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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2014, Volume 111, Issue 17, p. 6383
  Alveolar rhabdomyosarcoma (aRMS) is an aggressive myogenic childhood malignancy, not infrequently presenting as incurable metastatic disease. To identify... 
Rodents | Genetic engineering | Metastasis | Ribonucleic acid--RNA | Kinases | Tumors
Journal Article
Science Translational Medicine, ISSN 1946-6234, 08/2016, Volume 8, Issue 354, pp. 354ra114 - 354ra114
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2011, Volume 10, Issue 6, pp. 1028 - 1035
Journal Article
Blood, ISSN 0006-4971, 03/2014, Volume 123, Issue 10, pp. 1516 - 1524
Development of resistance to kinase inhibitors remains a clinical challenge. Kinase domain mutations are a common mechanism of resistance in chronic myeloid... 
MULTIPLE-MYELOMA | PROGENITOR CELLS | LUNG-CANCER | TYROSINE KINASE | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IMATINIB | FIBROBLAST-GROWTH-FACTOR | LEUKEMIA | HEMATOLOGY | ACTIVATING MUTATIONS | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Fibroblast Growth Factor 2 - chemistry | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Pyridazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Tumor Microenvironment - genetics | Protein Interaction Domains and Motifs - genetics | Fibroblast Growth Factor 2 - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Imidazoles - therapeutic use | Pyridazines - therapeutic use | Proto-Oncogene Proteins p21(ras) - metabolism | Tumor Microenvironment - drug effects | Signal Transduction | Imidazoles - pharmacology | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Drug Resistance, Neoplasm - genetics | Fibroblast Growth Factor 2 - genetics | Protein Kinase Inhibitors - therapeutic use | K562 Cells | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Proto-Oncogene Proteins c-abl - metabolism | Protein Kinase Inhibitors - pharmacology | Mutation | Mitogen-Activated Protein Kinases - metabolism | Myeloid Neoplasia
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 11/2014, Volume 13, Issue 11, pp. 2803 - 2811
Journal Article
Blood, ISSN 0006-4971, 03/2017, Volume 129, Issue 11, pp. e26 - e37
Journal Article
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, ISSN 0732-183X, 04/2020, Volume 38, Issue 10, pp. 1006 - 1018
Colony-stimulating factor-3 receptor ( )-T618I is a recurrent activating mutation in chronic neutrophilic leukemia (CNL) and to a lesser extent in atypical... 
Journal Article
Leukemia, ISSN 0887-6924, 12/2017, Volume 31, Issue 12, pp. 2752 - 2760
Journal Article
Current Hematologic Malignancy Reports, ISSN 1558-8211, 10/2017, Volume 12, Issue 5, pp. 432 - 441
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2016, Volume 22, Issue 1 Supplement, pp. IA04 - IA04
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 1, pp. 65 - 75
Tyrosine kinases are aberrantly activated in numerous malignancies, including acute myeloid leukemia (AML). To identify tyrosine kinases activated in AML, we... 
CELLCYCLE | ALLOGRAFT-REJECTION | POLYCYTHEMIA-VERA | MYELOPROLIFERATIVE DISORDERS | ONCOLOGY | CONSTITUTIVE ACTIVATION | TYROSINE KINASE JAK2 | PSEUDOKINASE DOMAIN | ACUTE MYELOID-LEUKEMIA | JANUS KINASE | CELL-LINES | MICE LACKING JAK3 | CELL BIOLOGY | RNA, Small Interfering - genetics | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | TYK2 Kinase | Janus Kinase 2 | Janus Kinase 3 | Protein-Tyrosine Kinases - genetics | Leukemia, Megakaryoblastic, Acute - genetics | Phosphorylation - drug effects | Leukemia, Megakaryoblastic, Acute - metabolism | Leukemia, Experimental - genetics | Leukemia, Experimental - pathology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Mice, Inbred C57BL | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Animals | Mutant Proteins - chemistry | Alleles | K562 Cells | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Benzamides | Leukemia, Megakaryoblastic, Acute - pathology | Leukemia, Experimental - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Allelomorphism | Proteins | Analysis | Oncology, Experimental | Research | Mass spectrometry | Phosphotransferases | Cancer
Journal Article