enooku, Kenichiro and Tsutsumi, Takeya and Kondo, Mayuko and Fujiwara, Naoto and Sasako, Takayoshi and Shibahara, Junji and Kado, Akira and Okushin, Kazuya and Fujinaga, Hidetaka and Nakagomi, Ryo and Minami, Tatsuya and Sato, Masaya and Uchino, Koji and Nakagawa, Hayato and Kondo, Yuji and Asaoka, Yoshinari and Tateishi, Ryosuke and Ueki, Kohjiro and Ikeda, Hitoshi and Yoshida, Haruhiko and Moriya, Kyoji and Yotsuyanagi, Hiroshi and Kadowaki, Takashi and Koike, Kazuhiko
Journal of gastroenterology, ISSN 0944-1174, 02/2020, Volume 55, Issue 2, pp. 227 - 243
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Medical colleges | Medical research | Liver | Burn out (Psychology) | Fatty acids | Glucose tolerance tests | Risk factors | Carnitine | Proteins | Analysis | Physiological aspects | Genetic research | Medicine, Experimental | Liver cirrhosis | Liver diseases | Transcription | Diabetes mellitus | Dyslipidemia | Metabolism | Glucose tolerance | Cirrhosis | Fatty liver | Biopsy | Fibrosis | Protein transport | Index Medicus
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4. Full Text Hepatic IRS1 and beta-catenin expression is associated with histological progression and overt diabetes emergence in NAFLD patients
by Enooku, Kenichiro and Kondo, Mayuko and Fujiwara, Naoto and Sasako, Takayoshi and Shibahara, Junji and Kado, Akira and Okushin, Kazuya and Fujinaga, Hidetaka and Tsutsumi, Takeya and Nakagomi, Ryo and Minami, Tatsuya and Sato, Masaya and Nakagawa, Hayato and Kondo, Yuji and Asaoka, Yoshinari and Tateishi, Ryosuke and Ueki, Kohjiro and Ikeda, Hitoshi and Yoshida, Haruhiko and Moriya, Kyoji and Yotsuyanagi, Hiroshi and Kadowaki, Takashi and Fukayama, Masashi and Koike, Kazuhiko
Journal of gastroenterology, ISSN 0944-1174, 12/2018, Volume 53, Issue 12, pp. 1261 - 1275
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver diseases | Liver | Dyslipidemia | mRNA | Glucose | Metabolism | Insulin | Glucose tolerance | Glucose metabolism | β-catenin | Insulin receptor substrate 1 | Fatty liver | Biopsy | Glucokinase | Fibrosis | Diabetes | Diabetes mellitus (non-insulin dependent)
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5. Full Text Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes
by Nagano, Takashi and Nagano, Kazuya and Nabeshi, Hiromi and Yoshida, Tokuyuki and Kamada, Haruhiko and Tsunoda, Shin-ichi and Gao, Jian-Qing and Higashisaka, Kazuma and Yoshioka, Yasuo and Tsutsumi, Yasuo
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 5, pp. 726 - 728
safety assessment | surface-modification | liver damage | Safety assessment | Liver damage | Surface-modification | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Amines - chemistry | Liver Function Tests | Cell Line | Cell Survival - drug effects | Nanoparticles - chemistry | Silicon Dioxide - chemistry | Alanine Transaminase - analysis | Nanoparticles - toxicity | Gadolinium - chemistry | Kupffer Cells - drug effects | Particle Size | Animals | Silicon Dioxide - toxicity | Carboxylic Acids - chemistry | Surface Properties | Female | Mice | Mice, Inbred BALB C | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - enzymology | Hepatocytes - drug effects | Alanine | Liver | Kupffer cells | Cytotoxicity | Gadolinium | Silica | Silicon dioxide | Nanoparticles | Chloride | Hepatocytes | Rodents | Alanine transaminase | Plasma levels | Amino groups | Index Medicus
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6. Full Text Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice
by Hirai, Toshiro and Yoshioka, Yasuo and Izumi, Natsumi and Ichihashi, Ko-Ichi and Handa, Takayuki and Nishijima, Nobuo and Uemura, Eiichiro and Sagami, Ko-Ichi and Takahashi, Hideki and Yamaguchi, Manami and Nagano, Kazuya and Mukai, Yohei and Kamada, Haruhiko and Tsunoda, Shin-Ichi and Ishii, Ken J and Higashisaka, Kazuma and Tsutsumi, Yasuo
Nature nanotechnology, ISSN 1748-3387, 09/2016, Volume 11, Issue 9, pp. 808 - 816
Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Index Medicus | Drainage | Nanoparticles | Silver | Nickel | Mice | Human behavior | Quantitative analysis | Lymph
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7. Full Text Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection
by Hirai, Toshiro and Yoshikawa, Tomoaki and Nabeshi, Hiromi and Yoshida, Tokuyuki and Tochigi, Saeko and Ichihashi, Ko-ichi and Uji, Miyuki and Akase, Takanori and Nagano, Kazuya and Abe, Yasuhiro and Kamada, Haruhiko and Itoh, Norio and Tsunoda, Shin-ichi and Yoshioka, Yasuo and Tsutsumi, Yasuo
Particle and fibre toxicology, ISSN 1743-8977, 02/2012, Volume 9, Issue 1, pp. 3 - 3
Allergy | Cytokines | Nanoparticle | Silica | Life Sciences & Biomedicine | Toxicology | Science & Technology | Interleukin-18 - immunology | Dermatophagoides pteronyssinus - immunology | Nanoparticles - chemistry | Humans | Injections, Intradermal - adverse effects | Silicon Dioxide - chemistry | Immunity, Active - immunology | Male | Dermatitis, Atopic - pathology | Nanoparticles - adverse effects | Silicon Dioxide - adverse effects | Particle Size | Animals | Dermatitis, Atopic - immunology | Mice | Cytokines - immunology | Nanoparticles | Usage | Research | Atopic dermatitis | Health aspects | Science | Gene expression | Manuscripts | Index Medicus
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8. Full Text UBL3 modification influences protein sorting to small extracellular vesicles
by Ageta, Hiroshi and Ageta-Ishihara, Natsumi and Hitachi, Keisuke and Karayel, Ozge and Onouchi, Takanori and Yamaguchi, Hisateru and Kahyo, Tomoaki and Hatanaka, Ken and Ikegami, Koji and Yoshioka, Yusuke and Nakamura, Kenji and Kosaka, Nobuyoshi and Nakatani, Masashi and Uezumi, Akiyoshi and Ide, Tomihiko and Tsutsumi, Yutaka and Sugimura, Haruhiko and Kinoshita, Makoto and Ochiya, Takahiro and Mann, Matthias and Setou, Mitsutoshi and Tsuchida, Kunihiro
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3936 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Animals | Humans | HEK293 Cells | Protein Processing, Post-Translational | HeLa Cells | Extracellular Vesicles - metabolism | Mice, Knockout | Protein Transport | Proteins | Ubiquitin | Vesicles | Protein folding | Rodents | Proteomics | Mice | Protein transport | Cell interactions | Exosomes | Membrane proteins | Index Medicus
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9. Full Text Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes
by Takashi Naganoa and † and Kazuya Naganoa and Hiromi Nabeshia and ‡ and Tokuyuki Yoshidaa and Haruhiko Kamadab and c and Shin-ichi Tsunodab and § and Jian-Qing Gaod and Kazuma Higashisakaa and Yasuo Yoshiokaa and e and f and Yasuo Tsutsumia and BIKEN Innovative Vaccine Research Alliance Laboratories and The Research Foundation for Microbial Diseases of Osaka University and fBIKEN Center for Innovative Vaccine Research and Development and Graduate School of Pharmaceutical Sciences and cThe Center for Advanced Medical Engineering and Informatics and Research Institute for Microbial Diseases and Present address:Division of Foods and bLaboratory of Biopharmaceutical Research and National Institutes of Biomedical Innovation and National Institute of Health Sciences and College of Pharmaceutical Sciences and Osaka University and Present address:Towa Pharmaceutical Co and Ltd and aLaboratory of Toxicology and Safety Science and Present address:Graduate School of Pharmaceutical Sciences and Zhejiang University and Kobe-Gakuin University and dInstitute of Pharmaceutics and eVaccine Creation Project and Health and Nutrition
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 5, pp. 726 - 728
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10. Full Text Catalytic removal of acetaldehyde in saliva by a Gluconobacter strain
by Yamaguchi, Haruhiko and Hosoya, Miho and Shimoyama, Takefumi and Takahashi, Seiji and Zhang, Jian Feng and Tsutsumi, Eri and Suzuki, Yukio and Suwa, Yoshihide and Nakayama, Toru
Journal of bioscience and bioengineering, ISSN 1389-1723, 09/2012, Volume 114, Issue 3, pp. 268 - 274
Alcoholic beverages | Gluconobacter | Upper aerodigestive tract cancer | Aldehyde dehydrogenase | Acetaldehyde | Food Science & Technology | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | Temperature | Acetaldehyde - metabolism | Ethanol - metabolism | Aldehyde Dehydrogenase, Mitochondrial | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Carcinoma, Squamous Cell - chemically induced | Mouth - metabolism | Aldehyde Dehydrogenase - genetics | Carcinogens - isolation & purification | Saliva - chemistry | Carcinogens - metabolism | Alcohol Drinking - adverse effects | Gluconobacter - metabolism | Alcoholic Beverages - adverse effects | Saliva - metabolism | Ethanol - adverse effects | Aldehyde Dehydrogenase - deficiency | Mouth - pathology | Alcohol Drinking - metabolism | Acetaldehyde - isolation & purification | Hydrogen-Ion Concentration | Prevention | Animal experimentation | Hydrogen peroxide | Cancer | Index Medicus
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11. Full Text Ecophysiological consequences of alcoholism on human gut microbiota: Implications for ethanol-related pathogenesis of colon cancer
by Tsuruya, Atsuki and Kuwahara, Akika and Saito, Yuta and Yamaguchi, Haruhiko and Tsubo, Takahisa and Suga, Shogo and Inai, Makoto and Aoki, Yuichi and Takahashi, Seiji and Tsutsumi, Eri and Suwa, Yoshihide and Morita, Hidetoshi and Kinoshita, Kenji and Totsuka, Yukari and Suda, Wataru and Oshima, Kenshiro and Hattori, Masahira and Mizukami, Takeshi and Yokoyama, Akira and Shimoyama, Takefumi and Nakayama, Toru
Scientific reports, ISSN 2045-2322, 06/2016, Volume 6, Issue 1, pp. 27923 - 27923
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Index Medicus
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