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by Andersson, Robin and Gebhard, Claudia and Miguel-Escalada, Irene and Hoof, Ilka and Bornholdt, Jette and Boyd, Mette and Chen, Yun and Zhao, Xiaobei and Schmidl, Christian and Suzuki, Takahiro and Ntini, Evgenia and Arner, Erik and Valen, Eivind and Li, Kang and Schwarzfischer, Lucia and Glatz, Dagmar and Raithel, Johanna and Lilje, Berit and Rapin, Nicolas and Bagger, Frederik Otzen and Jørgensen, Mette and Andersen, Peter Refsing and Bertin, Nicolas and Rackham, Owen and Burroughs, A. Maxwell and Baillie, J. Kenneth and Ishizu, Yuri and Shimizu, Yuri and Furuhata, Erina and Maeda, Shiori and Negishi, Yutaka and Mungall, Christopher J and Meehan, Terrence F and Lassmann, Timo and Itoh, Masayoshi and Kawaji, Hideya and Kondo, Naoto and Kawai, Jun and Lennartsson, Aneas and Daub, Carsten O and Heutink, Peter and Hume, David A and Jensen, Torben Heick and Suzuki, Harukazu and Hayashizaki, Yoshihide and Müller, Ferenc and Forrest, Alistair R. R and Carninci, Piero and Rehli, Michael and Sandelin, Albin and de Hoon, Michiel J. L and Haberle, Vanja and Kulakovskiy, Ivan V and Lizio, Marina and Mungall, Christoher J and Schmeier, Sebastian and Dimont, Emmanuel and Schmid, Christian and Schaefer, Ulf and Medvedeva, Yulia A and Plessy, Charles and Vitezic, Morana and Severin, James and Semple, Colin A and Young, Robert S and Francescatto, Margherita and Alam, Intikhab and Albanese, Davide and Altschuler, Gabriel M and Arakawa, Takahiro and Archer, John A. C and Arner, Peter and Babina, Magda and Rennie, Sarah and Balwierz, Piotr J and Beckhouse, Anthony G and Pradhan-Bhatt, Swati and Blake, Judith A and Blumenthal, Antje and Bodega, Beatrice and Bonetti, Alessano and Briggs, James and Brombacher, Frank and Califano, Anea and Cannistracti, Carlo V and Carbajo, Daniel and Chierici, Marco and Ciani, Yari and Clevers, Hans C and Dalla, Emiliano and Davis, Carrie A and Detmar, Michael and Diehl, Alexander D and Dohi, Taeko and bløs, Finn and Edge, Albert S. B and Edinger, Matthias and Ekwall, Karl and Endoh, Mitsuhiro and Enomoto, Hideki and ... and FANTOM Consortium and The FANTOM Consortium
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 455 - 461
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2013, Volume 20, Issue 8, pp. 923 - 928
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 07/2014, Volume 42, Issue 1, pp. W401 - W407
Major advances in genome editing have recently been made possible with the development of the TALEN and CRISPR/Cas9 methods. The speed and ease of implementing... 
EFFECTORS | MUTAGENESIS | SPECIFICITY | DESIGN TOOL | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRISPR-CAS9 SYSTEM | GENES | XENOPUS-TROPICALIS | DROSOPHILA | CAS9 NUCLEASE | RNA, Guide - metabolism | Humans | Rats | Deoxyribonucleases - metabolism | Algorithms | Animals | Genetic Engineering | CRISPR-Cas Systems | Mice | Software | Internet | Genome | Genomics - methods
Journal Article
Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, pp. 11750 - 11750
The CRISPR/Cas system uses guide RNAs (gRNAs) to direct sequence-specific DNA cleavage. Not every gRNA elicits cleavage and the mechanisms that govern gRNA... 
SYSTEM | CRISPR | DESIGN | COMPLEX | HUMAN GENOME | ENDONUCLEASE | ZEBRAFISH | DETERMINANTS | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | TARGET DNA | Animals | RNA, Guide - chemistry | RNA, Guide - metabolism | Base Sequence | CRISPR-Associated Proteins - metabolism | Zebrafish | Genome | Nucleic Acid Conformation | Index Medicus
Journal Article