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1. Prognostic value of the biomarkers serum amyloid A and nitric oxide in patients with sepsis
by Mei-Hong Yu and Min-Hua Chen and Fang Han and Qian Li and Ren-Hua Sun and Yue-Xing Tu
International Immunopharmacology, ISSN 1567-5769, 09/2018, Volume 62, p. 287
Health care | Medical prognosis | Nitric oxide | Biomarkers | Sepsis | Medical diagnosis
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2. Full Text Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine
by Cai, Mao-Hua and Xu, Xiao-Gang and Yan, Shi-Li and Sun, Ze and Ying, Yin and Wang, Bai-Kui and Tu, Yue-Xing
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1621 - 11
Trichostatin A (TSA) possess histone deacetylase (HDAC) inhibitory potential, can reverse the deactivation of tumor suppressor genes and inhibit tumor cell... 
THERAPY | ACETYLATION | CYTOTOXICITY | MULTIDISCIPLINARY SCIENCES | BIOLOGY | Cell Survival - drug effects | Neoplastic Stem Cells - drug effects | Humans | Pancreatic Neoplasms - pathology | Histone Deacetylases - metabolism | Hydroxamic Acids - metabolism | Deoxycytidine - metabolism | Cell Line, Tumor | Histone Deacetylase Inhibitors - metabolism | Antimetabolites, Antineoplastic - metabolism | Deoxycytidine - analogs & derivatives | Neoplastic Stem Cells - physiology | Apoptosis | Vimentin | Cell proliferation | Histone deacetylase | Chromatin | Deactivation | Gemcitabine | Oct-4 protein | Exploration | mRNA | siRNA | E-cadherin | Cell growth | Lysine | Pancreatic cancer | Cell lines | Stem cells | Tumor suppressor genes | Trichostatin A | Methylation
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3. Full Text Prognostic value of the biomarkers serum amyloid A and nitric oxide in patients with sepsis
by Yu, Mei-Hong and Chen, Min-Hua and Han, Fang and Li, Qian and Sun, Ren-Hua and Tu, Yue-Xing
International Immunopharmacology, ISSN 1567-5769, 09/2018, Volume 62, pp. 287 - 292
Sepsis is a major cause of mortality among critically ill patients in the intensive care unit (ICU). Alterations in serum amyloid A (SAA) and nitric oxide (NO)... 
Serum amyloid A nitric oxide | CRP | Sepsis | Septic shock | APACHE II score | Mortality | MANAGEMENT | IMMUNOLOGY | DEFINITIONS | SIRS | PHARMACOLOGY & PHARMACY | INFECTION | DYSFUNCTION | EPIDEMIOLOGY | Nitric Oxide - blood | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Critical Illness | Male | Biomarkers - blood | Shock, Septic - mortality | Sepsis - mortality | Sensitivity and Specificity | Shock, Septic - blood | Female | Sepsis - blood | APACHE | Serum Amyloid A Protein - analysis | Medical research | Care and treatment | Prognosis | C-reactive protein | Nitric oxide | Analysis | Medicine, Experimental | Biological markers
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4. Full Text WITHDRAWN: Inhibition of CHOP weakens the promotion of chronic intermittent hypoxia on epithelial cells apoptosis via inhibiting PI3K-Akt and NF-?B signaling pathways
by Wang, Yi-Bin and Ni, Yin and Sun, Ren-Hua and Mou, Xiao-Zhou and Han, Fang and Li, Qian and Huang, Hai-Jun and Liu, Jing-Quan and Tu, Yue-Xing
Oncotarget, ISSN 1949-2553, 12/2017, Issue 5
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5. Full Text Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
by Chen, Fei and Chen, Jianing and Yang, Linbin and Liu, Jiang and Zhang, Xiaoqian and Zhang, Yin and Tu, Qingqiang and Yin, Dong and Lin, Dechen and Wong, Ping-Pui and Huang, Di and Xing, Yue and Zhao, Jinghua and Li, Mengfeng and Liu, Qiang and Su, Fengxi and Su, Shicheng and Song, Erwei
Nature Cell Biology, ISSN 1465-7392, 04/2019, Volume 21, Issue 4, pp. 498 - 510
Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-associated macrophages (TAMs) enhance the aerobic glycolysis and apoptotic... 
HETEROGENEITY | INHIBITION | MICROENVIRONMENT | GLUCOSE-METABOLISM | GROWTH | RESISTANCE | METASTATIC NICHE FORMATION | HYPOXIA | PROMOTE | PROGRESSION | CELL BIOLOGY | Transducers | Hydroxylation | Chemoresistance | Breast cancer | Macrophages | Ribonucleic acid--RNA | Glycolysis | Breast | Lactic acid | Feedforward | Tumors | Apoptosis | Cancer
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6. Full Text Mass spectrometric U-series dating of Huanglong Cave in Hubei Province, central China: Evidence for early presence of modern humans in eastern Asia
by Shen, Guanjun and Wu, Xianzhu and Wang, Qian and Tu, Hua and Feng, Yue-xing and Zhao, Jian-xin
Journal of Human Evolution, ISSN 0047-2484, 08/2013, Volume 65, Issue 2, pp. 162 - 167
Most researchers believe that anatomically modern humans (AMH) first appeared in Africa 160-190 ka ago, and would not have reached eastern Asia until ∼50 ka... 
Anatomically modern humans | Huanglong Cave | U-series dating | China | SOUTHERN CHINA | GUANGXI | ETHIOPIA | VARIABILITY | AFRICA | EVOLUTIONARY BIOLOGY | EVOLUTION | HOMINID SITE | ANTHROPOLOGY | REMAINS | AGE | Biological Evolution | Caves - chemistry | Radiometric Dating | Humans | Mass Spectrometry | Geologic Sediments - chemistry | Tooth - chemistry | Uranium - chemistry | Chronology as Topic | Fossils | Human evolution | Fossil hominids | Mass spectrometry | Analysis
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7. Full Text Bacteria-Instructed Click Chemistry between Functionalized Gold Nanoparticles for Point-of-Care Microbial Detection
by Mou, XZ and Chen, XY and Wang, JH and Zhang, ZT and Yang, YM and Shou, ZX and Tu, YX and Du, XC and Wu, C and Zhao, Y and Qiu, L and Jiang, PJ and Chen, CY and Huang, DS and Li, YQ
ACS APPLIED MATERIALS & INTERFACES, ISSN 1944-8244, 07/2019, Volume 11, Issue 26, pp. 23093 - 23101
Bacterial infections pose mounting public health concerns and cause an enormous medical and financial burden today. Rapid and sensitive detection of pathogenic... 
GENETIC DETECTION | SYSTEM | INFECTIONS | QUANTIFICATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | chronic wound healing | NANOSCIENCE & NANOTECHNOLOGY | MECHANISMS | COLORIMETRIC DETECTION | nanofibers | biofilm eradication | pH-switchable drug release | antimicrobial hydrogel | STAPHYLOCOCCUS-AUREUS | PATHOGENS
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8. Full Text Regorafenib suppresses colon tumorigenesis and the generation of drug resistant cancer stem-like cells via modulation of miR-34a associated signaling
by Cai, Mao-Hua and Xu, Xiao-Gang and Yan, Shi-Li and Sun, Ze and Ying, Yin and Wang, Bai-Kui and Tu, Yue-Xing
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 07/2018, Volume 37, Issue 1, pp. 151 - 11
Background: Colorectal cancer (CRC) is one of the most prevalent malignancies in the world and developed drug resistance has represented one of the most... 
Cancer stem-like cells | Regorefanib | 5-fluouracil resistant colon cancer | WNT/β-catenin signaling and miR-34a | INVASION | METASTASIS | ONCOLOGY | WNT/beta-catenin signaling and miR-34a | SUSCEPTIBILITY | PROLIFERATION | MICRORNA-34A | EXPRESSION | Genetic aspects | Colon cancer | Research | Drug resistance | Drug therapy | Colorectal cancer | Breast cancer | Metastasis | Kinases | Cancer therapies | Proteins | Cell growth | Chemotherapy | MicroRNAs | Pancreatic cancer | Stem cells | Tumorigenesis | Prostate cancer
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9. Full Text Ovatodiolide targets chronic myeloid leukemia stem cells by epigenetically upregulating hsa-miR-155, suppressing the BCR-ABL fusion gene and dysregulating the PI3K/AKT/mTOR pathway
by Tu, YX and Wang, SB and Fu, LQ and Li, SS and Guo, QP and Wu, Y and Mou, XZ and Tong, XM
ONCOTARGET, ISSN 1949-2553, 01/2018, Volume 9, Issue 3, pp. 3267 - 3277
Chronic myeloid leukemia (CML) is a myeloproliferative pathology, originating from the hematopoietic cancer stem cells (hCSCs) due to the Bcl-Abl Philadelphia... 
CML | diterpenoid ovatodiolide | TYROSINE KINASE | CD34(+)/CD38(-) | MICRORNAS | CANCER | CELL BIOLOGY | PI3K/AKT/mTOR | THERAPY | COMPLETE CYTOGENETIC REMISSION | IMATINIB MESYLATE TREATMENT | STAT5 | DIFFERENTIATION | hematopoietic stem cells | INHIBITOR | TUMORIGENESIS
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10. Full Text Ovatodiolide targets chronic myeloid leukemia stem cells by epigenetically upregulating hsa-miR-155, suppressing the BCRABL fusion gene and dysregulating the PI3K/AKT/mTOR pathway
by Tu, Yue-Xing and Wang, Shi-Bing and Fu, Luo-Qin and Li, Shuang-Shuang and Guo, Qian-Peng and Wu, Yi and Mou, Xiao-Zhou and Tong, Xiang-Min
Oncotarget, 2018, Volume 9, Issue 3, pp. 3267 - 3277
CD38 | CML | PI3K/AKT/mTOR | CD34 | Hematopoietic stem cells | Diterpenoid ovatodiolide
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11. Full Text Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2–p53 interaction
by Zheng, Guang-hui and Shen, Jia-jia and Zhan, Yue-chen and Yi, Hong and Xue, Si-tu and Wang, Zhen and Ji, Xing-yue and Li, Zhuo-rong
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2014, Volume 81, pp. 277 - 288
A novel class of small-molecule inhibitors of MDM2–p53 interaction with a ( )-3-benzylideneindolin-2-one scaffold was identified using an integrated virtual... 
Antiproliferative activity | Small-molecule inhibitors | MDM2–p53 interaction | MDM2-p53 interaction | ACTIVATION | DOMAIN | CHEMISTRY, MEDICINAL | PROTEIN-PROTEIN INTERACTION | P53 PATHWAY | DISCOVERY | OPTIMIZATION | ANTAGONISTS | BINDING | EFFICIENCY | Molecular Weight | Antineoplastic Agents - chemical synthesis | HCT116 Cells | Humans | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Animals | Protein Binding - drug effects | Drug Design | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Molecular Structure | Cell Cycle - drug effects | Neoplasms, Experimental - drug therapy | Proto-Oncogene Proteins c-mdm2 - metabolism | Drug Screening Assays, Antitumor | Tumor proteins | Colorectal cancer | Index Medicus
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12. Serum Proteomic Changes as Candidate Biomarkers of Intermediate Liver Fibrosis in Chronic Hepatitis B Infection
by Dai, Yi-Ning and Tu, Yue-Xing and Meng, Di and Chen, Mei-Juan and Zhang, Jia-Jie and Gong, Yu-Han and Tong, Yong-Xi and Wang, Ming-Shan and Pan, Hong-Ying and Huang, Hai-Jun
OMICS A Journal of Integrative Biology, ISSN 1536-2310, 03/2019, Volume 23, Issue 3, pp. 167 - 179
Chronic hepatitis B (CHB) is a major global health burden. Liver fibrosis, an insidious process, is the main histopathological change in CHB that might lead to... 
precision medicine | microbial proteomics | diagnostic medicine | liver fibrosis biomarkers | hepatitis B | Proteomics | TAFI DEFICIENCY | proteomics | MODELS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DISEASE | GENETICS & HEREDITY | EPIDEMIOLOGY
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13. Full Text Age of Maba hominin site in southern China: Evidence from U-series dating of Southern Branch Cave
by Shen, Guanjun and Tu, Hua and Xiao, Dongfang and Qiu, Licheng and Feng, Yue-xing and Zhao, Jian-xin
Quaternary Geochronology, ISSN 1871-1014, 10/2014, Volume 23, pp. 56 - 62
Maba hominin, one of the key representatives of archaic in China, was originally attributed to around the Middle-Late Pleistocene transition (∼130 ka) based on... 
Middle Pleistocene | Maba hominin | Speleothem calcite | Southern China | U-series dating | Archaic Homo sapiens | URANIUM | MODERN HUMANS | HUMAN-EVOLUTION | ETHIOPIA | MODEL | HOMO HEIDELBERGENSIS | AFRICA | ORIGIN | GEOGRAPHY, PHYSICAL | GEOSCIENCES, MULTIDISCIPLINARY | ASIA | Archaeology
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14. Full Text Design, synthesis and antiproliferative activity of a novel class of indole-2-carboxylate derivatives
by Ji, Xing-yue and Xue, Si-tu and Zhan, Yue-chen and Shen, Jia-jia and Wu, Lin-tao and Jin, Jie and Wang, Zhen and Li, Zhuo-rong
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2014, Volume 83, pp. 409 - 418
Based on the chemical structure of Pyrroloquinoline quinone (PQQ), a novel class of indole-2-carboxylate derivatives was designed, synthesized and assayed for... 
PQQ | ROS generation | Antiproliferative activities | Indole-2-carboxylate derivatives | PYRROLOQUINOLINE QUINONE PQQ | NORTOPSENTIN | COENZYME | CHEMISTRY, MEDICINAL | PHYSIOLOGICAL IMPORTANCE | ANALOGS | ANTITUMOR-ACTIVITY | INHIBITOR | Chemistry Techniques, Synthetic | Intracellular Space - drug effects | Reactive Oxygen Species - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Proteolysis - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Intracellular Space - metabolism | Drug Design | Cell Line, Tumor | Inhibitory Concentration 50 | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Cell Cycle - drug effects | Indoles - chemistry | Drug Screening Assays, Antitumor | Etoposide | Quinone | Lead compounds
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15. Full Text miR-133b Downregulation Reduces Vulnerable Plaque Formation in Mice with AS through Inhibiting Macrophage Immune Responses
by Zheng, Cheng-Gen and Chen, Bing-Yu and Sun, Ren-Hua and Mou, Xiao-Zhou and Han, Fang and Li, Qian and Huang, Hai-Jun and Liu, Jing-Quan and Tu, Yue-Xing
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 06/2019, Volume 16, pp. 745 - 757
Atherosclerosis (AS) is a chronic inflammatory disease characterized by accumulating deposition of lipids in the arterial intima. Notably, macrophages... 
atherosclerosis | Notch-signaling pathway | macrophage | plaque formation | microRNA-133b | Animal models | Immune response | Leukocyte migration | Therapeutic applications | Genes | MiRNA | Lipids | Smooth muscle | Macrophages | Manuscripts | Cholesterol | Inflammatory diseases | Signal transduction | Lipoproteins | Arteriosclerosis | MicroRNAs | Apoptosis
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16. Full Text SAA1 increases NOX4/ROS production to promote LPS-induced inflammation in vascular smooth muscle cells through activating p38MAPK/NF-κB pathway
by Yu, Mei-Hong and Li, Xi and Li, Qian and Mo, Shi-Jing and Ni, Yin and Han, Fang and Wang, Yi-Bin and Tu, Yue-Xing
BMC Molecular and Cell Biology, ISSN 2661-8850, 06/2019, Volume 20, Issue 1, p. 15
Background To investigate the effects of serum amyloid A1 (SAA1) on lipopolysaccharide (LPS) -induced inflammation in vascular smooth muscle cells (VSMCs).... 
Vascular smooth muscle cell | Inflammation | p38MAPK/NF-κB | Serum amyloid A1 | NOX-4/ROS | LPS | PHYSIOLOGY | p38MAPK/NF-kappa B | INVOLVEMENT | ATHEROSCLEROSIS | VARIANT | CELL BIOLOGY | SERUM AMYLOID-A | LIPOPOLYSACCHARIDE | LOW-GRADE INFLAMMATION | DYSFUNCTION | EXPRESSION | NADPH OXIDASES | Oxidative stress | Toxicity | Smooth muscle | Cardiovascular disease | Kinases | NAD(P)H oxidase | Western blotting | Lipopolysaccharides | Interleukin 6 | Proteins | Signal transduction | NOX4 protein | Atherosclerosis | Physiology | Amyloid | Interleukin 8 | NF-κB protein | Superoxide | siRNA | Chemiluminescence | Tumor necrosis factor-α | IL-1β | Interleukin 17 | Polymerase chain reaction | Protein expression | Monocyte chemoattractant protein 1
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17. Determining the geochemical variability of fine-grained basalt sources/quarries for facilitating prehistoric interaction studies in Polynesia
by MARSHALL Weisler and ROBERT Bolhar and MICHEL Charleux and J TYLER Faith and YUE-XING Feng and EMMA ST Pierre
Archaeology in Oceania, ISSN 0728-4896, 07/2016, Volume 51, Issue 2, p. 158
  Polynesian adze sourcing studies that rely on geochemical analyses to assign distant artefacts to a source or quarry have been undertaken for more than three... 
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18. Full Text Synthesis and anti-influenza virus activities of a novel class of gastrodin derivatives
by Xue, Si-Tu and He, Wei-Ying and Ma, Lin-Lin and Wang, Hui-Qiang and Wang, Bo and Zheng, Guang-Hui and Ji, Xing-Yue and Zhang, Tian and Li, Yu-Huan and Jiang, Jian-Dong and Li, Zhuo-Rong
Molecules, ISSN 1420-3049, 04/2013, Volume 18, Issue 4, pp. 3789 - 3805
A series of substituted aryl glycoside analogues of gastrodin have been identified as potential anti-influenza agents. The most potent inhibitor 1a exhibited... 
Influenza virus inhibitors | Synthesis | Aryl glycoside | Gastrodin | synthesis | influenza virus inhibitors | gastrodin | aryl glycoside | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | ISOLATED WORLDWIDE | CHEMISTRY, MULTIDISCIPLINARY | Antiviral Agents - pharmacology | Glucosides - pharmacology | Neuraminidase - metabolism | Structure-Activity Relationship | Influenza A Virus, H1N1 Subtype - drug effects | Influenza A Virus, H1N1 Subtype - growth & development | Glucosides - chemical synthesis | Animals | Viral Matrix Proteins - antagonists & inhibitors | Benzyl Alcohols - pharmacology | Hemagglutination - drug effects | Antiviral Agents - chemical synthesis | Inhibitory Concentration 50 | Female | Neuraminidase - antagonists & inhibitors | Viral Matrix Proteins - metabolism | Mice | Benzyl Alcohols - chemical synthesis | Oseltamivir - pharmacology
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19. Synthesis and Antiviral Activities of Synthetic Glutarimide Derivatives
by Xing-yue Ji and Zhao-jin Zhong and Si-tu Xue and Shuai Meng and Wei-ying He and Rong-mei Gao and Yu-huan Li and Zhuo-rong Li
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 11/2010, Volume 58, Issue 11, p. 1436
  A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral... 
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20. Full Text Ceramic-Polymer Composites with Low Dielectric Loss for Microwave Antennas and Wireless Sensors
by Zhang, Li and Li, Long Tu and Yue, Zhen Xing
Key Engineering Materials, ISSN 1013-9826, 07/2015, Volume 655, pp. 153 - 158
The low dielectric loss ceramic-polymer composites were prepared by extrusion processing technique with high density polyethylene (HDPE) as matrix and high... 
Microwave antennas | Polymer-ceramic composites | Microwave dielectrics | Dielectric loss | Ceramic powders | Polyethylenes | Dielectric constant | High density | Dielectric properties | Ceramics
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