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1. Full Text Tfh cell response in influenza vaccines in humans: what is visible and what is invisible
by Ueno, Hideki
Current Opinion in Immunology, ISSN 0952-7915, 08/2019, Volume 59, pp. 9 - 14
Elucidating the immune mechanism by which seasonal influenza vaccines induce a protective immune response is of great importance to gain insights into the... 
Influenza vaccines | Antigens | Medical colleges | Microbiology | Analysis | Influenza | Vaccination | World health | B cells
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2. Full Text Regulation of human helper T cell subset differentiation by cytokines
by Schmitt, Nathalie and Ueno, Hideki
Current Opinion in Immunology, ISSN 0952-7915, 2015, Volume 34, pp. 130 - 136
Highlights • Development of Th1, Th2, Th9, and Th22 is largely similar between mice and humans. • TGF-β and STAT3 signals promote Th17 differentiation in both... 
Allergy and Immunology | Cell Differentiation | Animals | T-Lymphocytes, Helper-Inducer - immunology | Humans | T-Lymphocytes, Helper-Inducer - cytology | Cytokines - immunology | Cytokines | T cells | Transforming growth factors | Cell differentiation
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3. Full Text T follicular helper cells in human autoimmunity
by Ueno, Hideki
Current Opinion in Immunology, ISSN 0952-7915, 2016, Volume 43, pp. 24 - 31
Highlights • Tfh and GC response is hyperactivated in human autoimmune diseases. • Aberrant Tfh response can be monitored by the analysis of cTfh cells. •... 
Allergy and Immunology | B-CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | EARLY RHEUMATOID-ARTHRITIS | PRIMARY SJOGRENS-SYNDROME | DENDRITIC CELLS | LYMPHOID NEOGENESIS | MEMORY TFH CELLS | CHEMOATTRACTANT CXCL13 | IMMUNOLOGY | ANTIBODY-RESPONSES | MYASTHENIA-GRAVIS | Autoimmunity | T-Lymphocyte Subsets - immunology | B-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - immunology | Germinal Center - immunology | Humans | Autoimmune Diseases - immunology | Programmed Cell Death 1 Receptor - metabolism | Cell Differentiation | Inflammation | Inducible T-Cell Co-Stimulator Protein - metabolism | Autoantibodies - biosynthesis | Analysis
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4. Full Text Human Circulating T Follicular Helper Cell Subsets in Health and Disease
by Ueno, Hideki
Journal of Clinical Immunology, ISSN 0271-9142, 05/2016, Volume 36, Issue 1, pp. 34 - 39
T follicular helper (Tfh) cells are specialized to provide help to B cells and to induce durable antibody response. Our knowledge on the biology of Tfh cells... 
autoimmune diseases | ctfh cells | humans | T follicular helper cells | t cell differentiation | subsets | GERMINAL CENTER | IMMUNOLOGY | FH CELLS | CXC CHEMOKINE RECEPTOR-5 | LUPUS NEPHRITIS | IN-VIVO | MEMORY TFH CELLS | DIFFERENTIATION | ICOS | EXPRESSION | CENTER B-CELL | T-Lymphocyte Subsets - immunology | Gene Expression | Disease Susceptibility | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | T-Lymphocyte Subsets - cytology | Humans | Autoimmune Diseases - immunology | Autoimmune Diseases - genetics | Cell Differentiation - genetics | Cell Differentiation - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Animals | T-Lymphocyte Subsets - metabolism | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Biomarkers | Lymphocyte Count | Autoimmune Diseases - metabolism | Cell Movement | Viral antibodies | Antibodies | B cells | T cells | Cell differentiation | Vaccination
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5. Full Text Location, Location, Location
by Ueno, Hideki
Immunity, ISSN 1074-7613, 08/2018, Volume 49, Issue 2, pp. 197 - 199
The B7 receptor PD-1 is highly expressed by T follicular helper (Tfh) cells and represents one of the major markers for Tfh cells localized within the germinal... 
CELLS | CXCR3 | IMMUNOLOGY | Medical colleges | Antigens | Dendritic cells | PD-1 protein | Organs | Cytotoxicity | T cell receptors | Roles | Kinases | B7 antigen | Immunity | Germinal centers | Lymphocytes | Ligands | Chemokines | Binding sites
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6. Full Text Pathophysiology of T follicular helper cells in humans and mice
by Ueno, Hideki and Banchereau, Jacques and Vinuesa, Carola G
Nature Immunology, ISSN 1529-2908, 01/2015, Volume 16, Issue 2, pp. 142 - 152
Follicular helper T cells (T-FH cells) compose a heterogeneous subset of CD4(+) T cells that induce the differentiation of B cells into plasma cells and memory... 
GERMINAL CENTER FORMATION | CXC CHEMOKINE RECEPTOR-5 | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SIMIAN IMMUNODEFICIENCY VIRUS | PROTEIN-COUPLED RECEPTOR | NONOBESE DIABETIC MICE | CHRONIC LYMPHOCYTIC-LEUKEMIA | MEMORY TFH CELLS | IMMUNOLOGY | ANTIBODY-RESPONSES | CENTER B-CELL | T-Lymphocyte Subsets - immunology | Animals | T-Lymphocyte Subsets - pathology | T-Lymphocytes, Helper-Inducer - immunology | Humans | Palatine Tonsil - physiopathology | Immunologic Memory | T-Lymphocytes, Helper-Inducer - pathology | Antigen-Presenting Cells - immunology | Palatine Tonsil - immunology | Medical research | Immune response | Medicine, Experimental | Research | T cells | Cell differentiation | Health aspects
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7. Full Text Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial
by Anand, Sonia S and Bosch, Jackie and Eikelboom, John W and Connolly, Stuart J and Diaz, Rafael and Widimsky, Peter and Aboyans, Victor and Alings, Marco and Kakkar, Ajay K and Keltai, Katalin and Maggioni, Aldo P and Lewis, Basil S and Störk, Stefan and Zhu, Jun and Lopez-Jaramillo, Patricio and O'Donnell, Martin and Commerford, Patrick J and Vinereanu, Dragos and Pogosova, Nana and Ryden, Lars and Fox, Keith A A and Bhatt, Deepak L and Misselwitz, Frank and Varigos, John D and Vanassche, Thomas and Avezum, Alvaro A and Chen, Edmond and Branch, Kelley and Leong, Darryl P and Bangdiwala, Shrikant I and Hart, Robert G and Yusuf, Salim and SALA, JORGELINA and CARTASEGNA, LUIS and VICO, MARISA and HOMINAL, MIGUEL ANGEL and HASBANI, EDUARDO and CACCAVO, ALBERTO and ZAIDMAN, CESAR and VOGEL, DANIEL and HRABAR, ADRIAN and SCHYGIEL, PABLO OMAR and CUNEO, CARLOS and LUQUEZ, HUGO and MACKINNON, IGNACIO J and AHUAD GUERRERO, RODOLFO ANDRES and COSTABEL, JUAN PABLO and BARTOLACCI, INES PALMIRA and MONTANA, OSCAR and BARBIERI, MARIA and GOMEZ VILAMAJO, OSCAR and GARCIA DURAN, RUBEN OMAR and SCHIAVI, LILIA BEATRIZ and GARRIDO, MARCELO and INGARAMO, ADRIAN and BORDONAVA, ANSELMO PAULINO and PELAGAGGE, MARIA JOSE and NOVARETTO, LEONARDO and ALBISU DI GENNERO, JUAN PABLO and IBANEZ SAGGIA, LUZ MARIA and ALVAREZ, MOIRA and VITA, NESTOR ALEJANDRO and MACIN, STELLA MARIS and DRAN, RICARDO DARIO and CARDONA, MARCELO and GUZMAN, RANDOLPH and GUZMAN, LUIS and SARJANOVICH, RODOLFO JUAN and CUADRADO, JESUS and NANI, SEBASTIAN and LITVAK BRUNO, MARCOS RAUL and CHACON, CAROLINA and MAFFEI, LAURA ELENA and GRINFELD, DIEGO and VENSENTINI, NATALIA and MAJUL, CLAUDIO RODOLFO and LUCIARDI, HECTOR LUCAS and GONZALEZ COLASO, PATRICIA DEL CARMEN and FERRE PACORA, FREDY ANTONI and VAN DEN HEUVEL, PAUL and VERHAMME, PETER and ECTOR, BAVO and DEBONNAIRE, PHILIPPE and VAN DE BORNE, PHILIPPE and LEROY, JEAN and SCHROE, HERMAN and VRANCKX, PASCAL and ELEGEERT, IVAN and HOFFER, ETIENNE and DUJARDIN, KARL and INDIO DO BRASIL, CLARISSE and PRECOMA, DALTON and ABRANTES, JOSE ANTONIO and MANENTI, EULER and REIS, GILMAR and SARAIVA, JOSE and MAIA, LILIA and HERNANDES, MAURO and ROSSI, PAULO and ROSSI DOS SANTOS, FABIO and ... and COMPASS Investigators
The Lancet, ISSN 0140-6736, 01/2018, Volume 391, Issue 10117, pp. 219 - 229
Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these... 
MORTALITY | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | MANAGEMENT | THERAPY | OUTPATIENTS | CARDIOVASCULAR EVENT RATES | PREVENTION | RISK | Myocardial Infarction - epidemiology | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Carotid Artery Diseases - complications | Male | Peripheral Arterial Disease - complications | Rivaroxaban - administration & dosage | Aspirin - administration & dosage | Factor Xa Inhibitors - administration & dosage | Incidence | Dose-Response Relationship, Drug | Rivaroxaban - adverse effects | Aspirin - adverse effects | Platelet Aggregation Inhibitors - administration & dosage | Cardiovascular Diseases - mortality | Female | Stroke - epidemiology | Aspirin - therapeutic use | Lower Extremity - surgery | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Myocardial Infarction - etiology | Rivaroxaban - therapeutic use | Carotid Artery Diseases - drug therapy | Platelet Aggregation Inhibitors - adverse effects | Stroke - prevention & control | Double-Blind Method | Drug Administration Schedule | Peripheral Arterial Disease - drug therapy | Carotid Artery Diseases - epidemiology | Morbidity | Factor Xa Inhibitors - therapeutic use | Stroke - etiology | Peripheral Arterial Disease - epidemiology | Factor Xa Inhibitors - adverse effects | Aged | Myocardial Infarction - prevention & control | Amputation - statistics & numerical data | Hemorrhage - chemically induced | Lower Extremity - blood supply | Cardiac arrhythmia | Anticoagulants | Aspirin | Stroke | Heart attacks | Medical imaging | Mortality | Clinical trials | Cardiovascular disease | Patients | Disease control | Carotid arteries | Disease prevention | Coronary vessels | Blood pressure | Carotid artery | Acute coronary syndromes | Thromboembolism | Health risk assessment
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8. Full Text Phenotype and functions of memory Tfh cells in human blood
by Schmitt, Nathalie and Bentebibel, Salah-Eddine and Ueno, Hideki
Trends in Immunology, ISSN 1471-4906, 2014, Volume 35, Issue 9, pp. 436 - 442
Highlights • CXCR5+ CD4+ T cells represent a circulating memory compartment of Tfh lineage cells. • Blood memory Tfh cells are composed of phenotypically and... 
Allergy and Immunology | human blood | T follicular helper cells | subsets | Subsets | Human blood | CHEMOKINE RECEPTOR EXPRESSION | EXTRAFOLLICULAR ANTIBODY-RESPONSES | IMMUNOLOGY | HELPER T-CELLS | CUTTING EDGE | B-CELL | IMMUNE-RESPONSES | IN-VIVO | GERMINAL-CENTERS | DIFFERENTIATION | ICOS | T-Lymphocyte Subsets - immunology | Animals | Receptors, CXCR5 - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Humans | Autoimmune Diseases - immunology | Immunologic Memory | Immunophenotyping - methods | Vaccines | Blood Circulation | Blood Cells - immunology | Studies | Antigens | Genotype & phenotype | Hypotheses | Lymphocytes | Rodents | Influenza | Biology | Autoimmune diseases | Immune system
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9. Full Text Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial
by Connolly, Stuart J and Eikelboom, John W and Bosch, Jackie and Dagenais, Gilles and Dyal, Leanne and Lanas, Fernando and Metsarinne, Kaj and O'Donnell, Martin and Dans, Anthony L and Ha, Jong-Won and Parkhomenko, Alexandr N and Avezum, Alvaro A and Lonn, Eva and Lisheng, Liu and Torp-Pedersen, Christian and Widimsky, Petr and Maggioni, Aldo P and Felix, Camilo and Keltai, Katalin and Hori, Masatsugu and Yusoff, Khalid and Guzik, Tomasz J and Bhatt, Deepak L and Branch, Kelley R H and Cook Bruns, Nancy and Berkowitz, Scott D and Anand, Sonia S and Varigos, John D and Fox, Keith A A and Yusuf, Salim and SALA, JORGELINA and CARTASEGNA, LUIS and VICO, MARISA and HOMINAL, MIGUEL ANGEL and HASBANI, EDUARDO and CACCAVO, ALBERTO and ZAIDMAN, CESAR and VOGEL, DANIEL and HRABAR, ADRIAN and SCHYGIEL, PABLO OMAR and CUNEO, CARLOS and LUQUEZ, HUGO and MACKINNON, IGNACIO J and AHUAD GUERRERO, RODOLFO ANDRES and COSTABEL, JUAN PABLO and BARTOLACCI, INES PALMIRA and MONTANA, OSCAR and BARBIERI, MARIA and GOMEZ VILAMAJO, OSCAR and GARCIA DURAN, RUBEN OMAR and SCHIAVI, LILIA BEATRIZ and GARRIDO, MARCELO and INGARAMO, ADRIAN and BORDONAVA, ANSELMO PAULINO and PELAGAGGE, MARIA JOSE and NOVARETTO, LEONARDO and ALBISU DI GENNERO, JUAN PABLO and IBANEZ SAGGIA, LUZ MARIA and ALVAREZ, MOIRA and VITA, NESTOR ALEJANDRO and MACIN, STELLA MARIS and DRAN, RICARDO DARIO and CARDONA, MARCELO and GUZMAN, RANDOLPH and GUZMAN, LUIS and SARJANOVICH, RODOLFO JUAN and CUADRADO, JESUS and NANI, SEBASTIAN and LITVAK BRUNO, MARCOS RAUL and CHACON, CAROLINA and MAFFEI, LAURA ELENA and GRINFELD, DIEGO and VENSENTINI, NATALIA and MAJUL, CLAUDIO RODOLFO and LUCIARDI, HECTOR LUCAS and GONZALEZ COLASO, PATRICIA DEL CARMEN and FERRE PACORA, FREDY ANTONI and VAN DEN HEUVEL, PAUL and VERHAMME, PETER and ECTOR, BAVO and DEBONNAIRE, PHILIPPE and VAN DE BORNE, PHILIPPE and LEROY, JEAN and SCHROE, HERMAN and VRANCKX, PASCAL and ELEGEERT, IVAN and HOFFER, ETIENNE and DUJARDIN, KARL and INDIO DO BRASIL, CLARISSE and PRECOMA, DALTON and ABRANTES, JOSE ANTONIO and MANENTI, EULER and REIS, GILMAR and SARAIVA, JOSE and MAIA, LILIA and HERNANDES, MAURO and ROSSI, PAULO and ROSSI DOS SANTOS, FABIO and ZIMMERMANN, SERGIO LUIZ and RECH, RAFAEL and ... and COMPASS Investigators and COMPASS investigators
The Lancet, ISSN 0140-6736, 01/2018, Volume 391, Issue 10117, pp. 205 - 218
Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of... 
PREVENTION | MEDICINE, GENERAL & INTERNAL | ORAL RIVAROXABAN | Myocardial Infarction - epidemiology | Cardiovascular Diseases - prevention & control | Humans | Male | Rivaroxaban - administration & dosage | Aspirin - administration & dosage | Factor Xa Inhibitors - administration & dosage | Dose-Response Relationship, Drug | Rivaroxaban - adverse effects | Aspirin - adverse effects | Platelet Aggregation Inhibitors - administration & dosage | Cardiovascular Diseases - mortality | Female | Stroke - epidemiology | Aspirin - therapeutic use | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Rivaroxaban - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Stroke - prevention & control | Double-Blind Method | Drug Administration Schedule | Coronary Artery Disease - drug therapy | Morbidity | Factor Xa Inhibitors - therapeutic use | Factor Xa Inhibitors - adverse effects | Aged | Coronary Artery Disease - epidemiology | Myocardial Infarction - prevention & control | Hemorrhage - chemically induced | Anticoagulants | Aspirin | Stroke | Heart attacks | Mortality | Coronary artery | Clinical trials | Cardiovascular disease | Coronary artery disease | Disease control | Disease prevention | Coronary vessels | Acute coronary syndromes | Thromboembolism | Health risk assessment | Drug therapy | Heart diseases
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