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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 11/2018, Volume 175, Issue 4, pp. 901 - 902
Diseases leading to immune activation and autoinflammatory phenotypes may provide a reservoir of potentially druggable pathways for optimizing immune adjuvants... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | G proteins | Immunotherapy | Statins | Resveratrol
Journal Article
Journal Article
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 7/2019, Volume 68, Issue 7, pp. 1171 - 1178
Immune checkpoint inhibitors are now standard-of-care treatments for metastatic cutaneous melanoma. However, for rare sub-groups, such as mucosal melanomas,... 
Pembrolizumab | Immunology | Medicine & Public Health | Immunotherapy | Ipilimumab | Anti-CTLA4 | Oncology | Cancer Research | Anti-PD1 | Mucosal melanoma | SURVIVAL | SAFETY | CHOICE CHEMOTHERAPY | COMBINED NIVOLUMAB | OPEN-LABEL | IMMUNOLOGY | CHECKMATE 037 | ONCOLOGY | UVEAL | ANTI-PD-1 | Metastasis | Drug therapy | Health aspects | Analysis | Melanoma | CTLA-4 protein | Mucosal immunity | Immune checkpoint | Rectum | Vagina | Head and neck | Tumors | Metastases | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 758 - 758
Journal Article
Cancer Research, ISSN 0008-5472, 11/2009, Volume 69, Issue 21, pp. 8332 - 8340
Journal Article
by Aaij, R and Adeva, B and Adinolfi, M and Aidala, CA and Ajaltouni, Z and Akar, S and Albicocco, P and Albrecht, J and Alessio, F and Alexander, M and Albero, AA and Ali, S and Alkhazov, G and Cartelle, PA and Alves, AA and Amato, S and Amerio, S and Amhis, Y and An, L and Anderlini, L and Andreassi, G and Andreotti, M and Andrews, JE and Appleby, RB and Archilli, F and d'Argent, P and Romeu, JA and Artamonov, A and Artuso, M and Arzymatov, K and Aslanides, E and Atzeni, M and Audurier, B and Bachmann, S and Back, JJ and Baker, S and Balagura, V and Baldini, W and Baranov, A and Barlow, RJ and Barsuk, S and Barter, W and Baryshnikov, F and Batozskaya, V and Batsukh, B and Battista, V and Bay, A and Beddow, J and Bedeschi, F and Bediaga, I and Beiter, A and Bel, LJ and Beliy, N and Bellee, V and Belloli, N and Belous, K and Belyaev, I and Ben-Haim, E and Bencivenni, G and Benson, S and Beranek, S and Berezhnoy, A and Bernet, R and Berninghoff, D and Bertholet, E and Bertolin, A and Betancourt, C and Betti, F and Bettler, MO and van Beuzekom, M and Bezshyiko, I and Bhasin, S and Bhom, J and Bian, L and Bifani, S and Billoir, P and Birnkraut, A and Bizzeti, A and Bjorn, M and Blago, MP and Blake, T and Blanc, F and Blusk, S and Bobulska, D and Bocci, V and Garcia, OB and Boettcher, T and Bondar, A and Bondar, N and Borghi, S and Borisyak, M and Borsato, M and Bossu, F and Boubdir, M and Bowcock, TJV and Bozzi, C and Braun, S and Brodski, M and Brodzicka, J and Gonzalo, AB and ... and LHCb Collaboration
PHYSICAL REVIEW LETTERS, ISSN 0031-9007, 07/2018, Volume 121, Issue 5
The first measurement of the lifetime of the doubly charmed baryon Xi(++)(cc) is presented, with the signal reconstructed in the final state Lambda... 
HEAVY BARYONS | DECAY | PHYSICS, MULTIDISCIPLINARY | TOOL | Physics - High Energy Physics - Experiment
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2012, Volume 18, Issue 1, pp. 263 - 272
Journal Article
by Aaij, R and Abellán Beteta, C and Adeva, B and Adinolfi, M and Aidala, C A and Ajaltouni, Z and Akar, S and Albicocco, P and Albrecht, J and Alessio, F and Alexander, M and Alfonso Albero, A and Alkhazov, G and Alvarez Cartelle, P and Alves Jr, A A and Amato, S and Amerio, S and Amhis, Y and An, L and Anderlini, L and Andreassi, G and Andreotti, M and Andrews, J E and Archilli, F and d’Argent, P and Arnau Romeu, J and Artamonov, A and Artuso, M and Arzymatov, K and Aslanides, E and Atzeni, M and Audurier, B and Bachmann, S and Back, J J and Baker, S and Balagura, V and Baldini, W and Baranov, A and Barlow, R J and Barrand, G C and Barsuk, S and Barter, W and Bartolini, M and Baryshnikov, F and Batozskaya, V and Batsukh, B and Battig, A and Battista, V and Bay, A and Beddow, J and Bedeschi, F and Bediaga, I and Beiter, A and Bel, L J and Belin, S and Beliy, N and Bellee, V and Belloli, N and Belous, K and Belyaev, I and Ben-Haim, E and Bencivenni, G and Benson, S and Beranek, S and Berezhnoy, A and Bernet, R and Berninghoff, D and Bertholet, E and Bertolin, A and Betancourt, C and Betti, F and Bettler, M O and van Beuzekom, M and Bezshyiko, Ia and Bhasin, S and Bhom, J and Bifani, S and Billoir, P and Birnkraut, A and Bizzeti, A and Bjørn, M and Blago, M P and Blake, T and Blanc, F and Blusk, S and Bobulska, D and Bocci, V and Boente Garcia, O and Boettcher, T and Bondar, A and Bondar, N and Borghi, S and Borisyak, M and Borsato, M and Bossu, F and Boubdir, M and Bowcock, T J. V and Bozzi, C and Braun, S and Brodski, M and ... and LHCb Collaboration and The LHCb collaboration
Journal of High Energy Physics, ISSN 1029-8479, 4/2019, Volume 2019, Issue 4, pp. 1 - 36
Journal Article
Physical Review Letters, ISSN 0031-9007, 09/2017, Volume 119, Issue 11
A highly significant structure is observed in the Lambda K-+(c)-pi(+)pi(+) mass spectrum, where the Lambda(+)(c) baryon is reconstructed in the decay mode... 
MONTE-CARLO | GENERATOR | MASSES | B-C MESONS | DECAY | SPECTROSCOPY | PHYSICS, MULTIDISCIPLINARY | HADRONIC PRODUCTION | VERSION | HEAVY BARYONS | GENXICC | Physics - High Energy Physics - Experiment
Journal Article
by Aaij, R and Beteta, CA and Adeva, B and Adinolfi, M and Aidala, CA and Ajaltouni, Z and Akar, S and Albicocco, P and Albrecht, J and Alessio, F and Alexander, M and Albero, AA and Alkhazov, G and Cartelle, PA and Alves, AA and Amato, S and Amhis, Y and An, L and Anderlini, L and Andreassi, G and Andreotti, M and Andrews, JE and Archilli, F and Romeu, JA and Artamonov, A and Artuso, M and Arzymatov, K and Aslanides, E and Atzeni, M and Audurier, B and Bachmann, S and Back, JJ and Baker, S and Balagura, V and Baldini, W and Baranov, A and Barlow, RJ and Barsuk, S and Barter, W and Bartolini, M and Baryshnikov, F and Batozskaya, V and Batsukh, B and Battig, A and Battista, V and Bay, A and Bedeschi, F and Bediaga, I and Beiter, A and Bel, LJ and Belin, S and Beliy, N and Bellee, V and Belloli, N and Belous, K and Belyaev, I and Bencivenni, G and Ben-Haim, E and Benson, S and Beranek, S and Berezhnoy, A and Bernet, R and Berninghoff, D and Bertholet, E and Bertolin, A and Betancourt, C and Betti, F and Bettler, MO and Bezshyiko, I and Bhasin, S and Bhom, J and Bieker, MS and Bifani, S and Billoir, P and Birnkraut, A and Bizzeti, A and Bjorn, M and Blago, MP and Blake, T and Blanc, F and Blusk, S and Bobulska, D and Bocci, V and Garcia, OB and Boettcher, T and Bondar, A and Bondar, N and Borghi, S and Borisyak, M and Borsato, M and Boubdir, M and Bowcock, TJV and Bozzi, C and Braun, S and Brodski, M and Brodzicka, J and Gonzalo, AB and Brundu, D and Buchanan, E and Buonaura, A and ...
PHYSICAL REVIEW LETTERS, ISSN 0031-9007, 07/2019, Volume 123, Issue 3
The radiative decay Lambda(0 )(b)-> Lambda gamma is observed for the first time using a data sample of proton-proton collisions corresponding to an integrated... 
PHYSICS, MULTIDISCIPLINARY | POLARIZATION | TOOL | Physics - High Energy Physics - Experiment
Journal Article
by Aaij, R and Abellán Beteta, C and Adeva, B and Adinolfi, M and Aidala, C. A and Ajaltouni, Z and Akar, S and Albicocco, P and Albrecht, J and Alessio, F and Alexander, M and Alfonso Albero, A and Alkhazov, G and Alvarez Cartelle, P and Alves, A. A and Amato, S and Amhis, Y and An, L and Anderlini, L and Andreassi, G and Andreotti, M and Andrews, J. E and Archilli, F and d’Argent, P and Arnau Romeu, J and Artamonov, A and Artuso, M and Arzymatov, K and Aslanides, E and Atzeni, M and Audurier, B and Bachmann, S and Back, J. J and Baker, S and Balagura, V and Baldini, W and Baranov, A and Barlow, R. J and Barsuk, S and Barter, W and Bartolini, M and Baryshnikov, F and Batozskaya, V and Batsukh, B and Battig, A and Battista, V and Bay, A and Bedeschi, F and Bediaga, I and Beiter, A and Bel, L. J and Belin, S and Beliy, N and Bellee, V and Belloli, N and Belous, K and Belyaev, I and Ben-Haim, E and Bencivenni, G and Benson, S and Beranek, S and Berezhnoy, A and Bernet, R and Berninghoff, D and Bertholet, E and Bertolin, A and Betancourt, C and Betti, F and Bettler, M. O and van Beuzekom, M and Bezshyiko, Ia and Bhasin, S and Bhom, J and Bieker, M. S and Bifani, S and Billoir, P and Birnkraut, A and Bizzeti, A and Bjørn, M and Blago, M. P and Blake, T and Blanc, F and Blusk, S and Bobulska, D and Bocci, V and Boente Garcia, O and Boettcher, T and Bondar, A and Bondar, N and Borghi, S and Borisyak, M and Borsato, M and Boubdir, M and Bowcock, T. J. V and Bozzi, C and Braun, S and Brodski, M and Brodzicka, J and Brossa Gonzalo, A and Brundu, D and ... and LHCb Collaboration
Physical Review Letters, ISSN 0031-9007, 05/2019, Volume 122, Issue 21, pp. 1 - 211803
A search for charge-parity (CP) violation in D0→K−K+ and D0→π−π+ decays is reported, using pp collision data corresponding to an integrated luminosity of 5.9 ... 
Hadrons | Mesons | Flavor (particle physics) | Decay | Luminosity | Charm (particle physics) | Matter & antimatter
Journal Article