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Journal Article
MOLECULES, ISSN 1420-3049, 06/2013, Volume 18, Issue 6, pp. 6383 - 6407
Journal Article
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 11/2018, Volume 62, Issue 11
Targeting lanosterol 14 alpha-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but... 
Candida albicans | antifungal | Saccharomyces cerevisiae expression | fungal pathogen | lanosterol 14α-demethylase | Candida glabrata | cytochrome P450 | HUMAN ENZYME | lanosterol 14 alpha-demethylase | CYTOCHROME-P450 | MICROBIOLOGY | HIGHLY POTENT INHIBITOR | CYP51 | YEAST | ERGOSTEROL | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | BINDING | EPIDEMIOLOGY | FLUCONAZOLE
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 03/2018, Volume 62, Issue 3
Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the... 
lanosterol 14 alpha-demethylase | CYTOCHROME-P450 | SUBSTITUTION | ASPERGILLUS-FUMIGATUS | REDUCED SUSCEPTIBILITY | voriconazole | CROSS-RESISTANCE | MICROBIOLOGY | itraconazole | CYP51A | antifungal resistance | CYP51 | fungal infections | X-ray crystallography | fluconazole | AMINO-ACID | drug resistance mechanisms | AZOLE RESISTANCE | PHARMACOLOGY & PHARMACY | BINDING | Fungal Proteins - chemistry | Fluconazole - pharmacology | Fluconazole - chemistry | Saccharomyces cerevisiae - genetics | Sterol 14-Demethylase - genetics | Aspergillus fumigatus - enzymology | Substrate Specificity | Crystallography, X-Ray | Saccharomyces cerevisiae - drug effects | Antifungal Agents - chemistry | Histidine - metabolism | Recombinant Fusion Proteins - metabolism | Itraconazole - pharmacology | Candida albicans - genetics | Fluconazole - metabolism | Microbial Sensitivity Tests | Antifungal Agents - metabolism | Cloning, Molecular | Protein Interaction Domains and Motifs | Antifungal Agents - pharmacology | Itraconazole - metabolism | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Catalytic Domain | Gene Expression | Genetic Vectors - chemistry | Oligopeptides - genetics | Genetic Vectors - metabolism | Histidine - genetics | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Itraconazole - chemistry | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Aspergillus fumigatus - genetics | Protein Binding | Recombinant Fusion Proteins - genetics | Saccharomyces cerevisiae - enzymology | Sterol 14-Demethylase - metabolism | Kinetics | Mutation | Sterol 14-Demethylase - chemistry | Candida albicans - enzymology | Fungal Proteins - metabolism
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 07/2017, Volume 69, Issue 3, pp. 316 - 353
Journal Article
Scientific Reports, ISSN 2045-2322, 05/2016, Volume 6, Issue 1, p. 26213
Emergence of fungal strains showing resistance to triazole drugs can make treatment of fungal disease problematic. Triazole resistance can arise due to single... 
VORICONAZOLE | CYTOCHROME-P450 | ASPERGILLUS-FUMIGATUS | MULTIDISCIPLINARY SCIENCES | AZOLE RESISTANCE | SUSCEPTIBILITY | MECHANISMS | TR46/Y121F/T289A MUTATION | BINDING | EPIDEMIOLOGY | CYP51
Journal Article
Tetrahedron, ISSN 0040-4020, 03/2018, Volume 74, Issue 12, pp. 1184 - 1190
JO146, a mixture of two diastereomers of a peptidic phosphonate inhibitor for Chlamydial HtrA (CtHtrA), has reported activity against species in both human and... 
HtrA inhibition | JO146 | Chlamydia | Protease | Diastereomers | COMPLEX | SERINE PROTEASES | CRYSTAL-STRUCTURE | CHEMISTRY, ORGANIC | NEUTROPHIL ELASTASE | HTRA | CATHEPSIN-G | DERIVATIVES | BINDING
Journal Article