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1. Full Text The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus
by Akira Uruno and Yuki Furusawa and Yoko Yagishita and Toshiaki Fukutomi and Hiroyuki Muramatsu and Takaaki Negishi and Akira Sugawara and Thomas W. Kensler and Masayuki Yamamoto
Molecular and Cellular Biology, ISSN 0270-7306, 08/2013, Volume 33, Issue 15, pp. 2996 - 3010
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cytoskeletal Proteins - genetics | Diabetes Mellitus - genetics | Male | Muscle, Skeletal - metabolism | Obesity - genetics | Gene Knockdown Techniques | Gene Deletion | Cytoskeletal Proteins - metabolism | Female | NF-E2-Related Factor 2 - genetics | Kelch-Like ECH-Associated Protein 1 | Gluconeogenesis | Cell Line | Blood Glucose - analysis | Mice, Inbred C57BL | Gene Expression Regulation | Diabetes Mellitus - metabolism | Obesity - metabolism | Insulin - metabolism | Animals | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Blood Glucose - metabolism | Index Medicus
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2. Full Text The Keap1–Nrf2 system as an in vivo sensor for electrophiles
by Uruno, Akira and Motohashi, Hozumi
Nitric oxide, ISSN 1089-8603, 2011, Volume 25, Issue 2, pp. 153 - 160
Reactive cysteine | ARE/EpRE | Oxidative stress | Transcription | Electrophile | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Inactivation, Metabolic | Cell Proliferation | Oxidative Stress | Cytoskeletal Proteins - genetics | Humans | Transcriptional Activation | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Structure-Activity Relationship | Autophagy | Maf Transcription Factors, Small - genetics | Ubiquitination | Cell Nucleus - metabolism | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Xenobiotics - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Cytoprotection | Amino Acid Sequence | Signal Transduction | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Animals | Cell Nucleus - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Maf Transcription Factors, Small - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Nitric Oxide - metabolism | Ubiquitin | Hydrogen peroxide | Quinone | Amino acids | Glutamate | Antioxidants | Chemotherapy | Ligases | Glutathione transferase | Nitric oxide | Heme | Sensors | Cancer | Index Medicus
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3. Full Text Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study
by Kogure, Mana and Hirata, Takumi and Nakaya, Naoki and Tsuchiya, Naho and Nakamura, Tomohiro and Narita, Akira and Miyagawa, Ken and Koshimizu, Hiroshi and Obara, Taku and Metoki, Hirohito and Uruno, Akira and Kikuya, Masahiro and Sugawara, Junichi and Kuriyama, Shinichi and Tsuji, Ichiro and Kure, Shigeo and Hozawa, Atsushi
Hypertension research, ISSN 0916-9636, 01/2020, Volume 43, Issue 1, pp. 62 - 71
Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hypertension | Sodium | Potassium | Home health care | Monitoring systems | Index Medicus
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4. Full Text Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults
by Hirata, Takumi and Nakamura, Tomohiro and Kogure, Mana and Tsuchiya, Naho and Narita, Akira and Miyagawa, Ken and Nochioka, Kotaro and Uruno, Akira and Obara, Taku and Nakaya, Naoki and Metoki, Hirohito and Kikuya, Masahiro and Sugawara, Junichi and Kuriyama, Shinichi and Tsuji, Ichiro and Kure, Shigeo and Hozawa, Atsushi
Hypertension research, ISSN 0916-9636, 01/2020, Volume 43, Issue 1, pp. 23 - 29
Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Hypertension | Blood pressure | Efficiency | Sleep deprivation | Index Medicus
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5. Full Text The Keap1–Nrf2 system and diabetes mellitus
by Uruno, Akira and Yagishita, Yoko and Yamamoto, Masayuki
Archives of biochemistry and biophysics, ISSN 0003-9861, 01/2015, Volume 566, pp. 76 - 84
Keap1 | Glucose metabolism | Pancreatic β-cells | Nrf2 | Diabetes mellitus | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Oxidative Stress | Signal Transduction | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin-Secreting Cells - metabolism | Ubiquitination | Animals | Proteolysis | NF-E2-Related Factor 2 - metabolism | NF-E2-Related Factor 2 - genetics | Diabetes Mellitus, Type 2 - pathology | Insulin-Secreting Cells - pathology | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Pancreatic beta cells | Diabetes | Index Medicus
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6. Full Text Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma
by Inoue, Daisuke and Suzuki, Takashi and Mitsuishi, Yoichiro and Miki, Yasuhiro and Suzuki, Satoshi and Sugawara, Shunichi and Watanabe, Mika and Sakurada, Akira and Endo, Chiaki and Uruno, Akira and Sasano, Hironobu and Nakagawa, Takayuki and Satoh, Kennichi and Tanaka, Nobuyuki and Kubo, Hiroshi and Motohashi, Hozumi and Yamamoto, Masayuki
Cancer science, ISSN 1347-9032, 04/2012, Volume 103, Issue 4, pp. 760 - 766
Life Sciences & Biomedicine | Oncology | Science & Technology | Prognosis | Lung Neoplasms - mortality | Sequestosome-1 Protein | Humans | Lung Neoplasms - metabolism | Middle Aged | Carcinoma, Non-Small-Cell Lung - metabolism | Male | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - metabolism | Animals | NF-E2-Related Factor 2 - metabolism | Female | Aged | Mice | Adaptor Proteins, Signal Transducing - metabolism | Adenocarcinoma - mortality | Index Medicus | Original
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7. Full Text Nrf2 protects pancreatic β-cellss from oxidative and nitrosative stress in diabetic model mice
by Yagishita, Yoko and Fukutomi, Toshiaki and Sugawara, Akira and Kawamura, Hiroshi and Takahashi, Tetsu and Pi, Jingbo and Uruno, Akira and Yamamoto, Masayuki
Diabetes (New York, N.Y.), ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 605 - 618
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8. Full Text Nrf2 Protects Pancreatic beta-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice
by Yagishita, Yoko and Fukutomi, Toshiaki and Sugawara, Akira and Kawamura, Hiroshi and Takahashi, Tetsu and Pi, Jingbo and Uruno, Akira and Yamamoto, Masayuki
Diabetes (New York, N.Y.), ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 605 - 618
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Oxidative Stress | Cytoskeletal Proteins - genetics | Diabetes Mellitus - genetics | Oleanolic Acid - analogs & derivatives | Insulin-Secreting Cells - metabolism | Aging | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Insulin - genetics | Kelch-Like ECH-Associated Protein 1 | Promoter Regions, Genetic | Diabetes Mellitus - metabolism | Gene Expression Regulation - physiology | Rats | Blood Glucose | Mice, Transgenic | Mice, Knockout | Insulin - metabolism | Animals | Imidazoles | Nitric Oxide Synthase Type II - genetics | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Abridged Index Medicus
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9. Keapl-Nrf2 system in the maintenance of glucose metabolisms homeostasis
by Uruno, Akira
Seikagaku, ISSN 0037-1017, 2018, Volume 90, Issue 1, pp. 103 - 106
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10. Full Text Effects of PPARγ on hypertension, atherosclerosis, and chronic kidney disease
by Sugawara, Akira and Uruno, Akira and Kudo, Masataka and Matsuda, Ken and Yang, Chul Woo and Ito, Sadayoshi
Endocrine journal, ISSN 0918-8959, 2010, Volume 57, Issue 10, pp. 847 - 852
Thromboxane | Angiotensin II | Thiazolidinediones | Kidney | Endothelium | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Antihypertensive Agents - pharmacology | Atherosclerosis - drug therapy | Vasodilator Agents - pharmacology | Vasodilator Agents - therapeutic use | Humans | Hypertension - drug therapy | Antihypertensive Agents - therapeutic use | Atherosclerosis - metabolism | Disease Progression | Hypertension - metabolism | Renal Insufficiency, Chronic - drug therapy | Renal Insufficiency, Chronic - metabolism | PPAR gamma - physiology | Thiazolidinediones - therapeutic use | Animals | Kidney Failure, Chronic - prevention & control | PPAR gamma - agonists | Ligands | Thiazolidinediones - pharmacology | Diabetic Nephropathies - prevention & control | PPAR gamma - genetics | Index Medicus
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11. Full Text Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress
by Yagishita, Yoko and Uruno, Akira and Fukutomi, Toshiaki and Saito, Ritsumi and Saigusa, Daisuke and Pi, Jingbo and Fukamizu, Akiyoshi and Sugiyama, Fumihiro and Takahashi, Satoru and Yamamoto, Masayuki
Cell reports (Cambridge), ISSN 2211-1247, 02/2017, Volume 18, Issue 8, pp. 2030 - 2044
leptin resistance | Nrf2 | proopiomelanocortin | pancreatic beta-cells | Trsp | selenoproteins | insulin resistance | oxidative stress | hypothalamus | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Antioxidants - metabolism | Leptin - metabolism | Oxidative Stress - physiology | Diabetes Mellitus - metabolism | RNA, Transfer, Amino Acid-Specific - metabolism | Mice, Knockout | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Hypothalamus - metabolism | Promoter Regions, Genetic - physiology | Insulin Resistance - physiology | NF-E2-Related Factor 2 - metabolism | Signal Transduction - physiology | Mice | Index Medicus
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