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Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. e20083 - e20083
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 01/2017, Volume 12, Issue 1, pp. S1145 - S1146
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. e23184 - e23184
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 01/2017, Volume 12, Issue 1, pp. S1145 - S1146
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 01/2017, Volume 12, Issue 1, pp. S1354 - S1355
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 01/2017, Volume 12, Issue 1, pp. S1354 - S1355
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 5512 - 5512
Journal Article
Oncology Reports, ISSN 1021-335X, 10/2018, Volume 40, Issue 4, pp. 1994 - 2004
Arginine depletion has shown anticancer effects among arginine auxotrophic cancers. An anti-proliferative effect of pegylated arginase (BCT-100) has been shown... 
Xenograft models | Lung adenocarcinoma | Pegylated arginase | Ornithine decarboxylase 1 inhibitor | Apoptosis | pegylated arginase | ornithine decarboxylase 1 inhibitor | xenograft models | lung adenocarcinoma | IN-VIVO PROLIFERATION | apoptosis | CELL-CYCLE ARREST | MECHANISMS | CANCER | RECOMBINANT HUMAN ARGINASE | ARGININE DEPLETION | POLYAMINES | ONCOLOGY | GROWTH-FACTOR | HUMAN HEPATOCELLULAR-CARCINOMA | Lung Neoplasms - drug therapy | Ornithine Decarboxylase - chemistry | Ornithine Decarboxylase - metabolism | Adenocarcinoma - pathology | Apoptosis - drug effects | Ornithine - metabolism | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Polyethylene Glycols - chemistry | Adenocarcinoma - drug therapy | Ornithine Decarboxylase Inhibitors - pharmacology | Xenograft Model Antitumor Assays | Adenocarcinoma - metabolism | Animals | Mice, Nude | Arginase - administration & dosage | Biomarkers, Tumor - metabolism | Female | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Tumor Cells, Cultured | Arginine - metabolism | Adenocarcinoma | Enzymes | Care and treatment | Lung cancer | Development and progression | Genetic aspects | Regulation | Health aspects | Carboxylases | Enzyme inhibitors | Arginine | Respiratory agents | Models | Drug therapy | Polyamines | High performance liquid chromatography | Enzyme-linked immunosorbent assay | Cancer | Leukemia | Melanoma | Clinical trials | Mesothelioma | Kinases | Cancer therapies | Proteins | Liver cancer | Cell growth | Cell cycle | Protein expression | Tumors
Journal Article
Cancer Cell International, ISSN 1475-2867, 10/2018, Volume 18, Issue 1, pp. 156 - 16
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, p. e77053
Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and... 
CANCER-CELLS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | HUMAN GLIOMAS | IMAGE-BASED SCREENS | CENTRAL-NERVOUS-SYSTEM | BRAIN-BARRIER MODEL | ADHERENT CULTURE | PHASE-I | TUMOR-INITIATING CELLS | Small Molecule Libraries - pharmacology | Glioblastoma - enzymology | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Glioblastoma - genetics | Swine | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Neoplastic Stem Cells - pathology | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Drug Screening Assays, Antitumor - methods | Cell Cycle Proteins - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Thiophenes - pharmacology | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tumor Suppressor Protein p53 - deficiency | Blood-Brain Barrier - drug effects | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Animals | Cell Cycle Checkpoints - drug effects | Glioblastoma - pathology | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Neoplastic Stem Cells - enzymology | Indans - pharmacology | Viral antibodies | Polo | Brain tumors | Stem cells | Antibodies | Tumor proteins | Glioblastoma multiforme | Neuroimaging | Image processing | Polo-like kinase 1 | Laboratories | p53 Protein | Brain cancer | Glioblastoma | Childrens health | Membrane permeability | Stem cell transplantation | Kinases | Cancer therapies | Defects | Allografts | Blood-brain barrier | Clonal deletion | DNA methylation | Deletion | Polo-like kinase | Cyclin-dependent kinase inhibitors | Pharmaceutical industry | Bioinformatics | Pharmaceutical sciences | Medical research | Antibody microarrays | INK4 protein | Permeability | Gene expression | Medical screening | Endothelial cells | Image analysis | Sensitivity | Brain research | Inhibitors | Neural stem cells | Adults | Mutation | Molecular biology | Human behavior | Tumors | Cancer
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 06/2014, Volume 1843, Issue 6, pp. 1162 - 1171
Journal Article
ONCOGENESIS, ISSN 2157-9024, 02/2019, Volume 8, Issue 3, pp. 18 - 11
Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate... 
VITRO | ACTIVATION | EFFICACY | ONCOLOGY | IN-VIVO PROLIFERATION | DOWN-REGULATION | HUMAN HEPATOCELLULAR-CARCINOMA | CANCER | RECOMBINANT HUMAN ARGINASE | ARSENIC TRIOXIDE | Cell culture | Immunosuppression | Arginine | Xenografts | Biomarkers | Arginase | Lung carcinoma | Ornithine | Mcl-1 protein | BIM protein | Apoptosis
Journal Article
Respiratory Research, ISSN 1465-9921, 05/2017, Volume 18, Issue 1, pp. 80 - 11
Background: Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in... 
Cell cycle arrest | Mesothelioma | BCT-100 | Pegylated arginase | Xenografts | Apoptosis | SURVIVAL | EFFICACY | IN-VIVO PROLIFERATION | DEPLETION | CELL-CYCLE ARREST | CANCER | RECOMBINANT HUMAN ARGINASE | THERAPY | RESPIRATORY SYSTEM | ARGININE DEPRIVATION | HUMAN HEPATOCELLULAR-CARCINOMA | Lung Neoplasms - drug therapy | Mesothelioma - pathology | Apoptosis - drug effects | Humans | Lung Neoplasms - pathology | Polyethylene Glycols - chemistry | Treatment Outcome | Antineoplastic Agents - administration & dosage | Mesothelioma - drug therapy | Pleural Neoplasms - drug therapy | Dose-Response Relationship, Drug | Animals | Mice, Nude | Arginase - administration & dosage | Cell Line, Tumor | Female | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Pleural Neoplasms - pathology | Immunohistochemistry | Cell culture | Biotechnology | Animal models | Bcl-2 protein | Leukemia | Lung cancer | Medical services | Staining | Clinical trials | Cytotoxicity | Arginase | Amino acids | Hepatocellular carcinoma | In vitro testing | Polyamines | Caspase-3 | Cancer therapies | Cyclin-dependent kinase 4 | Anticancer properties | Proteins | Liver cancer | Arginine | Cell cycle | Cleavage | Localization | Enzyme-linked immunosorbent assay | Tumor cells | Myeloid leukemia | Melanoma | Poly(ADP-ribose) polymerase | Caspase | Tumor cell lines | Survival | Cisplatin | Cyclins | Chemotherapy | Reagents | Bcl protein | Protein expression | Position (location) | Acute myeloid leukemia | Viability | Biotechnology industry | Tumors | Research
Journal Article
MedChemComm, ISSN 2040-2503, 6/2013, Volume 4, Issue 7, pp. 119 - 1113
The synthesis and biological properties of a structurally novel, potent and non-peptidic inhibitor of peptidylarginine deiminase are described. The novel... 
CHEMISTRY, MEDICINAL | CITRULLINATED PROTEINS | AUTOIMMUNITY | BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal Article
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