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6,7-benzomorhan scaffold (2) 2
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analgesics - metabolism (2) 2
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ChemPlusChem, ISSN 2192-6506, 12/2015, Volume 80, Issue 12, p. 1786
Dithiocarbamates (DTCs) are an interesting class of ligands that have been extensively investigated. These compounds have great potential in the field of... 
Antioxidants | Fungicides | Ionization | Copper compounds | Nuclear magnetic resonance spectroscopy | Superoxide | Mass spectrometry | Chelates
Journal Article
Pharmaceuticals, ISSN 1424-8247, 06/2018, Volume 11, Issue 2, p. 40
(−)- - -Normetazocine represents a rigid scaffold able to mimic the tyramine moiety of endogenous opioid peptides, and the introduction of different... 
Calcium mobilization | Benzomorphan | Opioid receptors | Radioligand binding | Proteins | Ligands | Pharmacology | Peptides | Narcotics | Nitrogen
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2019, Volume 168, pp. 189 - 198
The pivotal role of the stereocenter at the -substituent of the 6,7-benzomorphan scaffold was investigated combining synthetic and pharmacological approaches.... 
BRET | Pain | Tail flick test | Multitarget | Asymmetric synthesis | β-arrestin | Radioligand competition binding | G-protein | CHEMISTRY, MEDICINAL | beta-arrestin | TOLERANCE | LP1 | BETA-ARRESTIN 2 | PROFILE | LIGANDS | ANALGESIA | SCAFFOLD | Synthesis | Diastereomers | Analysis | Protein binding | Organic compounds | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2019, Volume 174, pp. 226 - 235
A new set of 5-chlorobenzoxazole- and 5-chlorobenzothiazole-based derivatives containing the azepane ring as a basic moiety was designed, synthesized and... 
Pain | Sigma-1 receptors | Benzothiazole | Benzoxazole | Sigma-2 receptors | Cancer | Apoptosis | CHEMISTRY, MEDICINAL | ANTAGONIST | HIGH-AFFINITY | MODEL | IDENTIFICATION | SELECTIVE LIGANDS | POTENT | 5-HT1A | DERIVATIVES | BINDING | SCAFFOLD
Journal Article
Natural product research, ISSN 1478-6419, 04/2019, pp. 1 - 7
Rosmarinus officinalis L. (RO), an aromatic plant used as food condiment and in traditional medicine, exerts numerous beneficial properties including... 
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, pp. 70 - 82
Persistent pain states, such as those caused by nerve injury or inflammation, are associated with altered sensations, allodynia and hyperalgesia, that are... 
Micro-electrode array (MEA) | Opioid receptors | Electrophysiological behaviour | LP1 | Inflammatory pain | Neuropathic pain | MU-AGONIST/DELTA-ANTAGONIST | TOLERANCE | SPINAL-CORD | MECHANISMS | MICROELECTRODE ARRAYS | NEUROSCIENCES | RAT MODEL | GAP-JUNCTIONS | PHARMACOLOGY & PHARMACY | RECEPTORS | Receptors, Opioid, delta - metabolism | Spinal Cord - drug effects | Spinal Cord - metabolism | Frontal Lobe - metabolism | Embryo, Mammalian | Neuralgia - metabolism | Analgesics, Opioid - pharmacology | Male | Neurons - cytology | Benzomorphans - metabolism | Receptors, Opioid, mu - agonists | Neuralgia - immunology | Receptors, Opioid, delta - antagonists & inhibitors | Neurons - metabolism | Spinal Cord - cytology | Frontal Lobe - cytology | Neurons - drug effects | Benzomorphans - pharmacology | Disease Models, Animal | Nerve Tissue Proteins - antagonists & inhibitors | Chronic Pain - drug therapy | Receptors, Opioid, mu - metabolism | Nerve Tissue Proteins - agonists | Cells, Cultured | Neurons - immunology | Rats | Analgesics, Opioid - therapeutic use | Random Allocation | Chronic Pain - immunology | Mice, Inbred Strains | Rats, Sprague-Dawley | Neuralgia - drug therapy | Nerve Tissue Proteins - metabolism | Spinal Cord - immunology | Chronic Pain - metabolism | Animals | Benzomorphans - therapeutic use | Frontal Lobe - drug effects | Frontal Lobe - immunology | Ligands | Mice | Analgesics, Opioid - metabolism | Care and treatment | Carrageenin | Pain | Analgesics | Neurons | Analysis | Index Medicus | Indexing in process
Journal Article
Life Sciences, ISSN 0024-3205, 2012, Volume 90, Issue 1, pp. 66 - 70
Journal Article
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