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Science, ISSN 0036-8075, 8/2010, Volume 329, Issue 5993, pp. 841 - 845
African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis... 
Haplotypes | Kidneys | Focal segmental glomerulosclerosis | REPORTS | Diabetic nephropathies | African Americans | Disease risk | Kidney diseases | Chromosomes | Genetic mutation | Genotypes | 9 GENE MYH9 | POLYMORPHISMS | POSITIVE SELECTION | MULTIDISCIPLINARY SCIENCES | NATURAL-SELECTION | RHODESIENSE | HUMAN SERUM | STAGE RENAL-DISEASE | GENOME | Sequence Deletion | Lipoproteins, HDL - genetics | Lipoproteins, HDL - blood | Glomerulosclerosis, Focal Segmental - genetics | Humans | Lipoproteins, HDL - metabolism | Myosin Heavy Chains - genetics | Kidney Failure, Chronic - ethnology | Molecular Motor Proteins - genetics | Case-Control Studies | Trypanosoma brucei rhodesiense - metabolism | Apolipoproteins - genetics | Glomerulosclerosis, Focal Segmental - ethnology | Trypanosomiasis, African - genetics | Recombinant Proteins - metabolism | Genetic Predisposition to Disease | Genetic Association Studies | Apolipoproteins - metabolism | Gene Frequency | Africa | Selection, Genetic | African Americans - genetics | Logistic Models | Apolipoproteins - blood | Immunity, Innate | Linkage Disequilibrium | Kidney Failure, Chronic - genetics | Trypanosomiasis, African - parasitology | Alleles | Apolipoprotein L1 | Hypertension - complications | Polymorphism, Single Nucleotide | Cohort Studies | Kidney Failure, Chronic - etiology | Genetic aspects | Demographic aspects | Health aspects | Proteins | Mutation | Population genetics
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7467, pp. 430 - 434
The African parasite Trypanosoma brucei gambiense accounts for 97% of human sleeping sickness cases(1). T. b. gambiense resists the specific human innate... 
GENE | BLOOD-STREAM FORMS | HAPTOGLOBIN-HEMOGLOBIN RECEPTOR | MULTIDISCIPLINARY SCIENCES | LYTIC FACTOR | MEMBRANES | DIFFERENTIATION | GLYCOPROTEIN | TRYPANOLYTIC FACTOR | EXPRESSION | INNATE IMMUNITY | Parasites - physiology | Variant Surface Glycoproteins, Trypanosoma - metabolism | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | Serum - parasitology | Cysteine Proteases - metabolism | Haptoglobins - metabolism | Apolipoproteins - antagonists & inhibitors | Cell Membrane - chemistry | Trypanosoma brucei gambiense - drug effects | Lipoproteins, HDL - antagonists & inhibitors | Lipoproteins, HDL - chemistry | Parasites - pathogenicity | Cell Membrane - metabolism | Apolipoproteins - toxicity | Trypanosoma brucei gambiense - physiology | Hemolysis | Protein Structure, Secondary | Animals, Genetically Modified | Apolipoproteins - metabolism | Trypanosoma brucei gambiense - pathogenicity | Africa | Hemoglobins - metabolism | Lipid Metabolism | Apolipoproteins - blood | Trypanosomiasis, African - parasitology | Animals | Apolipoprotein L1 | Lipoproteins, HDL - toxicity | Hydrophobic and Hydrophilic Interactions | Variant Surface Glycoproteins, Trypanosoma - chemistry | Serum - chemistry | Physiological aspects | Lipid membranes | Serum | Properties | Trypanosoma brucei | Peptides | Parasites | Mutation | Chemical Sciences
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6093, pp. 463 - 466
The parasite Trypanosoma brucei possesses a large family of transmembrane receptor—like adenylate cyclases. Activation of these enzymes requires the... 
Myeloid cells | Plasmids | Liver | REPORTS | Cell lines | Infections | Parasitism | Parasites | Parasitemia | Trypanosome | Parasite hosts | ACTIVATION | INFECTIONS | DOMAIN | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | GENES | SURFACE GLYCOPROTEIN | ALPHA | AFRICAN TRYPANOSOMIASIS | EXPRESSION SITE | FAMILY | Tumor Necrosis Factor-alpha - blood | Protozoan Proteins - genetics | Trypanosoma brucei brucei - enzymology | Recombinant Fusion Proteins - metabolism | Protozoan Proteins - metabolism | Myeloid Cells - immunology | Protozoan Proteins - chemistry | Host-Parasite Interactions | Cyclic AMP - metabolism | Trypanosoma brucei brucei - growth & development | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Catalytic Domain | Mutagenesis, Site-Directed | Mice, Inbred C57BL | Trypanosomiasis, African - metabolism | Adenylyl Cyclases - metabolism | Immunity, Innate | Trypanosomiasis, African - immunology | Trypanosomiasis, African - parasitology | Animals | Adenylyl Cyclases - chemistry | Liver - cytology | Mice | Enzyme Activation | Adenylyl Cyclases - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Phagocytosis | Trypanosoma brucei brucei - immunology | Physiological aspects | Host-parasite relationships | Enzymes | Immune response | Trypanosoma | Health aspects | Proteins | Parasitology | Immunology | Genomics | Kinases | Polymorphism
Journal Article
European Journal of Immunology, ISSN 0014-2980, 08/2016, Volume 46, Issue 8, pp. 1854 - 1866
Journal Article
Journal Article
Nutrition and Metabolism, ISSN 1743-7075, 11/2016, Volume 13, Issue 1, pp. 1 - 13
Background: Metabolic syndrome (MetS) is characterized by systemic disturbances that increase cardiovascular risk. Adiponectin (Ad) exhibits a cardioprotective... 
Animal model | Obesity | Differential regulation | Multimer | Metabolic syndrome | MOLECULAR-WEIGHT ADIPONECTIN | ADIPOR2 | INDUCED INSULIN-RESISTANCE | BETA-CELL FUNCTION | SKELETAL-MUSCLE | NUTRITION & DIETETICS | ADIPOKINES | GENE-EXPRESSION | LEPTIN RESISTANCE | Nutrition | Metabolism
Journal Article
Molecular Microbiology, ISSN 0950-382X, 08/2015, Volume 97, Issue 3, p. 397
  Human apolipoprotein L1 (APOL1) kills African trypanosomes except Trypanosoma rhodesiense and Trypanosoma gambiense, the parasites causing sleeping sickness.... 
Hemoglobin | Glycoproteins | Parasites | RNA polymerase | Apolipoproteins | Gene expression
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2013, Volume 9, Issue 10, p. e1003731
Journal Article
Molecular Microbiology, ISSN 0950-382X, 11/2014, Volume 94, Issue 3, pp. 625 - 636
Journal Article
Molecular Microbiology, ISSN 0950-382X, 11/2014, Volume 94, Issue 3, p. 625
  Normal human serum (NHS) confers human resistance to infection by the parasite Trypanosoma brucei owing to the trypanolytic activity of apolipoprotein L1... 
Genomics | Hemoglobin | Bacteria | Apolipoproteins | Ribonucleic acid--RNA | Deoxyribonucleic acid--DNA
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2013, Volume 9, Issue 10
  Background In order to promote infection, the blood-borne parasite Trypanosoma brucei releases factors that upregulate arginase expression and activity in... 
Immunology | Rodents | Liver | Infections | Parasites | Gene expression | Polyamines
Journal Article
Molecular Microbiology, ISSN 0950-382X, 08/2015, Volume 97, Issue 3, pp. 397 - 407
Summary Human apolipoprotein L1 (APOL1) kills African trypanosomes except Trypanosoma rhodesiense and Trypanosoma gambiense, the parasites causing sleeping... 
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