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Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2013, Volume 368, Issue 19, pp. 1781 - 1790
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2011, Volume 364, Issue 23, pp. 2187 - 2198
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 244 - 13
FLT3 mutations are prevalent in AML patients and confer poor prognosis. Crenolanib, a potent type I pan-FLT3 inhibitor, is effective against both internal... 
TARGETED THERAPY | AML | INTERNAL TANDEM DUPLICATION | ACTIVATION | FLT3 INHIBITORS | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | PROGNOSTIC RELEVANCE | MUTATIONS | SORAFENIB | CHEMOTHERAPY | Humans | Middle Aged | Male | Antineoplastic Combined Chemotherapy Protocols - pharmacology | fms-Like Tyrosine Kinase 3 - genetics | Piperidines - pharmacology | HEK293 Cells | Aged, 80 and over | Inhibitory Concentration 50 | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Pyrimidinones - pharmacology | Epigenesis, Genetic - drug effects | Tandem Repeat Sequences - genetics | Benzimidazoles - therapeutic use | Leukemia, Myeloid, Acute - pathology | Membrane Proteins - genetics | Pyrimidinones - therapeutic use | Isocitrate Dehydrogenase - genetics | Treatment Outcome | Mutation - genetics | Whole Exome Sequencing | Drug Resistance, Neoplasm - genetics | Animals | Mutation - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | GTP Phosphohydrolases - genetics | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Benzimidazoles - pharmacology | Aged | Mice | Protein Kinase Inhibitors - pharmacology | Pyridones - therapeutic use | Pyridones - pharmacology | Drug Screening Assays, Antitumor | Leukemia, Myeloid, Acute - genetics | Tyrosine | Regulators | Transcription factors | Myeloid leukemia | Leukemia | Genetic diversity | Kinases | Patients | Molecular modelling | Epigenetics | Mutation | Acute myeloid leukemia | Protein-tyrosine kinase
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2012, Volume 366, Issue 18, pp. 1696 - 1704
Journal Article