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Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7280, pp. 501 - 506
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr-Abl, we recently reported the discovery of... 
CELL LUNG-CANCER | KINASE-INHIBITOR | SELECTIVE INHIBITOR | C-ABL | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | DYNAMICS | MUTATIONS | LYMPHOBLASTIC-LEUKEMIA | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Transplantation, Heterologous | Piperazines - chemistry | Pyrimidines - chemistry | Pyrimidines - metabolism | Antineoplastic Agents - metabolism | Mass Spectrometry | Bone Marrow Transplantation | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Binding Sites | Disease Models, Animal | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Crystallization | Antineoplastic Combined Chemotherapy Protocols | Models, Molecular | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mutation - genetics | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - genetics | Animals | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Benzamides | Fusion Proteins, bcr-abl - metabolism | Drug Resistance, Neoplasm - drug effects | Nilotinib | Dasatinib | Drug resistance in microorganisms | Usage | Nuclear magnetic resonance spectroscopy | Research | Chronic myeloid leukemia | X-ray crystallography | Chromosome abnormalities | Gene mutations | Analysis | Genetic aspects | Diagnosis | Binding proteins | Drug therapy | Health aspects | Proteins | Studies | Competition | Enzymes | E coli | Kinases | Drug resistance | Crystal structure | Index Medicus
Journal Article
Scientific reports, ISSN 2045-2322, 07/2016, Volume 6, Issue 1, p. 29706
The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. The structural/dynamic behavior of the complex... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2013, Volume 110, Issue 5, p. E368
  Proteins denature not only at high, but also at low temperature as well as high pressure. These denatured states are not easily accessible for experiment,... 
Proteins | Temperature | Nuclear magnetic resonance--NMR | Atmospheric pressure | Protein folding | Alcohol | Methanol
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2010, Volume 132, Issue 9, pp. 3196 - 3203
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 03/2010, Volume 132, Issue 9, pp. 3196 - 3203
Journal Article
ChemBioChem, ISSN 1439-4227, 09/2013, Volume 14, Issue 14, p. 1799
  Protein kinases are highly dynamic and complex molecules. Here we present high-pressure and relaxation studies of the activated p38[alpha] mitogen-activated... 
Kinases | Bioinformatics
Journal Article
ChemBioChem, ISSN 1439-4227, 09/2013, Volume 14, Issue 14, p. 1799
Protein kinases are highly dynamic and complex molecules. Here we present high-pressure and relaxation studies of the activated p38[alpha] mitogen-activated... 
Rheumatoid factor | Nuclear magnetic resonance spectroscopy | Phosphotransferases | Mitogens
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2010, Volume 132, Issue 9, pp. 3196 - 3203
Journal Article
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