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The Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2017, Volume 172, p. 231
Abiraterone acetate (AA), the prodrug of abiraterone, is FDA-approved for the treatment of castration-resistant prostate cancer. Abiraterone is metabolized in... 
Diastereoisomers | Mass spectroscopy | Liquid chromatography | Quantitation | Metabolites | Castration | Ionization | Formic acid | Acetonitrile | Acetic acid | Prostate cancer | Prostate | Validation studies | Steroids
Journal Article
AIDS Research and Human Retroviruses, ISSN 0889-2229, 09/2017, Volume 33, Issue 9, p. 941
This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of... 
Binding | Polysaccharides | Antibodies | Lectins | Mannose | Exposure | Masking | Epitopes | Neutralization
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 347 - 351
Prostate cancer resistance to castration occurs because tumours acquire the metabolic capability of converting precursor steroids to 5... 
ANDROGEN RECEPTOR | 3-BETA-HYDROXYSTEROID DEHYDROGENASE | CYP17A1 INHIBITION | MECHANISM | TESTOSTERONE | RATIONALE | MULTIDISCIPLINARY SCIENCES | INCREASED SURVIVAL | CHEMOTHERAPY | EXPOSURE | ENZALUTAMIDE | Chromatin - metabolism | Prostatic Neoplasms - metabolism | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Androgen Receptor Antagonists - therapeutic use | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Androgens - biosynthesis | Male | Androstenes - pharmacology | Androgen Receptor Antagonists - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Biotransformation | Cell Division | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Prostatic Neoplasms - drug therapy | Dihydrotestosterone - metabolism | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Androstenes - therapeutic use | 5-alpha Reductase Inhibitors - therapeutic use | Prostatic Neoplasms, Castration-Resistant - drug therapy | Phenylthiohydantoin - analogs & derivatives | Androgen Receptor Antagonists - metabolism | Xenograft Model Antitumor Assays | Androstenes - chemistry | Animals | Biosynthetic Pathways - drug effects | Survival Analysis | 5-alpha Reductase Inhibitors - pharmacology | Androstenes - metabolism | Prostatic Neoplasms - enzymology | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 5-alpha Reductase Inhibitors - metabolism | Androgens - metabolism | Enzymes | Testosterone | Androgens | Metabolites | Ligands | Gene expression | Prostate cancer | Tumors
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 547 - 551
Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer, which is otherwise driven by intratumoral... 
ACTIVATION | CYP17A1 INHIBITION | RAT | MULTIDISCIPLINARY SCIENCES | ANDROGEN-RECEPTOR | BIOLOGY | MEN | RESISTANCE | STEROID 5-ALPHA-REDUCTASE | DIHYDROTESTOSTERONE | DEHYDROGENASE | Physiological aspects | Prostate cancer | Care and treatment | Enzymes | Androgens | Metabolites | Oxidation | Metabolism | Gene expression | Steroids
Journal Article
Synthetic Communications, ISSN 0039-7911, 11/2011, Volume 41, Issue 21, pp. 3177 - 3185
A simple, efficient, safe, high-yielding and rapid microwave-assisted method for the preparation of protected p-bromomethyl and p-dibromomethylanilines was... 
microwave-assisted reactions | Benzyl bromides | NBS bromination | radical bromination | DESIGN | SIDE-CHAIN BROMINATION | BENZYLIC BROMINATIONS | ANTIFUNGAL ACTIVITY | CHEMISTRY, ORGANIC | MOLECULES | N-BROMOSUCCINIMIDE | SAPONINS | SYSTEMS | INHIBITORS | DERIVATIVES
Journal Article
Journal Article
Green Chemistry, ISSN 1463-9262, 01/2011, Volume 13, Issue 4, pp. 928 - 933
An environmentally friendly benzyl mono- and di-bromination synthetic procedure was developed that is superior to the classic carbon tetrachloride bromination... 
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 231 - 239
Journal Article
Folia microbiologica, ISSN 0015-5632, 05/2019, pp. 1 - 6
Ascochyta blight of chickpea is caused by Ascochyta rabiei (Pass.) Labr. which is primarily seedborne. For rapid detection and precise identification of A.... 
Amplification | Polymerase chain reaction | Pathogens | Plant diseases | Sensitivity | Sensitivity analysis | Blight | Chickpeas | Real time | Deoxyribonucleic acid--DNA
Journal Article
Journal Article
Synthetic Communications, ISSN 0039-7911, 11/2011, Volume 41, Issue 21, pp. 3177 - 3185
Journal Article
Journal of Clinical and Experimental Hepatology, ISSN 0973-6883, 2015, Volume 5, Issue 1, pp. 51 - 68
Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome. Prevalence of metabolic risk factors including diabetes mellitus,... 
Endocrinology & Metabolism | Gastroenterology and Hepatology | nonalcoholic steatohepatitis | NAFLD | cryptogenic cirrhosis | NASH | insulin resistance | Insulin resistance | Nonalcoholic steatohepatitis | Cryptogenic cirrhosis | IFG, Impaired Fasting Glucose | GTT, Glucose Tolerance Test | PROCAM, Prospective Cardiovascular Munster study | IGT, Impaired Glucose Tolerance | EBP, Enhancer-Binding Protein | VHCC, Virus-related HCC | MRE, Magnetic Resonance Elastography | MS, Metabolic syndrome | T2DM, Type 2 Diabetes Mellitus | PCOS, Polycystic Ovarian Syndrome | TTG, Anti-tissue transglutaminase | ALT, Alanine Aminotransferase | TG, Triglycerides | IR, Insulin resistance | ARFI, Acoustic Radiation Forced Impulse | HOMA-IR, Homeostasis Model Assessment for Insulin Resistance | PPG, Post-Prandial Glucose | EMA, Anti-Endomysial antibodies | FMD, Flow-Mediated Vasodilatation | CC, Cryptogenic Cirrhosis | VLDL, Very Low Density Lipoprotein | CT, Computed Tomography | FPG, Fasting Plasma Glucose | HCC, Hepatocellular Carcinoma | IRS-1, Insulin Receptor Substrate-1 | DM, Diabetes Mellitus | NAFLD, Non-alcoholic fatty liver disease | NF-κβ, Nuclear Factor Kappa Β | FFA, Free Fatty Acids | NASH, Non-Alcoholic Steatohepatitis | CAD, Coronary artery disease | AST, Aspartate Aminotransferase | WHO, World Health Organization | APO C3, Apolipoprotein C3 | HTN, Hypertension | NAFLD – Position Paper | IKK-β, Inhibitor of nuclear factor kappa-B kinase beta | BMI, Body mass index | ITT, Insulin Tolerance Test | TE, Transient elastography | CK 18, Cytokeratin 18 | HTG, Hepatic triglyceride | SREBP, Sterol-Regulatory Element-Binding Protein | LFTs, Liver Function Tests | ATPIII, Adult Treatment Panel III | CIMT, Carotid Intima Media Thickness
Journal Article
Nature, ISSN 0028-0836, 7/2015, Volume 523, Issue 7560, pp. 347 - 351
Prostate cancer resistance to castration occurs because tumors acquire the metabolic capability of converting precursor steroids to 5α-dihydrotestosterone... 
Journal Article
Green Chemistry, ISSN 1463-9262, 04/2011, Volume 13, Issue 4, pp. 928 - 933
An environmentally friendly benzyl mono- and di-bromination synthetic procedure was developed that is superior to the classic carbon tetrachloride bromination... 
PROTECTING GROUPS | SIDE-CHAIN BROMINATION | N-BROMOSUCCINIMIDE | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | WATER
Journal Article
Drug and Chemical Toxicology, ISSN 0148-0545, 01/2019, Volume 42, Issue 1, pp. 65 - 75
The present work discusses the establishment of a green route for the rapid synthesis of silver nanoparticles (AgNPs) using an alcoholic extract of Reinwardtia... 
cytotoxicity potential | antimicrobial activity | antioxidant activity | Silver nanoparticle | GREEN SYNTHESIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | LEAF | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2010, Volume 51, Issue 17, pp. 2215 - 2217
Microwave-assisted preparation of cyclic imides is superior with respect to isolated yield and length of reaction time when compared to conventional methods of... 
N-SUBSTITUTED MALEIMIDES | ORGANIC-SYNTHESIS | MITSUNOBU REACTION | IRRADIATION | MALEIC-ANHYDRIDE | ALKYL | HETEROCYCLES | ACIDS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | PHTHALIMIDE DERIVATIVES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2011, Volume 52, Issue 16, pp. 1835 - 1838
Tagged and activated -glucose was introduced as a building block for branched oligosaccharides. This building block was the oligosaccharide branching point at... 
CHEMISTRY, ORGANIC | CARBOHYDRATE | LIQUID SUPPORTED GLYCOSYLATION | SUGARS | Synthesis (chemistry) | Branched | Tetrahedrons | Glycosides | Activation | Oligosaccharides | Glucose | Monosaccharides
Journal Article