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Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 31, pp. 4897 - 4902
Journal Article
Vaccine, ISSN 0264-410X, 2007, Volume 26, Issue 2, pp. 201 - 214
Summary The recognition of specific pathogen associated molecular patterns (PAMPs) by members of the Toll-like receptor (TLR) family is critical for the... 
Allergy and Immunology | Toll-like receptors | M2e | Influenza A | Innate immunity | Vaccine | MEDICINE, RESEARCH & EXPERIMENTAL | influenza A | toll-like receptors | NUCLEAR TRANSPORT | EXTRACELLULAR DOMAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | A VIRUS | M1 PROTEIN | vaccine | PROTECTIVE IMMUNITY | innate immunity | IMMUNOSTIMULATORY DNA | MATRIX PROTEIN-2 | IN-VIVO | VETERINARY SCIENCES | Enzyme-Linked Immunosorbent Assay - methods | Orthomyxoviridae Infections - prevention & control | Recombinant Fusion Proteins - immunology | Viral Matrix Proteins - genetics | Orthomyxoviridae Infections - physiopathology | Influenza A virus - genetics | Antigens, Bacterial - immunology | Antigens, Viral - genetics | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Antigens, Bacterial - genetics | Epitopes - immunology | Flagellin - genetics | Flagellin - immunology | Orthomyxoviridae Infections - pathology | Vaccines, Synthetic - genetics | Antigens, Viral - immunology | Animals | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Escherichia coli - genetics | Weight Loss | Survival Analysis | Recombinant Fusion Proteins - genetics | Mice | Mice, Inbred BALB C | Viral Matrix Proteins - immunology | Influenza vaccines | Monoclonal antibodies | Peptides | Recombinant proteins | Immunity | Influenza | Proteins | Studies | Antigens | Pandemics | Aqueous solutions | Ligands | T cell receptors | Vaccines | Deoxyribonucleic acid--DNA | Immune system
Journal Article
Vaccine, ISSN 0264-410X, 2010, Volume 28, Issue 52, pp. 8268 - 8274
Abstract Background The need for worldwide seasonal and pandemic vaccine production has increased interest in the development of innovative technologies for... 
Allergy and Immunology | Clinical trials | Influenza | Vaccine | UNITED-STATES | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | VIRUS | PROTEIN | DISEASE | ANTIBODY | SERUM | IMMUNOLOGY | Influenza Vaccines - administration & dosage | Humans | Middle Aged | Male | Neutralization Tests | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Hemagglutination Inhibition Tests | Young Adult | Vaccination - methods | Vaccines, Synthetic - adverse effects | Flagellin - genetics | Adult | Female | C-Reactive Protein - analysis | Antibodies, Bacterial - blood | Placebos - administration & dosage | Cytokines - blood | Flagellin - immunology | Gene Expression | Hemagglutinins, Viral - genetics | Vaccines, Synthetic - genetics | Influenza Vaccines - adverse effects | Injections, Intramuscular | Hemagglutinins, Viral - immunology | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Escherichia coli - genetics | Adolescent | Vaccines, Synthetic - administration & dosage | Influenza viruses | Medical colleges | Safety and security measures | Swine influenza | Lectins | Youth | Teenagers | Vaccines | Cell culture | Pandemics | Cytokines | E coli | Viruses | Ligands | Headache | C-reactive protein | Immune response | TLR5 protein | Vaccination | Flagellin | Fatigue | Antibody response | Pain | Immunogenicity | Virions | Hemagglutinins | Toll-like receptors | Islands | pandemics | Manganese
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 30, Issue 39, pp. 5761 - 5769
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20928
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 30, Issue 48, pp. 6833 - 6838
Highlights ► Generated two formats of recombinant flagellin-HA vaccines targeting 3 H5N1 HPAIV. ► The vaccines protect ferrets against a lethal... 
Allergy and Immunology | Flagellin | Toll-like receptor 5 | H5N1 | Prokaryotic expression | Subunit vaccine | Influenza | ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | SAFETY | FUSION VACCINE | LETHAL CHALLENGE | IMMUNOLOGY | TRIAL | IMMUNOGENICITY | TRANSMISSION | Orthomyxoviridae Infections - prevention & control | Influenza Vaccines - administration & dosage | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Male | Virus Shedding | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Vaccination - methods | Injections, Subcutaneous | Flagellin - administration & dosage | Flagellin - genetics | Adjuvants, Immunologic - genetics | Recombinant Fusion Proteins - administration & dosage | Disease Models, Animal | Nasal Mucosa - virology | Hemagglutinin Glycoproteins, Influenza Virus - administration & dosage | Vaccines, Synthetic - genetics | Ferrets | Animals | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Influenza A Virus, H5N1 Subtype - immunology | Survival Analysis | Recombinant Fusion Proteins - genetics | Mice | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | Influenza viruses | Influenza vaccines | Virus diseases | Avian influenza | Health aspects | Proteins | Pandemics | E coli | Laboratories | Plasmids | Viruses | Vaccines | Manufacturing | Chromatography | Eggs | Fowl plague | Immunization | TLR5 protein | Immunoglobulin G | Lung | Immunity | Antibody response | Infection | Song | Immunogenicity | Hemagglutinins | Toll-like receptors | Influenza A | pandemics
Journal Article
Journal of Virology, ISSN 0022-538X, 12/2005, Volume 79, Issue 24, pp. 15547 - 15555
Journal Article
Science, ISSN 0036-8075, 7/2004, Volume 305, Issue 5683, pp. 528 - 532
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV)... 
Antiretrovirals | Animals | Viremia | Antivirals | Viruses | Reports | Infections | Cellular immunity | Integrase inhibitors | Viral load | HIV 1 | CELLS | HIV | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | TRANSCRIPTION | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | Anti-HIV Agents - pharmacology | HIV Integrase Inhibitors - pharmacology | Integrase Inhibitors - blood | Drug Resistance, Viral | Integrase Inhibitors - pharmacology | Macaca mulatta | HIV Integrase - metabolism | HIV Integrase Inhibitors - administration & dosage | Leukocytes, Mononuclear - virology | Viral Load | Anti-HIV Agents - administration & dosage | CD4-Positive T-Lymphocytes - immunology | Acquired Immunodeficiency Syndrome - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Simian Immunodeficiency Virus - genetics | HIV-1 - physiology | Anti-HIV Agents - therapeutic use | Integrases - metabolism | Anti-HIV Agents - blood | Integrase Inhibitors - therapeutic use | Acquired Immunodeficiency Syndrome - virology | Naphthyridines - blood | Virus Replication - drug effects | HIV-1 - drug effects | Cells, Cultured | CD4 Lymphocyte Count | Viremia - drug therapy | HIV-1 - genetics | Acquired Immunodeficiency Syndrome - drug therapy | Simian Immunodeficiency Virus - enzymology | Simian Immunodeficiency Virus - physiology | HIV Integrase - genetics | Integrase Inhibitors - administration & dosage | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | Naphthyridines - therapeutic use | HIV Integrase Inhibitors - therapeutic use | HIV Integrase Inhibitors - blood | HIV-1 - enzymology | Mutation | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Integrases - genetics | Naphthyridines - administration & dosage | Simian Immunodeficiency Virus - drug effects | Naphthyridines - pharmacology | Physiological aspects | Research | HIV (Viruses) | Drug therapy | Chemotherapy | Immunology | Monkeys & apes | Human immunodeficiency virus--HIV | Immune system
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 34, pp. 4317 - 4323
Highlights • Designed a novel vaccine format (D3Ins) for fusion of an Influenza B globular head domain and flagellin. • The D3Ins format supports strong TLR5... 
Allergy and Immunology | Influenza B vaccine | Flagellin domain 3 insertion | HA globular head | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE |